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NeoReviews Jul 2024
Topics: Humans; Beckwith-Wiedemann Syndrome; Hernia, Umbilical; Female; Pregnancy; Adult; Prenatal Diagnosis; Ultrasonography, Prenatal; Infant, Newborn
PubMed: 38945972
DOI: 10.1542/neo.25-7-e457 -
NeoReviews Jul 2024Bronchopulmonary dysplasia (BPD) is the heterogeneous chronic lung developmental disease of prematurity, which is often accompanied by multisystem comorbidities.... (Review)
Review
Bronchopulmonary dysplasia (BPD) is the heterogeneous chronic lung developmental disease of prematurity, which is often accompanied by multisystem comorbidities. Pulmonary vascular disease and pulmonary hypertension (PH) contribute significantly to the pathogenesis and pathophysiology of BPD and dramatically influence the outcomes of preterm infants with BPD. When caring for those patients, clinicians should consider the multitude of phenotypic presentations that fall under the "BPD-PH umbrella," reflecting the need for matching therapies to specific physiologies to improve short- and long-term outcomes. Individualized management based on the patient's prenatal and postnatal risk factors, clinical course, and cardiopulmonary phenotype needs to be identified and prioritized to provide optimal care for infants with BPD-PH.
Topics: Humans; Bronchopulmonary Dysplasia; Hypertension, Pulmonary; Infant, Newborn; Infant, Premature; Risk Factors
PubMed: 38945971
DOI: 10.1542/neo.25-7-e415 -
NeoReviews Jul 2024
Topics: Humans; Hypercalcemia; Infant, Newborn; Female; Male
PubMed: 38945969
DOI: 10.1542/neo.25-7-e434 -
NeoReviews Jul 2024
Topics: Humans; Infant, Newborn; Hyperferritinemia; Fever; Male; Female
PubMed: 38945968
DOI: 10.1542/neo.25-7-e452 -
NeoReviews Jul 2024
Topics: Humans; Double Outlet Right Ventricle; Female; Pregnancy; Infant, Newborn; Ultrasonography, Prenatal; Follow-Up Studies; Adult
PubMed: 38945967
DOI: 10.1542/neo.25-7-e466 -
NeoReviews Jul 2024
Topics: Humans; Graves Disease; Female; Pregnancy; Infant, Newborn; Pregnancy Complications; Thyroid Diseases
PubMed: 38945965
DOI: 10.1542/neo.25-7-e447 -
NeoReviews Jul 2024
Topics: Humans; Infant, Newborn; Cyanosis; Male; Female
PubMed: 38945964
DOI: 10.1542/neo.25-7-e443 -
Experimental & Molecular Medicine Jul 2024The senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and contributes to lung injury in the setting of idiopathic pulmonary fibrosis...
The senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and contributes to lung injury in the setting of idiopathic pulmonary fibrosis (IPF). Yes-associated protein 1 (YAP1) is essential for cell growth and organ development; however, the role of YAP1 in AT2 cells during pulmonary fibrosis is still unclear. YAP1 expression was found to be downregulated in the AT2 cells of PF patients. Deletion of YAP1 in AT2 cells resulted in lung injury, exacerbated extracellular matrix (ECM) deposition, and worsened lung function. In contrast, overexpression of YAP1 in AT2 cells promoted alveolar regeneration, mitigated pulmonary fibrosis, and improved lung function. In addition, overexpression of YAP1 alleviated bleomycin (BLM) -induced senescence of alveolar epithelial cells both in vivo and in vitro. Moreover, YAP1 promoted the expression of peroxiredoxin 3 (Prdx3) by directly interacting with TEAD1. Forced expression of Prdx3 inhibited senescence and improved mitochondrial dysfunction in BLM-treated MLE-12 cells, whereas depletion of Prdx3 partially abrogated the protective effect of YAP1. Furthermore, overexpression of Prdx3 facilitated self-repair of the injured lung and reduced ECM deposition, while silencing Prdx3 attenuated the antifibrotic effect of YAP1. In conclusion, this study demonstrated that YAP1 alleviates lung injury and pulmonary fibrosis by regulating Prdx3 expression to improve mitochondrial dysfunction and block senescence in AT2 cells, revealing a potential novel therapeutic strategy for pulmonary fibrosis.
PubMed: 38945958
DOI: 10.1038/s12276-024-01277-0 -
Annals of Thoracic and Cardiovascular... 2024In this review, we summarize the modifications made in the Japanese Classification of Esophageal Cancer 12th edition, identify several issues, and discuss the prospects... (Review)
Review
In this review, we summarize the modifications made in the Japanese Classification of Esophageal Cancer 12th edition, identify several issues, and discuss the prospects for the next 13th edition.
Topics: Humans; Esophageal Neoplasms; Japan; Neoplasm Staging; Predictive Value of Tests; Terminology as Topic; Prognosis
PubMed: 38945946
DOI: 10.5761/atcs.ra.24-00061 -
Magnetic Resonance in Medical Sciences... 2024This special issue of Magnetic Resonance in Medical Sciences is dedicated to "Advanced Techniques for MR Neuroimaging," featuring nine review articles authored by...
This special issue of Magnetic Resonance in Medical Sciences is dedicated to "Advanced Techniques for MR Neuroimaging," featuring nine review articles authored by leading experts. The reviews cover advancements in reproducible research practices, diffusion tensor imaging along the perivascular space, myelin imaging using magnetic susceptibility source separation, spinal cord quantitative MRI analysis, tractometry of visual white matter pathways, deep learning-based image enhancement, arterial spin labeling, the potential of radiomics, and MRI-based quantification of brain oxygen metabolism. These articles provide a comprehensive update on cutting-edge technologies and their applications in clinical and research settings, highlighting their impact on improving diagnostic accuracy and understanding of neurological disorders.
Topics: Humans; Neuroimaging; Magnetic Resonance Imaging; Brain; Diffusion Tensor Imaging; Image Processing, Computer-Assisted; Nervous System Diseases; Deep Learning
PubMed: 38945942
DOI: 10.2463/mrms.e.2024-1000