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Cancer Investigation Sep 2023This study aimed to reveal the drug-repurposing candidates for colorectal cancer (CRC) drug-repurposing methods and network biology approaches. A novel, differentially...
This study aimed to reveal the drug-repurposing candidates for colorectal cancer (CRC) drug-repurposing methods and network biology approaches. A novel, differentially co-expressed, highly interconnected, and co-regulated prognostic gene module was identified for CRC. Based on the gene module, polyethylene glycol (PEG), gallic acid, pyrazole, cordycepin, phenothiazine, pantoprazole, cysteamine, indisulam, valinomycin, trametinib, BRD-K81473043, AZD8055, dovitinib, BRD-A17065207, and tyrphostin AG1478 presented as drugs and small molecule candidates previously studied in the CRC. Lornoxicam, suxamethonium, oprelvekin, sirukumab, levetiracetam, sulpiride, NVP-TAE684, AS605240, 480743.cdx, HDAC6 inhibitor ISOX, BRD-K03829970, and L-6307 are proposed as novel drugs and small molecule candidates for CRC.
Topics: Humans; Drug Repositioning; Colorectal Neoplasms; Gene Regulatory Networks; Prognosis; Computational Biology
PubMed: 37682113
DOI: 10.1080/07357907.2023.2255672