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Pharmaceuticals (Basel, Switzerland) May 2024Public perception contrasts scientific findings on the depression-related effects of cannabis. However, earlier studies were performed when cannabis was predominantly... (Review)
Review
Public perception contrasts scientific findings on the depression-related effects of cannabis. However, earlier studies were performed when cannabis was predominantly illegal, its production was mostly uncontrolled, and the idea of medical cannabis was incipient only. We hypothesized that recent changes in attitudes and legislations may have favorably affected research. In addition, publication bias against cannabis may have also decreased. To investigate this hypothesis, we conducted a review of research studies published over the last three years. We found 156 relevant research articles. In most cross-sectional studies, depression was higher in those who consumed cannabis than in those who did not. An increase in cannabis consumption was typically followed by an increase in depression, whereas withdrawal from cannabis ameliorated depression in most cases. Although medical cannabis reduced depression in most studies, none of these were placebo-controlled. In clinical studies published in the same period, the placebo also ameliorated depression and, in addition, the average effect size of the placebo was larger than the average effect size of medical cannabis. We also investigated the plausibility of the antidepressant effects of cannabis by reviewing molecular and pharmacological studies. Taken together, the reviewed findings do not support the antidepressant effects of herbal cannabis.
PubMed: 38931356
DOI: 10.3390/ph17060689 -
Molecules (Basel, Switzerland) Jun 2024This research aimed to encapsulate the fruit extract to increase its stability for incorporation into food products such as jelly or jelly powder. After extraction, the...
This research aimed to encapsulate the fruit extract to increase its stability for incorporation into food products such as jelly or jelly powder. After extraction, the nanoliposomes containing the extract were prepared in ratios of 60-0, 50-10, 40-20, and 30-30 lecithin-to-cholesterol. The effects of lecithin-to-cholesterol concentrations on the related parameters were then evaluated. The results showed that the average particle size was in the range of 95.05 to 164.25 nm, and with an increasing cholesterol concentration, the particle size of the nanoliposomes increased. The addition of cholesterol increased the zeta potential from -60.40 to -68.55 millivolt. Furthermore, cholesterol led to an increase in encapsulation efficiency, and even improved the stability of phenolic compounds loaded in nanoliposomes during storage time. Fourier transform infrared (FTIR) spectroscopy confirmed the successful loading of the extract. Field emission scanning electron microscopy (FE-SEM) analysis revealed nano-sized spherical and almost-elliptical liposomes. For jelly powders, the water solubility index ranged from 39.5 to 43.7% ( > 0.05), and the hygroscopicity values ranged between 1.22 and 9.36 g/100 g ( < 0.05). In conclusion, nanoencapsulated extract displayed improved stability and can be used in jelly preparation without any challenge or unfavorable perception.
Topics: Liposomes; Plant Extracts; Capparis; Particle Size; Nanoparticles; Lecithins; Cholesterol; Drug Compounding; Spectroscopy, Fourier Transform Infrared; Solubility
PubMed: 38930869
DOI: 10.3390/molecules29122804 -
Foods (Basel, Switzerland) Jun 2024Despite its importance as an undesirable food texture, the phenomenon of chalkiness remains understudied. sensations presumably arise from fine particulates found in...
Despite its importance as an undesirable food texture, the phenomenon of chalkiness remains understudied. sensations presumably arise from fine particulates found in foods, but semantic overlap with other common descriptors of small particles, like gritty or sandy, is unclear. Here, we compare the usage of with related descriptors, and determine the effect of particle size, concentration, and xanthan content on ratings in a model beverage. A 2 factorial design with starch particle size (D = 33.8 and 64.6 µm), starch concentrations (10 and 20% /), and xanthan content (0.075 and 0.15% /) was used. Participants' salivary flow rate was also assessed. A multi-sip taste test was performed where naïve consumers (n = 82; 39% men, 60% women; age range = 18-79 years) rated the intensity of , , , , , and at 0, 30, and 60 s after each of three consecutive sips. All attribute ratings were highly correlated, with , , and being more closely correlated with each other than or . Although was still reported 60 s after consumption, no evidence of build-up was found with repeated sips. A larger size and higher concentration increased ratings, with the low-salivary-flow group reporting greater ratings for relative to the high-flow group. Our results suggest consumer percepts of small particles are overlapping but not entirely redundant. This suggests researchers and product developers should carefully distinguish between these descriptors when trying to understand consumer perception of food products containing fine particles.
PubMed: 38928793
DOI: 10.3390/foods13121852 -
Revista Gaucha de Enfermagem 2024To analyze the effectiveness of Bach flower therapy compared to placebo in reducing perceived stress levels in primary health care nursing professionals. (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVE
To analyze the effectiveness of Bach flower therapy compared to placebo in reducing perceived stress levels in primary health care nursing professionals.
METHOD
Pragmatic, parallel randomized clinical trial conducted with 87 primary care nursing professionals with self-identified stress, from October 2021 to June 2022, in the cities of Osasco and São Paulo, Brazil. The intervention group (n=43) received the collective flower formula, and the placebo group (n=44) received only the diluent. Data analysis was performed using the linear mixed model, and effect size was measured by partial Eta squared, significance level 5%.
RESULTS
Data analysis showed a significant reduction in perceived stress levels within groups (p=0.038). However, there was no significant difference between the study groups (p=0.750). Participants in the intervention group reported a greater perception of changes than participants in the placebo group, but without statistical significance (p=0,089).
CONCLUSION
The floral formula was not more effective than the placebo formula in reducing perceived stress. There was a significant stress reduction among nursing professionals in both study groups, although with a small effect size.
Topics: Humans; Female; Male; Adult; Flowers; Primary Care Nursing; Middle Aged; Occupational Stress; Phytotherapy; Stress, Psychological; Brazil
PubMed: 38922232
DOI: 10.1590/1983-1447.2024.20230132.en -
Behavioral Sciences (Basel, Switzerland) Jun 2024The pervasive integration of digital platforms into daily life has amplified their perceived indispensability. This study investigates the factors influencing this...
The pervasive integration of digital platforms into daily life has amplified their perceived indispensability. This study investigates the factors influencing this perception across countries with contrasting platform landscapes, focusing on platform quality and usage patterns. We conducted surveys in Finland and Korea, countries representing distinct platform ecosystems. The results revealed higher perceived indispensability in Korea than in Finland, with usefulness and habitual platform use emerging as significant predictors of indispensability in both countries. However, the specific aspects of platform quality influencing this perception diverged. In Finland, the platform's comprehensiveness and security risk significantly impacted indispensability, while social interaction features played a negligible role. Conversely, in Korea, social interaction features significantly influenced indispensability, while platform comprehensiveness and security risk were non-significant. These findings underscore the multifaceted nature of digital platform indispensability, shaped by the interaction of platform quality and usage patterns. The contextual variations highlighted by our cross-country comparison suggest that a one-size-fits-all approach to platform regulation or user education may be ineffective. Future research should explore these cultural and platform-specific nuances to devise tailored policies.
PubMed: 38920834
DOI: 10.3390/bs14060502 -
Scientific Reports Jun 2024As the global population ages, understanding of the effect of aging on visual perception is of growing importance. This study investigates age-related changes in...
As the global population ages, understanding of the effect of aging on visual perception is of growing importance. This study investigates age-related changes in adulthood along size perception through the lens of three visual illusions: the Ponzo, Ebbinghaus, and Height-width illusions. Utilizing the Bayesian conceptualization of the aging brain, which posits increased reliance on prior knowledge with age, we explored potential differences in the susceptibility to visual illusions across different age groups in adults (ages 20-85 years). To this end, we used the BTPI (Ben-Gurion University Test for Perceptual Illusions), an online validated battery of visual illusions developed in our lab. The findings revealed distinct patterns of age-related changes for each of the illusions, challenging the idea of a generalized increase in reliance on prior knowledge with age. Specifically, we observed a systematic reduction in susceptibility to the Ebbinghaus illusion with age, while susceptibility to the Height-width illusion increased with age. As for the Ponzo illusion, there were no significant changes with age. These results underscore the complexity of age-related changes in visual perception and converge with previous findings to support the idea that different visual illusions of size are mediated by distinct perceptual mechanisms.
Topics: Humans; Aged; Adult; Middle Aged; Aged, 80 and over; Female; Male; Aging; Young Adult; Size Perception; Visual Perception; Illusions; Bayes Theorem
PubMed: 38918501
DOI: 10.1038/s41598-024-65405-6 -
DEN Open Apr 2025For early gastrointestinal lesions, size is an important factor in the selection of treatment. Virtual scale endoscope (VSE) is a newly developed endoscope that can...
OBJECTIVES
For early gastrointestinal lesions, size is an important factor in the selection of treatment. Virtual scale endoscope (VSE) is a newly developed endoscope that can measure size more accurately than visual measurement. This study aimed to investigate whether VSE measurement is accurate for early gastrointestinal lesions of various sizes and morphologies.
METHODS
This study prospectively enrolled patients with early gastrointestinal lesions ≤20 mm in size visually. Lesion sizes were measured in the gastrointestinal tract visually, on endoscopic resection specimens with VSE, and finally on endoscopic resection specimens using a ruler. The primary endpoint was the normalized difference (ND) of VSE measurement. The secondary endpoints were the ND of visual measurement and the variation between NDs of VSE and visual measurements. ND was calculated as (100 × [measured size - true size] / true size) (%). True size was defined as size measured using a ruler.
RESULTS
This study included 60 lesions from April 2022 to December 2022, with 20 each in the esophagus, stomach, and colon. The lesion size was 14.0 ± 6.3 mm (mean ± standard deviation). Morphologies were protruded, slightly elevated, and flat or slightly depressed type in 8, 24, and 28 lesions, respectively. The primary endpoint was 0.3 ± 8.8%. In the secondary endpoints, the ND of visual measurement was -1.7 ± 29.3%, and the variability was significantly smaller in the ND of VSE measurement than in that of visual measurement ( < 0.001, F-test).
CONCLUSIONS
VSE measurement is accurate for early gastrointestinal lesions of various sizes and morphologies.
PubMed: 38903962
DOI: 10.1002/deo2.386 -
Frontiers in Psychology 2024The increasingly digital and multicultural 21st-century society requires future teachers to be prepared for the changes and challenges they may encounter. Not only...
UNLABELLED
The increasingly digital and multicultural 21st-century society requires future teachers to be prepared for the changes and challenges they may encounter. Not only language and digital competences, but critical-thinking and problem-solving skills are needed. Moreover, well developed socio-affective abilities, empathy among them, are also key when dealing with others. This is even more relevant when teachers are to work with a non-mainstream population, such as adult migrants with low literacy levels, and to design student-centered curricula or activities. Empathy is a multifaceted process involving, among others, perception, intellection, affect and other sensory aspects of the lived experience. It has been argued that the first-person perspective-taking involved in empathic engagement must necessarily involve rational computation and cognitively mediated processing. Training future teachers in the Pedagogy of Multiliteracies is a means to integrate multimodal digital instruction and aggregate cognitive as well as socio-emotional features to the education of future language teachers.
METHOD
A mixed-method pre-post study was conducted with 48 trainee teachers who participated in stand-alone digital multiliteracy interventions, in which they were encouraged to envisage themselves as future teachers of low-literate migrants. Policy documents such as the reference guide on Literacy and Second Language Learning for the Linguistic Integration of Adult Migrants, journal articles, audiovisual resources as well as examples of existing educational materials aimed at the target audience, were made available to them on an online platform. In two separate studies, trainees were encouraged to collaboratively produce two different multimodal outputs. The Revised Scale of Ethnocultural Empathy was administered before and after the intervention, subjecting the data obtained to quantitative analysis. Qualitative data was also collected to gain a better understanding of the affective and cognitive processes experienced by the participants.
RESULTS
Simple statistical analysis coupled with the comparison of means was used to respond to the research questions. Statistical hypothesis testing, including correlations and non-parametric statistics were used to analyze the relationship between each of the factors within the RSEE and the participants, considering the different interventions applied. Non-parametric tests (U-Mann Whitney) were used to compare the differences between the levels of ethnocultural empathy of the participants in the two studies. Significant differences were found in Factor 3 (Empathy) and Factor 5 (Anxiety) between the groups and their post-intervention results, with a value of 0.053 and 0.038, respectively. The effect size r was calculated, obtaining a size effect of 0.625 for Factor 3 (Empathy) and 0.674 for Factor 5 (Anxiety). These results indicate that the significant differences and the size effect between both groups are large. U-Mann Whitney non-parametric analysis also revealed gender differences in Factor 3 (Empathy), showing females higher levels than males. Effect size r analysis showed a large size effect of 0.708 for Factor 3 (Empathy). The findings pertaining to gender-related differences in empathy levels confirm the conclusions drawn by previous studies. When contrasting study 1 and 2, statistical differences were also shown after the intervention for the 'Anxiety and Lack of Multicultural Self-efficacy' factor. The qualitative data analysis was carried out with Atlas.ti v.8, in order to isolate and categorize the broader themes and the most significant explanatory quotes extracted from the participants' records and interviews. The results reveal the learning strategies that each group of learners applied to successfully complete the task at hand, as well as the participants' deployment of their critical thinking skills and the awakening of a sense of awareness of their own professional competence development process.
CONCLUSION
This study set out to compare how effective two digital multiliteracy interventions were in developing future language teachers' ethnocultural empathy and cognitive abilities when appraising the educational needs of low-literacy migrants. Despite the small sample size, the study certainly adds to our understanding of the impact of multimodal tasks involving critical thinking skills on trainees' cognitive and affective abilities. Besides, it expands the growing body of research that points to the desirability of embedding digitally-based content creation tasks in training curricula for future language teachers.
PubMed: 38903477
DOI: 10.3389/fpsyg.2024.1398457 -
Sensors (Basel, Switzerland) May 2024In this study, an innovative laser 3D-scanning technology is proposed to scan pipe inner walls in order to solve the problems of the exorbitant expenses and operational...
In this study, an innovative laser 3D-scanning technology is proposed to scan pipe inner walls in order to solve the problems of the exorbitant expenses and operational complexities of the current equipment for the 3D data acquisition of the pipe inner wall, and the difficulty of both the efficiency and accuracy of traditional light stripe-center extraction methods. The core of this technology is the monocular-structured light 3D scanner, the image processing strategy based on tracking speckles, and the improved gray barycenter method. The experimental results demonstrate a 52% reduction in the average standard error of the improved gray barycenter method when compared to the traditional gray barycenter method, along with an 83% decrease in the operation time when compared to the Steger method. In addition, the size data of the inner wall of the pipe obtained using this technology is accurate, and the average deviation of the inner diameter and length of the pipe is less than 0.13 mm and 0.41 mm, respectively. In general, it not only reduces the cost, but also ensures high efficiency and high precision, providing a new and efficient method for the 3D data acquisition of the inner wall of the pipe.
PubMed: 38894345
DOI: 10.3390/s24113554 -
NeuroImage. Clinical Jun 2024Childhood maltreatment (CM) is a major risk factor for the development of major depressive disorder (MDD). To gain more knowledge on how adverse childhood experiences...
BACKGROUND
Childhood maltreatment (CM) is a major risk factor for the development of major depressive disorder (MDD). To gain more knowledge on how adverse childhood experiences influence the development of brain architecture, we studied functional connectivity (FC) alterations of neural networks of depressed patients with, or without the history of CM.
METHODS
Depressed patients with severe childhood maltreatment (n = 18), MDD patients without maltreatment (n = 19), and matched healthy controls (n = 20) were examined with resting state functional MRI. History of maltreatment was assessed with the 28-item Childhood Trauma Questionnaire. Intra- and inter-network FC alterations were evaluated using FMRIB Software Library and CONN toolbox.
RESULTS
We found numerous intra- and inter-network FC alterations between the maltreated and the non-maltreated patients. Intra-network FC differences were found in the default mode, visual and auditory networks, and cerebellum. Network modelling revealed several inter-network FC alterations connecting the default mode network with the executive control, salience and cerebellar networks. Increased inter-network FC was found in maltreated patients between the sensory-motor and visual, cerebellar, default mode and salience networks.
LIMITATIONS
Relatively small sample size, cross-sectional design, and retrospective self-report questionnaire to assess adverse childhood experiences.
CONCLUSIONS
Our findings confirm that severely maltreated depressed patients display numerous alterations of intra- and inter-network FC strengths, not only in their fronto-limbic circuits, but also in sensory-motor, visual, auditory, and cerebellar networks. These functional alterations may explain that maltreated individuals typically display altered perception and are prone to develop functional neurological symptom disorder (conversion disorder) in adulthood.
PubMed: 38889524
DOI: 10.1016/j.nicl.2024.103632