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Transplant International : Official... Oct 2014Hepatic venous outflow reconstruction is of critical significance in pediatric patients undergoing living donor liver transplantation. Accurate knowledge of the...
Hepatic venous outflow reconstruction is of critical significance in pediatric patients undergoing living donor liver transplantation. Accurate knowledge of the anatomical variations is important to obtain appropriate size segmental grafts. The diameter of the hepatic veins and the potential risk of complications at the level of the anastomosis require an adequate primary vascular reconstruction. We describe a venous outflow reconstruction technique, in a living related left lateral lobe graft, with unfavorable hepatic venous anatomy.
Topics: Child; Female; Follow-Up Studies; Graft Survival; Hepatic Veins; Humans; Liver; Liver Circulation; Liver Neoplasms; Liver Transplantation; Living Donors; Pancreatic Neoplasms; Plastic Surgery Procedures; Risk Assessment; Treatment Outcome; Vascular Surgical Procedures
PubMed: 24963596
DOI: 10.1111/tri.12388 -
Modern Pathology : An Official Journal... Oct 2014Solid-pseudopapillary neoplasms are rare, but are distinctive pancreatic tumors of low-malignant potential. While the histogenesis of these tumors is unclear, they are...
Solid-pseudopapillary neoplasms are rare, but are distinctive pancreatic tumors of low-malignant potential. While the histogenesis of these tumors is unclear, they are often associated with gain-of-function mutations in the catenin (cadherin-associated protein), beta 1 (88 kDa), or CTNNB1 gene, resulting in nuclear accumulation of CTNNB1. CTNNB1 is a central component of the Wnt signaling pathway and mediates gene expression through the lymphoid enhancer-binding factor 1 (LEF1) /T-cell factor transcription complex. Although LEF1 has a pivotal role in the transactivation of Wnt/CTNNB1 responsive genes, the status of LEF1 in solid-pseudopapillary neoplasms and other pancreatic tumors has not been examined. We analyzed both LEF1 and CTNNB1 in a large cohort of pancreatic tumors (n=155). In all cases of solid-pseudopapillary neoplasms including surgical resections (n=27) and cytologic samples (n=8) had strong and diffuse nuclear labeling for both LEF1 and CTNNB1. The surrounding uninvolved pancreatic parenchyma was devoid of any LEF1 staining. All resection and cytologic specimens from well-differentiated pancreatic neuroendocrine tumors (n=44; n=29, respectively), high-grade pancreatic neuroendocrine carcinomas (n=2; n=1), pancreatic ductal adenocarcinomas (n=25; n=12), and acinar cell carcinomas (n=9; n=2) studied were negative for both nuclear LEF1 and CTNNB1. However, nuclear LEF1 and CTNNB1 were detected in all four resected pancreatoblastomas (no cytologic specimens were available for immunolabeling), but primarily centered around and within squamoid corpuscles. In summary, abnormal CTNNB1 accumulation was accompanied by nuclear LEF1 overexpression in both solid-pseudopapillary neoplasms and pancreatoblastomas. But, in contrast to pancreatoblastomas, a diffuse, nuclear labeling was observed in solid-pseudopapillary neoplasms and further implicates the CTNNB1/LEF1 transcriptional complex in the development of solid-pseudopapillary neoplasms. In addition, as part of an immunohistochemical panel, LEF1 can be a useful ancillary stain in the diagnosis of solid-pseudopapillary neoplasms.
Topics: Adolescent; Adult; Aged; Biomarkers, Tumor; Carcinoma; Child; Female; Humans; Immunohistochemistry; Lymphoid Enhancer-Binding Factor 1; Male; Middle Aged; Pancreatic Neoplasms; Young Adult; beta Catenin
PubMed: 24658583
DOI: 10.1038/modpathol.2014.40 -
Radiology Case Reports 2009The case of a six-month-old child with pancreatoblastoma is presented. Pancreatoblastoma is a rare primary neoplasm of childhood, usually presenting in children ranging...
The case of a six-month-old child with pancreatoblastoma is presented. Pancreatoblastoma is a rare primary neoplasm of childhood, usually presenting in children ranging from 2 -8 years old. The radiologic findings vary from solid to complex masses. This case is unusual due to the young age of the patient.
PubMed: 27307808
DOI: 10.2484/rcr.v4i2.284