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The Iowa Orthopaedic Journal Dec 2023Cannabis is the most commonly used recreational drug in the USA. Studies evaluating cannabis use and its impact on outcomes following cervical spinal fusion (CF) are...
BACKGROUND
Cannabis is the most commonly used recreational drug in the USA. Studies evaluating cannabis use and its impact on outcomes following cervical spinal fusion (CF) are limited. This study sought to assess the impact of isolated (exclusive) cannabis use on postoperative outcomes following CF by analyzing outcomes like complications, readmissions, and revisions.
METHODS
The New York Statewide Planning and Research Cooperative System (SPARCS) was queried for patients who underwent CF between January 2009 and September 2013. Inclusion criteria were age ≥18 years and either a minimum 90-day (for complications and readmissions) or 2-year (for revisions) follow-up surveillance. Patients with systemic disease, osteomyelitis, cancer, trauma, and concomitant substance or polysubstance abuse/dependence were excluded. Patients with a preoperative International Classification of Diseases, 9th Edition, Clinical Modification (ICD-9-CM) diagnosis of isolated cannabis abuse (Cannabis) or dependence were identified. The primary outcome measures were 90-day complications, 90-day readmissions, and two-year revisions following CF. Cannabis patients were 1:1 propensity score-matched by age, gender, race, Deyo score, surgical approach, and tobacco use to non-cannabis users and compared for outcomes. Multivariate binary stepwise logistic regression models identified independent predictors of outcomes.
RESULTS
432 patients (n=216 each) with comparable age, sex, Deyo scores, tobacco use, and distribution of anterior or posterior surgical approaches were identified (all p>0.05). Cannabis patients were predominantly Black (27.8% vs. 12.0%), primarily utilized Medicaid (29.6% vs. 12.5%), and had longer LOS (3.0 vs. 1.9 days), all p≤0.001. Both cohorts experienced comparable rates of 90-day medical and surgical, as well as overall complications (5.6% vs. 3.7%) and two-year revisions (4.2% vs. 2.8%, p=0.430), but isolated cannabis patients had higher 90-day readmission rates (11.6% vs. 6.0%, p=0.042). Isolated cannabis use independently predicted 90-day readmission (Odds Ratio=2.0), but did not predict any 90-day complications or two year revisions (all p>0.05).
CONCLUSION
Isolated baseline cannabis dependence/abuse was associated with increased risk of 90-day readmission following CF. Further investigation of the physiologic impact of cannabis on musculoskeletal patients may elucidate significant contributory factors. .
Topics: Humans; Adolescent; Cannabis; Postoperative Complications; Spinal Fusion; Propensity Score; Spinal Diseases; Retrospective Studies
PubMed: 38213849
DOI: No ID Found -
Frontiers in Sociology 2023Labor trafficking in marijuana production remains a concealed epidemic within the expanding cannabis industry. This abstract brings attention to the systemic...
Labor trafficking in marijuana production remains a concealed epidemic within the expanding cannabis industry. This abstract brings attention to the systemic exploitation of vulnerable individuals engaged in cultivating, harvesting, and processing cannabis. It explores the factors contributing to labor trafficking, including demand for cheap labor, inadequate regulation, and the vulnerability of the workforce. By compiling published cases, both in peer-reviewed literature and the media, this perspective piece investigates the extent of health issues experienced by labor-trafficked victims. These include chronic pain from repetitive tasks, respiratory problems due to exposure to pesticides and other toxic substances, musculoskeletal injuries, malnutrition, and mental health disorders stemming from trauma and extreme stress. Additionally, this perspective article examines the factors contributing to poor health outcomes of labor-trafficked victims, including hazardous working conditions, lack of access to healthcare, and physical and psychological abuse. Addressing the health challenges faced by labor-trafficked victims in the cannabis industry requires multidimensional solutions: awareness among healthcare providers, comprehensive medical services, and mental health support. Furthermore, collaborative efforts among government agencies, healthcare providers, labor organizations, and the cannabis industry are essential in preventing trafficking and addressing the health disparities faced by labor-trafficked victims.
PubMed: 38152460
DOI: 10.3389/fsoc.2023.1244579 -
Drug and Alcohol Dependence Jan 2024Given the expanding legal cannabis market in the U.S., it is vital to understand how context impacts cannabis use. Therefore, we explored the effect of cannabis cues and...
PURPOSE
Given the expanding legal cannabis market in the U.S., it is vital to understand how context impacts cannabis use. Therefore, we explored the effect of cannabis cues and cannabis-use context on cannabis demand in 79 adults who reported smoking cannabis at least weekly.
METHODS
Participants completed a single laboratory session consisting of four hypothetical marijuana purchase tasks (MPTs) involving either a typical use situation or a driving or sleep context. The MPTs were alternated with exposure to cannabis or neutral picture cues based on block randomization by gender.
RESULTS
Cannabis cues increased self-reported craving for cannabis (p =.044) but did not significantly alter demand (ps =0.093-0.845). In the driving context, participants demonstrated a significant reduction in cannabis demand, indicated by lower intensity (p <0.001), O (p <0.001), and P (p <0.001), breakpoint (p =.003), and higher α (p <0.001). The sleep context was associated with significantly greater α (p <0.006) but nonsignificant effects for other indices (ps =0.123-0.707). Finally, cannabis cues increased O (p =.013) and breakpoint (p =.035) in the sleep context but not in the typical-use context.
CONCLUSIONS
These findings suggest that cannabis-use behavior is sensitive to contingencies surrounding driving after cannabis use and may also be sensitive to sleep contexts in the presence of cannabis cues. Since this is the first study to examine driving and sleep contexts, we caution against drawing broad conclusions until future research is conducted to replicate these findings.
Topics: Adult; Humans; Cannabis; Cues; Marijuana Smoking; Marijuana Abuse; Craving; Substance-Related Disorders; Hallucinogens; Cannabinoid Receptor Agonists
PubMed: 38101283
DOI: 10.1016/j.drugalcdep.2023.111057 -
PloS One 2023Weeds are one of the greatest threats to the growth of rice, and the loss of crops is greater in the early stage of rice growth. Traditional large-area spraying cannot...
Weeds are one of the greatest threats to the growth of rice, and the loss of crops is greater in the early stage of rice growth. Traditional large-area spraying cannot selectively spray weeds and can easily cause herbicide waste and environmental pollution. To realize the transformation from large-area spraying to precision spraying in rice fields, it is necessary to quickly and efficiently detect the distribution of weeds. Benefiting from the rapid development of vision technology and deep learning, this study applies a computer vision method based on deep-learning-driven rice field weed target detection. To address the need to identify small dense targets at the rice seedling stage in paddy fields, this study propose a method for weed target detection based on YOLOX, which is composed of a CSPDarknet backbone network, a feature pyramid network (FPN) enhanced feature extraction network and a YOLO Head detector. The CSPDarknet backbone network extracts feature layers with dimensions of 80 pixels ⊆ 80 pixels, 40 pixels ⊆ 40 pixels and 20 pixels ⊆ 20 pixels. The FPN fuses the features from these three scales, and YOLO Head realizes the regression of the object classification and prediction boxes. In performance comparisons of different models, including YOLOv3, YOLOv4-tiny, YOLOv5-s, SSD and several models of the YOLOX series, namely, YOLOX-s, YOLOX-m, YOLOX-nano, and YOLOX-tiny, the results show that the YOLOX-tiny model performs best. The mAP, F1, and recall values from the YOLOX-tiny model are 0.980, 0.95, and 0.983, respectively. Meanwhile, the intermediate variable memory generated during the model calculation of YOLOX-tiny is only 259.62 MB, making it suitable for deployment in intelligent agricultural devices. However, although the YOLOX-tiny model is the best on the dataset in this paper, this is not true in general. The experimental results suggest that the method proposed in this paper can improve the model performance for the small target detection of sheltered weeds and dense weeds at the rice seedling stage in paddy fields. A weed target detection model suitable for embedded computing platforms is obtained by comparing different single-stage target detection models, thereby laying a foundation for the realization of unmanned targeted herbicide spraying performed by agricultural robots.
Topics: Seedlings; Agriculture; Crops, Agricultural; Environmental Pollution; Herbicides; Marijuana Abuse; Oryza; Plant Weeds
PubMed: 38091355
DOI: 10.1371/journal.pone.0294709 -
JAMA Dec 2023Cannabis use is increasing among reproductive-age individuals and the risks associated with cannabis exposure during pregnancy remain uncertain.
IMPORTANCE
Cannabis use is increasing among reproductive-age individuals and the risks associated with cannabis exposure during pregnancy remain uncertain.
OBJECTIVE
To evaluate the association between maternal cannabis use and adverse pregnancy outcomes known to be related to placental function.
DESIGN, SETTING, AND PARTICIPANTS
Ancillary analysis of nulliparous individuals treated at 8 US medical centers with stored urine samples and abstracted pregnancy outcome data available. Participants in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be cohort were recruited from 2010 through 2013; the drug assays and analyses for this ancillary project were completed from June 2020 through April 2023.
EXPOSURE
Cannabis exposure was ascertained by urine immunoassay for 11-nor-9-carboxy-Δ9-tetrahydrocannabinol using frozen stored urine samples from study visits during the pregnancy gestational age windows of 6 weeks and 0 days to 13 weeks and 6 days (visit 1); 16 weeks and 0 days to 21 weeks and 6 days (visit 2); and 22 weeks and 0 days to 29 weeks and 6 days (visit 3). Positive results were confirmed with liquid chromatography tandem mass spectrometry. The timing of cannabis exposure was defined as only during the first trimester or ongoing exposure beyond the first trimester.
MAIN OUTCOME AND MEASURE
The dichotomous primary composite outcome included small-for-gestational-age birth, medically indicated preterm birth, stillbirth, or hypertensive disorders of pregnancy ascertained by medical record abstraction by trained perinatal research staff with adjudication of outcomes by site investigators.
RESULTS
Of 10 038 participants, 9257 were eligible for this analysis. Of the 610 participants (6.6%) with cannabis use, 32.4% (n = 197) had cannabis exposure only during the first trimester and 67.6% (n = 413) had ongoing exposure beyond the first trimester. Cannabis exposure was associated with the primary composite outcome (25.9% in the cannabis exposure group vs 17.4% in the no exposure group; adjusted relative risk, 1.27 [95% CI, 1.07-1.49]) in the propensity score-weighted analyses after adjustment for sociodemographic characteristics, body mass index, medical comorbidities, and active nicotine use ascertained via urine cotinine assays. In a 3-category cannabis exposure model (no exposure, exposure only during the first trimester, or ongoing exposure), cannabis use during the first trimester only was not associated with the primary composite outcome; however, ongoing cannabis use was associated with the primary composite outcome (adjusted relative risk, 1.32 [95% CI, 1.09-1.60]).
CONCLUSIONS AND RELEVANCE
In this multicenter cohort, maternal cannabis use ascertained by biological sampling was associated with adverse pregnancy outcomes related to placental dysfunction.
Topics: Female; Humans; Infant; Infant, Newborn; Pregnancy; Cannabis; Cohort Studies; Dronabinol; Hallucinogens; Marijuana Abuse; Maternal Exposure; Placenta; Placenta Diseases; Pregnancy Outcome; Premature Birth; Stillbirth; Pregnancy Complications
PubMed: 38085313
DOI: 10.1001/jama.2023.21146 -
Scientific Reports Dec 2023Plant-parasitic nematodes (PPNs) are vital soil organisms well-known to damage and reduce crop yield worldwide. Surveys were attempts to determine the impact of weed...
Plant-parasitic nematodes (PPNs) are vital soil organisms well-known to damage and reduce crop yield worldwide. Surveys were attempts to determine the impact of weed species on the communities and composition of nematodes in barley, wheat, quinoa, eggplant, and tomato crops in Alexandria and Ismailia regions of Egypt. During the surveys, eight occurring genera of nematodes were found namely; Meloidogyne spp, Pratylenchus spp, Helicotylenchus spp, Rotylenchulus spp, Xiphinema spp, Criconemoides spp, Ditylenchus spp, and Longidorus spp associated with the soil's rhizosphere of 28 weed species belonging to 12 families. Among these weeds, Hordeum marinum and Sonchus oleraceus were good hosts to nematode species. Both wheat and barley had higher nematode diversity than quinoa in the winter season. Pratylenchus spp, Meloidogyne spp and Rotylenchulus spp can be considered vital potential PPNs with economic importance. Nematode abundances and structural indices varied greatly based on the host weed species, crop types and soil characteristics. A positive correlation was monitored among weeds, nematode frequencies and relative abundances as well as their crops. Finally, weed species are critical components in nematode communities that may increase the incidence and severity of nematode risks based on crop type and soil characteristics. Therefore weeds should be managed properly to diminish reservoir sites when developing nematode management options.
Topics: Humans; Animals; Plant Weeds; Crops, Agricultural; Research Personnel; Tylenchida; Tylenchoidea; Hordeum; Marijuana Abuse; Rhabditida; Soil
PubMed: 38081941
DOI: 10.1038/s41598-023-49357-x -
Frontiers in Public Health 2023Substances and the people who use them have been dehumanized for decades. As a result, lawmakers and healthcare providers have implemented policies that subjected...
INTRODUCTION
Substances and the people who use them have been dehumanized for decades. As a result, lawmakers and healthcare providers have implemented policies that subjected millions to criminalization, incarceration, and inadequate resources to support health and wellbeing. While there have been recent shifts in public opinion on issues such as legalization, in the case of marijuana in the U.S., or addiction as a disease, dehumanization and stigma are still leading barriers for individuals seeking treatment. Integral to the narrative of "substance users" as thoughtless zombies or violent criminals is their portrayal in popular media, such as films and news.
METHODS
This study attempts to quantify the dehumanization of people who use substances (PWUS) across time using a large corpus of over 3 million news articles. We apply a computational linguistic framework for measuring dehumanization across three decades of New York Times articles.
RESULTS
We show that (1) levels of dehumanization remain high and (2) while marijuana has become less dehumanized over time, attitudes toward other substances such as heroin and cocaine remain stable.
DISCUSSION
This work highlights the importance of a holistic view of substance use that places all substances within the context of addiction as a disease, prioritizes the humanization of PWUS, and centers around harm reduction.
Topics: Humans; Dehumanization; Substance-Related Disorders; Social Stigma; Cannabis; Behavior, Addictive
PubMed: 38074754
DOI: 10.3389/fpubh.2023.1275975 -
Annals of Gastroenterology 2023Polysubstance use (PSU), the simultaneous use of 2 or more substances of abuse, is common in inflammatory bowel disease (IBD). Preliminary studies suggest it may be...
BACKGROUND
Polysubstance use (PSU), the simultaneous use of 2 or more substances of abuse, is common in inflammatory bowel disease (IBD). Preliminary studies suggest it may be associated with poor outcomes. This prospective study evaluated the impact of PSU on disease activity and healthcare resource utilization in IBD.
METHODS
This study was conducted in a tertiary IBD center between October 29, 2015, and December 31, 2019. Participants were assessed over 2 time points (index and follow-up outpatient appointments) separated by a minimum of 6 months. Demographics, endoscopic disease activity, and surveys assessing symptoms, healthcare resource utilization and substance use (tobacco, alcohol, marijuana, cocaine, methamphetamine, heroin, opioid, or benzodiazepine) were abstracted. We identified PSU during the index appointment and computed descriptive statistics and contingency table analyses, and multivariate logistic regression models at follow up to evaluate outcomes.
RESULTS
162 consecutively enrolled IBD patients were included. Seventy-five patients (46%) were polysubstance users at the index appointment. The most common cohorts were utilizing tobacco and alcohol (n=40) or tobacco and opioids (n=13). On bivariate and multivariate analyses, PSU during the index visit was positively associated with emergency department (ED) visits (odds ratio [OR] 2.51, 95% confidence interval [CI] 1.24-5.07; P=0.01) and negatively associated with extraintestinal manifestations (OR 0.37, 95%CI 0.18-0.74; P=0.005). Age, sex, disease activity, disease subtype and IBD-related symptoms were not associated with PSU.
CONCLUSIONS
IBD patients exhibiting PSU had increased risk of future ED visits. This study highlights the risks of PSU and reinforces the importance of appropriate substance use screening.
PubMed: 38023977
DOI: 10.20524/aog.2023.0835 -
NeuroImmune Pharmacology and... Sep 2023Following the emergence of SARS-CoV-2, various reports suggest that there has been a significant increase in substance abuse due to social distancing and related issues.... (Review)
Review
Following the emergence of SARS-CoV-2, various reports suggest that there has been a significant increase in substance abuse due to social distancing and related issues. Several reports have suggested the impact of chronic substance use on individuals' physiological and psychological health. Therefore, there is a need to know the impact of SARS-CoV-2 on persons with substance use disorders. Individuals with substance use disorders are the most vulnerable groups and are at a high risk of SARS-CoV-2 infection due to their already existing health issues associated with substance use. This review discusses some of the molecular and systemic/organic effects chronic substance use such as alcohol, nicotine, marijuana (cannabis), opioids, methamphetamine, and cocaine have on SARS-CoV-2 infectivity and its potential cause for worsened disease outcomes in persons with substance use disorder. This will provide healthcare providers, public health policies, and researchers with the needed knowledge to address some of the many challenges faced during the Covid-19 pandemic to facilitate treatment strategies for persons with substance use disorders.
PubMed: 38013836
DOI: 10.1515/nipt-2023-0004 -
Nature Genetics Dec 2023As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use... (Meta-Analysis)
Meta-Analysis
As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities. Here we performed a genome-wide association study of CanUD in the Million Veteran Program (MVP), followed by meta-analysis in 1,054,365 individuals (n = 64,314) from four broad ancestries designated by the reference panel used for assignment (European n = 886,025, African n = 123,208, admixed American n = 38,289 and East Asian n = 6,843). Population-specific methods were applied to calculate single nucleotide polymorphism-based heritability within each ancestry. Statistically significant single nucleotide polymorphism-based heritability for CanUD was observed in all but the smallest population (East Asian). We discovered genome-wide significant loci unique to each ancestry: 22 in European, 2 each in African and East Asian, and 1 in admixed American ancestries. A genetically informed causal relationship analysis indicated a possible effect of genetic liability for CanUD on lung cancer risk, suggesting potential unanticipated future medical and psychiatric public health consequences that require further study to disentangle from other known risk factors such as cigarette smoking.
Topics: Humans; Genetic Predisposition to Disease; Genome-Wide Association Study; Marijuana Abuse; Polymorphism, Single Nucleotide; Public Health; Veterans; Racial Groups
PubMed: 37985822
DOI: 10.1038/s41588-023-01563-z