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Korean Journal of Family Medicine Jun 2024Establishing cost-effective informal care services for lonely older adults living at home in developing countries can be an innovative approach for improving their...
Effectiveness of an Informal Home Care Support Intervention Program to Reduce Loneliness and Improve Quality of Life among Lonely Community-Dwelling Older Adults: A Feasibility Study.
BACKGROUND
Establishing cost-effective informal care services for lonely older adults living at home in developing countries can be an innovative approach for improving their well-being. This study investigated the effectiveness of an informal home care support intervention program (HoSIP) reducing the loneliness and improving quality of life of lonely community-dwelling older adults.
METHODS
This quasi-experimental pre-post study employed a non-randomized control group design with a 12-week intervention period and three follow-up points at the end of the HoSIP. Questionnaires were used to measure feelings of loneliness (20-item UCLA Loneliness Scale), quality of life (Control, Autonomy, Self-Realization and Pleasure Scale), general health (12-item General Health Questionnaire), social network (six-item Lubben Social Network Scale), social support (12-item Multidimensional Scale of Perceived Social Support), and self-care ability (17-item Self-care Ability Scale for the Elderly). Repeated-measures analysis of variance was used to gauge the effect of the intervention program over time and in comparison to the control group. Data analyses were performed using the IBM SPSS Statistics software (IBM Corp., USA).
RESULTS
We found a significant relationship between the outcome variables, including feelings of loneliness (P<0.001) and quality of life (P<0.001), at different stages of measurement. Despite the positive feasibility results, the implementation of the HoSIP faced challenges due to a lack of facilities (e.g., place restriction for holding educational classes, educational facilities like computers, video projector, and whiteboard at daycare center) and the absence of supporting organizations.
CONCLUSION
Utilizing the existing capabilities of older adults to provide online and face-to-face care services can be a cost-effective way to improve their quality of life and reduce loneliness. The process of facilitating such informal care services for lonely older adults should be managed by either governmental or non-governmental organizations to reduce the rate of social isolation among this vulnerable population.
PubMed: 38852950
DOI: 10.4082/kjfm.23.0269 -
Brain, Behavior, and Immunity Jun 2024Major depressive disorder (MDD) is a global health burden characterized by persistent low mood, deprivation of pleasure, recurrent thoughts of death, and physical and...
Major depressive disorder (MDD) is a global health burden characterized by persistent low mood, deprivation of pleasure, recurrent thoughts of death, and physical and cognitive deficits. The current understanding of the pathophysiology of MDD is lacking, resulting in few rapid and effective antidepressant therapies. Recent studies have pointed to the sigma-1 (σ-1) receptor as a potential rapid antidepressant target; σ-1 agonists have shown promise in a variety of preclinical depression models. Hypidone hydrochloride (YL-0919), an independently developed antidepressant by our institute with faster onset of action and low rate of side effects, has recently emerged as a highly selective σ-1 receptor agonist; however, its underlying astrocyte-specific mechanism is unknown. In this study, we investigated the effect of YL-0919 treatment on gene expression in the prefrontal cortex of depressive-like mice by single-cell RNA sequencing. Furthermore, we knocked down σ-1 receptors on astrocytes in the medial prefrontal cortex of mice to explore the effects of YL-0919 on depressive-like behavior and neuroinflammation in mice. Our results demonstrated that astrocyte-specific knockdown of σ-1 receptor resulted in depressive-like behavior in mice, which was reversed by YL-0919 administration. In addition, astrocytic σ-1 receptor deficiency led to activation of the NF-κB inflammatory pathway, and crosstalk between reactive astrocytes and activated microglia amplified neuroinflammation, exacerbating stress-induced neuronal apoptosis. Furthermore, the depressive-like behavior induced by astrocyte-specific knockdown of the σ-1 receptor was improved by a selective NF-κB inhibitor, JSH-23, in mice. Our study not only reaffirms the σ-1 receptor as a key target of the faster antidepressant effect of YL-0919, but also contributes to the development of astrocytic σ-1 receptor-based novel drugs.
PubMed: 38852761
DOI: 10.1016/j.bbi.2024.06.008 -
Experimental Oncology May 2024Director of the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, Doctor of Biological...
Director of the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, Doctor of Biological Sciences Professor Liubov Heorhiivna Buchynska celebrates her 75th anniversary Liubov Heorhiivna Buchynska graduated from the Biological Department of the Taras Shevchenko State University in 1977 and has been working at the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine since 1977. In 1996, she became the Scientific Secretary of the Institute, in 2001 - the Deputy Director, and in 2021 - Director of the Institute. In 1989, L. Buchynska received her PhD degree and in 2012, she defended her doctoral thesis "Endometrioid cancer: taxonomy of genetic alterations of cancer cells and their role in determining malignancy potential" and received her doctoral degree in specialty "oncology". Since 2003, she has headed the Laboratory of Oncogenetics (nowadays - the Department of Genetics of Cancer and Oncohematology). In 2020, L. Buchynska was given the title of Professor in Biology. Prof. L. Buchynska is a well-known Ukrainian scientist in the field of oncogenetics and cytomorphology. Her long-term studies are characterized by a multidisciplinary approach to solving the problems of cancer biology and genetics. The innovation component occupies an important place in the fundamental studies by Prof. L. Buchynska aimed at implementing technologies for early and differential diagnosis of the precancerous and cancerous processes and assessing the course of the disease in patients with malignancies of the organs of the female reproductive system. Prof. L. Buchynska has authored more than 250 scientific papers and 7 patents of Ukraine. She is a co-author of three monographs. She pays special attention to research-and-organizational and educational activities and training of young researchers. She has supervised five PhD theses. For the last 10 years, she has been collaborating with the Bogomolets National Medical University lecturing biology. Prof. L. Buchynska is the Deputy Editor-in-Chief of the "Experimental Oncology" and "Oncology" journals, a member of the Scientific Council on the Problems of Malignant Neoplasms, a member of the Board of the National Association of Ukrainian Oncologists and the Non-governmental Organization "Ukrainian Society for Cancer Research". Prof. L. Buchynska was awarded the Bogomolets Prize of the National Academy of Sciences of Ukraine and a Certificate of Merit of the National Academy of Sciences of Ukraine. She was decorated with the Medal of Honor of the National Academy of Sciences of Ukraine "For Scientific Achievements". Holding the helm of the Institute in difficult times for our country, Liubov Heorhiivna is doing her best for a noble goal - fighting cancer. The administration and staff of the Institute have a great pleasure to congratulate Liubov Heorhiivna on her 75th anniversary and wish her good health, creative inspiration, and new scientific achievements. Administration and staff of the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine Editorial Board of Experimental Oncology.
Topics: History, 20th Century; History, 21st Century; Ukraine; Medical Oncology; Humans
PubMed: 38852048
DOI: No ID Found -
Social Cognitive and Affective... May 2024The smell of the own baby is a salient cue for human kin recognition and bonding. We hypothesized that infant body odors function like other cues of the Kindchenschema...
The smell of the own baby is a salient cue for human kin recognition and bonding. We hypothesized that infant body odors function like other cues of the Kindchenschema by recruiting neural circuits of pleasure and reward. In two functional magnetic resonance imaging studies, we presented infantile and post-pubertal body odors to nulliparae and mothers (N = 78). All body odors increased blood-oxygen-level-dependent (BOLD) response and functional connectivity in circuits related to olfactory perception, pleasure and reward. Neural activation strength in pleasure and reward areas positively correlated with perceptual ratings across all participants. Compared to body odor of post-pubertal children, infant body odors specifically enhanced BOLD signal and functional connectivity in reward and pleasure circuits, suggesting that infantile body odors prime the brain for prosocial interaction. This supports the idea that infant body odors are part of the Kindchenschema. The additional observation of functional connectivity being related to maternal and kin state speaks for experience-dependent priming.
Topics: Humans; Odorants; Female; Magnetic Resonance Imaging; Male; Infant; Adult; Smell; Brain; Olfactory Perception; Brain Mapping; Oxygen; Young Adult; Child; Reward; Pleasure
PubMed: 38850226
DOI: 10.1093/scan/nsae038 -
Journal of Adolescence Jun 2024The current investigation's central goal was to elucidate the complex features of peer teasing episodes that individuals use to interpret teasing as harmful versus...
INTRODUCTION
The current investigation's central goal was to elucidate the complex features of peer teasing episodes that individuals use to interpret teasing as harmful versus playful.
METHOD
In 2022-2023, we used semistructured interviews to gather retrospective reports of K-12 peer teasing experiences from a sample of 27 students from a university in southern Ontario, Canada (18-25 years old, 63% female, 78% White).
RESULTS
Content analysis revealed the multifaceted nature of teasing, with participants defining teasing as harmful, playful, or including elements of both harm and pleasure. Harmful teasing experiences often included content that was sensitive to the target, occurred between both friends and nonfriends, and often included a power differential with the teasing perpetrator having more power than the target. Targets recalled negative emotional responses, with behavioral responses to mitigate the situation and reduce further teasing. In contrast, playful teasing often occurred between friends or close friends, was often motivated by positive interpersonal motives (e.g., for encouragement), and had positive impacts on the relationship between perpetrator and target. However, despite benign intent, some playful teasing was marked by negative emotional responses and feelings of harm.
CONCLUSIONS
Results have implications for uncovering the nuanced and complex nature of teasing, and provide a preliminary profile of harmful versus playful teasing interactions.
PubMed: 38847229
DOI: 10.1002/jad.12359 -
Emotion (Washington, D.C.) Jun 2024Anticipated emotions are the feelings one if a hypothetical future event were to occur, whereas anticipatory emotions are those one while imagining the event. There...
Anticipated emotions are the feelings one if a hypothetical future event were to occur, whereas anticipatory emotions are those one while imagining the event. There has been little direct comparison of these two forms of future-oriented emotion, and authors have typically focused on positive emotions (e.g., pleasure). Besides, their sensitivity to depressive symptoms-which may help to explain motivational problems in depression-has only recently been investigated (e.g., Anderson et al., 2023; Gamble et al., 2021). The present study (conducted September-November 2022) used innovative picture-and-text vignettes depicting everyday positive and negative future events, to which participants rated their anticipated and anticipatory responses on separate dimensions of valence (i.e., how positive or negative) and arousal (i.e., emotional intensity). Based on prior literature, anticipatory emotions were expected to be correlated with, yet weaker than, anticipated emotions, reflecting a conceptualization of anticipatory emotions as a "foretaste" of the affective response one expects in the future. We also predicted that high depressive symptoms would coincide with diminished emotion ratings overall and specifically for anticipatory emotions (tightly coupled with event expectations; Carrera et al., 2012). Results largely supported these preregistered predictions, yet anticipatory emotions (positive and negative) were only weaker in more highly depressed participants. Depressive symptoms may therefore affect how one currently feels about future possibilities without altering one's expectations of how such events would actually feel. Implications and future research objectives arising from this are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
PubMed: 38842877
DOI: 10.1037/emo0001371 -
Journal of Sports Science & Medicine Jun 2024People with overweight or obesity preferred high-intensity interval training (HIIT) due to the time-efficiency and pleasure. However, HIIT leads to delayed onset muscle... (Randomized Controlled Trial)
Randomized Controlled Trial
People with overweight or obesity preferred high-intensity interval training (HIIT) due to the time-efficiency and pleasure. However, HIIT leads to delayed onset muscle soreness (DOMS). The present study aimed to investigate the effects of omega-3 supplementation on DOMS, muscle damage, and acute inflammatory markers induced by cycling HIIT in untrained males with overweight or obesity. A randomized, double-blinded study was used in the present study. Twenty-four males with a sedentary lifestyle were randomly assigned to either receive omega-3 (O3) (4 g fish oil) or placebo (Con). Subjects consumed the capsules for 4 weeks and performed cycling HIIT at the 4 week. After 4 weeks-intervention, the omega-3 index of O3 group increased by 52.51% compared to the baseline. All subjects performed HIIT at 4 week. The plasma creatine kinase (CK) level of Con group increased throughout 48h after HIIT. While the CK level of O3 group increased only immediately and 24h after HIIT and decreased at 48h after HIIT. The white blood cell count (WBC) of Con group increased immediately after the HIIT, while O3 group did not show such increase. There was no change of CRP in both groups. O3 group had a higher reduction of calf pain score compared to Con group. O3 group also showed a recovery of leg strength faster than Con group. Omega-3 supplementation for 4 weeks lower increased CK level, reduced calf pain score, and recovery leg strength, DOMS markers after cycling HIIT.
Topics: Humans; Male; Myalgia; High-Intensity Interval Training; Double-Blind Method; Dietary Supplements; Creatine Kinase; Fatty Acids, Omega-3; Overweight; Obesity; Young Adult; C-Reactive Protein; Bicycling; Adult; Leukocyte Count; Muscle, Skeletal; Biomarkers; Sedentary Behavior
PubMed: 38841630
DOI: 10.52082/jssm.2024.317 -
International Journal of Biological... Jun 2024Depression is a neuropsychiatric disorder characterized by persistent pleasure loss and behavioral despair. However, the potential mechanisms and therapeutic targets for...
Depression is a neuropsychiatric disorder characterized by persistent pleasure loss and behavioral despair. However, the potential mechanisms and therapeutic targets for depression treatment remain unclear. Therefore, identifying the underlying pathogenesis of depression would promote the development of novel treatment and provide effective targets for antidepressant drugs. In this study, proteomics analysis showed that the expression level of phosphatase and actin regulator 4 (Phactr4) was significantly increased in the CA1 hippocampus of depressed rats. The upregulated Phactr4 might induce dysfunction of the synaptic structure via suppressing the p-LIMK/p-Cofilin signaling pathway, and promote neuroinflammation via activating the NF-κB/NLRP3 pathway, which ultimately contributes to the pathogenesis of depression. In contrast, the downregulation of Phactr4 in hippocampal CA1 of depressed rats alleviated depression-like behaviors, along with reducing neuroinflammation and improving synaptic plasticity. In conclusion, these findings provide evidence that Phactr4 plays an important role in regulating neuroinflammatory response and impairment of synaptic plasticity, effects seem to involve in the pathogenesis of depression, and Phactr4 may serve as a potential target for antidepressant treatment.
PubMed: 38838879
DOI: 10.1016/j.ijbiomac.2024.132854 -
BioEssays : News and Reviews in... Jun 2024Stem cell research is the product of cumulative, integrated effort between and within laboratories and disciplines. The many collaborative steps that lead to that... (Review)
Review
Stem cell research is the product of cumulative, integrated effort between and within laboratories and disciplines. The many collaborative steps that lead to that special "Eureka moment", when something that has been a puzzle perhaps for years suddenly become clear, is among the greatest pleasures of a scientific career. In this essay, the serendipitous pathway from first acquaintance with pluripotent stem cells to advanced cardiovascular models that emerged from studying development and disease will be described. Perhaps inspiration for later generations of stem cell researchers simply to follow whatever they find interesting.
PubMed: 38838059
DOI: 10.1002/bies.202400078 -
Facial Plastic Surgery : FPS Jun 2024It gives us great pleasure to guest edit this special edition on The Disfigured Face. We present a range of manuscripts covering the surgical and non-surgical aspects of...
It gives us great pleasure to guest edit this special edition on The Disfigured Face. We present a range of manuscripts covering the surgical and non-surgical aspects of managing facial paralysis. We are privileged to include articles from internationally renowned surgeons. We hope our readers enjoy reading these articles and should there be any questions, or errors, please do not hesitate to contact us Best wishes Eamon Shamil and Peter Andrews Facial Reanimation Multidisciplinary Team The Royal National ENT Hospital, University College London Hospitals NHS Foundation Trust, England.
PubMed: 38834175
DOI: 10.1055/a-2338-0797