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Wiadomosci Lekarskie (Warsaw, Poland :... 2024Aim: To study the Respiratory pathology of the upper respiratory tract, markers of the inflammatory response of the organism, Oxidative stress, Metabolic adaptation and...
OBJECTIVE
Aim: To study the Respiratory pathology of the upper respiratory tract, markers of the inflammatory response of the organism, Oxidative stress, Metabolic adaptation and possibilities of correction.
PATIENTS AND METHODS
Materials and Methods: The study group (n=111) included school-aged children (10-14 years old). The general group of inflammatory diseases of the respiratory tract (J000-J06) was considered, with a diagnosis of acute respiratory infection (ARI) of viral and bacterial origin and included local inflammationof the upper respiratory tract with presentation of acute pharyngitis (68.0%), acute bronchitis (22,0%), acute tonsillitis (10,0%).
RESULTS
Results: Dynamic observation of groups of children who received optimized (group 1, n=60) and basic (group 2, n=51) treatment was carried out. The level of the erythrocyte pool correlated with IL-1 (r=-0,29, p=0,03), IL-4 (r=0,32, p=0,01), TNF-α (r=-0,35 , p=0,006). Creatinine value correlated with IL-10 (r=0,3, p=0,005), γ-IFN (r=0,42, p=0,001), TNF-α (r=0,25, p=0,05). Correlations of ferritin presented positive correlation values with the level of total protein (r=0,26, p=0,04) and TNF-α (r=0,41, p=0,001).
CONCLUSION
Conclusions: After the optimized treatment, there was a significant decrease in the reliable levels of CRP and γ-IFN by 7 and 4,4 times (by groups) and 5,8 and 3,2 times (by groups), respectively. Correlation relationships of urea levels with IL-2,4 were detected. The level of the erythrocyte pool correlated with IL-1,4, TNF-α, Ferritin presented positive correlation values with the level of total protein,TNF-α .
Topics: Humans; Child; Adolescent; Male; Female; Respiratory Tract Infections; Biomarkers; Acute Disease; Tumor Necrosis Factor-alpha; Interleukin-4; Ferritins; Oxidative Stress
PubMed: 38691798
DOI: 10.36740/WLek202403124 -
IDCases 2024This article describes a case of polymicrobial pharyngitis and sinusitis complicated by intracranial complications and reviews similar cases in the literature.
OBJECTIVE
This article describes a case of polymicrobial pharyngitis and sinusitis complicated by intracranial complications and reviews similar cases in the literature.
CASE SUMMARY
A 21-year-old immunocompetent male presented with symptoms of sore throat, rhinorrhoea, lethargy, headache, and rash. Imaging demonstrated sinusitis, pre-septal sinusitis, peritonsillar abscess formation, subdural empyema and cerebritis. He was managed with endoscopic sinus surgery, craniotomy for evacuation of subdural empyema and antibiotics. Microbiological samples demonstrated growth of , , and . He subsequently developed a cerebral abscess requiring stereotactic needle drainage. After a prolonged course of antibiotics, the patient was discharge and made a good recovery.
DISCUSSION
is an uncommon cause of non-streptococcal pharyngitis that may occur alongside other microorganisms and is rarely associated with severe intracranial complications. This organism and its antibiotic susceptibility patterns should be considered in complicated upper respiratory tract infections in immunocompetent hosts. Penicillins and macrolide antibiotics form the mainstay of therapy for .
PubMed: 38690576
DOI: 10.1016/j.idcr.2024.e01960 -
BMC Pediatrics Apr 2024Sleep-disordered breathing (SDB) may lead to poor asthma control in children.
BACKGROUND
Sleep-disordered breathing (SDB) may lead to poor asthma control in children.
OBJECTIVE
To identify risk factors of SDB in children with asthma and assess its impact on asthma control.
METHODS
In this cross-sectional study, we collected data of outpatients with asthma at the Children's Hospital of Chongqing Medical University from June 2020 to August 2021. The Pediatric Sleep Questionnaire-Sleep-Related Breathing Disorder and the age-appropriate asthma control tests Childhood Asthma Control Test and Test for Respiratory and Asthma Control in Kids were completed.
RESULTS
We enrolled 397 children with a male-to-female ratio of 1.7:1 and a mean age of 5.70 ± 2.53 years. The prevalence of SDB was 21.6%. Allergic rhinitis (odds ratio OR = 3.316), chronic tonsillitis (OR = 2.246), gastroesophageal reflux (OR = 7.518), adenoid hypertrophy (OR = 3.479), recurrent respiratory infections (OR = 2.195), and a family history of snoring (OR = 2.048) were risk factors for the development of combined SDB in children with asthma (p < 0.05). Asthma was poorly controlled in 19.6% of the children. SDB (OR = 2.391) and irregular medication use (OR = 2.571) were risk factors for poor asthma control (p < 0.05).
CONCLUSIONS
Allergic rhinitis, chronic tonsillitis, gastroesophageal reflux, adenoid hypertrophy, recurrent respiratory infections, and a family history of snoring were independent risk factors for the development of SDB in children with asthma. SDB and irregular medication use were independent risk factors for poor asthma control.
Topics: Humans; Asthma; Male; Female; Risk Factors; Cross-Sectional Studies; Sleep Apnea Syndromes; Child; Child, Preschool; Rhinitis, Allergic; Prevalence; China; Tonsillitis; Snoring; Adenoids; Respiratory Tract Infections
PubMed: 38689232
DOI: 10.1186/s12887-024-04762-7 -
The American Journal of Tropical... Jun 2024The COVID-19 pandemic has altered the epidemiology of many common childhood infections, including Group A streptococcal (GAS) disease. Acute post-streptococcal...
The COVID-19 pandemic has altered the epidemiology of many common childhood infections, including Group A streptococcal (GAS) disease. Acute post-streptococcal glomerulonephritis (APSGN) is a nonsuppurative complication of GAS pharyngitis and pyoderma. It remains the most common cause of pediatric acute glomerulonephritis globally. In Counties Manukau, New Zealand, APSGN rates have previously been shown to be the highest in the country, with marked ethnic and socioeconomic disparities. We performed a retrospective review of children aged 0-14 years who were discharged from Kidz First Hospital, Counties Manukau, between 2015 and 2023 and met the Strep A Vaccine Global Consortium consensus definition of APSGN. We describe a marked, sustained reduction in APSGN hospitalizations, temporally associated with the COVID-19 pandemic. This ongoing reduction in APSGN incidence is notable in light of contrasting reports of increasing incidence of rheumatic fever in New Zealand and invasive GAS disease internationally.
Topics: Humans; New Zealand; COVID-19; Streptococcal Infections; Glomerulonephritis; Child; Child, Preschool; Adolescent; Incidence; Infant; Male; Retrospective Studies; Female; Streptococcus pyogenes; SARS-CoV-2; Infant, Newborn; Hospitalization; Acute Disease
PubMed: 38688264
DOI: 10.4269/ajtmh.23-0762 -
Journal of Pediatric Gastroenterology... Jul 2024
Topics: Humans; Necrosis; Postoperative Complications; Uvula; Male; Female
PubMed: 38686836
DOI: 10.1002/jpn3.12239 -
Postgraduate Medicine Apr 2024Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome and familial Mediterranean fever (FMF) are autoinflammatory disorders typically... (Observational Study)
Observational Study
The evaluation of depression and anxiety levels of mothers of patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome and familial Mediterranean fever.
OBJECTIVE
Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome and familial Mediterranean fever (FMF) are autoinflammatory disorders typically characterized by recurrent fever attacks. These recurrent fever attacks can lead to depression and anxiety in mothers of these patients. This study aimed to compare the depression and anxiety levels in mothers of PFAPA and FMF patients.
METHODS
This study is a cross-sectional observational study. 48 mothers of children with FMF and 70 mothers of children with PFAPA participated in the study. Mothers in these two groups were compared in terms of anxiety and depression by using the validated Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI).
RESULTS
Depression and anxiety scores of mothers were found to be similar in FMF and PFAPA groups. Moderate or high level of anxiety was seen in 32% of mothers of patients with PFAPA and 27% of mothers of patients with FMF. 23% of mothers of patients with PFAPA were evaluated as having moderate or severe depression, and 18% of mothers of patients with FMF were evaluated as having moderate depression. There was no statistically significant difference between the duration, frequency of attacks, recurrent hospitalizations, sociodemographic characteristics, and inventory scores.
CONCLUSION
Depression and anxiety scores of mothers with children diagnosed with FMF and PFAPA are similar. These two diseases affect families psychosocially at similar levels. It is important to provide psychosocial support to families.
Topics: Humans; Female; Mothers; Familial Mediterranean Fever; Stomatitis, Aphthous; Cross-Sectional Studies; Adult; Anxiety; Depression; Pharyngitis; Lymphadenitis; Child; Male; Syndrome; Child, Preschool; Fever; Adolescent; Young Adult; Psychiatric Status Rating Scales
PubMed: 38683959
DOI: 10.1080/00325481.2024.2347829 -
The Annals of Otology, Rhinology, and... Jul 2024To describe the design and construction of a reproducible, low-cost, peritonsillar abscess (PTA) incision and drainage simulator and assess its impact on trainees'...
OBJECTIVES
To describe the design and construction of a reproducible, low-cost, peritonsillar abscess (PTA) incision and drainage simulator and assess its impact on trainees' confidence.
METHODS
The 2-part simulator we developed consisted of a manikin head with a fixed, partially open mouth and a modular PTA mold. The mold is created by injecting a lotion and water mixture into plastic bubbles, followed by silicone solidification. Neodymium magnets secure the silicone-abscess packet to the manikin's palate. The simulator was utilized during an academic otolaryngology residency training program Annual Otolaryngology Boot Camp. A self-assessment Likert scale questionnaire was used to evaluate participants' confidence before and after simulator training. Fourth-year medical students and junior (first and second year) residents who participated in the boot camp and agreed to complete the evaluation were included.
RESULTS
Three medical students, 17 PGY-1, and 10 PGY-2 residents agreed to complete the evaluation. All trainees agreed the model was useful for learning skills. The overall post-training confidence Likert scores of participants, and PGY-1 residents in particular, significantly improved compared to their pre-training scores ( < .001).
CONCLUSIONS
Our model offers an affordable and efficient training opportunity for residents to enhance their competence in managing PTAs. This approach, with its simple yet effective design and low production cost, shows potential for scalability on a broader scale.
Topics: Humans; Peritonsillar Abscess; Internship and Residency; Drainage; Clinical Competence; Otolaryngology; Simulation Training; Manikins; Models, Anatomic; Education, Medical, Graduate
PubMed: 38682302
DOI: 10.1177/00034894241249611 -
Lancet (London, England) Apr 2024
Topics: Humans; Tonsillitis; Tonsillectomy; Recurrence; Randomized Controlled Trials as Topic
PubMed: 38677858
DOI: 10.1016/S0140-6736(24)00187-9 -
Lancet (London, England) Apr 2024
Topics: Humans; Tonsillitis; Tonsillectomy; Recurrence; Child; Treatment Outcome
PubMed: 38677857
DOI: 10.1016/S0140-6736(24)00190-9 -
Lancet (London, England) Apr 2024
Topics: Humans; Tonsillitis; Tonsillectomy; Recurrence; Child; Treatment Outcome
PubMed: 38677856
DOI: 10.1016/S0140-6736(24)00189-2