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BMC Ophthalmology Aug 2023Pterygium is a common ocular surface disease. Pterygium combined with corneal perforation is rare.
BACKGROUND
Pterygium is a common ocular surface disease. Pterygium combined with corneal perforation is rare.
CASE PRESENTATION
A 28-year-old female patient visited our outpatient clinic due to sudden onset of blurred vision and increased tearing in her left eye. The visual acuity was 1.0 OD and intraocular pressure (IOP) of 19.5 mmHg for the right eye with no significant abnormalities found in the anterior and posterior segments. The visual acuity of her left eye was 0.06, and IOP was 6.2 mmHg. A triangular vascular membranous tissue was seen in her left eye below the nose growing into the cornea and the pupil area was not touched. Slit-lamp examination revealed a tiny round corneal perforation in 8 o'clock position of the lesion area. Hospital diagnosis was given as pterygium combined with corneal perforation. The patient was treated with levofloxacin eye drops and autologous serum-based eye drops.
CONCLUSIONS
We report a rare case of pterygium combined with corneal perforation. Perforation is a very rare complication of pterygium. This patient received proper treatment and good result was seen. This article aimed to improve clinicians' understanding of pterygium.
Topics: Humans; Female; Adult; Pterygium; Corneal Perforation; Cornea; Ophthalmic Solutions
PubMed: 37641016
DOI: 10.1186/s12886-023-03084-z -
Journal of Ophthalmic & Vision Research 2023To assess the autofluorescence size and properties of pterygium and pinguecula by anterior segment autofluorescence (AS-AF) imaging and demonstrate the difference of...
PURPOSE
To assess the autofluorescence size and properties of pterygium and pinguecula by anterior segment autofluorescence (AS-AF) imaging and demonstrate the difference of autofluorescence size presented in AS-AF imaging compared to the extend size of the conjunctival lesion measured by anterior segment slit-lamp photography (AS-SLE).
METHODS
Twenty-five patients with primary pterygium and twenty-five with pinguecula were included in the study. In addition, 25 normal subjects were also enrolled as the control group. The AS-AF characteristics of pterygium and pinguecula lesions were analyzed. The size of lesions displayed in the AS-SLE photography versus the AS-AF images were also compared. AS-AF images were obtained using a Heidelberg retina angiograph which focused on the anterior segment. AS-SLE photography was acquired using a digital imaging system (BX900 HAAG-STREIT).
RESULTS
There were 44 (58.7%) male and 31 (41.3%) female patients; 19 (76%) and 20 (80%) patients had bilateral pterygium and pinguecula, respectively. All pinguecula lesions reflected hyperautofluorescence pattern in the AS-AF imaging. In 24 (96%) patients, the hyperautofluoresecence pattern was larger than the size of the clinical lesions displayed with the AS-SLE photography. Twenty-one (84%) patients with pterygium reflected a hyperautofluorescence pattern in AS-AF images; in one (4%) patient, the hyperautofluorescence pattern was larger than the clinical lesion size and four (16%) patients had no autofluorescence patterns in the AS-AF images. In the control group, in 14 (56%) subjects, a hypoautofluorescent pattern was revealed in the conjunctiva in AS-AF images. However, in 11 (44%) patients, hyperautofluorescence patterns were detected.
CONCLUSION
AS-AF is a useful modality to monitor vascularization in conjunctival lesions. Pingueculae and pterygium show hyperautofluorescence in AS-AF imaging. The real size of the pinguecula lesions may be estimated with AS-AF characteristics, mostly presenting larger than the area size in AS-SLE photography. The autofluorescence size of the pterygium is smaller than the extent of visible pterygium in slit-lamp photography.
PubMed: 37600917
DOI: 10.18502/jovr.v18i3.13773 -
American Journal of Ophthalmology Case... Dec 2023To report our initial experience in patients with primary pterygium surgery who had a transparent intrastromal corneal lenticule as a free graft obtained during small...
PURPOSE
To report our initial experience in patients with primary pterygium surgery who had a transparent intrastromal corneal lenticule as a free graft obtained during small incision lenticule extraction (SMILE) surgery.
OBSERVATIONS
This study enrolled five eyes of 5 patients with pterygium who were surgically treated with single or double free lenticule that was sutured to the defective area of the nasal corneosclera immediately following pterygium excision. All cases with pterygium were primary, and topical mitomycin C was not used at the time of surgery. The mean age of the patients was 51.0 years and 2 of the 5 eyes belonged to male subjects. The patients were followed up for an average of six months. During the follow-up period, the lenticule grafts demonstrated no sign of rejection and were intact in all cases. All patients recovered well with no complications or recurrences at six months postoperatively.
CONCLUSIONS AND IMPORTANCE
This report suggests that transparent corneal lenticules obtained during SMILE laser surgery may be used as an alternative novel graft source for the surgical treatment of patients with primary pterygium. It appears to be a safe, easy, cost- and time-effective reliable method.
PubMed: 37560555
DOI: 10.1016/j.ajoc.2023.101897 -
Contrast Media & Molecular Imaging 2023[This retracts the article DOI: 10.1155/2022/5844973.].
Retracted: Efficacy and Safety of Amniotic Membrane Transplantation Combined with Closure of Tenon Capsule and Bulbar Conjunctival Space in the Treatment of Primary Pterygium.
[This retracts the article DOI: 10.1155/2022/5844973.].
PubMed: 37547636
DOI: 10.1155/2023/9767031 -
La Medicina Del Lavoro Aug 2023Globally, hundreds of millions of outdoor workers are exposed to solar radiation (SR) for the majority of their working life. Such occupational exposure is known to...
Globally, hundreds of millions of outdoor workers are exposed to solar radiation (SR) for the majority of their working life. Such occupational exposure is known to induce various adverse health effects to the eyes, mainly related to its ultraviolet (UV) component. The present work is a call-to-action aimed at raising the awareness on the need of health surveillance for the prevention of the chronic ocular diseases in outdoor workers. Photo-chemical chronic damage can induce pterygium at the outer layer of the eye and cataract in the lens. Considering carcinogenic effects, rare squamous-cells tumors of the cornea and/or of the conjunctiva and the ocular melanomas are associated with UV radiation exposure. Solar UV-related eye diseases should be considered as "occupational diseases" when there is sufficient exposure in workers, but they are often not recognized, and/or frequently not reported to the national compensation authorities. Therefore, to prevent the burden of these work-related eye pathologies, an adequate risk assessment with identification of appropriate preventive measures, and a provision of periodic health surveillance to the exposed workers, in particular considering those at higher risk of exposure or with individual susceptibility, should be urgently implemented.
Topics: Humans; Ultraviolet Rays; Sunlight; Risk Assessment; Cataract; Occupational Exposure
PubMed: 37534422
DOI: 10.23749/mdl.v114i4.14657 -
Indian Journal of Ophthalmology Aug 2023The use of human amniotic membrane transplantation is rapidly increasing for the management of various ocular surface disorders. Despite its numerous advantages,...
BACKGROUND
The use of human amniotic membrane transplantation is rapidly increasing for the management of various ocular surface disorders. Despite its numerous advantages, amniotic membrane is not widely available due to the lack of awareness among ophthalmologists regarding its preparation and preservation techniques.
PURPOSE
To provide an instructional video demonstrating the technique of harvesting, preparation, preservation of human amniotic membrane, and its uses in the management of ocular surface diseases.
SYNOPSIS
The amniotic membrane is the innermost layer of the human placenta. Properties of the amniotic membrane, like the presence of various growth factors, anti-inflammatory and anti-angiogenic factors, and its low immunogenicity, contribute to its ability to promote epithelial growth and differentiation with the reduction in fibrosis during healing. To harvest amniotic membrane, informed consent is obtained from a patient undergoing an elective caesarian section, and the donor is screened to exclude the risk of infections. Under sterile precautions, the amniotic membrane is separated from the chorion and washed free of blood clots. With the epithelial surface up, the amniotic membrane is spread uniformly without folds or tears on individually sterilized 0.22 μm nitrocellulose filter papers of the required sizes. The prepared filter paper with the adherent amniotic membrane is placed in freshly prepared Dulbecco's Modified Eagle's Medium and stored at -80°C. The amniotic membrane can be used for surgical procedures like symblepharon release, pterygium or dermoid excision, perforated ulcers, nonhealing epithelial defects, etc.
HIGHLIGHTS
Instructional videos demonstrating the preparation and preservation of amniotic membrane are very sparse. This video clearly explains how any ophthalmologist can learn to prepare and preserve the human amniotic membrane and gives a glimpse of its properties, advantages, and scope of use.
VIDEO LINK
https://youtu.be/8HfSjXUKoiY.
Topics: Pregnancy; Female; Humans; Amnion; Eye Diseases; Conjunctiva; Plastic Surgery Procedures; Pterygium
PubMed: 37530302
DOI: 10.4103/IJO.IJO_674_23 -
Cancers Jul 2023The pivotal role of p53 in the regulation of a vast array of cellular functions has been the subject of extensive research. The biological activity of p53 is not... (Review)
Review
The pivotal role of p53 in the regulation of a vast array of cellular functions has been the subject of extensive research. The biological activity of p53 is not strictly limited to cell cycle arrest but also includes the regulation of homeostasis, DNA repair, apoptosis, and senescence. Thus, mutations in the p53 gene with loss of function represent one of the major mechanisms for cancer development. As expected, due to its key role, p53 is expressed throughout the human body including the eye. Specifically, altered p53 signaling pathways have been implicated in the development of conjunctival and corneal tumors, retinoblastoma, uveal melanoma, and intraocular melanoma. As non-selective cancer chemotherapies as well as ionizing radiation can be associated with either poor efficacy or dose-limiting toxicities in the eye, reconstitution of the p53 signaling pathway currently represents an attractive target for cancer therapy. The present review discusses the role of p53 in the pathogenesis of these ocular tumors and outlines the various pharmacological activators of p53 that are currently under investigation for the treatment of ocular malignancies.
PubMed: 37509256
DOI: 10.3390/cancers15143593