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Marine Drugs Apr 2022Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents... (Review)
Review
Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pharmaceutical uses of fucoxanthin for boosting human health and disease management. Due to its unique chemical structure and action as a single compound with multi-targets of health effects, it has attracted mounting attention from the scientific community, resulting in an escalated number of scientific publications from January 2017 to February 2022. Fucoxanthin has remained the most popular option for anti-cancer and anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory and microbial diseases, in a variety of model systems. Despite much pharmacological evidence from in vitro and in vivo findings, fucoxanthin in clinical research is still not satisfactory, because only one clinical study on obesity management was reported in the last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, and clinical perspective of fucoxanthin are substantially addressed. Nevertheless, fucoxanthin and its derivatives are shown to be safe, non-toxic, and readily available upon administration. This review will provide pharmacological insights into fucoxanthin, underlying the diverse molecular mechanisms of health benefits. However, it requires more activity-oriented translational research in humans before it can be used as a multi-target drug.
Topics: Carotenoids; Humans; Neoplasms; Seaweed; Xanthophylls
PubMed: 35621930
DOI: 10.3390/md20050279 -
The Science of the Total Environment Aug 2022Cancer is one of the most deadly diseases on the planet. Over the past decades, numerous antineoplastic compounds have been discovered from natural resources such as...
Marine biome-derived secondary metabolites, a class of promising antineoplastic agents: A systematic review on their classification, mechanism of action and future perspectives.
Cancer is one of the most deadly diseases on the planet. Over the past decades, numerous antineoplastic compounds have been discovered from natural resources such as medicinal plants and marine species as part of multiple drug discovery initiatives. Notably, several marine flora (e.g. Ascophyllum nodosum, Sargassum thunbergii) have been identified as a rich source for novel cytotoxic compounds of different chemical forms. Despite the availability of enormous chemically enhanced new resources, the anticancer potential of marine flora and fauna has received little attention. Interestingly, numerous marine-derived secondary metabolites (e.g., Cytarabine, Trabectedin) have exhibited anticancer effects in preclinical cancer models. Most of the anticancer drugs obtained from marine sources stimulated apoptotic signal transduction pathways in cancer cells, such as the intrinsic and extrinsic pathways. This review highlights the sources of different cytotoxic secondary metabolites obtained from marine bacteria, algae, fungi, invertebrates, and vertebrates. Furthermore, this review provides a comprehensive overview of the utilisation of numerous marine-derived cytotoxic compounds as anticancer drugs, as well as their modes of action (e.g., molecular target). Finally, it also discusses the future prospects of marine-derived drug developments and their constraints.
Topics: Animals; Antineoplastic Agents; Aquatic Organisms; Biological Products; Drug Discovery; Ecosystem; Neoplasms
PubMed: 35490806
DOI: 10.1016/j.scitotenv.2022.155445 -
Anais Da Academia Brasileira de Ciencias 2022Hypertension is a factor that contributes to the risk of chronic diseases. The inhibition of angiotensin-I converting enzyme (ACE) is a useful therapeutic approach to...
Hypertension is a factor that contributes to the risk of chronic diseases. The inhibition of angiotensin-I converting enzyme (ACE) is a useful therapeutic approach to the hypertension treatment. The algae have been an alternative for the production of ACE inhibitory (ACEi) peptides from enzymatic hydrolysis due to their protein-rich biomass. The aim of this study was to systematically review the literature regarding the production, composition and activity of ACEi peptides derived from algae proteins. Systematic database searches identified 648 related articles. Among these, only 14 were selected according to the eligibility criteria to this review. Macroalgae are more studied than microalgae as sources of ACEi peptides. Furthermore, hydrolysates by thermolysin or bromelain exhibited the highest ACEi activity compared to other enzymes. The main features of the peptides with high ACE inhibition are low molecular weight, short amino acids sequence and non-competitive inhibition pattern. In vivo studies using hydrolysates and peptides derived from algae proteins showed antihypertensive activity in spontaneously hypertensive rats (SHR). Thus, it is suggested that ACEi peptides derived from algae can be considered as potential antihypertensive.
Topics: Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Antihypertensive Agents; Hypertension; Peptides; Rats
PubMed: 35319622
DOI: 10.1590/0001-3765202220201636 -
Carbohydrate Polymers May 2022Studies on the effect of sulfated polysaccharides from seaweed on bone regeneration have increased in recent years. However, there is no consensus on how to use them and... (Review)
Review
Studies on the effect of sulfated polysaccharides from seaweed on bone regeneration have increased in recent years. However, there is no consensus on how to use them and their real effectiveness in that process. Thereby, we carried out a systematic review to answer the question "Do the sulfated polysaccharides from seaweeds promote osteogenesis?". Searches were performed in Pubmed, Scopus, and Web of Knowledge databases. A total of 599 articles were selected, resulting in 14 eligible studies. Results showed that the sulfated polysaccharides from seaweeds increase the osteogenic markers evaluated. Nevertheless, due to the lack of standardization on protocols used, the results should be cautiously interpreted. In addition, studies using animal models are still scarce, and the results with cellular models cannot always be extrapolated to systems that are more complex. Despite the study limitations, the use of sulfated polysaccharides appears to promote in vitro osteogenesis and enhance bone regeneration.
Topics: Animals; Bone Regeneration; Polysaccharides; Seaweed; Sulfates; Sulfur Oxides
PubMed: 35287916
DOI: 10.1016/j.carbpol.2022.119204 -
Bioengineered Feb 2022This work is a systematic review that reports state-of-the-art in removal of pharmaceuticals from water and wastewater by photosynthetic organisms in photobioreactors....
This work is a systematic review that reports state-of-the-art in removal of pharmaceuticals from water and wastewater by photosynthetic organisms in photobioreactors. The PRISMA protocol-based review of the most recent literature data from the last 10 years (2011-2021) was reported. Articles were searched by the combination of the following keywords: photobioreactor, pharmaceuticals, drugs, hormones, antibiotics, biodegradation, removal, wastewater treatment. The review focuses on original research papers (not reviews), collected in 3 scientific databases: Scopus, Web of Knowledge, PubMed. The review considered the following factors: type of microorganisms, type of micropollutants removed, degradation efficiency and associated products, types of photosynthetic organisms and photobioreactor types. The conclusion from the systematic review is that the main factors that limit widespread pharmaceuticals removal in photobioreactors are high costs and the problem of low efficiency related with low concentrations of pharmaceuticals. The review indicated a need for further research in this area due to increasing amounts of metabolites in the food chain, such as p-aminophenol and estrone, which can cause harm to people and ichthyofauna. Pharmaceuticals removal can be improved by adapting the type of microorganism used to the type of contamination and implementing photoperiods, which increase the removal efficiency of e.g. sulfamethazine by up to 28%. In the future, it is necessary to search for new solutions in terms of the construction of photobioreactors, as well as for more effective species in terms of pharmaceuticals biodegradation that can survive the competition with other strains during water and wastewater treatment.
Topics: Biodegradation, Environmental; Pharmaceutical Preparations; Photobioreactors; Water Pollutants, Chemical
PubMed: 35132911
DOI: 10.1080/21655979.2022.2036906 -
Marine Drugs Nov 2021While complex lipids of seaweeds are known to display important phytochemical properties, their full potential is yet to be explored. This review summarizes the findings...
While complex lipids of seaweeds are known to display important phytochemical properties, their full potential is yet to be explored. This review summarizes the findings of a systematic survey of scientific publications spanning over the years 2000 to January 2021 retrieved from Web of Science (WoS) and Scopus databases to map the state of the art and identify knowledge gaps on the relationship between the complex lipids of seaweeds and their reported bioactivities. Eligible publications (270 in total) were classified in five categories according to the type of studies using seaweeds as raw biomass (category 1); studies using organic extracts (category 2); studies using organic extracts with identified complex lipids (category 3); studies of extracts enriched in isolated groups or classes of complex lipids (category 4); and studies of isolated complex lipids molecular species (category 5), organized by seaweed phyla and reported bioactivities. Studies that identified the molecular composition of these bioactive compounds in detail (29 in total) were selected and described according to their bioactivities (antitumor, anti-inflammatory, antimicrobial, and others). Overall, to date, the value for seaweeds in terms of health and wellness effects were found to be mostly based on empirical knowledge. Although lipids from seaweeds are little explored, the published work showed the potential of lipid extracts, fractions, and complex lipids from seaweeds as functional ingredients for the food and feed, cosmeceutical, and pharmaceutical industries. This knowledge will boost the use of the chemical diversity of seaweeds for innovative value-added products and new biotechnological applications.
Topics: Animals; Anti-Inflammatory Agents; Aquatic Organisms; Lipids; Seaweed; Structure-Activity Relationship
PubMed: 34940685
DOI: 10.3390/md19120686 -
The Science of the Total Environment Feb 2022Manufactured silica nanoparticles are used worldwide in large volumes for a variety of applications. An exposure of environmental organisms is therefore likely, and... (Meta-Analysis)
Meta-Analysis Review
Manufactured silica nanoparticles are used worldwide in large volumes for a variety of applications. An exposure of environmental organisms is therefore likely, and several data on the ecotoxicology of silica nanoparticles to different organisms have been published in recent years. This systematic review compiles and assesses these studies, in order to analyse the sensitivity distribution across different organisms. On this basis, maximum acceptable environmental concentrations are suggested and potential environmental risks are discussed. 1429 papers were retrieved from the scientific literature (Scopus), the U.S. ECOTOX knowledge database. 63 studies were finally included in the review and appraised according to the nanoCRED criteria. A total of 219 ecotoxicological endpoints recorded in 38 species (7 taxonomic groups) were condensed into a species sensitivity distribution. The resulting concentration that is hazardous for a maximum of 5% of exposed species (HC05) is 130 μg/L, from which a PNEC of 30 μg/L is estimated by applying an assessment factor of 5. These concentrations are 1-3 orders of magnitudes above the concentrations modelled to occur in European aquatic ecosystems. Algae and bacteria have a comparatively low sensitivity to MSNP exposure, likely because their cell wall forms a protective barrier against nanoparticle exposure. Similarly, embryonic stages of fish also show a comparatively low sensitivity due to the protection from their chorion. However, the fish species Labeo rohita and Oncorhynchus mykiss are among the most sensitive species. The ecotoxicity of silica nanoparticles is linked to the number of hydroxyl groups on their surface, corresponding to findings from human toxicological studies. It is recommended that future ecotoxicological studies use explicit concentration-response designs, use proven biocide-free testing material, comparatively apply mass and surface area as exposure metrics, and provide important metainformation in the study report.
Topics: Animals; Aquatic Organisms; Cyprinidae; Ecosystem; Ecotoxicology; Humans; Nanoparticles; Risk Assessment; Silicon Dioxide; Water Pollutants, Chemical
PubMed: 34653448
DOI: 10.1016/j.scitotenv.2021.150893 -
Journal of Medical Virology Dec 2021To systematically evaluate the effectiveness and safety of the SARS-CoV-2 vaccines currently undergoing clinical trials. (Review)
Review Meta-Analysis
OBJECTIVE
To systematically evaluate the effectiveness and safety of the SARS-CoV-2 vaccines currently undergoing clinical trials.
METHODS
PubMed, EMBASE, and Cochrane Library databases were searched to collect open human COVID-19 vaccines randomized controlled trials, without limiting the search time and language. The research papers collected in the above-mentioned databases were initially screened according to the title and abstract content and merged, and the repeated ones were removed. After reading the full text of the remaining research, the studies that did not meet the inclusion criteria were excluded, and finally, nine studies were obtained. After extracting the statistical data of adverse events in the study, load them into Review Manager for heterogeneity analysis.
RESULTS
The incidence of adverse reactions of inactivated virus vaccines, RNA vaccines, and adenovirus vector vaccines was higher than that of placebo. Common adverse reactions included pain, swelling, and fever at the injection site.
CONCLUSION
From the perspective of effectiveness, RNA vaccine > adenovirus vector vaccine > inactivated virus vaccine. From the perspective of safety, the incidence of adverse reactions of the three vaccines is higher than that of a placebo, and the incidence of adverse reactions of the adenovirus vector vaccine is higher.
Topics: Adenovirus Vaccines; COVID-19; COVID-19 Vaccines; Humans; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Vaccination; Vaccines, Inactivated; Vaccines, Synthetic
PubMed: 34264528
DOI: 10.1002/jmv.27203 -
Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies.Nutrients Jun 2021To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. Articles were selected by using PubMed,...
To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. Articles were selected by using PubMed, ScienceDirect, Scopus, and Medline, assessed from 1 May 2019 to 1 July 2020. The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42020169103. Most of the studies explore algae polysaccharides (43.2%), followed by mushrooms (13.5%), plants (13.5%), fruits (10.8%), fungus (2.7%), bacteria, (2.7%), and sea animals (2.7%). A total of 8.1% investigated only in vitro models, 62.1% evaluated only in vivo models, and 29.7% evaluated in vitro and in vivo models. The mechanism of action involves apoptosis, inhibition of cellular proliferation, angiogenesis, and antimetastatic effects through multiple pathways. Findings included here support further investigations on the anti-tumor effect of polysaccharides. Some polysaccharides, such as fucoidan and β-glucans, deserve detailed and structured studies aiming at translational research on breast tumors, since they are already used in the clinical practice of other proposals of human health.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Polysaccharides; Publication Bias; Risk
PubMed: 34200897
DOI: 10.3390/nu13062008 -
Marine Drugs May 2021Air pollution has recently become a subject of increasing concern in many parts of the world. The World Health Organization (WHO) estimated that nearly 4.2 million early...
Air pollution has recently become a subject of increasing concern in many parts of the world. The World Health Organization (WHO) estimated that nearly 4.2 million early deaths are due to exposure to fine particles in polluted air, which causes multiple respiratory diseases. Algae, as a natural product, can be an alternative treatment due to potential biofunctional properties and advantages. This systematic review aims to summarize and evaluate the evidence of metabolites derived from algae as potential anti-inflammatory agents against respiratory disorders induced by atmospheric particulate matter (PM). Databases such as Scopus, Web of Science, and PubMed were systematically searched for relevant published full articles from 2016 to 2020. The main key search terms were limited to "algae", "anti-inflammation", and "air pollutant". The search activity resulted in the retrieval of a total of 36 publications. Nine publications are eligible for inclusion in this systematic review. A total of four brown algae (, , and ) with phytosterol, polysaccharides and polyphenols were reported in the nine studies. The review sheds light on the pathways of particulate matter travelling into respiratory systems and causing inflammation, and on the mechanisms of actions of algae in inhibiting inflammation. Limitations and future directions are also discussed. More research is needed to investigate the potential of algae as anti-inflammatory agents against PM in in vivo and in vitro experimental models, as well as clinically.
Topics: Air Pollutants; Animals; Anti-Inflammatory Agents; Humans; Particulate Matter; Phaeophyceae; Respiratory Tract Diseases
PubMed: 34070821
DOI: 10.3390/md19060317