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Journal of Pharmacy & Bioallied Sciences Feb 2024In the realm of orthodontics, the evaluation of treatment outcomes is a pivotal aspect. In recent times, artificial intelligence (AI) models have garnered attention as...
BACKGROUND
In the realm of orthodontics, the evaluation of treatment outcomes is a pivotal aspect. In recent times, artificial intelligence (AI) models have garnered attention as potential tools for predicting these outcomes. These AI models have the potential to enhance treatment planning and decision-making processes. However, a comprehensive assessment of their effectiveness and accuracy is essential before their widespread integration.
MATERIALS AND METHODS
In this study, we assessed the capability of AI models to predict treatment outcomes in orthodontics. A sample of 30 patients undergoing orthodontic treatment was selected. Various patient-specific parameters, including age, initial malocclusion severity, and treatment approach, were collected. The AI model was trained using a dataset comprising historical treatment cases and their respective outcomes. Subsequently, the trained AI model was applied to predict the treatment outcomes for the selected patients.
RESULTS
The results of this study indicated a moderate level of accuracy in the predictions made by the AI model. Out of the 30 patients, the model accurately predicted treatment outcomes for 22 patients, yielding a success rate of approximately 73%. However, the model exhibited limitations in accurately predicting outcomes for cases involving complex malocclusions or those requiring non-standard treatment approaches.
CONCLUSION
In conclusion, this study underscores the potential of AI models in predicting treatment outcomes in orthodontics. While the AI model demonstrated promising accuracy in the majority of cases, its efficacy was diminished in complex and non-standard cases. Therefore, while AI models can serve as valuable tools to aid orthodontists in treatment planning, they should be utilized in conjunction with clinical expertise to ensure optimal decision-making and patient care.
PubMed: 38595553
DOI: 10.4103/jpbs.jpbs_852_23 -
Journal of Pharmacy & Bioallied Sciences Feb 2024To evaluate the influence of variations in the upper sulcus depth, nasal tip protrusion, and nasolabial angle on the esthetic perception of profiles.
OBJECTIVE
To evaluate the influence of variations in the upper sulcus depth, nasal tip protrusion, and nasolabial angle on the esthetic perception of profiles.
DESIGN
A web-based survey study and was conducted in the Department of Orthodontics and Dentofacial Orthopaedics. This survey was conducted for a period of 10 months and included orthodontists practicing in India.
METHODS
This study included lateral cephalograms of the most esthetic profiles from a set of 30 profiles that were within Holdaways norms; the most esthetic profile was determined by a panel of two orthodontists and two general dentists. The most esthetic profile photograph will be transferred to a computer in Corel software. The outline of the profile will remain the same, with the inner aspect converted into a dark area (black); now, the profile is completely converted into facial silhouettes. This black facial silhouette is presented to avoid any distractions and bias. There will be a total of 27 silhouettes by various combinations of increased, decreased, and normal values for nasolabial angle, upper sulcus depth, and nasal tip protrusions.
RESULTS
Both the orthodontist and layman chose the most favored profile as a normal profile having a normal nasal tip, normal nasolabial angle, and normal upper sulcus depth, whereas among dentists, 50% chose the most favored profile in which the nasolabial angle was normal but the nasal tip and upper labial sulcus were decreased. When it comes to the least favored profiles, opinions varied between orthodontists, dentists, and laymen.
CONCLUSION
The perception of facial esthetics has always been and still is varied between the layman, the dentist, and the orthodontists. Profiles with normal to sharp noses with normal and increased nasolabial angles were considered more attractive than the others. Profiles with fuller upper labial sulci were considered least attractive with other parameters changing.
PubMed: 38595513
DOI: 10.4103/jpbs.jpbs_529_23 -
Journal of Pharmacy & Bioallied Sciences Feb 2024Platelet-rich fibrin (PRF) is a biocompatible fibrin matrix that acts as a resorbable membrane, collecting platelet cytokines, growth factors, and cells and releasing... (Review)
Review
Platelet-rich fibrin (PRF) is a biocompatible fibrin matrix that acts as a resorbable membrane, collecting platelet cytokines, growth factors, and cells and releasing them. It is easily extracted from blood. Many dentists use PRF, a concentrated growth factor solution, to treat various lesions and regenerate tooth and oral tissues. This research examines the pros, cons, and suggestions of using PRF in dentistry.
PubMed: 38595504
DOI: 10.4103/jpbs.jpbs_435_23 -
Journal of Pharmacy & Bioallied Sciences Feb 2024The research project focuses on the creation and assessment of an innovative computer vision system designed to identify dental irregularities in individuals undergoing...
AIM
The research project focuses on the creation and assessment of an innovative computer vision system designed to identify dental irregularities in individuals undergoing orthodontic treatment.
MATERIALS AND METHODS
To establish the computer vision system, a comprehensive dataset of dental images was collected, encompassing various orthodontic cases. The system's algorithm was trained to recognize patterns indicative of common dental anomalies, such as malocclusions, spacing issues, and misalignments. Rigorous testing and refinement of the algorithm were conducted to enhance its accuracy and reliability.
RESULTS
The validation of the system was carried out using the dental records and images of the 40 patients. The computer vision system's performance was evaluated against assessments made by experienced orthodontists. The results demonstrated a commendable level of concurrence between the system's automated detections and the orthodontists' evaluations, suggesting its potential as a valuable diagnostic tool.
CONCLUSION
In conclusion, the development and validation of this novel computer vision system exhibit promising outcomes in its ability to automatically detect dental anomalies in orthodontic patients.
PubMed: 38595489
DOI: 10.4103/jpbs.jpbs_752_23 -
Journal of Pharmacy & Bioallied Sciences Feb 2024The purpose of this study was to determine the effect of common methods of sterilization on the tensile strength of Beta titanium, Stainless steel, Australian Stainless...
OBJECTIVE
The purpose of this study was to determine the effect of common methods of sterilization on the tensile strength of Beta titanium, Stainless steel, Australian Stainless steel, Copper Nickel-Titanium, and Nickel-Titanium wires. It also aimed to evaluate the changes in tensile strength values caused by repeated cycles of sterilization.
MATERIALS AND METHODS
A sample of 225 orthodontic wires, i.e., beta-titanium, stainless steel, Australian stainless steel, copper nickel-titanium, and nickel-titanium wires, were collected from different manufacturers. These wires were divided into three groups, which consists of Groups 1, 2, and 3. Four methods of sterilization used in this study were as follows: (i) autoclave (250°F for 20 min), (ii) dry heat sterilization (375°F for 20 min), (iii) ethylene oxide sterilization (54°C for 4 hrs), and (iv) 2.45% acidic glutaraldehyde (10 hrs).
RESULTS
The results of this study showed that there was increase in tensile strength of beta-titanium and nickel-titanium wires using autoclave and dry heat sterilization. No statistically significant difference in tensile strength of stainless steel and Australian stainless steel archwires. The tensile strength of copper nickel-titanium wires decreased following 0, 1, and 5 cycles of sterilization.
CONCLUSION
The lack of statistically significant differences established in the study of new and sterilized orthodontic archwires gives us reason to conclude that the orthodontic arch wires can be sterilized because the sterilizing processes do not affect their tensile strength and the orthodontists could thus ensure the maximum safety of their patients.
PubMed: 38595471
DOI: 10.4103/jpbs.jpbs_432_23 -
Journal of Pharmacy & Bioallied Sciences Feb 2024Mini-screws, also known as temporary anchorage devices (TADs), offer enhanced control and versatility in orthodontic treatment by providing stable anchorage points. This...
Mini-screws, also known as temporary anchorage devices (TADs), offer enhanced control and versatility in orthodontic treatment by providing stable anchorage points. This clinical study aims to evaluate the effectiveness of mini-screw-supported molar intrusion in orthodontic practice. For this clinical study, a cohort of 40 orthodontic patients with various malocclusions requiring molar intrusion as part of their treatment plan was recruited. The age range of the participants spanned from 14 to 35 years, representing a diverse patient population. The intervention involved the implementation of mini-screw-supported molar intrusion on one side of the maxillary arch in each patient. To achieve this, temporary mini-screws were strategically placed, and a combination of orthodontic forces and mini-screw anchorage was employed to intrude the molars. The primary outcome measure for this study was the amount of molar intrusion achieved, which was quantified in millimeters from the initial evaluation to the final visit. Additionally, the duration of treatment required to achieve the desired molar intrusion was recorded in months. The results of this clinical study demonstrated that mini-screw-supported molar intrusion was an effective and safe orthodontic technique. On average, a significant mean molar intrusion amount of 4.8 mm (standard deviation [SD] ± 0.6) was achieved with the mini-screw-supported approach. Furthermore, the treatment duration required to attain the desired molar intrusion was relatively short, with a mean of 6.2 months (SD ± 1.1). In conclusion, this clinical study provides evidence that mini-screw-supported molar intrusion is an effective and safe approach in orthodontic practice. It offers orthodontists the advantage of enhanced control and predictability in molar intrusion procedures.
PubMed: 38595451
DOI: 10.4103/jpbs.jpbs_957_23 -
Journal of Pharmacy & Bioallied Sciences Feb 2024Open bite is a common orthodontic malocclusion that can have functional and aesthetic implications. Traditional orthodontic treatments have been used to correct open...
BACKGROUND
Open bite is a common orthodontic malocclusion that can have functional and aesthetic implications. Traditional orthodontic treatments have been used to correct open bites, but the effectiveness of Invisalign, a clear aligner therapy, in open bite correction remains a topic of interest.
MATERIALS AND METHODS
A retrospective analysis was conducted on a cohort of 50 patients with open bites who underwent Invisalign treatment. Pre-treatment and post-treatment records, including cephalometric radiographs, dental models, and clinical photographs, were assessed. The open bite was defined as a negative overbite greater than 2 mm. Treatment duration, number of aligners used, and patient compliance were also recorded. Statistical analysis, including paired t-tests and subjective patient feedback, was employed to evaluate the treatment outcomes.
RESULTS
The mean pre-treatment open bite was -3.5 mm (SD = 1.2), and the mean treatment duration was 18 months (SD = 2.5). On average, patients received 24 sets of aligners (SD = 4.1) during the treatment. Post-treatment evaluation showed that the mean overbite improved to + 1.5 mm (SD = 0.8), indicating successful open bite correction. The paired -test revealed a statistically significant difference between pre-treatment and post-treatment open bite measurements ( < 0.001). Patient satisfaction was high, with 90% of participants reporting improved aesthetics and comfort.
CONCLUSION
Invisalign treatment demonstrates effectiveness in correcting open bites, with statistically significant improvements in overbite measurements.
PubMed: 38595389
DOI: 10.4103/jpbs.jpbs_1058_23 -
Journal of Pharmacy & Bioallied Sciences Feb 2024To assess and contrast the efficacy of transcutaneous electrical nerve stimulation (TENS) therapy and topical anesthetic gel in reducing the level of pain associated...
AIM
To assess and contrast the efficacy of transcutaneous electrical nerve stimulation (TENS) therapy and topical anesthetic gel in reducing the level of pain associated with the placement of orthodontic separators.
MATERIALS AND METHODS
A cohort of 40 individuals, aged between 16 and 20 years, who were in need of fixed orthodontic treatment, was chosen for the study. Elastomeric separators were positioned bilaterally adjacent to the first molars in all participants, who were subsequently separated into two distinct cohorts. Those in group I received topical anesthetic gel, while those in group II underwent TENS therapy. After the placement of separators, the assessment of pain was conducted using the Visual Analog Scale (VAS) at specific intervals: Immediately after placement, 6, 12, 24, and 48 hours.
RESULT
TENS group showed a significantly lower VAS score compared to the local anesthetic gel group at immediate, 6 hours, and 12 hours.
CONCLUSION
Following the placement of elastomeric separators, it was found that TENS was more successful at reducing pain.
PubMed: 38595351
DOI: 10.4103/jpbs.jpbs_871_23 -
Scientific Reports Apr 2024Endocrine therapy (ET) for breast cancer treatment is associated with cognitive complaints, but their etiology is poorly understood. To address this, we developed and...
Endocrine therapy (ET) for breast cancer treatment is associated with cognitive complaints, but their etiology is poorly understood. To address this, we developed and implemented an ambulatory assessment protocol consisting of wearable activity monitors, brief surveys of affect, context, and perceived impairments, and ultra-brief performance-based measures of cognition. Newly diagnosed, ER/PR+, stage 0-III, female breast cancer patients, were recruited. Ambulatory assessments were conducted on smart phones and wearable activity monitors were used to monitor sleep and physical activity. Participants were asked to complete five 7-day measurement bursts (one before starting ET and one each month for 4 consecutive months while on ET). We observed a consent rate of 36%, 27 women completed the study. Of the women that withdrew, 91% dropped prior to the midpoint of follow up. There were no significant differences in demographics, clinical breast cancer characteristics, sleep or physical activity patterns, or measures of cognition between women who completed versus withdrew. Women who did not complete the study provided fewer valid days of baseline data. In conclusion, while some women may be overwhelmed with their cancer diagnosis, we did not identify any predictive characteristics of women whom did not complete the study. This novel method enables the prospective study of psychological changes associated with cancer treatment, capturing a wide array of information about behavior, experience, and cognition, thus providing a picture of the lived experiences of cancer patients before and during exposure to ET.
Topics: Humans; Female; Breast Neoplasms; Feasibility Studies; Prospective Studies; Sleep; Cognition
PubMed: 38594369
DOI: 10.1038/s41598-024-58724-1 -
Journal of Clinical Medicine Mar 2024Incisor retraction is often a crucial phase in ongoing orthodontic treatment, with significant implications for alveolar remodeling mechanisms. There are two prevailing... (Review)
Review
Incisor retraction is often a crucial phase in ongoing orthodontic treatment, with significant implications for alveolar remodeling mechanisms. There are two prevailing theories which seek to explain this. According to the first, teeth move with the bone, while according to the second, teeth move within the bone. This systematic review seeks to assess morphometric changes in the maxillary alveolar process resulting from incisor retraction following premolar extraction and to evaluate the potential for bone remodeling associated with orthodontic movement. The study was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The following electronic databases were searched: PubMed, Google Scholar, Web of Science EMBASE and the Cochrane Central Register of Controlled Trials. The databases were searched using the following keywords: "Bone remodeling and retraction of incisors", "Alveolar bone and incisor retraction", "Bone thickness and incisor retraction", and "Bone changes and orthodontic treatment". Search filters were utilized to identify relevant papers and articles written in English and published during the last 10 years. Based on the information provided in their abstracts, papers and articles were selected according to the following criteria: randomized clinical trials (RCTs), controlled clinical prospective trials (CCTs), and retrospective studies. Articles unrelated to the study's scope or failing to meet inclusion criteria were excluded. These generally comprised individual case reports, case series reports, literature reviews, experimental studies, studies with limited data (including conference abstracts and journal writings), studies involving an unrepresentative group of patients (less than 10 patients), studies concerning patients with syndromes, and animal experiments. The remaining articles which were deemed relevant underwent comprehensive reference review and such journals as the American Journal of Orthodontics, Dentofacial Orthopedics, International Orthodontics, Journal of Clinical Orthodontics, and Angle Orthodontist were manually searched. Seven articles meeting the inclusion criteria articles were selected for final evaluation, with a total of 284 participants, including 233 women and 51 men. During the analysis of the results included in the publications, a lack of homogeneity was observed, rendering a reliable statistical analysis and heterogeneity assessment unobtainable. Noteworthy disparities in methodologies and measurements posed a risk of drawing inappropriate conclusions. Consequently, emphasis was placed on qualitative analysis, emphasizing the need for standardization in future studies of a similar nature, to enable valid and comparable analyses. The research findings incorporated in this review demonstrate that significant bone loss occurs because of incisor retraction, which diminishes distance between the bone surface and the root surface on the palatal aspect. The magnitude of this change may vary, contingent upon both the extent of incisor displacement and alterations in their inclination, thereby affecting the positioning of the root tips. This change is significantly higher in adults than in growing adolescents. The rationale behind this assertion lies in the widely recognized phenomenon of declining cellular activity with advancing age. The decrease in the speed and intensity of cellular changes may explain the diminished capacity for remodeling as patient age increases. There is ongoing discourse regarding alterations in the volume of bone on the labial aspect of the alveolar process. Further research is necessary to measure whether bone remodeling during orthodontic movement is contingent upon other factors, such as the speed and biomechanics of retraction, the level of applied orthodontic force, and the patient age.
PubMed: 38592367
DOI: 10.3390/jcm13051503