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Journal of Agricultural and Food... Sep 2023The health hazard posed by Hg makes it imperative to develop a fast and convenient means for detecting Hg in water samples and living objects. While fluorescence sensing...
The health hazard posed by Hg makes it imperative to develop a fast and convenient means for detecting Hg in water samples and living objects. While fluorescence sensing technology is considered a promising candidate, the poor water solubility and fluorescence quenching in aqueous solutions of most existing probes limit their practical application. To overcome this, we developed a natural flavylium-inspired fluorescent probe with excellent water solubility. Our probe demonstrated outstanding performance of high sensitivity (LOD = 0.47 nM), fast response (<10 min), and great selectivity for Hg. Notably, we validated its applicability in real water, urine samples, and living cells. Furthermore, the probe was successfully applied to evaluate the effectiveness of antidotes for clinical Hg poisoning.
Topics: Antidotes; Fluorescent Dyes; Mercury; Fluorescence; Water
PubMed: 37639577
DOI: 10.1021/acs.jafc.3c04537 -
Ecotoxicology and Environmental Safety Oct 2023Intrauterine exposure to heavy metals may adversely affect the developing fetus and health later in life, while certain trace elements may be protective. There is...
Intrauterine exposure to heavy metals may adversely affect the developing fetus and health later in life, while certain trace elements may be protective. There is limited data on their dynamic fluctuation in circulating concentration of women from preconception to pregnancy and the degree of transplacental passage to fetus. Such information is critically needed for an optimal design of research studies and intervention strategies. In the present study, we profiled the longitudinal patterns and trajectories of metal(loid)s and trace elements from preconception to late pregnancy and in newborns. We measured whole blood metal(loid)s in women at preconception, 16, 24 and 32 weeks of gestation and in cord blood in 100 mother-newborn pairs. Our data showed that the mean concentrations of mercury (Hg), lead (Pb), rubidium (Rb), manganese (Mn), and iron (Fe) were lower during early-, mid-, and late-pregnancy than at preconception. Copper (Cu), and calcium (Ca) concentrations increased after pregnancy (Cu 798 versus 1353, 1488, and 1464 μg/L). Concentrations at preconception were correlated with those during pregnancy for all examined metal(loid)s. Maternal Hg, Pb, and Se concentrations at late-pregnancy were correlated with those in newborn cord blood in various degrees (correlation coefficients: Hg 0.66, Pb 0.29, Se 0.39). The estimated placental transfer ratio for toxic metal(loid)s ranging from 1.68 (Hg) to 0.18 (Cd). Two trajectory groups were identified for Hg, Pb, Cd, Se concentrations. Hg concentrations may be correlated with maternal education levels. The study is the first to present longitudinal circulating concentration trajectories of toxic metal(loid)s and trace elements from preconception to pregnancy stages. A high degree of transplacental passage was observed in toxic metals Pb and Hg which may pose hazards to the developing fetus.
Topics: Female; Infant, Newborn; Pregnancy; Humans; Trace Elements; Cadmium; Lead; Placenta; Metals, Heavy; Mercury; Heavy Metal Poisoning; Fetal Blood
PubMed: 37625333
DOI: 10.1016/j.ecoenv.2023.115394 -
Journal of Biochemical and Molecular... Dec 2023Gut microbiota plays a functionally important part in retaining the homeostasis of host physiology, however, under exposure of various heavy metals, the composition of... (Review)
Review
Gut microbiota plays a functionally important part in retaining the homeostasis of host physiology, however, under exposure of various heavy metals, the composition of gut biota is disturbed in relation to species diversity and richness. Ever since the increase of microbiome-related studies during the last decade, many research studies have delivered an understanding of the reasons and concerns of gut microbiota-related modifications. During the past decade, it's been confirmed from various studies that heavy metals poisoning alters the microbial composition, which results in changes in gene expression, alteration in metabolism, immunity, neurological dysfunction, and causes various other disorders. The present comprehensive review is summarizing an attempt to enumerate the key findings from recent clinical or preclinical studies related to the influence of heavy metals on gut microbiota published recently. Google, PubMed, Science Direct, Scopus, and Google Scholar were employed as primary search engines using the keywords such as "heavy metals, gut microbiota, dysbiosis, and intestinal microbiota" for finding relevant research articles from the past 10 years and some old important articles. Here, we tried to provide insight into some of the key timelines and scientific findings from reported literature, like the effects of heavy metals such as arsenic, cadmium, lead, and mercury on the general body and specifically on the gut microbiota of different model organisms. So, it is important to increase awareness against heavy metal-induced toxicity and formulate guidelines for the benefit of the environment.
Topics: Gastrointestinal Microbiome; Metals, Heavy; Cadmium; Arsenic
PubMed: 37593904
DOI: 10.1002/jbt.23485 -
Biological Trace Element Research Apr 2024Chromium (Cr), total arsenic (As), inorganic arsenic (iAs), cadmium (Cd), mercury (Hg), methylmercury (MeHg), and lead (Pb) were analyzed in in Agaricus blazei,...
Chromium (Cr), total arsenic (As), inorganic arsenic (iAs), cadmium (Cd), mercury (Hg), methylmercury (MeHg), and lead (Pb) were analyzed in in Agaricus blazei, Tricholoma matsutake, Pholiota nameko, agrocybe aegirit, Boletus edulis, Auricularia auricula, and Lentinus edodes collected from online supermarket in China from 2015 to 2017. The order of mean concentrations for the five heavy metals in edible mushrooms was As > Cd > Cr > Pb > Hg. No positive correlation was found between total As and iAs, nor between total Hg and MeHg. The contents of iAs were at a low level except for A. blazei samples. The contents of MeHg were at a low level in all test mushroom samples. And Cr, Cd, and Pb pollution were common problems in the test mushroom samples. The comprehensive factor pollution index was between 0.569 (A. auricula) and 3.056 (B. edulis). The THQ values for the five heavy metals from P. nameko, A. auricula, A. aegirit, and L. edodes samples were less than 1. The hazard index (HI) values of A. blazei, T. matsutake, and B. edulis samples for adults and children were greater than 1, indicating significant health hazard to the adults and children consumers. The cancer risk (CR) values for iAs ranged from 3.82 × 10 (T. matsutake) to 8.61 × 10 (A. blazei), indicating no potential carcinogenic risk to the consumers. The order for carcinogenic risk of each edible mushroom species was A. blazei > L. edodes > P. nameko > A. aegirit > A. auricula > B. edulis > T. matsutake.
Topics: Adult; Child; Humans; Arsenic; Cadmium; Methylmercury Compounds; Lead; Supermarkets; Metals, Heavy; Mercury; Chromium; China; Agaricales; Risk Assessment; Environmental Monitoring; Soil Pollutants
PubMed: 37526876
DOI: 10.1007/s12011-023-03779-w -
Clinical Case Reports Jul 2023Patients that are taking Ayurvedic supplements have an increased risk of heavy metal toxicity. Lead, arsenic, and mercury are frequently identified in these supplements...
Patients that are taking Ayurvedic supplements have an increased risk of heavy metal toxicity. Lead, arsenic, and mercury are frequently identified in these supplements and can cause clinically significant toxicity. Clinicians should screen patients routinely for use of non-pharmaceutical medications and supplements.
PubMed: 37492071
DOI: 10.1002/ccr3.7733 -
Environmental Science and Pollution... Aug 2023The Réunion harrier is an endemic raptor on Réunion Island. Several threats endanger its population, poisoning by rodenticides being considered as the main one...
The Réunion harrier is an endemic raptor on Réunion Island. Several threats endanger its population, poisoning by rodenticides being considered as the main one currently. No information is available on its exposure to other chemicals notably trace metal elements such as lead (Pb), mercury (Hg), and cadmium (Cd). The Réunion harrier is still a victim of poaching nowadays. When shooting is not lethal, animals may carry embedded shot in their body and thus be exposed to toxic level of Pb as demonstrated for other raptors. Moreover, recent monitoring suggests a decrease of its breeding success over time. It is known that Hg and Cd could impair reproduction and disturb embryo development in birds. The aim is to measure metal concentrations in the tissues of 30 carcasses of harrier collected from 2016 to 2021. Lead was analyzed in the liver and humerus, while Hg and Cd were measured in livers. Concentrations were compared to toxicological reference values. Overall, the Réunion harrier was not exposed to toxic levels of Pb or Cd. For Hg, 53% of the individuals have residues higher than the threshold compatible with oxidative stress, and 13% have liver concentrations above those compatible with reproduction impairment. A positive correlation was found between the proportion of urban habitat in a 55 km area centered on the location where the harrier was found and the concentration of Hg in the liver. We conclude that Hg exposure could be a threat for the Réunion harrier population and recommend monitoring the exposure of the most sensitive stages, i.e., embryos and nestlings, to this metal with non-invasive methods.
Topics: Animals; Cadmium; Reunion; Lead; Mercury; Birds; Raptors; Metals, Heavy; Environmental Monitoring
PubMed: 37452238
DOI: 10.1007/s11356-023-28748-7 -
Journal of Biochemical and Molecular... Oct 2023Mercury is a toxic, environmentally heavy metal that can cause severe damage to all organs, including the nervous system. The functions of puerarin include antioxidant,...
Mercury is a toxic, environmentally heavy metal that can cause severe damage to all organs, including the nervous system. The functions of puerarin include antioxidant, anti-inflammatory, nerve cell repair, regulation of autophagy, and so forth. But because of the limited oral absorption of puerarin, it affects the protective effect on brain tissue. The nano-encapsulation of Pue can improve its limitation. Therefore, this study investigated the protective effect of Pue drug-loaded PLGA nanoparticles (Pue-PLGA-nps) on brain injury induced by mercuric chloride (HgCl ) in mice. The mice were divided into normal saline (NS) group, HgCl (4 mg/kg) group, Pue-PLGA-nps (50 mg/kg) group, HgCl + Pue (4 mg/kg + 30 mg/kg) group, and HgCl + Pue-PLGA-nps (4 mg/kg + 50 mg/kg) group. After 28 days of treatment, the mice were observed for behavioral changes, antioxidant capacity, autophagy and inflammatory response, and mercury levels in the brain, blood, and urine were measured. The results showed that HgCl toxicity caused learning and memory dysfunction in mice, increased mercury content in brain and blood, and increased serum levels of interleukin (IL-6), IL-1β, and tumor necrosis factor-α in the mice. HgCl exposure decreased the activity of T-AOC, superoxide dismutase, and glutathione peroxidase, and increased the expression of malondialdehyde in the brain of mice. Moreover, the expression levels of TRIM32, toll-like receptor 4 (TLR4), and LC3 proteins were upregulated. Both Pue and Pue-PLGA-nps interventions mitigated the changes caused by HgCl exposure, and Pue-PLGA-nps further enhanced this effect. Our results suggest that Pue-PLGA-nps can ameliorate HgCl -induced brain injury and reduce Hg accumulation, which is associated with inhibition of oxidative stress, inflammatory response, and TLR4/TRIM32/LC3 signaling pathway.
Topics: Mice; Animals; Antioxidants; Mercuric Chloride; Toll-Like Receptor 4; Brain; Oxidative Stress; Polylactic Acid-Polyglycolic Acid Copolymer; Mercury; Brain Injuries; Nanoparticles
PubMed: 37401655
DOI: 10.1002/jbt.23425 -
Environmental Science and Pollution... Aug 2023The concentrations of potentially toxic metals like lead (Pb), cadmium (Cd), and mercury (Hg) in healthy lactating mothers of Lahore city were estimated during 2020-2021...
The concentrations of potentially toxic metals like lead (Pb), cadmium (Cd), and mercury (Hg) in healthy lactating mothers of Lahore city were estimated during 2020-2021 with the help of a flame atomic absorption spectrometer (FAAS). Seventy samples of breast milk were collected from two different age groups, namely, G-1 (25-30 years) and G-2 (31-40 years). The results showed that Cd contents were below the detection limit of the measuring instrument; however, the Pb and Hg contents were detected with great ease. The mean concentrations of Pb and Hg in the G-1 corresponding to the age between 25 and 30 years were observed to be 1.914 ± 0.493 μg/L and 10.432 ± 3.249 μg/L, respectively. For the G-2 with an age limit between 31 and 40 years, the concentrations of Pb and Hg were estimated to be 2.045 ± 0.502 μg/L and 11.527 ± 3.231 μg/L, respectively. The T-test analysis of concentrations of these toxic metals indicated a significant correlation between the content levels of Pb and Hg (p < 0.05). The observed values of toxic metals were significantly more frequent than those suggested by WHO (World Health Organization). An increase in the concentrations of Pb and Hg is directly associated with the location of the target population. As a result, it is turned out that the majority of the lactating woman with significantly high levels of Pb and Hg belongs to industrial areas of Lahore. To avoid such conditions, residential areas must be at larger distances, in addition, to strictly abiding by the environmental policies of the government.
Topics: Humans; Female; Adult; Milk, Human; Cadmium; Lead; Lactation; Pakistan; Mercury; Heavy Metal Poisoning; Metals, Heavy
PubMed: 37395883
DOI: 10.1007/s11356-023-28517-6 -
Journal of Hazardous Materials Aug 2023Chlorine poisoning effects are still challenging to develop efficient catalysts for applications in chlorobenzene (CB) and mercury (Hg) oxidation. Herein,...
Three-dimensional porous CuO-modified CeO-AlO catalysts with chlorine resistance for simultaneous catalytic oxidation of chlorobenzene and mercury: Cu-Ce interaction and structure.
Chlorine poisoning effects are still challenging to develop efficient catalysts for applications in chlorobenzene (CB) and mercury (Hg) oxidation. Herein, three-dimensional porous CuO-modified CeO-AlO catalysts with macroporous framework and mesoporous walls prepared via a dual template method were employed to study simultaneous oxidation of CB and Hg. CuO-modified CeO-AlO catalysts with three-dimensional porous structure exhibited outstanding activity and stability for simultaneous catalytic oxidation of CB and Hg. The results demonstrated that the addition of CuO into CeO-AlO can simultaneously enhance the acid sites and redox properties through the electronic inductive effect between CuO and CeO (Cu+Ce↔Cu+Ce). Importantly, the synergistic effect between Cu and Ce species can induce abundant oxygen vacancies formation, produce more reactive oxygen species and facilitate oxygen migration, which is beneficial for the deep oxidation of chlorinated intermediates. Moreover, macroporous framework and mesoporous nanostructure dramatically improved the specific surface area for enhancing the contact efficiency between reactants and active sites, leading to a remarkable decrease of byproducts deposition. CB and Hg had function of mutual promotion in this reaction system. In tune with the experimental results, the possible mechanistic pathways for simultaneous catalytic oxidation of CB and Hg were proposed.
PubMed: 37163894
DOI: 10.1016/j.jhazmat.2023.131585 -
Cirugia Espanola Oct 2023
Topics: Humans; Mercury; Lymphatic System
PubMed: 36933888
DOI: 10.1016/j.cireng.2023.03.002