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Vector Borne and Zoonotic Diseases... Aug 2021is a pathogen that is known to cause spotted fever, a zoonosis that is endemic in several regions of the Americas. However, no systematic review and meta-analysis has... (Meta-Analysis)
Meta-Analysis
is a pathogen that is known to cause spotted fever, a zoonosis that is endemic in several regions of the Americas. However, no systematic review and meta-analysis has been conducted to estimate the prevalence of this rickettsial disease in the Americas. Therefore, the objective of this study was to estimate the prevalence of in ticks in the Americas. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed and data were retrieved from four electronic databases: MEDLINE/PubMed, SciELO, ScienceDirect, and Directory of Open Access Journals. The pooled prevalence and heterogeneity were determined using a random-effects model and using Cochran's test and index, respectively. Publication bias was assessed using a funnel plot and Egger's method. The pooled prevalence of in ticks was highest in Colombia (17.00%; confidence interval [95% CI]: 7.01-30.24), followed by Mexico (9.89%; 95% CI: 2.03-22.74), Panama (2.76%; 95% CI: 0.45-6.93), Brazil (2.03%; 95% CI: 0.66-4.14), and the United States (0.50%; 95% CI: 0.15-1.05). The tick species most frequently infected by were sensu lato (6.23%; 95% CI: 2.79-10.92) and (4.36%; 95% CI: 0.25-13.14). It can be suggested that studies aiming to identify the potential vectors of should be conducted more intensively to better understand the epidemiology of spotted fever in the Americas.
Topics: Animals; Prevalence; Rhipicephalus sanguineus; Rickettsia; Rickettsia rickettsii; Rocky Mountain Spotted Fever; Spotted Fever Group Rickettsiosis
PubMed: 34010063
DOI: 10.1089/vbz.2021.0004 -
Clinical Immunology (Orlando, Fla.) Nov 2020We conducted a systematic review to identify cases of infection-induced anti-myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
BACKGROUND
We conducted a systematic review to identify cases of infection-induced anti-myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
METHODS
PubMed/Medline databases were searched from inception to July of 2020, according to PRISMA guidelines.
RESULTS
Among the 618 abstracts identified, 18 articles describing 23 patients (60.9% female, mean age 50.5 years) were included. Median time between infection and vasculitis development was 3 months. Five (21.7%) patients expired during follow-up. Vasculitis regressed after the resolution of infection in 12/23 (52.2%). ANCA titers decreased significantly on follow-up in 14/16 patients and in all survivors in which they were measured. Pathogens reported included Mycobacterium spp., Coccidioides spp., Rickettsia rickettsii, Staphylococcus spp., EBV, CMV and Dengue virus.
CONCLUSIONS
MPO-AAV can occur after infection and may regress after its resolution. Infection should be considered in cases of MPO-AAV, as immunosuppressive treatment can have catastrophic results if the infection is not adequately treated.
Topics: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Humans; Immunosuppressive Agents; Infections; Peroxidase
PubMed: 32961330
DOI: 10.1016/j.clim.2020.108595