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Oncotarget Jul 2024
Correction: BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV.
Topics: Animals; Herpesvirus 8, Human; Mice; Mice, Inbred BALB C; Antibodies, Neutralizing; Viral Envelope Proteins; Antibodies, Viral; Vaccines, Virus-Like Particle; Humans; Ultraviolet Rays
PubMed: 38953905
DOI: 10.18632/oncotarget.28600 -
Oncotarget Jul 2024
Topics: Pancreatic Neoplasms; Humans; Adenocarcinoma; Drug Screening Assays, Antitumor; Antineoplastic Agents
PubMed: 38953899
DOI: 10.18632/oncotarget.28556 -
Oncotarget Jul 2024Single-agent TAS102 (trifluridine/tipiracil) and regorafenib are FDA-approved treatments for metastatic colorectal cancer (mCRC). We previously reported that regorafenib...
Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status.
Single-agent TAS102 (trifluridine/tipiracil) and regorafenib are FDA-approved treatments for metastatic colorectal cancer (mCRC). We previously reported that regorafenib combined with a fluoropyrimidine can delay disease progression in clinical case reports of multidrug-resistant mCRC patients. We hypothesized that the combination of TAS102 and regorafenib may be active in CRC and other gastrointestinal (GI) cancers and may in the future provide a treatment option for patients with advanced GI cancer. We investigated the therapeutic effect of TAS102 in combination with regorafenib in preclinical studies employing cell culture, colonosphere assays that enrich for cancer stem cells, and . TAS102 in combination with regorafenib has synergistic activity against multiple GI cancers including colorectal and gastric cancer, but not liver cancer cells. TAS102 inhibits colonosphere formation and this effect is potentiated by regorafenib. anti-tumor effects of TAS102 plus regorafenib appear to be due to anti-proliferative effects, necrosis and angiogenesis inhibition. Growth inhibition by TAS102 plus regorafenib occurs in xenografted tumors regardless of p53, KRAS or BRAF mutations, although more potent tumor suppression was observed with wild-type p53. Regorafenib significantly inhibits TAS102-induced angiogenesis and microvessel density in xenografted tumors, as well inhibits TAS102-induced ERK1/2 activation regardless of RAS or BRAF status . TAS102 plus regorafenib is a synergistic drug combination in preclinical models of GI cancer, with regorafenib suppressing TAS102-induced increase in microvessel density and p-ERK as contributing mechanisms. The TAS102 plus regorafenib drug combination may be further tested in gastric and other GI cancers.
Topics: Humans; Trifluridine; Phenylurea Compounds; Animals; Pyridines; Drug Synergism; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Neovascularization, Pathologic; Xenograft Model Antitumor Assays; Neoplastic Stem Cells; Gastrointestinal Neoplasms; Uracil; Mice; STAT3 Transcription Factor; Thymine; Drug Combinations; Cell Line, Tumor; Pyrrolidines; Mutation; Antineoplastic Combined Chemotherapy Protocols; MAP Kinase Signaling System; Signal Transduction; Cell Proliferation; Angiogenesis
PubMed: 38953895
DOI: 10.18632/oncotarget.28602 -
Acta Ophthalmologica Jul 2024To characterise the retinal vasculometry of a Danish eye and vision cohort and examine associations with systolic blood pressure (BP), diastolic BP, mean arterial BP,...
Longitudinal associations of retinal vessel morphology with intraocular pressure and blood pressure at follow-up visit-Findings from a Danish eye and vision cohort, Project FOREVER.
PURPOSE
To characterise the retinal vasculometry of a Danish eye and vision cohort and examine associations with systolic blood pressure (BP), diastolic BP, mean arterial BP, and intraocular pressure (IOP).
DESIGN
Longitudinal study.
METHODS
The retinal vasculature of fundus images from the FOREVER (Finding Ophthalmic Risks and Evaluating the Value of Eye exams and their predictive Reliability) cohort was analysed using a fully automated image analysis program. Longitudinal associations of retinal vessel morphology at follow-up visit with IOP (baseline and follow-up) and BP (follow-up) were examined using multilevel linear regression models adjusting for age, sex and retinal vasculometry at baseline as fixed effects and person as random effect. Width measurements were additionally adjusted for the spherical equivalent.
RESULTS
A total of 2089 subjects (62% female) with a mean age of 61 (standard deviation 8) years and a mean follow-up period of 4.1 years (SD 0.6 years) were included. The mean arteriolar diameter was approximately 20% thinner than the mean venular diameter, and venules were about 21%-23% less tortuous than arterioles. BP at follow-up was associated with decreased arteriolar diameter from baseline to follow-up. After adjusting for baseline IOP, IOP at follow-up was associated with increased arteriolar tortuosity above baseline (0.59%, 95% CI 0.08-1.10, p-value 0.024).
CONCLUSION
In a Danish eye and vision cohort, variations in BP and alterations in IOP over time were associated with changes in the width and tortuosity of retinal vessels. Our findings contribute novel insights into retinal vascular alterations over time.
PubMed: 38953839
DOI: 10.1111/aos.16737 -
Indian Journal of Public Health Apr 2024
Topics: Humans; COVID-19 Vaccines; India; COVID-19; Female; Male; SARS-CoV-2; Adult; Vaccination Hesitancy; Middle Aged; Patient Acceptance of Health Care
PubMed: 38953834
DOI: 10.4103/ijph.ijph_1509_22 -
Indian Journal of Public Health Apr 2024
Topics: India; Humans; Hot Temperature; Extreme Heat
PubMed: 38953832
DOI: 10.4103/ijph.ijph_14_24 -
Indian Journal of Public Health Apr 2024Cancer patients suffer from complicated chemotoxicity. Pharmacogenomics can help stratify patients by predicting their response to treatment and susceptibility toward...
Cancer patients suffer from complicated chemotoxicity. Pharmacogenomics can help stratify patients by predicting their response to treatment and susceptibility toward severe side effects. The spindle-assembly checkpoint (SAC) is an important pathway that is activated by platinum and taxane compounds and plays a crucial role in their cytotoxic activity. This study investigated a SAC component, Budding Uninhibited by Benzimidazoles 3 (BUB3), its expression, and genetic variants in advanced ovarian cancer patients treated with paclitaxel-carboplatin chemotherapy. Among 80 patients, BUB3 expression correlated with chemosensitivity, suggesting its potential as a predictive marker for chemotherapy response. However, high BUB3 expression was associated with a higher risk of poor survival. In addition, genetic polymorphisms in BUB3 (rs11248416 and rs11248419) were significantly linked to chemotherapy-related toxicities, with rs11248416 showing a negative impact on the patient's physical quality of life.
Topics: Humans; Female; Paclitaxel; Ovarian Neoplasms; Carboplatin; Middle Aged; M Phase Cell Cycle Checkpoints; Antineoplastic Combined Chemotherapy Protocols; Polymorphism, Single Nucleotide; Cell Cycle Proteins; Adult; Antineoplastic Agents; Quality of Life
PubMed: 38953826
DOI: 10.4103/ijph.ijph_809_23 -
Indian Journal of Public Health Apr 2024India has run a nationwide vaccination campaign against COVID-19, which has recently introduced a precaution (third) dose for health workers. This study assessed the...
INTRODUCTION
India has run a nationwide vaccination campaign against COVID-19, which has recently introduced a precaution (third) dose for health workers. This study assessed the perception and attitude of health workers toward the Indian vaccination campaign against COVID-19, with an emphasis on this major change.
MATERIALS AND METHODS
A printed questionnaire was distributed among health-care workers at the Medical College of West Bengal. The completed forms were analyzed.
RESULTS
Most of the participants were doctors (83.7%). Although all had received two doses of vaccine before, 44.4% were unwilling to be vaccinated with the third dose in the present scenario. The majority (63.8%) of the patients were concerned about side effects. The emergence of new COVID strains (65.6%) was viewed as a threat to the effectiveness of the vaccines. Participants with higher age, comorbidities, and those with the perception that the third dose was being introduced appropriately and would be effective against newer strains of the vaccine tended to be more willing to get vaccinated with the precaution dose compared to their counterparts.
CONCLUSION
A dilemma regarding the acceptance of precaution doses was noted among health workers. This warrants the availability of more comprehensive information to increase acceptance of these vaccines.
Topics: Humans; India; COVID-19 Vaccines; Male; COVID-19; Female; Adult; Health Personnel; SARS-CoV-2; Attitude of Health Personnel; Middle Aged; Surveys and Questionnaires; Vaccination; Young Adult; Vaccination Hesitancy
PubMed: 38953812
DOI: 10.4103/ijph.ijph_544_23 -
Indian Journal of Public Health Apr 2024Air pollution is a significant issue for a developing country like India and the air quality index (AQI) forecasting helps to predict air quality levels in advance and...
BACKGROUND
Air pollution is a significant issue for a developing country like India and the air quality index (AQI) forecasting helps to predict air quality levels in advance and allows individuals to take precautionary measures to protect their health.
OBJECTIVES
The study aimed to forecast the AQI for an industrial area (SIDCUL, Haridwar City) using a time series regression model.
MATERIALS AND METHODS
Three years of existing AQI data points (post-COVID-19) were collected from the Uttarakhand Pollution Control Board for the SIDCUL area of Haridwar City and tried to know the status of AQI values for the following 12 months. Trend and seasonality components were seen through the decomposition process. Further, the augmented Dickey-Fuller test was applied to check the stationarity of the series before finalizing the best-suited time series model for forecasting the AQI values.
RESULTS
With the help of autocorrelation function (ACF)/partial ACF plots, a seasonal autoregressive integrated moving average (ARIMA) (0,1,0) (1,0,0)[12] model was selected with the minimum akaike information criterion (253.143) and mean absolute percentage error (17.42%). The AQI values have also been forecasted for this industrial area (SIDCUL) for the following year.
CONCLUSION
The seasonal ARIMA (0,1,0) (1,0,0)[12] model may be helpful to forecast the AQI values for a nonstationary time series dataset. Research indicates that the air of the SIDCUL area will become moderately polluted and may cause breathing discomfort to asthma patients' health. The scientists might apply this model to other polluted regions of the country so that the public and the government can take preventive measures in advance.
Topics: India; Humans; Air Pollution; Risk Assessment; Public Health; COVID-19; Forecasting; Seasons; Air Pollutants; Industry; SARS-CoV-2; Cities
PubMed: 38953809
DOI: 10.4103/ijph.ijph_279_23 -
Indian Journal of Public Health Apr 2024India is at a critical stage to eliminate filariasis. Uncovering the factors governing may help taking appropriate measures to achieve the goal.
BACKGROUND
India is at a critical stage to eliminate filariasis. Uncovering the factors governing may help taking appropriate measures to achieve the goal.
OBJECTIVES
This study evaluated the acceptance of "mass drug administration" (MDA) for prophylaxis against filariasis and the factors facilitating and interfering with it.
MATERIALS AND METHODS
A cross-sectional study was conducted in a tribal endemic area of India from May 2022 to October 2022. A validated 29-item self-administered questionnaire was used to collect the data. Items were grouped under "knowledge," "social processes," "think and feel," "practical factors," and "motivation/hesitancy" domains.
RESULTS
Of 101 participants, majority were aware of the disease (92.1%), its vector (74.3%), at least one disability caused (87.2%), and governmental scheme of MDA (69.3%). Two-thirds never received and 85.1% did not receive MDA within 1 year. 68.3% refused of distribution of MDA to their doorstep. Majority were concerned for getting MDA for self and their family/friends; however, 49.5% showed inability to take independent decision. More than 30% disagreed to get MDA had it been available. The region with the highest concerns for adverse drug effects showed minimum MDA consumption than others (P < 0.05). MDA acceptance/consumption was significantly associated with knowledge about disability caused, distribution of drugs by a health-care representative to doorstep, behavior of the representative, and concerns about potential adverse drug effects.
CONCLUSION
MDA coverage was inadequate in the study population. Level of knowledge, practical difficulties in getting drugs, inapt thinking/concerns, motivation, awareness about disabilities caused, door-to-door drug distribution, and behavior of health-care representative(s), were identified as factors significantly affecting acceptance of MDA.
Topics: Humans; Elephantiasis, Filarial; Cross-Sectional Studies; India; Female; Male; Adult; Health Knowledge, Attitudes, Practice; Mass Drug Administration; Patient Acceptance of Health Care; Middle Aged; Filaricides; Young Adult; Endemic Diseases; Surveys and Questionnaires; Adolescent
PubMed: 38953805
DOI: 10.4103/ijph.ijph_312_23