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Foods (Basel, Switzerland) May 2024Veterinary medications are necessary for both contemporary animal husbandry and food production, but their residues can linger in foods obtained from animals and pose a... (Review)
Review
Veterinary medications are necessary for both contemporary animal husbandry and food production, but their residues can linger in foods obtained from animals and pose a dangerous human risk. In this review, we aim to highlight the sources, occurrence, human exposure pathways, and human health effects of drug residues in food-animal products. Following the usage of veterinary medications, pharmacologically active compounds known as drug residues can be found in food, the environment, or animals. They can cause major health concerns to people, including antibiotic resistance development, the development of cancer, teratogenic effects, hypersensitivity, and disruption of normal intestinal flora. Drug residues in animal products can originate from variety of sources, including water or food contamination, extra-label drug use, and ignoring drug withdrawal periods. This review also examines how humans can be exposed to drug residues through drinking water, food, air, and dust, and discusses various analytical techniques for identifying these residues in food. Furthermore, we suggest some potential solutions to prevent or reduce drug residues in animal products and human exposure pathways, such as implementing withdrawal periods, monitoring programs, education campaigns, and new technologies that are crucial for safeguarding public health. This review underscores the urgency of addressing veterinary drug residues as a significant and emerging public health threat, calling for collaborative efforts from researchers, policymakers, and industry stakeholders to develop sustainable solutions that ensure the safety of the global food supply chain.
PubMed: 38890858
DOI: 10.3390/foods13111629 -
Archives of Public Health = Archives... Jun 2024Tuberculosis (TB) treatment is more challenging for patients with silicosis, as it complicates the diagnosis of both diseases and increases mortality risk. Silicosis, an...
Tuberculosis (TB) treatment is more challenging for patients with silicosis, as it complicates the diagnosis of both diseases and increases mortality risk. Silicosis, an incurable occupational disease, confounds the diagnosis of TB and vice versa, making it more difficult to accurately identify and treat either condition. Moreover, TB appears to accelerate the progression of silicosis. Exposure to silica dust, a common cause of silicosis, can also trigger latent TB to become active TB. This correspondence outlines a proposed framework for implementing collaborative TB-silicosis activities in India, aimed at improving early diagnosis and management for both diseases. An expert panel of medical professionals developed this framework through online consultations in October and November 2022. The panel's goal was to establish a consensus on integrating TB-silicosis activities, with a focus on early detection and proper management. The framework suggests testing all patients with silicosis for active TB and screening workers exposed to silica dust for latent TB infection. It also recommends that patients with TB who have a history of occupational exposure to silica dust should be tested for silicosis. Reliable diagnostic tools, such as chest X-rays, are emphasized, providing guidance on their use for both diseases. The proposed collaborative TB-silicosis framework offers a structured approach to identifying and managing these two diseases, contributing to the global goal of eliminating silicosis by 2030 and aligning with the World Health Organization's targets for reducing TB incidence and mortality. It recommends specific strategies for implementation, including testing, referral systems, and workplace-based interventions. The framework also underscores the need for coordinated efforts among stakeholders, including the ministries of health, labor, industry, and environment. This correspondence provides valuable insights into how India can successfully implement collaborative TB-silicosis activities, serving as a model for other regions with similar challenges.
PubMed: 38890764
DOI: 10.1186/s13690-024-01325-1 -
Journal of Investigational Allergology... Jun 2024Sensitization to Blomia tropicalis is associated with asthma in various tropical and subtropical countries; however, information about the specific molecular components...
BACKGROUND AND OBJECTIVE
Sensitization to Blomia tropicalis is associated with asthma in various tropical and subtropical countries; however, information about the specific molecular components associated with this disease is scarce. Using molecular diagnosis, we sought to identify B tropicalis allergens associated with asthma in Colombia.
METHODS
Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés). The study sample included children and adults (mean [SD] age, 28 [17] years). Cross-reactivity between Blo t 5 and Blo t 21 was evaluated using ELISA-inhibition.
RESULTS
Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés). The study sample included children and adults (mean [SD] age, 28 [17] years). Cross-reactivity between Blo t 5 and Blo t 21 was evaluated using ELISA-inhibition.
CONCLUSION
Although Blo t 5 and Blo t 21 are considered common sensitizers, this is the first report of their association with asthma. Both components should be included in molecular panels for diagnosis of allergy in the tropics.
Topics: Humans; Asthma; Immunoglobulin E; Adult; Male; Female; Case-Control Studies; Child; Adolescent; Colombia; Allergens; Young Adult; Middle Aged; Antigens, Plant; Cross Reactions; Tropical Climate; Prevalence; Child, Preschool
PubMed: 38888580
DOI: 10.18176/jiaci.0892 -
Heliyon Jun 2024Dust removal coatings for polyimide (PI)-based photovoltaic modules used in lunar rovers were fabricated successfully through the blade-coating method using silicon...
Dust removal coatings for polyimide (PI)-based photovoltaic modules used in lunar rovers were fabricated successfully through the blade-coating method using silicon dioxide (SiO) nanoparticles and γ-aminopropyltriethoxysilane (KH550). The dust removal performance, morphology, transparency, and adhesive force of the coating can be optimized by adjusting the pH and the mass ratios of SiO and KH550. The designed coating demonstrates excellent dust removal performance, achieving an percentage of over 85 %. Moreover, the coating has minimal impact on the transparency of the PI substrate and exhibits strong adhesion to it. Additionally, the coating shows remarkable resistance to both high and low temperatures. Even after undergoing five cycles of thermal treatment ranging from -196 to 160 °C, there were no significant changes in the morphology or dust removal performance of the coating. Therefore, this coating exhibits tremendous potential for application in the dust removal of photovoltaic modules in lunar rovers.
PubMed: 38882304
DOI: 10.1016/j.heliyon.2024.e31985 -
ACS Omega Jun 2024In exploring the viability of perovskite solar cells (PSCs) for Mars missions, our study first delved into their temperature endurance in conditions mimicking the...
In exploring the viability of perovskite solar cells (PSCs) for Mars missions, our study first delved into their temperature endurance in conditions mimicking the Martian climate, revealing remarkable thermal stability within the temperature range of 173-303 K. We then pioneered the examination of PSC resilience to electrostatic discharge (ESD), a critical factor given the frequent Martian dust activities. In a custom-built Martian simulation chamber, we discovered that ESD exposure dramatically reduced the power conversion efficiency of these devices by more than half (55.4%) in just 90 s. This groundbreaking research not only advances our understanding of the potential of PSCs for Mars exploration but also opens new avenues for optimizing solar technology in extreme environments.
PubMed: 38882146
DOI: 10.1021/acsomega.4c02887 -
ACS Omega Jun 2024The impacts of the composition and properties of tar products on their utilization are of great importance, while the consequences of varying tar separation conditions...
The impacts of the composition and properties of tar products on their utilization are of great importance, while the consequences of varying tar separation conditions on distillation fractions remain underexplored. Solid impurities in special tar products (e.g., subsurface in situ pyrolysis-derived tar-like substances) can contribute to the separation as well. In the present study, low-temperature coal tar (LTCT) was used as an analogue to pyrolysis product, mixed with semi-coke and coal dust, representing pyrolytic byproducts and nonpyrolytic substances, respectively. The LTCT mixtures were tested with vacuum distillation at various pressures and temperatures. The results revealed the role of pressure in fraction distribution across temperatures, with higher pressure concentrating fractions at lower temperatures. The impact of solid impurities on distillation primarily stemmed from adsorption. Minimal concentrations of solid impurities carried coal dust/semi-coke into the distillation, but higher levels retained them in the residue. The adsorption of coal dust was quite high at lower temperatures and waned as temperature increased, unlike semi-coke, which had consistent adsorption throughout the distillation. The present study can advance the understanding of vacuum distillation for tar products in the presence of solid impurities, offering a framework for the effective distillation/utilization of coal tar. By probing separation conditions, tar properties, and solid impurity effects, the present research will refine strategies for optimizing coal tar use, crucial for enhancing energy security and sustainable progress in China.
PubMed: 38882087
DOI: 10.1021/acsomega.4c01513 -
ACS Omega Jun 2024Hydraulic fracturing generates fractures in a coal seam, which has been extensively used in coal mining and disaster management. To study the influences of water...
Hydraulic fracturing generates fractures in a coal seam, which has been extensively used in coal mining and disaster management. To study the influences of water injection pressure and time on the propagation of hydraulic fracture, we conducted true triaxial hydraulic fracturing experiments under acoustic emission monitoring. Five briquette specimens were prepared by molding the mixture of coal powder, cement, river sand, and distilled water under 60 MPa to simulate the properties of coal seam. True triaxial loading was used to simulate the in situ stress environment of the coal seam. Hydraulic fracturing experiments on the test specimens were conducted under different water injection pressures and times. The following conclusions have been drawn. At the fixed injection time, increasing water injection pressure promotes the propagation of hydraulic fracture and the migration of water in the coal seam after the fractures are connected. The number of fractures increases from 3 to 8 as the water injected pressure increased from 3 to 9 MPa. Under the constant water injection pressure, the increase in longitudinal wave velocity in the test specimen decreases with the prolongation of water injection time. When the water reaches the action boundary of the water injection pressure, the water stops moving. At this moment, the water injection time has no effect on the longitudinal wave velocity anymore. The fracturing influence range can be increased by increasing the water injection pressure to produce a fracture network of a large radius with many fractures. Appropriately prolonging hydraulic fracturing time can ensure that the fracturing fluid fully moistens the coal seam and thus effectively reduces dust pollution.
PubMed: 38882068
DOI: 10.1021/acsomega.4c00980 -
Scientific Reports Jun 2024Traditional DID models overlook variations in policy intensity, causing estimation deviations from the actual situation and a limited understanding of the influence...
Traditional DID models overlook variations in policy intensity, causing estimation deviations from the actual situation and a limited understanding of the influence mechanism. In response, the Intensity Modified SDID Model is built to examine the influence mechanism of ETS's carbon reductions. Moreover, through model extensions, the study explores the spatiotemporal characteristics and heterogeneities of ETS's effects. Results show that: (1) "Dual-circulation" influence mechanism is confirmed, where ETS directly contributes to carbon reductions (2.70% to 10.0% impact) through external pathways, and internal pathways continuously strengthen reduction effects, comprehensive mechanisms are thereby formed and enhanced based on interaction among internal and external pathways. (2) Reasonable ETS levels are estimated and proposed to achieve "Dual Carbon Target", constraining nationwide carbon quotas by 20 billion tons/year, increasing carbon trading volumes by 80 thousand tons/year, and elevating the carbon trading prices by 100 RMB (14 USD) per ton. (3) ETS's carbon reduction effects are identified with temporal and spatial characteristics, temporally, effects peak in the 4th period (Event) but diminish in the 5th period (Event), spatially, effects peak in areas distancing around 1000 km but disappear beyond 1500 km. (4) ETS also has synergistic effects with atmospheric pollution reduction, including industrial emissions of sulfur dioxide and smoke (dust), but are insignificant to industrial emissions of wastewater and solid waste.
PubMed: 38880799
DOI: 10.1038/s41598-024-64250-x -
Scientific Reports Jun 2024The 2021 tuberculosis (TB) preventive treatment guidelines in India included silicosis as a screening group, yet latent TB infection (LTBI) testing for...
The 2021 tuberculosis (TB) preventive treatment guidelines in India included silicosis as a screening group, yet latent TB infection (LTBI) testing for silica-dust-exposed individuals is underemphasized. Focusing on an estimated 52 million silica-dust-exposed workers, particularly agate-stone workers in Khambhat, Gujarat, our study aims to estimate LTBI prevalence, identify predictors, and gather insights from TB and silicosis experts. Employing a sequential explanatory mixed-methods approach, a cross-sectional study involved 463 agate-stone workers aged ≥ 20 years in Khambhat, using IGRA kits for LTBI testing. In-depth interviews with experts complemented quantitative findings. Among agate-stone workers, 58% tested positive for LTBI, with predictors including longer exposure, type of work, and BCG vaccination. Our findings reveal a nearly double burden of LTBI compared to the general population, particularly in occupations with higher silica dust exposure. Experts advocate for including silica-dust-exposed individuals in high-risk groups for LTBI testing, exploring cost-effective alternatives like improved skin sensitivity tests, and shorter TB preventive treatment regimens to enhance compliance. Future research should explore upfront TB preventive treatment for silica-dust-exposed individuals with high LTBI prevalence and optimal exposure duration. This study underscores the urgent need for policy changes and innovative approaches to TB prevention among silica-dust-exposed populations, impacting global occupational health strategies.
Topics: Humans; India; Silicon Dioxide; Male; Latent Tuberculosis; Dust; Adult; Occupational Exposure; Cross-Sectional Studies; Silicosis; Female; Middle Aged; Prevalence
PubMed: 38879714
DOI: 10.1038/s41598-024-64837-4 -
Environment International Jul 2024Organophosphorus compounds (OPs) are widely used as flame retardants (FRs) and plasticizers, yet strategies for comprehensively screening of suspect OPs in environmental...
Organophosphorus compounds (OPs) are widely used as flame retardants (FRs) and plasticizers, yet strategies for comprehensively screening of suspect OPs in environmental samples are still lacking. In this work, a neoteric, robust, and general suspect screening technique was developed to identify novel chemical exposures by use of ultra-high performance liquid chromatography-Q Exactive hybrid quadrupole-Orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS). We firstly established a suspect chemical database which had 7,922 OPs with 4,686 molecular formulas, and then conducted suspect screening in n = 50 indoor dust samples, n = 76 sediment samples, and n = 111 water samples. By use of scoring criteria such as retention time prediction models, we successfully confirmed five compounds by comparison with their authentic standards, and prioritized three OPs candidates including a nitrogen/fluorine-containing compound, that is dimethyl {1H-indol-3-yl[3-(trifluoromethyl)anilino]methyl} phosphonate (DMITFMAMP). Given that the biodegradation half-life values in water (t) of DMITFMAMP calculated by EPI Suite is 180 d, it is considered to be potentially persistent. This strategy shows promising potential in environmental pollution assessment, and can be expected to be widely used in future research.
Topics: Organophosphorus Compounds; Environmental Monitoring; Flame Retardants; Dust; Chromatography, High Pressure Liquid; Environmental Pollutants; Geologic Sediments; Water Pollutants, Chemical; Mass Spectrometry
PubMed: 38875816
DOI: 10.1016/j.envint.2024.108802