-
Genome Announcements Apr 2016Strains belonging to the genus Aerococcus are causative agents of human and animal infections, including urogenital infections, bacteremia/septicemia, and infective...
Complete Genome Sequences of Aerococcus christensenii CCUG 28831T, Aerococcus sanguinicola CCUG 43001T, Aerococcus urinae CCUG 36881T, Aerococcus urinaeequi CCUG 28094T, Aerococcus urinaehominis CCUG 42038 BT, and Aerococcus viridans CCUG 4311T.
Strains belonging to the genus Aerococcus are causative agents of human and animal infections, including urogenital infections, bacteremia/septicemia, and infective endocarditis. This study reports the first fully closed and complete genome sequences of six type strains belonging to the genus Aerococcus using a combination of Illumina HiSeq and PacBio sequencing technologies.
PubMed: 27103727
DOI: 10.1128/genomeA.00302-16 -
IDCases 2016Aerococcus urinae is a rare bacteria usually associated with urinary tract infection. It is unusually associated with endocarditis. To date only 18 cases have been...
Aerococcus urinae is a rare bacteria usually associated with urinary tract infection. It is unusually associated with endocarditis. To date only 18 cases have been reported. Among these cases, the majority had aortic valve involvement. Three had mitral and aortic valve involvement, and two had mitral and tricuspid valve involvement. We present the first reported case of A. urinae associated aortic and tricuspid valve endocarditis. Timely recognition and appropriate treatment of this fatal infection is essential to decrease morbidity and mortality.
PubMed: 27051583
DOI: 10.1016/j.idcr.2016.01.007 -
Clinical Microbiology and Infection :... Jan 2016Aerococci have often been misidentified as streptococci in microbiology laboratories, leading to an underestimation of these bacteria as causes of human infections. An... (Review)
Review
Aerococci have often been misidentified as streptococci in microbiology laboratories, leading to an underestimation of these bacteria as causes of human infections. An increased awareness of aerococci and the introduction of matrix-assisted laser desorption ionization time-of-flight mass spectrometry, has led to an increased isolation of Aerococcus urinae and Aerococcus sanguinicola from human urine and blood. The two species are found in human urine and can cause urinary tract infections (UTI). Aerococcus urinae can, in older males with underlying urinary tract conditions, cause invasive infections such as urosepsis or infective endocarditis. The prognosis of invasive aerococcal infections appears to be relatively favourable despite the old age of patients and their many comorbidities. Though clinical breakpoints are still not in place, aerococci seem to be sensitive to penicillins, carbapenems and vancomycin. There is synergy between penicillin and aminoglycosides against some A. urinae isolates and this combination is often used in aerococcal infective endocarditis. The treatment of complicated aerococcal UTI is not obvious as many isolates are resistant to fluoroquinolones. In addition, A. urinae is resistant to sulphamethoxazole, and there are methodological problems in the determination of trimethoprim sensitivity. In complicated UTI, ampicillin is probably a safe treatment option, whereas nitrofurantoin is probably effective in uncomplicated UTI. Treatment studies in aerococcal infections are needed as is a better understanding of the natural niches for aerococci and the pathogenesis and clinical course of aerococcal infections.
Topics: Aerococcus; Anti-Bacterial Agents; Blood; Endocarditis, Bacterial; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Sepsis; Urinary Tract Infections; Urine
PubMed: 26454061
DOI: 10.1016/j.cmi.2015.09.026 -
Clinical Microbiology and Infection :... Jan 2016
Topics: Aerococcus; Aged; Bacteriological Techniques; DNA, Bacterial; DNA, Ribosomal; Female; Gram-Positive Bacterial Infections; Humans; Male; Molecular Diagnostic Techniques; Polymerase Chain Reaction; RNA, Ribosomal, 16S; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
PubMed: 26363405
DOI: 10.1016/j.cmi.2015.08.026 -
Case Reports in Urology 2015
PubMed: 26356421
DOI: 10.1155/2015/490560 -
Case Reports in Urology 2015A 49-year-old male presented to the emergency with hematuria and pain in the shaft of the penis for one day. The patient was found to be in a state of shock. The shaft...
A 49-year-old male presented to the emergency with hematuria and pain in the shaft of the penis for one day. The patient was found to be in a state of shock. The shaft of the penis and the scrotum were swollen and tender. No skin necrosis was observed and no crepitus was palpable. Serum white count (WBC) was 29.5 × 10(3)/μL. A CT scan showed gas in the corpus spongiosum. Antibiotics were started with IV metronidazole, vancomycin, and piperacillin/tazobactam. Metronidazole was then replaced by clindamycin. Exploration was performed but no necrotic tissue was identified. Cystourethroscopy revealed dusky looking urethra. A suprapubic tube and a urethral catheter were placed in the bladder. WBC trended down to 13.9 × 10(3)/μL on the fourth postoperative day. Urine culture grew Aerococcus urinae and blood cultures grew Alpha Hemolytic Streptococcus. On the sixth day, the patient was feeling worse and WBC increased. MRI revealed absent blood flow to the corpus spongiosum. Urethroscopy revealed necrosis of the urethra. Urethrectomy was performed via perineal approach. The patient immediately improved. The patient was discharged on the sixth postoperative day to continue ampicillin/sulbactam IV every 6 hours for a total of 4 weeks from the day of urethrectomy.
PubMed: 26171271
DOI: 10.1155/2015/136147 -
Journal of Global Infectious Diseases 2015Aerococcus urinae is an aerobic, alpha hemolytic gram positive coccus bacterium that grows in pairs or clusters. We report the first case of vertebral osteomyelitis due...
Aerococcus urinae is an aerobic, alpha hemolytic gram positive coccus bacterium that grows in pairs or clusters. We report the first case of vertebral osteomyelitis due to A. urinae. This has not been previously reported in the literature.
PubMed: 26069429
DOI: 10.4103/0974-777X.157246 -
Revista Espanola de Quimioterapia :... Apr 2015Urinary tract infections (UTIs) are one of the most frequent both in the community and in hospitals infectious diseases. The etiology of urinary tract infections is well...
Urinary tract infections (UTIs) are one of the most frequent both in the community and in hospitals infectious diseases. The etiology of urinary tract infections is well established but may vary depending on various factors such as age, the presence of underlying diseases such as diabetes, instrumental procedures such as urinary catheterization or exposure to antibiotics or previous hospitalizations. UTIs diagnosed cases were retrospectively reviewed for unusual microorganisms over a period of 3 years (2011-2013) in the Microbiology Laboratory of the Hospital Virgen de las Nieves of Granada (Spain), following the standard operating procedure, which we describe four cases caused by Trichosporon asahii, Aerococcus urinae, Pasteurella bettyae and Neisseria sicca. Hence the importance of having in the Clinical Microbiology Laboratory of the tools necessary to detection UTIs and reach a correct identification in all cases.
Topics: Adult; Aged; Bacteria; Colony Count, Microbial; Cross Infection; Gram-Negative Bacterial Infections; Hospitals; Humans; Male; Middle Aged; Neisseria sicca; Neisseriaceae Infections; Pasteurella; Retrospective Studies; Spain; Trichosporon; Trichosporonosis; Urinary Tract Infections
PubMed: 25904515
DOI: No ID Found -
New Microbes and New Infections Jan 2015
PubMed: 25755882
DOI: 10.1016/j.nmni.2014.11.002 -
The New Microbiologica Oct 2014We analyzed the in vitro susceptibility to several ?-lactams and vancomycin of 80 Aerococcus urinae isolates collected during 2011-2012 in Switzerland. MICs were...
We analyzed the in vitro susceptibility to several ?-lactams and vancomycin of 80 Aerococcus urinae isolates collected during 2011-2012 in Switzerland. MICs were determined by Etest (bioMérieux) on Müller-Hinton agar with 5% sheep blood and interpreted according to the CLSI and EUCAST criteria set for viridans streptococci. MIC50/90 for penicillin, amoxicillin, ceftriaxone and vancomycin were 0.016/0.064 mg/l, 0.032/0.064 mg/l, 0.125/0.5 mg/l and 0.38/0.5 mg/l, respectively. Three (3.8%) isolates were resistant to ceftriaxone regardless of the criteria used (MICs ?2 mg/l); one of them was also non-susceptible to penicillin (MIC of 0.25 mg/l) according to CLSI. β-lactam resistance in A. urinae is a concern and suggests that more studies are needed to determine the molecular mechanisms of such resistance.
Topics: Aerococcus; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Gram-Positive Bacterial Infections; Humans; Male; Microbial Sensitivity Tests; Switzerland; beta-Lactams
PubMed: 25387295
DOI: No ID Found