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Pharmaceutics May 2024Citrulline (CHNO) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In...
Citrulline (CHNO) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal ureido group on its aliphatic chain, which also appears to coordinate. Here, two new mixed complexes of citrulline were made with 1,10-phenanthroline and 2,2'-bipyridine. These compounds, once dissolved in water, gave aquo-complexes that were subject to DFT studies and in vitro toxicity studies on cancer cell lines (HeLa, MDA-MB-231, HCT 15, and MCF7) showed promising results. Docking studies with DNA were also conducted, indicating potential anticancer properties.
PubMed: 38931869
DOI: 10.3390/pharmaceutics16060747 -
Pharmaceutics May 2024Fluoropyrimidine (FP) drugs are central components of combination chemotherapy regimens for the treatment of colorectal cancer (CRC). FP-based chemotherapy has improved... (Review)
Review
Fluoropyrimidine (FP) drugs are central components of combination chemotherapy regimens for the treatment of colorectal cancer (CRC). FP-based chemotherapy has improved survival outcomes over the last several decades with much of the therapeutic benefit derived from the optimization of dose and delivery. To provide further advances in therapeutic efficacy, next-generation prodrugs and nanodelivery systems for FPs are being developed. This review focuses on recent innovative nanodelivery approaches for FP drugs that display therapeutic promise. We summarize established, clinically useful FP prodrug strategies, including capecitabine, which exploit tumor-specific enzyme expression for optimal anticancer activity. We then describe the use of FP DNA-based polymers (e.g., CF10) for the delivery of activated FP nucleotides as a nanodelivery approach with proven activity in pre-clinical models and with clinical potential. Multiple nanodelivery systems for FP delivery show promise in CRC pre-clinical models and we review advances in albumin-mediated FP delivery, the development of mesoporous silica nanoparticles, emulsion-based nanoparticles, metal nanoparticles, hydrogel-based delivery, and liposomes and lipid nanoparticles that display particular promise for therapeutic development. Nanodelivery of FPs is anticipated to impact CRC treatment in the coming years and to improve survival for cancer patients.
PubMed: 38931855
DOI: 10.3390/pharmaceutics16060734 -
Pharmaceutics May 2024Antibiotic-resistant strains of are being viewed as a serious threat by various public health agencies. Identifying novel targets in this important pathogen is crucial...
Antibiotic-resistant strains of are being viewed as a serious threat by various public health agencies. Identifying novel targets in this important pathogen is crucial to the development of new effective antibacterial formulations. We investigated the antibacterial effect of a colloidal nanosilver formulation, Silversol, against an antibiotic-resistant strain of using appropriate in vitro assays. Moreover, we deciphered the molecular mechanisms underlying this formulation's anti- activity using whole transcriptome analysis. Lower concentrations of the test formulation exerted a bacteriostatic effect against this pathogen, and higher concentrations exerted a bactericidal effect. Silversol at sub-lethal concentration was found to disturb multiple physiological traits of such as growth, antibiotic susceptibility, membrane permeability, efflux, protein synthesis and export, biofilm and exopolysaccharide production, etc. Transcriptome data revealed that the genes coding for transcriptional regulators, efflux machinery, transferases, β-lactam resistance, oxidoreductases, metal homeostasis, virulence factors, and arginine biosynthesis are expressed differently under the influence of the test formulation. Genes ( and ) involved in arginine biosynthesis emerged among the major targets of Silversols antibacterial activity against .
PubMed: 38931848
DOI: 10.3390/pharmaceutics16060726 -
Sensors (Basel, Switzerland) Jun 2024This article shows an all-dielectric metasurface consisting of "H"-shaped silicon disks with tilted splitting gaps, which can detect the temperature and refractive index...
This article shows an all-dielectric metasurface consisting of "H"-shaped silicon disks with tilted splitting gaps, which can detect the temperature and refractive index (RI). By introducing asymmetry parameters that excite the quasi-BIC, there are three distinct Fano resonances with nearly 100% modulation depth, and the maximal quality factor (Q-factor) is over 10. The predominant roles of different electromagnetic excitations in three distinct modes are demonstrated through near-field analysis and multipole decomposition. A numerical analysis of resonance response based on different refractive indices reveals a RI sensitivity of 262 nm/RIU and figure of merit (FOM) of 2183 RIU. This sensor can detect temperature fluctuations with a temperature sensitivity of 59.5 pm/k. The proposed metasurface provides a novel method to induce powerful TD resonances and offers possibilities for the design of high-performance sensors.
PubMed: 38931726
DOI: 10.3390/s24123943 -
Sensors (Basel, Switzerland) Jun 2024Lithium, a critical natural resource integral to modern technology, has influenced diverse industries since its discovery in the 1950s. Of particular interest is...
Lithium, a critical natural resource integral to modern technology, has influenced diverse industries since its discovery in the 1950s. Of particular interest is lithium-7, the most prevalent lithium isotope on Earth, playing a vital role in applications such as batteries, metal alloys, medicine, and nuclear research. However, its extraction presents significant environmental and logistical challenges. This article explores the potential for lithium exploration on the Moon, driven by its value as a resource and the prospect of cost reduction due to the Moon's lower gravity, which holds promise for future space exploration endeavors. Additionally, the presence of lithium in the solar wind and its implications for material transport across celestial bodies are subjects of intrigue. Drawing from a limited dataset collected during the Apollo missions (Apollo 12, 15, 16, and 17) and leveraging artificial intelligence techniques and sample expansion through bootstrapping, this study develops predictive models for lithium-7 concentration based on spectral patterns. The study areas encompass the Aitken crater, Hadley Rima, and the Taurus-Littrow Valley, where higher lithium concentrations are observed in basaltic lunar regions. This research bridges lunar geology and the formation of the solar system, providing valuable insights into celestial resources and enhancing our understanding of space. The data used in this study were obtained from the imaging sensors (infrared, visible, and ultraviolet) of the Clementine satellite, which significantly contributed to the success of our research. Furthermore, the study addresses various aspects related to statistical analysis, sample quality validation, resampling, and bootstrapping. Supervised machine learning model training and validation, as well as data import and export, were explored. The analysis of data generated by the Clementine probe in the near-infrared (NIR) and ultraviolet-visible (UVVIS) spectra revealed evidence of the presence of lithium-7 (Li-7) on the lunar surface. The distribution of Li-7 on the lunar surface is non-uniform, with varying concentrations in different regions of the Moon identified, supporting the initial hypothesis associating surface Li-7 concentration with exposure to solar wind. While a direct numerical relationship between lunar topography and Li-7 concentration has not been established due to morphological diversity and methodological limitations, preliminary results suggest significant economic and technological potential in lunar lithium exploration and extraction.
PubMed: 38931715
DOI: 10.3390/s24123931 -
Sensors (Basel, Switzerland) Jun 2024Additive manufacturing (AM) enables the spatially configurable 3D integration of sensors in metal components to realize smart materials and structures. Outstanding...
Additive manufacturing (AM) enables the spatially configurable 3D integration of sensors in metal components to realize smart materials and structures. Outstanding sensing capabilities and size compatibility have made fiber optic sensors excellent candidates for integration in AM components. In this study, fiber Bragg grating (FBG) sensors were embedded in Inconel 718 tensile coupons printed using laser powder bed fusion AM. On-axis (fiber runs through the coupon's center of axis) and off-axis (fiber is at 5° and 10° to the coupon's center of axis) sensors were buried in epoxy resin inside narrow channels that run through the coupons. FBGs' spectral evolutions during embedment in the coupons were examined and cyclic loading experiments were conducted to analyze and evaluate the sensor integration process, complex strain loading, process flaws, and sensing performance. This study also demonstrates that the AM process-born deficiencies such as poor surface finish and staircase effects can be detrimental to the embedded sensors and their sensing performance.
PubMed: 38931700
DOI: 10.3390/s24123919 -
Sensors (Basel, Switzerland) Jun 2024This paper presents a compact wideband circularly polarized cross-dipole antenna with a low-pass filter response. It consists of two pairs of folded cross-dipole arms...
This paper presents a compact wideband circularly polarized cross-dipole antenna with a low-pass filter response. It consists of two pairs of folded cross-dipole arms printed separately on both sides of the top substrate, and the two dipole arms on the same surface are connected by an annular phase-shifting delay line to generate circular polarization. A bent metal square ring and four small metal square rings around the cross-dipoles are employed to introduce new resonant frequencies, effectively extending the impedance and axial-ratio bandwidth. Four square patches printed on the middle substrate are connected to the ground plane by the vertical metal plates in order to reduce the antenna height. Thus, a compact wideband circularly polarized antenna is realized. In addition, a transmission zero can be introduced at the upper frequency stopband by the bent metal square rings, without using extra filter circuits. For verification, the proposed model is implemented and tested. The overall size of the model is 90mm×90mm×33mm (0.37λ0×0.37λ0×0.14λ0; λ0 denotes the center operating frequency). The measured impedance bandwidth and 3 dB axial-ratio (AR) bandwidth are 53.3% and 41%, respectively. An upper-band radiation suppression level greater than 15 dB is realized, indicating a good low-pass filter response.
PubMed: 38931698
DOI: 10.3390/s24123914 -
Sensors (Basel, Switzerland) Jun 2024A review of the state of research in the development of conductometric gas sensors based on II-VI semiconductors is given. It was shown that II-VI compounds indeed have... (Review)
Review
A review of the state of research in the development of conductometric gas sensors based on II-VI semiconductors is given. It was shown that II-VI compounds indeed have properties that are necessary for the development of highly efficient gas sensors. In this case, to achieve the required parameters, all approaches developed for metal oxides can be used. At the same time, during a detailed review, it was concluded that sensors based on II-VI compounds have no prospects for appearing on the gas sensor market. The main obstacle is the instability of the surface state, which leads to poor reproducibility of parameters and drift of sensor characteristics during operation.
PubMed: 38931646
DOI: 10.3390/s24123861 -
Sensors (Basel, Switzerland) Jun 2024Nowadays, 3D printing is becoming an increasingly common option for the manufacturing of sensors, primarily due to its capacity to produce intricate geometric shapes....
Nowadays, 3D printing is becoming an increasingly common option for the manufacturing of sensors, primarily due to its capacity to produce intricate geometric shapes. However, a significant challenge persists in integrating multiple materials during printing, for various reasons. In this study, we propose a straightforward approach that combines 3D printing with metal coating to create an array of resistive force sensors from a single material. The core concept involves printing a sensing element using a conductive material and subsequently separating it into distinct parts using metal-coated lines connected to the electrical ground. This post-printing separation process involves manual intervention utilizing a stencil and metallic spray. The primary obstacle lies in establishing a sufficient contact surface between the sprayed metal and the structure, to ensure effective isolation among different zones. To address this challenge, we suggest employing a lattice structure to augment the contact surface area. Through experimental validation, we demonstrate the feasibility of fabricating two sensing elements from a single-material 3D-printed structure, with a maximum electrical isolation ratio between the sensors of above 30. These findings hold promise for the development of a new generation of low-tech 3D-printed force/displacement sensor arrays.
PubMed: 38931638
DOI: 10.3390/s24123854 -
Sensors (Basel, Switzerland) Jun 2024Metal-organic frameworks (MOFs) stand out as remarkable materials renowned for their exceptionally high surface area and large number of pores, making them invaluable...
Metal-organic frameworks (MOFs) stand out as remarkable materials renowned for their exceptionally high surface area and large number of pores, making them invaluable for diverse sensing applications including gas, biomedical, chemical, and optical sensing. Traditional methods of molecule infusion and release often involve a large number of crystals with varying shapes and sizes, leading to averaged outcomes across a heterogeneous crystal population. In this study, we present continuous monitoring of the infusion and release dynamics of model drug molecules, specifically vitamin B, within individual Tb-mesoMOF crystals. Our findings underscore the critical influence of crystal size and shape on the infusion and diffusion processes and corresponding color change, underscoring the necessity to account for these factors in the design of large-scale systems. Leveraging optical microscopy, we employed a histogram-based algorithm for image processing, enabling automated tracking of diffusion phenomena. This investigation offers crucial insights into the dynamics of these processes, laying the groundwork for optimizing parameters in future sensing systems.
PubMed: 38931625
DOI: 10.3390/s24123842