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Veterinary Dermatology Dec 2023Few studies report the treatment and recurrence rate in anal sacculitis (AS).
BACKGROUND
Few studies report the treatment and recurrence rate in anal sacculitis (AS).
OBJECTIVES
Retrospective study reporting the management, recurrence and concurrent diseases in dogs with AS in a primary care practice.
ANIMALS
One hundred and ninety privately owned dogs in Sweden.
MATERIALS AND METHODS
Clinical records of dogs diagnosed with AS between 2018 and 2021 were reviewed, and management, time until clinical resolution, number of recurrent episodes and comorbidites were recorded.
RESULTS
The 190 dogs developed 290 episodes of AS. The most common management, in 235 of 290 (81.0%) episodes, was flushing ± infusion of an antimicrobial product into the sacs ± prescription of a nonsteroidal anti-inflammatory drug (NSAID), providing resolution in 213 of 235 (90.6%) episodes. Median time to resolution was one week (range 1-16 weeks), with resolution seen within one week in 205 of 290 (70.7%) episodes. A single episode of AS developed in 126 of 190 (66.3%) dogs. Dogs with concurrent cutaneous allergic disease were more likely (p < 0.001) to have recurrence of AS when compared to dogs with other comorbidities. Cutaneous allergic disease occurred more often (p < 0.001) in dogs with AS than in the practice population.
CONCLUSIONS AND CLINICAL RELEVANCE
Local treatment of the anal sacs ± systemic NSAID was the most common treatment, inducing clinical resolution in the majority of dogs. Cutaneous allergic disease was the most common concurrent diagnosis, with higher recurrence rate of AS compared to other diseases and occurring in higher prevalence than in the practice population. Further studies are needed to determine if management of cutaneous allergic disease would reduce the risk of AS.
Topics: Animals; Dogs; Retrospective Studies; Anus Diseases; Skin; Anal Sacs; Anti-Inflammatory Agents, Non-Steroidal; Dog Diseases; Treatment Outcome
PubMed: 37731183
DOI: 10.1111/vde.13205 -
IEEE Transactions on Pattern Analysis... Dec 2023This article studies the challenging two-view 3D reconstruction problem in a rigorous sparse-view configuration, which is suffering from insufficient correspondences in...
This article studies the challenging two-view 3D reconstruction problem in a rigorous sparse-view configuration, which is suffering from insufficient correspondences in the input image pairs for camera pose estimation. We present a novel Neural One-PlanE RANSAC framework (termed NOPE-SAC in short) that exerts excellent capability of neural networks to learn one-plane pose hypotheses from 3D plane correspondences. Building on the top of a Siamese network for plane detection, our NOPE-SAC first generates putative plane correspondences with a coarse initial pose. It then feeds the learned 3D plane correspondences into shared MLPs to estimate the one-plane camera pose hypotheses, which are subsequently reweighed in a RANSAC manner to obtain the final camera pose. Because the neural one-plane pose minimizes the number of plane correspondences for adaptive pose hypotheses generation, it enables stable pose voting and reliable pose refinement with a few of plane correspondences for the sparse-view inputs. In the experiments, we demonstrate that our NOPE-SAC significantly improves the camera pose estimation for the two-view inputs with severe viewpoint changes, setting several new state-of-the-art performances on two challenging benchmarks, i.e., MatterPort3D and ScanNet, for sparse-view 3D reconstruction.
PubMed: 37698973
DOI: 10.1109/TPAMI.2023.3314745 -
Acta Neurologica Taiwanica Sep 2023Non-Hodgkin lymphoma (NHL) is the most common type of lymphoma, and its extranodal manifestation is rare. Skeletal muscle involvement is noted in only 1.1% of patients...
PURPOSE
Non-Hodgkin lymphoma (NHL) is the most common type of lymphoma, and its extranodal manifestation is rare. Skeletal muscle involvement is noted in only 1.1% of patients with NHL. Here, we present a case of high-grade B-cell lymphoma (HGBL); it infiltrated the left neural foramina from the left psoas muscle before encroaching on the whole spinal canal and subsequently invading the contralateral neural foramina from T12 to L3.
CASE REPORT
A 43-year-old man with HGBL who could function independently presented with numbness and weakness of the left thigh 2 months after a diagnosis of infiltrative lymphoma in the left psoas muscle. His symptoms were urine incontinence and unsteady gait. A neurological examination revealed weakness in the left psoas and quadriceps with hyporeflexia and hypesthesia. Lumbar spine magnetic resonance imaging (MRI) revealed intraspinal extradural invasion from T12 to L3 with multiple left-sided root compression despite the resolution of primary psoas lymphoma. At 6 weeks after symptom onset, his symptoms progressed to weakness, numbness, and hyporeflexia of the bilateral lower extremities with preserved anal sensation. Follow- up MRI revealed the progression of intraspinal invasion, which spread through the spinal canal and invaded the contralateral neural foramina from T12 to L3. The patient was finally bound to a wheelchair.
CONCLUSION
Clinicians must check for possible intraspinal involvement in patients with HGBL, particularly patients with known paraspinal soft-tissue involvement. The resolved infiltration of the soft tissue does not preclude the possibility of further neurological involvement. Additionally, MRI may provide higher resolution findings for clarifying the structure of the neural foramina and thecal sac. Keyword: Non-Hodgkin's Lymphoma, high-grade B-cell lymphoma, plexopathy.
Topics: Male; Humans; Adult; Hypesthesia; Reflex, Abnormal; Lymphoma, Non-Hodgkin; Data Compression; Lymphoma, B-Cell
PubMed: 37674424
DOI: No ID Found -
The Canadian Veterinary Journal = La... Sep 2023An 11-year-old castrated mixed-breed dog was diagnosed with a unilateral anal sac mass. Anal sacculectomy was performed without complication. Histopathology of the mass...
An 11-year-old castrated mixed-breed dog was diagnosed with a unilateral anal sac mass. Anal sacculectomy was performed without complication. Histopathology of the mass was consistent with a well-differentiated mast cell tumor. Analyses for the Ki-67 protein, KIT expression pattern, and the presence of mutations were done. Recovery from surgery was unremarkable and repeat staging revealed no evidence of mast cell disease at 4, 8, and 12 mo after surgery. To the authors' knowledge, primary mast cell neoplasia of the anal sac has not previously been reported in the veterinary literature. Key clinical message: Although mast cell tumors of the perineal region are commonly encountered in veterinary practice, the anal sac represents a novel location for this disease. Cytology of anal sac masses can be a useful diagnostic tool to confirm the diagnosis, guide staging, and assist in treatment decisions.
Topics: Dogs; Animals; Anal Sacs; Mast Cells; Perineum; Neoplasms; Dog Diseases
PubMed: 37663027
DOI: No ID Found -
Analytical Chemistry Aug 2023Single-atom catalysts (SACs), a novel kind of electrocatalysts with full metal utilization, have been developed as unique signal amplifiers in several sensing platforms....
Single-atom catalysts (SACs), a novel kind of electrocatalysts with full metal utilization, have been developed as unique signal amplifiers in several sensing platforms. Herein, based on theoretical prediction of the oxygen reduction reaction (ORR) mechanism on different atom sites, we constructed dual-atomic-site catalysts (DACs), Fe/Mn-N-C, to catalyze luminol-dissolved oxygen electrochemiluminescence (ECL). Computational simulation indicated that the weak adsorption of OH* on a single Fe site was overcome by introducing Mn as the secondary metallic active site, resulting in a synergic dual-site cascade mechanism. The superior catalytic activity of Fe/Mn-N-C DACs for the ORR was proven by the highly efficient cathodic luminol ECL, surpassing the performance of single-site catalysts (SACs), Fe-N-C and Mn-N-C. Furthermore, the ECL system, enhanced by a cascade reaction, exhibited remarkable sensitivity to ascorbic acid, with a detection limit of 0.02 nM. This research opens up opportunities for enhancing both the ECL efficiency and sensing performance by employing a rational atomic-scale design for DACs.
PubMed: 37599579
DOI: 10.1021/acs.analchem.3c00891 -
Journal of the American Veterinary... Nov 2023To report the short-term and long-term outcomes of dogs that underwent the modified closed and traditional closed anal sacculectomy procedures for the treatment of anal...
OBJECTIVE
To report the short-term and long-term outcomes of dogs that underwent the modified closed and traditional closed anal sacculectomy procedures for the treatment of anal sac neoplasia.
ANIMALS
90 client-owned dogs.
METHODS
The medical records of 2 tertiary referral hospitals were reviewed to identify dogs that underwent anal sacculectomy for treatment of anal sac neoplasia between January 2016 and December 2020. Data collected included signalment and preoperative diagnostic findings. The occurrence of intraoperative and postoperative complications, short-term outcomes, and long-term outcomes were also collected. Descriptive statistics were calculated to summarize dog signalment information, and recurrence, metastasis, and survival proportions were compared between techniques using Fisher exact tests.
RESULTS
35 and 55 dogs, respectively, underwent the modified or traditional closed anal sacculectomy procedure. Minor postoperative complications that resolved with minimal intervention occurred in 5 of 35 (14.3%) modified approach dogs and 12 of 55 (21.8%) traditional approach dogs. Tumor recurrence was confirmed in 8 of 35 (22.9%) modified and 8 of 55 (26.4%) traditional approach dogs and was suspected in 3 of 35 (8.6%) and 6 of 55 (13.2%; P = .68), respectively. Confirmed metastatic disease was identified in 8 of 35 (22.9%) and 14 of 53 (26.4%) modified and traditional approach dogs, respectively, and was suspected in 4 of 35 (11.4%) and 7 of 53 (13.2%). Sixty-three (70%) dogs survived to study conclusion.
CLINICAL RELEVANCE
No benefits in complication rate or local recurrence were identified in dogs following the modified approach as opposed to the traditional closed anal sacculectomy technique.
Topics: Humans; Dogs; Animals; Anal Sacs; Neoplasm Recurrence, Local; Anus Neoplasms; Medical Records; Postoperative Complications; Dog Diseases; Retrospective Studies
PubMed: 37586695
DOI: 10.2460/javma.23.05.0239 -
Analytica Chimica Acta Sep 2023Single-atom catalysts (SACs) have attracted much attention due to their excellent catalytic activity, but the improvement of atomic loading which means that weight...
Single-atom catalysts (SACs) have attracted much attention due to their excellent catalytic activity, but the improvement of atomic loading which means that weight fraction (wt%) of metal atom was still facing great challenges. In this work, iron and molybdenum co-doped dual single-atom catalysts (Fe/Mo DSACs) was prepared for the first time by using the soft template sacrifice strategy, which improved significantly the atomic load and exhibited both the oxidase-like (OXD) activity and the dominant peroxidase-like (POD) activity. Further experiments reveal that Fe/Mo DSACs can not only catalyze O to generate O and O, but also catalyze HO to generate a large number of •OH, which caused 3, 3', 5, 5'-tetramethylbenzidine (TMB) to be oxidized to oxTMB, accompanied by the color changing from colorless to blue. The steady-state kinetic test showed that Michaelis-Menten constant (K) values and the maximum initial velocity values (V) of the POD activity of Fe/Mo DSACs were 0.0018 mM and 12.6 × 10 M s, respectively. The corresponding catalytic efficiency was tens of times higher than Fe SACs and Mo SACs, which proves that the synergistic effect between Fe and Mo has significantly improved the catalytic ability. Based on the excellent POD activity of Fe/Mo DSACs, a colorimetric sensing platform combined with TMB was proposed to realize the sensitive detection of HO and uric acid (UA) in a wide range, with limits of detection as low as 0.13 and 0.18 μM, respectively. Finally, accurate and reliable results were obtained in the detection of HO in cells, and of UA in human serum and urine.
Topics: Humans; Hydrogen Peroxide; Uric Acid; Peroxidase; Peroxidases; Catalysis; Colorimetry
PubMed: 37423669
DOI: 10.1016/j.aca.2023.341543 -
Analytical Chemistry Jul 2023The tris(bipyridine)ruthenium(II) (Ru(bpy))-tripropylamine anodic electrochemiluminescence (ECL) system has been widely applied in commercial bioanalysis. However, the...
The tris(bipyridine)ruthenium(II) (Ru(bpy))-tripropylamine anodic electrochemiluminescence (ECL) system has been widely applied in commercial bioanalysis. However, the presence of amine compounds in the biological environment results in unavoidable anodic interference signals, which hinder further extensive use of the system. In contrast, the cathodic Ru(bpy) ECL system can overcome these limitations. The Ru(bpy)/peroxydisulfate (SO, PDS) ECL system has been extensively employed due to its ability to produce a sulfate radical anion (SO) with strong oxidation ability, which enhances the ECL signal. However, the symmetrical molecular structure of PDS makes it challenging to be activated and causes low luminescence efficiency. To address this issue, we propose an efficient Ru(bpy)-based ternary ECL system that uses the iron-nitrogen-carbon single-atom catalyst (Fe-N-C SAC) as an advanced accelerator. Fe-N-C SAC can efficiently activate PDS into reactive oxygen species at a lower voltage, which significantly boosts the cathodic ECL emission of Ru(bpy). Benefiting from the outstanding catalytic activity of Fe-N-C SAC, we successfully established an ECL biosensor that detects alkaline phosphatase activity with high sensitivity, demonstrating the feasibility of practical application.
PubMed: 37421333
DOI: 10.1021/acs.analchem.3c01822 -
Scientific Reports Jul 2023Naturally occurring canine cancers have remarkable similarities to their human counterparts. To better understand these similarities, we investigated 671 client-owned... (Comparative Study)
Comparative Study
Naturally occurring canine cancers have remarkable similarities to their human counterparts. To better understand these similarities, we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types, including those whose mutation profile are unknown (anal sac carcinoma and neuroendocrine carcinoma) or understudied (thyroid carcinoma, soft tissue sarcoma and hepatocellular carcinoma). We discovered mutations in 50 well-established oncogenes and tumor suppressors, and compared them to those reported in human cancers. As in human cancer, TP53 is the most commonly mutated gene, detected in 22.5% of canine tumors overall. Canine tumors share mutational hotspots with human tumors in oncogenes including PIK3CA, KRAS, NRAS, BRAF, KIT and EGFR. Hotspot mutations with significant association to tumor type include NRAS G61R and PIK3CA H1047R in hemangiosarcoma, ERBB2 V659E in pulmonary carcinoma, and BRAF V588E (equivalent of V600E in humans) in urothelial carcinoma. Our findings better position canines as a translational model of human cancer to investigate a wide spectrum of targeted therapies.
Topics: Animals; Dogs; Oncogene Proteins; Mutation; Neoplasms; Humans; Antineoplastic Agents
PubMed: 37414794
DOI: 10.1038/s41598-023-37505-2 -
World Journal of Gastrointestinal... May 2023Perianal fistulising Crohn's disease (PFCD) and glandular anal fistula have many similarities on conventional magnetic resonance imaging. However, many patients with...
BACKGROUND
Perianal fistulising Crohn's disease (PFCD) and glandular anal fistula have many similarities on conventional magnetic resonance imaging. However, many patients with PFCD show concomitant active proctitis, but only few patients with glandular anal fistula have active proctitis.
AIM
To explore the value of differential diagnosis of PFCD and glandular anal fistula by comparing the textural feature parameters of the rectum and anal canal in fat suppression T2-weighted imaging (FS-T2WI).
METHODS
Patients with rectal water sac implantation were screened from the first part of this study (48 patients with PFCD and 22 patients with glandular anal fistula). Open-source software ITK-SNAP (Version 3.6.0, http://www.itksnap.org/) was used to delineate the region of interest (ROI) of the entire rectum and anal canal wall on every axial section, and then the ROIs were input in the Analysis Kit software (version V3.0.0.R, GE Healthcare) to calculate the textural feature parameters. Textural feature parameter differences of the rectum and anal canal wall between the PFCD group the glandular anal fistula group were analyzed using Mann-Whitney U test. The redundant textural parameters were screened by bivariate Spearman correlation analysis, and binary logistic regression analysis was used to establish the model of textural feature parameters. Finally, diagnostic accuracy was assessed by receiver operating characteristic-area under the curve (AUC) analysis.
RESULTS
In all, 385 textural parameters were obtained, including 37 parameters with statistically significant differences between the PFCD and glandular anal fistula groups. Then, 16 texture feature parameters remained after bivariate Spearman correlation analysis, including one histogram parameter (Histogram energy); four grey level co-occurrence matrix (GLCM) parameters (GLCM energy_all direction_offset1_SD, GLCM entropy_all direction_ offset4_SD, GLCM entropy_all direction_offset7_SD, and Haralick correlation_all direction_ offset7_SD); four texture parameters (Correlation_all direction_offset1_SD, cluster prominence _angle 90_offset4, Inertia_all direction_offset7_SD, and cluster shade_angle 45_offset7); five grey level run-length matrix parameters (grey level nonuniformity_angle 90_offset1, grey level nonuniformity_all direction_offset4_SD, long run high grey level emphasis_all direction_offset1_SD, long run emphasis_all direction_ offset4_ SD, and long run high grey level emphasis_all direction_offset4_SD); and two form factor parameters (surface area and maximum 3D diameter). The AUC, sensitivity, and specificity of the model of textural feature parameters were 0.917, 85.42%, and 86.36%, respectively.
CONCLUSION
The model of textural feature parameters showed good diagnostic performance for PFCD. The texture feature parameters of the rectum and anal canal in FS-T2WI are helpful to distinguish PFCD from glandular anal fistula.
PubMed: 37342861
DOI: 10.4240/wjgs.v15.i5.882