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Case Reports in Dermatology 2021Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare and severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA) characterized by...
Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare and severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA) characterized by intermittent pyrexia, acute onset of generalized ulceronecrotic lesions, and histopathology suggestive of PLEVA. Prompt diagnosis and treatment are necessary to halt the progression of this potentially fatal disease; however, the widely variable presentation of FUMHD in addition to its rarity poses a diagnostic challenge. We report the case of a previously healthy 43-year-old woman who presented to the emergency department with 1 month of generalized rash and intermittent fevers. Her only reported new exposure were elective intravenous vitamin infusions received at a medi-spa 1 week prior to onset of lesions. Initial evaluations were inconclusive, and confluent ulceronecrotic, hemorrhagic lesions appeared on approximately 90% of her body despite steroid, antibiotic, and cyclosporine therapy. Repeat histopathology was consistent with PLEVA, and in the context of her clinical presentation she was diagnosed with FUMHD. The patient rapidly attained remission with methotrexate therapy but sustained residual scarring.
PubMed: 33613228
DOI: 10.1159/000511537 -
Cureus Jun 2020Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare cutaneous eruption of erythematous macules and papules distributed over the flexural surfaces and the...
Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare cutaneous eruption of erythematous macules and papules distributed over the flexural surfaces and the trunk. Histopathologic analysis is useful in diagnosis, and dermoscopic findings have been described in several small case series. We present a case of a mid-20s female who was diagnosed with PLEVA based on clinical and histopathological findings, and we also demonstrate a unique dermoscopic finding. Additionally, we review the current literature detailing dermoscopy findings with associated histopathology in PLEVA and pityriasis lichenoides chronica (PLC).
PubMed: 32699720
DOI: 10.7759/cureus.8725 -
Indian Dermatology Online Journal 2020
PubMed: 32695726
DOI: 10.4103/idoj.IDOJ_455_18 -
Indian Journal of Dermatology,... 2020
Topics: Anti-Bacterial Agents; Azithromycin; Child; Combined Modality Therapy; Diagnosis, Differential; Humans; Male; Pityriasis Lichenoides; Rubella Vaccine; Ultraviolet Therapy
PubMed: 32474500
DOI: 10.4103/ijdvl.IJDVL_48_18 -
A Case Report of Pityriasis Lichenoides-Like Mycosis Fungoides in Children: A Challenging Diagnosis.Korean Journal of Family Medicine Jul 2021Primary cutaneous lymphomas are rare diseases among the general population, and even rarer in children. Mycosis fungoides (MF) is the most commonly diagnosed form in...
Primary cutaneous lymphomas are rare diseases among the general population, and even rarer in children. Mycosis fungoides (MF) is the most commonly diagnosed form in childhood. Several atypical clinical variants of MF have been reported, and pityriasis lichenoides-like MF (PL-like MF) is a recently described subtype. We report about a rare case of PL-like MF in an 11-year-old Malay boy with a 2-year history of multiple scaly erythematous papules associated with progressive and generalized hypopigmentation. This case report illustrates the significant dilemma in the diagnosis of the disease, particularly in the early stages, because its symptoms can mimic those of many common childhood inflammatory skin disorders. Later, the widespread hypopigmentation obscured the characteristic lesions, leading to misdiagnosis. Moreover, due to unfamiliarity of the disease, the diagnosis of PL-like MF was missed and delayed until only 2 years after the onset of the dermatosis. Therefore, primary care practitioners must have a high index of suspicion for this cutaneous neoplasm in children with persistent or worsening skin lesions, not responding to standard therapy, to ensure timely referral, diagnosis, and treatment.
PubMed: 32434301
DOI: 10.4082/kjfm.20.0036 -
Dermatology (Basel, Switzerland) 2021Mycoplasma pneumoniae pneumonia is sometimes associated with skin or mucous membrane eruptions. Available reviews do not address the association of Chlamydophila... (Review)
Review
BACKGROUND
Mycoplasma pneumoniae pneumonia is sometimes associated with skin or mucous membrane eruptions. Available reviews do not address the association of Chlamydophila pneumoniae pneumonia with skin eruptions. We therefore conducted a systematic review of the literature addressing this issue. The National Library of Medicine, Excerpta Medica, and Web of Science databases were employed.
SUMMARY
In two reports, skin lesions and especially urticaria were more common (p < 0.05) in atypical pneumonia caused by C. pneumoniae as compared with M. pneumoniae. We found 47 patients (<18 years, n = 16; ≥18 years, n = 31) affected by a C. pneumoniae atypical pneumonia, which was associated with erythema nodosum, erythema multiforme minus, erythema multiforme majus, isolated mucositis, or cutaneous vasculitis. We also found the case of a boy with C. pneumoniae pneumonia and acute generalized exanthematous pustulosis. We did not find any case of C. pneumoniae respiratory infection associated with either Gianotti-Crosti syndrome, pityriasis lichenoides et varioliformis acuta Mucha-Habermann, or varicella-like skin eruptions.
Topics: Chlamydophila Infections; Chlamydophila pneumoniae; Erythema Multiforme; Erythema Nodosum; Humans; Mucositis; Pneumonia; Skin Diseases; Skin Diseases, Vascular; Urticaria
PubMed: 32222707
DOI: 10.1159/000506460 -
Acta Dermato-venereologica Mar 2020The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A... (Observational Study)
Observational Study
The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A total of 872 included patients received 1,256 courses of phototherapy treatment: 76.9% narrow-band UVB (NBUVB); 9.6% systemic psoralen plus UVA (PUVA); 11.4% topical PUVA; and 2.1% UVA. Approximately a fifth of the treatments (n = 240, 19.1%) were associated with AEs, the most frequent of which was erythema (8.8%). Systemic PUVA had the highest rate of AEs (32.5%). Mycosis fungoides was the dermatosis with the highest rate of AE (36.9%). A total of 216 (17.2%) patients stopped treatment: 23.6% because of AEs (4.1% of all treatments). Treatment suspension due to AEs was associated with PUVA, both topical and systemic (p < 0.001), and diagnoses of mycosis fungoides (p <0.001), palmoplantar psoriasis (p = 0.002), hand eczema (p = 0.002) and pityriasis lichenoides (p = 0.01). In conclusion, one in every 5 patients receiving phototherapy had an AE, but few stopped treatment for this reason.
Topics: Adult; Aged; Dermatitis, Phototoxic; Eczema; Erythema; Female; Humans; Male; Middle Aged; Mycosis Fungoides; PUVA Therapy; Pain; Patient Dropouts; Pityriasis Lichenoides; Prospective Studies; Psoriasis; Skin Neoplasms
PubMed: 32179932
DOI: 10.2340/00015555-3453 -
Anais Brasileiros de Dermatologia 2020
Topics: Adrenal Cortex Hormones; Adult; Antimetabolites; Diphtheria-Tetanus Vaccine; Epidermis; Humans; Male; Necrosis; Pityriasis Lichenoides
PubMed: 32156502
DOI: 10.1016/j.abd.2019.06.009 -
Frontiers in Immunology 2020
Topics: Animals; Autoimmunity; Humans; Immunity, Innate; Inflammation; Keratins; Phenotype; Signal Transduction; Skin; Skin Diseases
PubMed: 32153585
DOI: 10.3389/fimmu.2020.00280 -
BMJ Case Reports Aug 2019
Topics: Acute Disease; Administration, Cutaneous; Adrenal Cortex Hormones; Adult; Anti-Retroviral Agents; Female; HIV Infections; Humans; Pityriasis Lichenoides
PubMed: 31451481
DOI: 10.1136/bcr-2019-231864