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Actas Dermo-sifiliograficas Jun 2024
PubMed: 38885901
DOI: 10.1016/j.ad.2024.06.003 -
Mediterranean Journal of Rheumatology Mar 2024Wilson disease is a rare genetic disorder, characterised by excessive deposition of copper in the liver, brain, and other tissues. Penicillamine, a copper-chelating...
INTRODUCTION
Wilson disease is a rare genetic disorder, characterised by excessive deposition of copper in the liver, brain, and other tissues. Penicillamine, a copper-chelating agent, is used in high doses in the treatment of Wilson disease leading to a variety of cutaneous reactions, including hyper-sensitivity reactions, pseudoxanthoma elasticum, elastosis perforans serpiginosa, anetoderma, and cutis laxa (CL). We present a rare case of localised CL induced by penicillamine for Wilson disease, in the absence of elastosis perforans serpiginosa.
CASE DESCRIPTION
A 41-year-old male with Wilson disease treated with long-term high-dose penicillamine was referred to us for a basal cell carcinoma on the scalp. On physical examination, diffusely flaccid and redundant skin on the right side of the neck were observed. Histopathology revealed findings consistent with CL.
CONCLUSION
Long-term treatment with penicillamine for Wilson disease may induce localized CL, possibly by direct inhibition of cross-linkage of collagen fibres.
PubMed: 38736957
DOI: 10.31138/mjr.280223.pil -
JAAD International Jun 2024
PubMed: 38545486
DOI: 10.1016/j.jdin.2024.02.002 -
Journal of Cutaneous Pathology Jun 2024Anetoderma or macular atrophy is a rare skin condition of unclear pathogenesis, often associated with autoimmune diseases and skin damage from various infections. Human...
Anetoderma or macular atrophy is a rare skin condition of unclear pathogenesis, often associated with autoimmune diseases and skin damage from various infections. Human immunodeficiency virus (HIV), syphilis, and poxviruses have been implicated in the development of anetoderma. A 37-year-old male patient with HIV and recent unprotected sexual encounters presented with more than 400 skin lesions, consistent with Mpox. Symptomatic treatment for Mpox resulted in acute symptom resolution. However, 8 months later he developed papular anetoderma lesions in areas previously affected by Mpox. Biopsy confirmed the loss of elastic fibers in the affected skin areas, leading to the diagnosis of Mpox-induced anetoderma. This report presents a unique case of anetoderma following Mpox in an HIV-positive patient.
Topics: Humans; Male; Adult; Anetoderma; HIV Infections; Trimethoprim, Sulfamethoxazole Drug Combination
PubMed: 38468572
DOI: 10.1111/cup.14606 -
The Journal of Dermatology Jun 2024
Topics: Female; Humans; Male; Anetoderma; Granuloma Annulare; Skin; Aged
PubMed: 38279669
DOI: 10.1111/1346-8138.17116 -
Journal of the European Academy of... Apr 2024
Topics: Humans; Anetoderma; Skin; Atrophy
PubMed: 37909245
DOI: 10.1111/jdv.19610 -
Actas Dermo-sifiliograficas Oct 2023
PubMed: 37797881
DOI: 10.1016/j.ad.2022.11.021