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Gynecological Endocrinology : the... Dec 2023The purpose of this study was to determine the association between kisspeptin levels and obesity in patients with polycystic ovary syndrome (PCOS) or in healthy...
The purpose of this study was to determine the association between kisspeptin levels and obesity in patients with polycystic ovary syndrome (PCOS) or in healthy controls and to explore the correlation between levels of kisspeptin and various endocrine and metabolic indices in each group. From August 2020 to December 2021, the clinical data of 78 patients with polycystic ovary syndrome and 78 healthy individuals were collected. The two groups were further divided into obese and non-obese groups based on a BMI cutoff of 25. Serum kisspeptin levels were measured using enzyme linked immunosorbent assay (ELISA). Pearson's correlation analysis was used to determine the correlation between PCOS and kisspeptin levels. The weight, body mass index (BMI), and waist circumference (WC), estradiol (E2), and testosterone (T) of the obese PCOS group were significantly higher than those of the study group ( < .05). WC, kisspeptin, triglycerides (TG), glucose (GLU), alanine amiotransferase (ALT), blood urea nitrogen (BUN), uric acid (UA), E2, luteinizing hormone (LH), prolactin (PRL), and T in the non-obese PCOS group were higher than those in the control group, and the difference was statistically significant ( < .05). Levels of E2 and TG in the obese PCOS group were significantly higher than those in the non-obese PCOS group ( < .05). Kisspeptin levels in the PCOS group exhibited a significant positive correlation with LH, T, and AMH levels; kisspeptin level positively correlated with T in the non-obese PCOS group and with anti-Müllerian hormone (AMH) in the obese PCOS group. Serum kisspeptin levels are associated with hormone levels in patients with PCOS. Kisspeptin correlates with distinct biochemical indices in obese versus non-obese groups, indicating that kisspeptin may play a role in the prognostication, treatment, and clinical evaluation of patients with varying BMI.
Topics: Female; Humans; Anti-Mullerian Hormone; Biomarkers; Body Mass Index; Follicle Stimulating Hormone; Kisspeptins; Luteinizing Hormone; Obesity; Polycystic Ovary Syndrome; Triglycerides; Case-Control Studies
PubMed: 37236245
DOI: 10.1080/09513590.2023.2215869 -
Diabetes, Obesity & Metabolism Aug 2023
Topics: Female; Humans; Overweight; Kisspeptins; Obesity; Appetite; Eating; Energy Intake; Body Mass Index
PubMed: 37039248
DOI: 10.1111/dom.15086 -
The Journal of Maternal-fetal &... Dec 2023A highly accurate serum marker for predicting viable pregnancy needs to be developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for this...
OBJECTIVE
A highly accurate serum marker for predicting viable pregnancy needs to be developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for this purpose.
METHODS
This systematic review evaluated the available data in the literature on the role of kisspeptin as a miscarriage biomarker. A literature search was conducted in the PubMed/Medline, Embase, Web of Science, and Scopus databases using the following keywords: (kisspeptin) AND (miscarriage OR pregnancy loss OR spontaneous abortion OR reproductive failure).
RESULTS
Seven case-control studies were selected for the systematic review. The included papers described the potential role of kisspeptin as a putative biomarker of pregnancy loss. Furthermore, two studies reported that changes in kisspeptin levels may be associated with unexplained infertility and low rates of embryo implantation in women undergoing assisted reproductive technology.
CONCLUSION
Kisspeptin might be used as a potential biomarker of pregnancy viability in the near future. However, studies with better evidence are needed to establish the applicability of kisspeptin as a diagnostic and prognostic tool.
Topics: Pregnancy; Female; Humans; Abortion, Spontaneous; Kisspeptins; Infertility; Reproductive Techniques, Assisted; Biomarkers; Pregnancy Rate; Live Birth; Fertilization in Vitro
PubMed: 37015836
DOI: 10.1080/14767058.2023.2197097 -
Psychiatria Polska Feb 2024The aim of the study was to assess concentrations of the following neuropeptides: phoenixin, spexin and kisspeptin in venous blood serum of children and adolescents...
OBJECTIVES
The aim of the study was to assess concentrations of the following neuropeptides: phoenixin, spexin and kisspeptin in venous blood serum of children and adolescents suffering from bipolar disorder, and by this their predictive efficiency in this disorder.
METHODS
The study covered 75 individuals with a mean age of 15.26 years (95% CI: 14.86-15.67), of which the study group comprised of 57 individuals diagnosed with bipolar affective disorder and the control group - 18 individuals with no psychiatric diagnosis and no pharmacological treatment. Phoenixin, spexin and kisspeptin levels were determined in the peripheral venous blood serum. Neuropeptide concentrations were measured with the enzyme-linked immunosorbent assay (ELISA).
RESULTS
The mean phoenixin concentration in the studied group equalled 1.57 ng/ml (95% CI: 1.35-1.79), while in the control group - 2.69 ng/ml (95% CI: 2.38-3; U Mann-Whitney test p-value < 0.05). For spexin, these results were 639.65 pg/ml (95% CI: 558.86-720.44) in the studied group, and 354.28 pg/ml (95% CI: 310.33-398.22; U Mann-Whitney test p-value < 0.05) in the control group. The observed differences were statistically significant. The mean concentration of kisspeptin levels in the studied group was 126.02 pg/ml (95% CI: 39.82-212.23; median: 59.85), while in the control group - 54.83 pg/ml (95% CI: 39.23-70.43; median: 51.3; U Mann-Whitney test p-value = 0.29), and the observed difference was not statistically significant.
CONCLUSIONS
The occurrence of bipolar disorder symptoms is statistically significantly linked with a decreased phoenixin concentration and to a small degree - with an increased spexin concentration in blood serum of patients. However, it is not linked with the kisspeptin concentration.
Topics: Humans; Bipolar Disorder; Kisspeptins; Female; Male; Adolescent; Peptide Hormones; Neuropeptides; Biomarkers; Case-Control Studies; Child; Enzyme-Linked Immunosorbent Assay
PubMed: 36989336
DOI: 10.12740/PP/OnlineFirst/155178 -
Gynecological Endocrinology : the... Dec 2023To explore the association of , , vitamin D receptor () estrogen receptor α () gene polymorphisms and the risk of early with fast puberty (EFP) risk, and with hormone...
OBJECTIVES
To explore the association of , , vitamin D receptor () estrogen receptor α () gene polymorphisms and the risk of early with fast puberty (EFP) risk, and with hormone levels in EFP cases, in Chinese girls.
METHODS
The analysis was based on the data of 141 girls with EFP and 152 girls without EFP. Clinical features were documented, and all SNP genotyping was conducted using SNaPshot method. Statistical analysis was performed to assess the association of the SNPs with EFP risk, and with hormone levels in EFP cases.
RESULTS
There was a significant association between rs7759938-C polymorphism in the gene and the risk for EFP in the recessive (TT + CT vs. CC) model ( = 0.040). Remarkably, rs5780218-delA polymorphism in the gene and rs2234693-C polymorphism in the gene were significantly associated with peak LH (luteinizing hormone) levels ( = 0.008, 0.045) and peak LH/FSH (follicle-stimulating hormone) ratio ( 0.007, 0.006). Additionally, on 7 of the 8 variant loci the alleles associated with increased levels of both peak LH levels and peak LH/FSH ratio in EFP cases were also associated with increased CPP risk.
CONCLUSIONS
Our findings indicate that rs7759938-C polymorphism in the gene might have a protective effect on EFP susceptibility. The most striking findings of this study is that, rs5780218-delA polymorphism in the gene and rs2234693-C polymorphism in the gene influenced levels of GnRH-stimulated peak LH and LH/FSH ratio, and in general CPP risk genes might also contributes to the abnormality of hormonal levels in EFP.
Topics: Female; Humans; East Asian People; Estrogen Receptor alpha; Follicle Stimulating Hormone, Human; Gonadotropin-Releasing Hormone; Kisspeptins; Luteinizing Hormone; Polymorphism, Single Nucleotide; Puberty; Puberty, Precocious; Receptors, Calcitriol; RNA-Binding Proteins
PubMed: 36828304
DOI: 10.1080/09513590.2023.2181653