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Tidsskrift For Den Norske Laegeforening... Aug 2023Lyme disease after a tick bite often presents as erythema migrans, yet less frequent variants of this disease, such as Borrelia lymphocytoma, multiple erythema migrans...
BACKGROUND
Lyme disease after a tick bite often presents as erythema migrans, yet less frequent variants of this disease, such as Borrelia lymphocytoma, multiple erythema migrans and neuroborreliosis, are also seen occasionally.
CASE PRESENTATION
We report a case of a tick-bitten child who first presented with an indistinct macular erythema around the left eye and a more distinct macular erythema on and around the left ear. The next day, she developed a facial palsy.
INTERPRETATION
The case was interpreted as facial multiple erythema migrans and Borrelia lymphocytoma on the ear, followed by neuroborreliosis. The diagnosis of lymphocytoma was made from clinical findings and PCR of skin biopsy. She recovered quickly after intravenous ceftriaxone and is now healthy.
Topics: Child; Female; Humans; Ear Diseases; Erythema Chronicum Migrans; Facial Dermatoses; Facial Paralysis; Lyme Neuroborreliosis; Pseudolymphoma; Tick Bites; Lyme Disease; Skin Diseases, Bacterial
PubMed: 37589351
DOI: 10.4045/tidsskr.23.0159 -
Innere Medizin (Heidelberg, Germany) Jan 2024A 33-year-old man presented to the authors' general medical practice with a striking alteration to the left nipple. After extensive diagnostic investigation to...
A 33-year-old man presented to the authors' general medical practice with a striking alteration to the left nipple. After extensive diagnostic investigation to identify in particular hemato-oncological diseases, a rare manifestation of an infection with Borrelia burgdorferi due to a tick bite was diagnosed. Antibiotic treatment with doxycycline over a period of 3 weeks led to complete restitution of the alteration.
Topics: Male; Humans; Adult; Borrelia burgdorferi Group; Lyme Disease; Borrelia burgdorferi; Tick Bites; Anti-Bacterial Agents
PubMed: 37581697
DOI: 10.1007/s00108-023-01558-2 -
Journal of Neuroinflammation Jul 2023Immune inflammatory responses play an important role in spinal cord injury (SCI); however, the beneficial and detrimental effects remain controversial. Many studies have...
BACKGROUND
Immune inflammatory responses play an important role in spinal cord injury (SCI); however, the beneficial and detrimental effects remain controversial. Many studies have described the role of neutrophils, macrophages, and T lymphocytes in immune inflammatory responses after SCI, although little is known about the role of B lymphocytes, and immunosuppression can easily occur after SCI.
METHODS
A mouse model of SCI was established, and HE staining and Nissl staining were performed to observe the pathological changes. The size and morphology of the spleen were examined, and the effects of SCI on spleen function and B cell levels were detected by flow cytometry and ELISA. To explore the specific mechanism of immunosuppression after SCI, B cells from the spleens of SCI model mice were isolated using magnetic beads and analyzed by 4D label-free quantitative proteomics. The level of inflammatory cytokines and iron ions were measured, and the expression of proteins related to the Tom20 pathway was quantified by western blotting. To clarify the relationship between iron ions and B cell pyroptosis after SCI, we used FeSO and CCCP, which induce oxidative stress to stimulate SCI, to interfere with B cell processes. siRNA transfection to knock down Tom20 (Tom20-KD) in B cells and human B lymphocytoma cell was used to verify the key role of Tom20. To further explore the effect of iron ions on SCI, we used deferoxamine (DFO) and iron dextran (ID) to interfere with SCI processes in mice. The level of iron ions in splenic B cells and the expression of proteins related to the Tom20-Bax-caspase-gasdermin E (GSDME) pathway were analyzed.
RESULTS
SCI could damage spleen function and lead to a decrease in B cell levels; SCI upregulated the expression of Tom20 protein in the mitochondria of B cells; SCI could regulate the concentration of iron ions and activate the Tom20-Bax-caspase-GSDME pathway to induce B cell pyroptosis. Iron ions aggravated CCCP-induced B cell pyroptosis and human B lymphocytoma pyroptosis by activating the Tom20-Bax-caspase-GSDME pathway. DFO could reduce inflammation and promote repair after SCI by inhibiting Tom20-Bax-caspase-GSDME-induced B cell pyroptosis.
CONCLUSIONS
Iron overload activates the Tom20-Bax-caspase-GSDME pathway after SCI, induces B cell pyroptosis, promotes inflammation, and aggravates the changes caused by SCI. This may represent a novel mechanism through which the immune inflammatory response is induced after SCI and may provide a new key target for the treatment of SCI.
Topics: Animals; Humans; Mice; B-Lymphocytes; bcl-2-Associated X Protein; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Caspases; Gasdermins; Inflammation; Iron; Pseudolymphoma; Pyroptosis; Spinal Cord Injuries
PubMed: 37480037
DOI: 10.1186/s12974-023-02848-0 -
The Journal of Dermatology Dec 2023
Topics: Humans; Pseudolymphoma; Ultraviolet Therapy; Ultraviolet Rays; B-Lymphocytes
PubMed: 37464576
DOI: 10.1111/1346-8138.16902 -
Canadian Journal of Ophthalmology.... Dec 2023
Topics: Humans; Birdshot Chorioretinopathy; Pseudolymphoma; Uvea; Fluorescein Angiography; Chorioretinitis
PubMed: 37369359
DOI: 10.1016/j.jcjo.2023.06.006 -
Indian Journal of Dermatology,... 2023
Topics: Humans; Pseudolymphoma; Gold; Patch Tests
PubMed: 37067105
DOI: 10.25259/IJDVL_1230_2021 -
Orbit (Amsterdam, Netherlands) Dec 2023This report included three cases of lymphoproliferative disorders developing from the lacrimal caruncle. The first case was an 11-year-old boy with reactive lymphoid... (Review)
Review
This report included three cases of lymphoproliferative disorders developing from the lacrimal caruncle. The first case was an 11-year-old boy with reactive lymphoid hyperplasia in the left lacrimal caruncle. The second case was an 80-year-old woman with reactive lymphoid hyperplasia in the right lacrimal caruncle. The third case was a 77-year-old man with follicular lymphoma in the left lacrimal caruncle. Our literature review of cases with lacrimal caruncular lesions showed 11 reported cases with reactive lymphoid hyperplasia and 17 with malignant lymphoma. There had been no previous report on follicular lymphoma in the lacrimal caruncle.
Topics: Male; Female; Humans; Aged, 80 and over; Child; Aged; Lacrimal Apparatus Diseases; Pseudolymphoma; Lymphoma, Follicular; Conjunctiva; Lymphoproliferative Disorders
PubMed: 35436180
DOI: 10.1080/01676830.2022.2056204