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Indian Journal of Nuclear Medicine :... 2023Polyneuropathy, organomegaly, endocrinopathy, M protein elevation, and skin changes (POEMS) syndrome is one of the rare paraneoplastic disorders of the multiorgan...
Polyneuropathy, organomegaly, endocrinopathy, M protein elevation, and skin changes (POEMS) syndrome is one of the rare paraneoplastic disorders of the multiorgan association whose initialism describes the principal clinical features as polyneuropathy, organomegaly, endocrinopathy, M-protein elevation, and skin changes caused by an underlying plasma cell disorder, one of the major diagnostic criteria for which is the presence of an osseous lesion. We present a case of POEMS syndrome with nearly all signs and symptoms on clinical and hematological examinations, which was further investigated with MRI of the whole spine and 18F-fluorodeoxyglucose positron emission tomography/computed tomography scan, as the latter is a very useful imaging modality for evaluation of any paraneoplastic syndromes, including myeloproliferative disorders such as plasmacytoma or multiple myeloma, and lymphoproliferative or other malignancies.
PubMed: 38390530
DOI: 10.4103/ijnm.ijnm_44_23 -
Radiology Case Reports May 2024A plasmacytoma is a cancerous growth of abnormal plasma cells that arise within osseous or soft tissue structures. In soft tissue structures, plasmacytomas can present...
A plasmacytoma is a cancerous growth of abnormal plasma cells that arise within osseous or soft tissue structures. In soft tissue structures, plasmacytomas can present as solitary or multiple masses in the absence of systemic involvement. Solitary plasmacytomas can be subcategorized as extramedullary plasmacytoma (derived from plasma cells located in soft tissues) or osseous plasmacytoma (derived from plasma cells located in the bone marrow). Infrequently, these tumors can arise as extramedullary lesions from the pancreas and present similarly to other tumors, such as pancreatic neuroendocrine tumors (PNETs). In this article, we report the case of a 62-year-old male with a diagnosis of solitary plasmacytoma of the pancreas. We focus on optimizing diagnosis and management through the application of radiological imaging modalities, specifically computed tomography (CT) scans and positron emission tomography-computed tomography (PET-CT) scans.
PubMed: 38390427
DOI: 10.1016/j.radcr.2024.01.065 -
Cureus Jan 2024Solitary extramedullary plasmacytoma (SEP) is a collection of plasma cells in soft tissue tumors characterized by monoclonal plasma cells without systemic symptoms or...
Solitary extramedullary plasmacytoma (SEP) is a collection of plasma cells in soft tissue tumors characterized by monoclonal plasma cells without systemic symptoms or evidence of bone disease. We present a case of SEP in a 49-year-old African American patient who presented with a slowly enlarging eyelid mass and underwent an excisional biopsy with ophthalmology before the diagnosis was confirmed by pathology in the absence of systemic symptoms or bone disease. Our review found only six confirmed cases of SEP of the eyelid described in the literature. In such cases, treatment is typically surgical excision or radiotherapy. Our patient was treated with radiation after the excision was incomplete. This case report adds another rare case of SEP of the eyelid to the literature.
PubMed: 38384603
DOI: 10.7759/cureus.52718 -
Frontiers in Immunology 2024Data on genomic susceptibility for adverse outcomes after hematopoietic stem cell transplantation (HSCT) for recipients are scarce.
INTRODUCTION
Data on genomic susceptibility for adverse outcomes after hematopoietic stem cell transplantation (HSCT) for recipients are scarce.
METHODS
We performed a genome wide association study (GWAS) to identify genes associated with survival/mortality, relapse, and severe graft-versus-host disease (sGvHD), fitting proportional hazard and subdistributional models to data of n=1,392 recipients of European ancestry from three centres.
RESULTS
The single nucleotide polymorphism (SNP) rs17154454, intronic to the neuronal growth guidant semaphorin 3C gene (, was genome-wide significantly associated with event-free survival (p=7.0x10) and sGvHD (p=7.5x10). Further associations were detected for SNPs in the Paxillin gene ( death without prior relapse or sGvHD, as well as for SNPs of the Plasmacytoma Variant Translocation 1 gene , a long non-coding RNA gene, the Melanocortin 5 Receptor and the WW Domain Containing Oxidoreductase gene (, all associated with the occurrence of sGvHD. Functional considerations support the observed associations.
DISCUSSION
Thus, new genes were identified, potentially influencing the outcome of HSCT.
Topics: Humans; Genome-Wide Association Study; Hematopoietic Stem Cell Transplantation; Graft vs Host Disease; Genomics; Recurrence
PubMed: 38384455
DOI: 10.3389/fimmu.2024.1280876 -
Bioengineered Dec 2024
Statement of Retraction: Circular RNA Plasmacytoma Variant Translocation 1 (CircPVT1) knockdown ameliorates hypoxia-induced bladder fibrosis by regulating the miR-203/Suppressor of Cytokine Signaling 3 (SOCS3) signaling axis.
PubMed: 38376860
DOI: 10.1080/21655979.2024.2299595 -
BMJ Case Reports Feb 2024We report a case of extramedullary plasmacytoma of the larynx that was eradicated by radiotherapy; however, 8 years later, the disease had progressed to multiple...
We report a case of extramedullary plasmacytoma of the larynx that was eradicated by radiotherapy; however, 8 years later, the disease had progressed to multiple myeloma. A mid -60s Japanese woman presented with a right-sided arytenoid mass in the larynx who underwent biopsy at another hospital. Based on the biopsy results, the patient was diagnosed with extramedullary plasma cell tumour and was referred to the Department of Otorhinolaryngology at our hospital. She received radiotherapy (50.4 Gy) and the laryngeal tumour was eradicated. Positron emission tomography/CT (PET-CT) revealed no abnormal accumulation in the larynx or whole body. After radiotherapy, the department of otorhinolaryngology, in consultation with Ddepartment of haematology performed follow-ups using laryngoscope, blood examination and PET-CT. Five years after the end of radiotherapy, the patient had no local recurrence or transition to multiple myeloma. However, 8 years later, blood examination and PET-CT revealed multiple myeloma. Laryngoscopy did not reveal any recurrent laryngeal tumour. Therefore, chemotherapy for multiple myeloma was administered at the department of haematology. Three months after the initiation of chemotherapy, the accumulation had disappeared in PET-CT. Three years have passed since chemotherapy initiation. At present, no recurrence or metastasis was observed in the larynx or whole body.
Topics: Female; Humans; Plasmacytoma; Multiple Myeloma; Laryngeal Neoplasms; Positron Emission Tomography Computed Tomography; Tomography, X-Ray Computed; Neoplasm Recurrence, Local; Larynx
PubMed: 38373810
DOI: 10.1136/bcr-2023-256747 -
Case Reports in Oncology 2024Multiple myeloma (MM) is a clonal neoplasm of plasma cells that may manifest as an extramedullary disease in rare cases.
INTRODUCTION
Multiple myeloma (MM) is a clonal neoplasm of plasma cells that may manifest as an extramedullary disease in rare cases.
CASE REPORT
In this case report, we present the rare occurrence of testicular relapse in a 39-year-old patient with IgA MM after 3 years of remission. We discuss the clinical course and management of this unusual presentation and provide a comprehensive literature review of testicular involvement by MM.
CONCLUSION
Despite advances in MM treatment, relapse remains common, highlighting the importance of careful follow-up and timely detection of disease recurrence at atypical sites. This case highlights the need for further research to standardize the diagnosis and treatment of testicular MM.
PubMed: 38371169
DOI: 10.1159/000536512 -
Cureus Jan 2024Solitary plasmacytoma (SPC) is a rare type of plasma cell dyscrasia characterized by the proliferation of neoplastic monoclonal plasma cells. It can involve bone or soft...
Solitary plasmacytoma (SPC) is a rare type of plasma cell dyscrasia characterized by the proliferation of neoplastic monoclonal plasma cells. It can involve bone or soft tissue without signs of systemic disease. The solitary bone plasmacytoma typically involves the axial skeleton, most commonly the vertebrae. This article presents a 58-year-old male with a history of Parkinson's disease, hypertension, and cervical spine degenerative joint disease. He arrived at the emergency department with severe thoracic and lumbar back pain, accompanied by numbness and weakness in both legs, which worsened with movement and deep breathing. Magnetic resonance imaging (MRI) findings revealed a sizable mass in the T11 vertebra, leading to thoracic spinal cord compression. Treatment included high-dose dexamethasone, and surgical intervention was undertaken. Subsequent pathology confirmed plasma cell dyscrasia. Radiotherapy and chemotherapy (lenalidomide and dexamethasone) were administered, resulting in no recurrence or new masses after two years. Solitary plasmacytoma is a rare disease with limited clinical trials due to the inability to accrue larger cohorts. Prompt diagnosis and staging of plasmacytomas, involving robust histopathological and radiographic methods, are needed to prevent further complications and possible progression to multiple myeloma. Radiation therapy is the primary treatment, with some studies showing the benefits of lenalidomide and dexamethasone. Further studies are needed to improve treatment options for these patients. This case report adds to the current literature the importance of a multidisciplinary approach to the treatment of SPC.
PubMed: 38371138
DOI: 10.7759/cureus.52460 -
The British Journal of Dermatology Feb 2024
Topics: Humans; Carcinoma, Squamous Cell; RNA, Long Noncoding; Plasmacytoma; Skin Neoplasms; Cell Line, Tumor
PubMed: 38366829
DOI: 10.1093/bjd/ljae031 -
International Journal of Surgery Case... Mar 2024Solitary ovarian plasmacytoma is a rare form of extramedullary plasmacytic tumor that develops outside the bone marrow.
INTRODUCTION
Solitary ovarian plasmacytoma is a rare form of extramedullary plasmacytic tumor that develops outside the bone marrow.
PRESENTATION OF CASE
We report the case of a 52-year-old female patient who consulted for pelvic pain and abdominal distension. Clinical examination revealed an abdominopelvic mass and a pelvic MRI confirmed a right ovarian mass. The diagnosis of ovarian plasmacytoma was made after exploratory laparotomy.
DISCUSSION
Extramedullary plasmacytoma (EMP) is rare and most often found in the upper aerodigestive tract, ovarian localization is exceptional. Histological and immunohistochemical features of EMP highlights similarities with multiple myeloma. EMP treatment options are discussed, including radiotherapy, surgery, and chemotherapy. The prognosis of EMP depends on several factors, including tumor size and timing of treatment.
CONCLUSION
Solitary ovarian plasmacytoma is a rare but important entity to consider in the diagnosis of abdominopelvic masses. Appropriate treatment, such as surgery combined with radiotherapy, can be effective, although regular monitoring is necessary due to the risk of relapse and transformation into multiple myeloma.
PubMed: 38364751
DOI: 10.1016/j.ijscr.2023.109096