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Environmental Science and Pollution... May 2023Potential toxic element (PTE) contamination in the Persian Gulf has become an important health concern in recent decades. This investigation aimed to meta-analyses of... (Meta-Analysis)
Meta-Analysis
Potential toxic element (PTE) contamination in the Persian Gulf has become an important health concern in recent decades. This investigation aimed to meta-analyses of potential toxic elements including lead (Pb), inorganic arsenic (As), cadmium (Cd), nickel (Ni), and mercury (Hg) in the coastal sediment of the Persian Gulf. In this study, an attempt was made to retrieve papers conducted on the concentration of PTE in the coastal sediment of the Persian Gulf by searching in international databases including Web of Science, Scopus, Embase, and PubMed. Meta-analysis concentration of PTE in the coastal sediment of the Persian Gulf was conducted using random effects model based on the country subgroup. Additionally, non-dietary risk assessment including non-carcinogenic and carcinogenic risks from ingestion, inhalation and dermal contact routes and ecological risk assessment was estimated. Seventy-eight papers with 81 data-reports (1650 sample size) were included in our meta-analysis. The rank order of heavy metals in coastal sediment of the Persian Gulf based on pooled concentration was Ni (65.44 mg/kg) > Pb (58.35 mg/kg) > As (23.78 mg/kg) > Cd (1.75 mg/kg) > Hg (0.77 mg/kg). The highest concentration of As, Cd, Pb, Ni, and Hg was observed in the coastal sediment of Saudi Arabia, Arab Emirates, Qatar, Iran, and Saudi Arabia, respectively. Although the I index in coastal sediment of the Persian Gulf was in grade 1 (uncontaminated) and grade 2 (slightly contaminated) but total target hazard quotient (TTHQ) of adults and adolescent was higher than 1 value in Iran, Saudi Arabic, United Arab Emirates, and Qatar. Total cancer risk (TCR) for adults and adolescent due to As was higher than 1E-6 in Iran, United Arab Emirates, and Qatar but TCR for adolescents due to As was higher than 1E-6 in Saudi Arabic. Therefore, it is recommended to monitor the concentration of PTE and implementation of programs to reduce the emission of PTE from resources in the Persian Gulf.
Topics: Adolescent; Adult; Humans; Cadmium; Environmental Monitoring; Geologic Sediments; Indian Ocean; Lead; Mercury; Metals, Heavy; Nickel; Receptors, Antigen, T-Cell; Risk Assessment; Water Pollutants, Chemical
PubMed: 37095211
DOI: 10.1007/s11356-023-26949-8 -
Experimental Dermatology Jul 2023Severe skin pain when exposed to long wave ultraviolet radiation or visible light is the main symptom of erythropoietic protoporphyria (EPP). Treatment options for EPP... (Review)
Review
Severe skin pain when exposed to long wave ultraviolet radiation or visible light is the main symptom of erythropoietic protoporphyria (EPP). Treatment options for EPP are inadequate and new treatments are needed but hampered by the lack of valid efficacy outcomes. Phototesting with well-defined illumination of the skin can be performed reliably. We aimed to provide an overview of phototest procedures used to evaluate EPP treatments. Systematic searches of Embase, MEDLINE and the Cochrane Library were performed. Searches identified 11 studies using photosensitivity as efficacy outcome. The studies used eight different phototest protocols. Illuminations were performed with a filtered high-pressure mercury arc, or a xenon arc lamp equipped with monochromator or filters. Some used broadband, others narrowband illumination. In all protocols phototests were performed on the hands or the back. Endpoints were minimal dose required to induce either first symptom of discomfort, erythema, urticaria or intolerable pain. Other endpoints were change in erythema intensity or diameter of any type of flare after exposure compared to before. In conclusion, protocols displayed extensive variability in illumination set-up and evaluation of phototest reactions. Implementation of a standardized phototest method will allow more consistent and reliable outcome evaluation in future therapeutic research of protoporphyric photosensitivity.
Topics: Humans; Protoporphyria, Erythropoietic; Ultraviolet Rays; Photosensitivity Disorders; Skin; Erythema
PubMed: 37052136
DOI: 10.1111/exd.14809 -
Circulation. Cardiovascular Quality and... Apr 2023Behavioral weight management programs (BWMPs) enhance weight loss in the short term, but longer term cardiometabolic effects are uncertain as weight is commonly... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Behavioral weight management programs (BWMPs) enhance weight loss in the short term, but longer term cardiometabolic effects are uncertain as weight is commonly regained. We assessed the impact of weight regain after BWMPs on cardiovascular risk factors, diabetes, and cardiovascular disease.
METHODS
Trial registries, 11 databases, and forward-citation searching (latest search, December 19) were used to identify articles published in English, from any geographical region. Randomized trials of BWMPs in adults with overweight/obesity reporting cardiometabolic outcomes at ≥12 months at and after program end were included. Differences between more intensive interventions and comparator groups were synthesized using mixed-effects, meta-regression, and time-to-event models to assess the impact of weight regain on cardiovascular disease incidence and risk.
RESULTS
One hundred twenty-four trials reporting on ≥1 cardiometabolic outcomes with a median follow-up of 28 (range, 11-360) months after program end were included. Median baseline participant body mass index was 33 kg/m; median age was 51 years. Eight and 15 study arms (7889 and 4202 participants, respectively) examined the incidence of cardiovascular disease and type 2 diabetes, respectively, with imprecise evidence of a lower incidence for at least 5 years. Weight regain in BWMPs relative to comparators reduced these differences. One and 5 years after program end, total cholesterol/HDL (high-density lipoprotein) ratio was 1.5 points lower at both times (82 studies; 19 003 participants), systolic blood pressure was 1.5 mm mercury and 0.4 mm lower (84 studies; 30 836 participants), and HbA1c (%) 0.38 lower at both times (94 studies; 28 083 participants). Of the included studies, 22% were judged at high risk of bias; removing these did not meaningfully change results.
CONCLUSIONS
Despite weight regain, BWMPs reduce cardiometabolic risk factors with effects lasting at least 5 years after program end and dwindling with weight regain. Evidence that they reduce the incidence of cardiovascular disease or diabetes is less certain. Few studies followed participants for ≥5 years.
REGISTRATION
URL: https://www.crd.york.ac.uk/PROSPERO/; Unique identifier: CRD42018105744.
Topics: Adult; Humans; Middle Aged; Diabetes Mellitus, Type 2; Cardiovascular Diseases; Incidence; Weight Reduction Programs; Weight Gain
PubMed: 36974678
DOI: 10.1161/CIRCOUTCOMES.122.009348 -
Association Between Non-alcoholic Fatty Liver Disease and Heavy Metal Exposure: a Systematic Review.Biological Trace Element Research Dec 2023Non-alcoholic fatty liver disease (NAFLD) is a debilitating disease with adverse effects including cirrhosis and hepatocellular carcinoma. Heavy metals can cause severe... (Review)
Review
Non-alcoholic fatty liver disease (NAFLD) is a debilitating disease with adverse effects including cirrhosis and hepatocellular carcinoma. Heavy metals can cause severe dysfunction in different body organs including the liver. This review offers the study regarding the positive or negative association between heavy metals exposure and non-alcoholic fatty liver disease. The method used in this study is a systematic review based on searching in the PubMed, Scopus, and Science direct databases with the keywords of fatty liver, non-alcohol fatty liver, heavy metal, mercury, cadmium, arsenic, chromium, thallium, lead, iron, zinc, and nickel. There were 2200 articles searched in databases, and after assessment, 28 articles were selected. Positive association is established between arsenic, cadmium, iron, lead, mercury, and fatty liver disease. A negative relationship is found between zinc, copper, and progressive fatty liver disease. Furthermore, laboratory methods for NAFLD diagnosis were examined according to the obtained manuscripts. Among the different diagnostic methods, magnetic resonance imaging (MRI) is a sensitive method.
Topics: Humans; Non-alcoholic Fatty Liver Disease; Cadmium; Arsenic; Metals, Heavy; Mercury; Iron; Zinc
PubMed: 36929113
DOI: 10.1007/s12011-023-03629-9 -
Annals of Indian Academy of Neurology 2022Stroke is the second largest cause of mortality (WHO 2014) and long-lasting disability worldwide. Many risk factors are associated with stroke, such as age, gender,...
BACKGROUND
Stroke is the second largest cause of mortality (WHO 2014) and long-lasting disability worldwide. Many risk factors are associated with stroke, such as age, gender, chronic illnesses, cardiovascular disease, lifestyle, and smoking. With global industrialization, the roles of environmental contaminants and their association with stroke are still unclear and have attracted much more attention.
MATERIALS AND METHODS
We conducted a systematic review on the environmental toxic metal contaminants and the risk of ischemic stroke. A comprehensive literature search was carried out till June 30, 2021 from databases such as PubMed, Science Direct, Embase, and Scopus. The quality of all the articles which met our inclusion criteria was assessed using Newcastle-Ottawa scaling, and four eligible studies were included for our systematic review.
RESULTS
The serum and urine cadmium concentrations were positively associated with the risk of ischemic stroke. There was an inverse association of serum and urine concentrations of mercury (Hg), serum concentration of gold and cerium with ischemic stroke, and the serum and urine concentrations of lead (Pb) had no association with ischemic stroke risk.
CONCLUSION
The study showed strong associations between heavy metals and ischemic stroke, but more studies are required to prove the associations.
PubMed: 36911452
DOI: 10.4103/aian.aian_530_22 -
Annals of Translational Medicine Jan 2023Recent studies have shown that the relationship between mercury exposure and diabetes is controversial. The aim of this study is to determine the relationship between...
BACKGROUND
Recent studies have shown that the relationship between mercury exposure and diabetes is controversial. The aim of this study is to determine the relationship between mercury exposure and diabetes using a systematic review and meta-analysis approach.
METHODS
We systematically searched PubMed, Web of Science, Cochrane, and Embase databases for cross-sectional, case-control, or cohort studies assessing the correlation between mercury exposure and diabetes in any population. Details of each included study were extracted using a pre-designed Excel spreadsheet. Quality assessment of cohort and case-control studies used the Newcastle-Ottawa Scale (NOS), whereas cross-sectional studies were assessed by the Agency for Healthcare Research and Quality (AHRQ) scale. Meta-analyses were performed using random-effects models to calculate the pooled odds ratio (OR), standardized mean difference (SMD), and their 95% confidence intervals (CIs). Subgroup and sensitivity analyses were employed to assess heterogeneity sources. Begg's and Egger's tests were used to evaluate publication bias.
RESULTS
Our meta-analysis included 8 eligible articles, comprising a total of 40,891 subjects, reporting mercury OR and/or concentrations. Among the included studies, one was a case control, one was a cohort study, and the rest were cross-sectional studies. Two studies were rated as high quality and six as medium quality. The results revealed no link between mercury exposure and diabetes (OR: 1.11, 95% CI: 0.80, 1.55, n=6, I=73.7%; and SMD: 0.41, 95% CI: -0.32, 1.14, n=3, I=88.7%). In the stratified male and female subgroups, the pooled OR was 0.71 (95% CI: 0.57, 0.90, n=3, I=0.0%), 1.11 (95% CI: 0.69, 1.79, n=3, I=67.7%). The Begg's test results revealed no significant publication bias (P=0.06), but the Egger's test results did (P=0.013). The sensitivity analysis confirmed the stability of our results.
CONCLUSIONS
No significant relationship was observed between mercury and diabetes mellitus. However, more well-designed studies on mercury exposure and diabetes risk are still needed, particularly on the type of mercury (i.e., elemental, inorganic, and organic), exposure time and dose, type of biological specimen, and the population's sex and age.
PubMed: 36819500
DOI: 10.21037/atm-22-6404 -
Environmental Science & Technology Jan 2023Toxic trace elements (TEs) can pose serious risks to ecosystems and human health. However, a comprehensive understanding of atmospheric emission inventories for several... (Review)
Review
Toxic trace elements (TEs) can pose serious risks to ecosystems and human health. However, a comprehensive understanding of atmospheric emission inventories for several concerning TEs has not yet been developed. In this study, we systematically reviewed the status and progress of existing research in developing atmospheric emission inventories of TEs focusing on global, regional, and sectoral scales. Multiple studies have strengthened our understanding of the global emission of TEs, despite attention being mainly focused on Hg and source classification in different studies showing large discrepancies. In contrast to those of developed countries and regions, the officially published emission inventory is still lacking in developing countries, despite the fact that studies on evaluating the emissions of TEs on a national scale or one specific source category have been numerous in recent years. Additionally, emissions of TEs emitted from waste incineration and traffic-related sources have produced growing concern with worldwide rapid urbanization. Although several studies attempt to estimate the emissions of TEs based on PM emissions and its source-specific chemical profiles, the emission factor approach is still the universal method. We call for more extensive and in-depth studies to establish a precise localization national emission inventory of TEs based on adequate field measurements and comprehensive investigation to reduce uncertainty.
Topics: Humans; Trace Elements; Air Pollutants; Ecosystem; Environmental Monitoring; Mercury
PubMed: 36661479
DOI: 10.1021/acs.est.2c07147 -
Revista Brasileira de Ginecologia E... Dec 2022The present review aimed to synthesize the evidence regarding mercury (Hg) exposure and hypertensive disorders of pregnancy (HDP).
OBJECTIVE
The present review aimed to synthesize the evidence regarding mercury (Hg) exposure and hypertensive disorders of pregnancy (HDP).
DATA SOURCES
The PubMed, BVS/LILACS, SciELO and UFRJ's Pantheon Digital Library databases were systematically searched through June 2021.
STUDY SELECTION
Observational analytical articles, written in English, Spanish, or Portuguese, without time restriction.
DATA COLLECTION
We followed the PICOS strategy, and the methodological quality was assessed using the Downs and Black checklist.
DATA SYNTHESIS
We retrieved 77 articles, of which 6 met the review criteria. They comprised 4,848 participants, of which 809 (16.7%) had HDP and 4,724 (97.4%) were environmentally exposed to Hg (fish consumption and dental amalgam). Mercury biomarkers evaluated were blood (four studies) and urine (two studies). Two studies found a positive association between Hg and HDP in the group with more exposure, and the other four did not present it. The quality assessment revealed three satisfactory and three good-rated studies (mean: 19.3 ± 1.6 out 28 points). The absence or no proper adjustment for negative confounding factor, such as fish consumption, was observed in five studies.
CONCLUSION
We retrieved only six studies, although Hg is a widespread toxic metal and pregnancy is a period of heightened susceptibility to environmental threats and cardiovascular risk. Overall, our review showed mixed results, with two studies reporting a positive association in the group with more exposure. However, due to the importance of the subject, additional studies are needed to elucidate the effects of Hg on HDP, with particular attention to adjusting negative confounding.
Topics: Humans; Pregnancy; Female; Animals; Mercury; Hypertension, Pregnancy-Induced; Maternal Exposure; Biomarkers
PubMed: 36580940
DOI: 10.1055/s-0042-1760215 -
Environmental Pollution (Barking, Essex... Feb 2023Filter feeding elasmobranchs may be considered as biological indicators of marine pollution, despite most of these species are under some degree of extinction risk.... (Review)
Review
Filter feeding elasmobranchs may be considered as biological indicators of marine pollution, despite most of these species are under some degree of extinction risk. Among threats to this taxonomic group, marine pollution might represent an additional concern for their survival. In this review, a comprehensive systematic search of scientific literature on pollutants in filter feeding elasmobranchs was conducted to evaluate the bioaccumulation patterns, and risk for human consumers. We found that, despite an increasing trend in the number of published studies, the geographical coverage is still very limited and most of the studies focused solely on trace elements (70.8%). Among sharks, Rhincodon typus was the most represented species (66.7%), while Mobula mobular the most studied ray species (41.7%). Comparing the levels of pollutants in filter feeders between ocean basins, this review highlighted that Hg, As and Cd levels are mostly higher in those areas affected by both strong natural and anthropogenic source of emissions, such as the Indian Ocean. With regards to OCs, ΣPCB levels in muscle of C. maximus were between 4.3 and 50.5 μg kg ww, highlighting a persistent contamination of PCB in the Mediterranean Sea. Some species exceeded the maximum allowable limits for foodstuff consumption for As, Cd and Pb. A total of 77.8% of the analyzed species exceeded the Environmental Quality Standards for Hg, while they were always below the EQS for HCB, PBDEs, PFOS and DDT. Given their feeding mechanism that continuously samples the marine environment, further investigations are urgently needed to determine not only the extent of contaminant exposure in different hotspot locations but also the risks posed to the elasmobranch health.
Topics: Animals; Humans; Environmental Monitoring; Cadmium; Mercury; Sharks; Environmental Pollutants; Water Pollutants, Chemical
PubMed: 36528198
DOI: 10.1016/j.envpol.2022.120881 -
Environmental Pollution (Barking, Essex... Feb 2023Anthropogenic activities contribute to nearly half of current Hg emissions to the atmosphere. In the marine habitat, oceanic predator fishes bioaccumulate Hg throughout... (Review)
Review
Anthropogenic activities contribute to nearly half of current Hg emissions to the atmosphere. In the marine habitat, oceanic predator fishes bioaccumulate Hg throughout their lives, making their consumption the main route of Hg exposure in humans. In this context, several publications, between 1973 and 2022, were selected, analyzed, and duly compiled, with the objective to investigate Hg contamination in nine species of bony fish: Thunnus thynnus (8 publications), Thunnus albacares (19), Thunnus obesus (7), Thunnus atlanticus (5), Thunnus alalunga (4), Katsuwonus pelamis (8), Xiphias gladius (18), Coryphaena hippurus (7) and Euthynnus alletteratus (4), as well as two species of cartilaginous fishes Prionace glauca (13 publications) and Isurus oxyrinchus (8). These studies totaled 5973 individuals. We classified species according to taxonomic groups and region of capture and found a significant difference between sharks and bony fishes, with higher Hg concentrations in sharks. The regions of occurrence were divided into 4 large areas (North Atlantic - NAO, South Atlantic - SAO, Equatorial Atlantic Ocean - EAO, and Mediterranean - MED), but no significant differences were observed when comparing the overall Hg concentrations in fish among regions (including all species). Additionally, a thorough discussion of the risks associated with human consumption of these species was conducted, as nine of the selected species presented individuals with Hg concentration values that exceeded the safety limits (1 ppm) set by health agencies worldwide.
Topics: Animals; Humans; Mercury; Sharks; Tuna; Oceans and Seas; Fishes
PubMed: 36509349
DOI: 10.1016/j.envpol.2022.120821