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Autism Research : Official Journal of... Aug 2022Autism spectrum disorder (ASD) is characterized by significant social functioning impairments, including (but not limited to) emotion recognition, mentalizing, and joint... (Meta-Analysis)
Meta-Analysis Review
Autism spectrum disorder (ASD) is characterized by significant social functioning impairments, including (but not limited to) emotion recognition, mentalizing, and joint attention. Despite extensive investigation into the correlates of social functioning in ASD, only recently has there been focus on the role of low-level sensory input, particularly visual processing. Extensive gaze deficits have been described in ASD, from basic saccadic function through to social attention and the processing of complex biological motion. Given that social functioning often relies on accurately processing visual information, inefficient visual processing may contribute to the emergence and sustainment of social functioning difficulties in ASD. To explore the association between measures of gaze and social functioning in ASD, a systematic review and meta-analysis was conducted. A total of 95 studies were identified from a search of CINAHL Plus, Embase, OVID Medline, and psycINFO databases in July 2021. Findings support associations between increased gaze to the face/head and eye regions with improved social functioning and reduced autism symptom severity. However, gaze allocation to the mouth appears dependent on social and emotional content of scenes and the cognitive profile of participants. This review supports the investigation of gaze variables as potential biomarkers of ASD, although future longitudinal studies are required to investigate the developmental progression of this relationship and to explore the influence of heterogeneity in ASD clinical characteristics. LAY SUMMARY: This review explored how eye gaze (e.g., where a person looks when watching a movie) is associated with social functioning in autism spectrum disorder (ASD). We found evidence that better social functioning in ASD was associated with increased eye gaze toward faces/head and eye regions. Individual characteristics (e.g., intelligence) and the complexity of the social scene also influenced eye gaze. Future research including large longitudinal studies and studies investigating the influence of differing presentations of ASD are recommended.
Topics: Attention; Autism Spectrum Disorder; Fixation, Ocular; Humans; Social Interaction; Visual Perception
PubMed: 35593039
DOI: 10.1002/aur.2729 -
Brazilian Journal of Otorhinolaryngology 2022To investigate ocular movements measures of vectoelectro-nystagmography and video-nystagmography in dyslexic children and compare with measures of typical children. (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
To investigate ocular movements measures of vectoelectro-nystagmography and video-nystagmography in dyslexic children and compare with measures of typical children.
METHODS
A systematic review of observational studies comparing the ocular movements differences between dyslexic and typical children with no publication date or language restriction. The literature survey included the bibliographic databases MEDLINE, ScienceDirect, Scopus, Web of Science, SciELO, Lilacs and CENTRAL. Gray literature databases were also searched, including: OpenGrey.eu, DissOnline.de, The New York Academy of Medicine and WorldCat. The meta-analysis was performed using software RevMan 5.3 (Cochran Collaboration).
RESULTS
A total of 2375 articles were found of which 113 fell within the inclusion criteria. Among these, 52 were duplicates (found in more than one research source), and 45 articles were selected for reading in full. Thirteen (13) articles were included for analysis and discussion. Meta-analysis showed statistical differences between the two groups for the total number of saccades and duration of fixation.
CONCLUSION
The study revealed that children with dyslexia have longer duration of fixation and fewer saccades during ocular movements on vectoelectro-nystagmography and video-nystagmography when compared to children without dyslexia.
Topics: Child; Humans; Fixation, Ocular; Dyslexia; Saccades; Reading; Eye Movements
PubMed: 35094959
DOI: 10.1016/j.bjorl.2021.10.006 -
Accident; Analysis and Prevention Nov 2019Novice drivers are statistically over-represented in reported road crashes, with recent evidence suggesting that some of this increased crash involvement may be a result... (Meta-Analysis)
Meta-Analysis
Novice drivers are statistically over-represented in reported road crashes, with recent evidence suggesting that some of this increased crash involvement may be a result of limitations in their cognitive processing. Such processing has typically been measured by recording drivers' patterns of eye movements, however, the exact ways in which eye movements are reported and interpreted varies substantially between different studies in the literature. Therefore, the objective of this systematic review was to investigate whether novice drivers and experienced drivers do differ in clear and reproducible ways in their visual search. Studies were identified through searches of Web of Science, Medline, TRID Database, and the TRB Research in Progress Database, with no restrictions on publication status. Studies were included if they compared the visual search of a novice driver group (<3 years driving experience) and an experienced driver group (>3 years driving experience) using an eye tracking method and reported at least one of the following four visual search outcomes: fixation durations, horizontal spread of search, vertical spread of search and number of fixations. Two reviewers independently screened searches and assessed the full texts of potentially included studies. Of the 235 studies initially identified 18 were included in the review, with 13 studies reporting sufficient data to be included in the meta-analysis for at least one outcome measure. Given that the included studies deployed a range of method types, additional sub-group analyses were conducted using this factor. Sensitivity analyses were also conducted by temporarily removing extreme experience groups (e.g. driving instructors and learner drivers) in order to test the effect of different levels of experience and training. The meta-analyses, along with support from results discussed narratively, revealed that novice drivers have a narrower horizontal spread of search compared to experienced drivers, however, there were no overall differences in fixation durations, vertical spread of search or number of fixations when the studies were pooled together. These findings have important primary implications for the development of novice training interventions, with novice drivers needing to develop a broader horizontal spread of visual search, but not to necessarily learn to fixate further down the road. Subgroup analyses also provided considerations for future research studies in terms of the experience of the driver groups, and the method type used.
Topics: Accidents, Traffic; Adolescent; Automobile Driving; Eye Movements; Female; Fixation, Ocular; Humans; Male; Time Factors
PubMed: 31473441
DOI: 10.1016/j.aap.2019.105266 -
Brain Injury 2019: Secondary to brain injury, many people develop eye movement disorders (oculomotor deficits). To clarify, optimize, and standardize the development of oculomotor...
: Secondary to brain injury, many people develop eye movement disorders (oculomotor deficits). To clarify, optimize, and standardize the development of oculomotor rehabilitation programs, we systematically reviewed the literature on vision rehabilitation interventions for oculomotor deficits in brain injury, focusing on those with broad clinical feasibility.: We searched MEDLINE (PubMed), CENTRAL, Scopus, and CINAHL databases for key title terms "oculomotor", "rehabilitation", or a related term, and "brain injury" or a related term in the title or abstract. We excluded case reports of a single patient, studies of non-oculomotor visual deficits, and articles in which the intervention and assessment methods were not explicitly identified.: Nine articles were included, six of which utilized computer-based training programs to elicit characteristic fixation, saccades, pursuit, vergence, and accommodative movements. Within the entire sample, interventions ranged from 3 to 10 weeks, and involved 2 to 5 training sessions per week.: Oculomotor rehabilitation interventions showed some efficacy in treating patients with brain injury; however, there were very few studies overall. Several eye movement types - fixation, saccades, pursuit, vergence, and accommodation - can be elicited manually by therapists. We eagerly await the development and implementation of new intervention programs for broad-based clinical practice.
Topics: Brain Injuries; Clinical Trials as Topic; Eye Movements; Humans; Ocular Motility Disorders
PubMed: 31455098
DOI: 10.1080/02699052.2019.1658225 -
Psychological Bulletin Oct 2019Perceptual-cognitive skills enable an individual to integrate environmental information with existing knowledge to be able to process stimuli and execute appropriate...
Perceptual-cognitive skills enable an individual to integrate environmental information with existing knowledge to be able to process stimuli and execute appropriate responses on complex tasks. Various underlying processes could explain how perceptual-cognitive skills impact on expert performance, as articulated in three theoretical accounts: (a) the long-term working memory theory, which argues that experts are able to encode and retrieve visual information from long-term working memory more than less experienced counterparts; (b) the information-reduction hypothesis, which suggests that experts can optimize the amount of information processed by selectively allocating their attentional resources to task relevant stimuli and ignore irrelevant stimuli; and (c) the holistic model of image perception, which proposes that experts are able to extract visual information from distal and para-foveal regions, allowing more efficient global-local processing of the scene. In this systematic review, we examine the validity of the aforementioned theories based on gaze features associated with the proposed processes. The information-reduction hypothesis was supported in most studies, except in medicine where the holistic model of image perception garners stronger support. These results indicate that selectively allocating attention toward important task-related information is the most important skill developed in experts across domains, whereas expertise in medicine is reflected more in an extended visual span. Large discrepancies in the outcomes of the papers reviewed suggest that there is not one theory that fits all domains of expertise. The review provides some essential building blocks, however, to help synthesize theoretical concepts across expertise domains. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Topics: Attention; Fixation, Ocular; Humans; Memory; Professional Competence; Psychological Theory; Task Performance and Analysis; Visual Perception
PubMed: 31414844
DOI: 10.1037/bul0000207 -
Developmental Neurorehabilitation Apr 2020Children with complex disabilities sometimes have difficulty communicating with their parents, caregivers, and teachers. For these children, eye gaze assistive...
Children with complex disabilities sometimes have difficulty communicating with their parents, caregivers, and teachers. For these children, eye gaze assistive technology can be used to facilitate communication. Eye gaze assistive technology outcomes for children and youth were analyzed in this systematic review. Database and hand-searches yielded 4412 unduplicated results, of which 11 articles were eligible for this review. Outcome measures, as well as environmental and personal factors, were mapped to the World Health Organization's International Classification of Functioning, Disability and Health framework. Communication outcomes were most prevalent and co-occurred with outcomes in all reported activities and participation domains. Environmental and personal factors were classified as either facilitators or as barriers in relation to device uptake and success. Although comprehensive professional and caregiver support was the primary facilitator for success, barriers could lead to rejection of the technology even when children were successful using the system.
Topics: Adolescent; Child; Disabled Children; Fixation, Ocular; Humans; Neurological Rehabilitation; Outcome Assessment, Health Care; Self-Help Devices
PubMed: 30987518
DOI: 10.1080/17518423.2019.1600066 -
Journal of Autism and Developmental... Mar 2019We conducted a meta-analysis of 18 studies to establish whether a relation exists between Reading the Mind in the Eye Test (RMET) performance and intelligence quotient... (Comparative Study)
Comparative Study Meta-Analysis
We conducted a meta-analysis of 18 studies to establish whether a relation exists between Reading the Mind in the Eye Test (RMET) performance and intelligence quotient (IQ) in individuals diagnosed with autism-spectrum disorders (ASD) and controls, taking into account relevant characteristics such as age, gender, and autism quotient. Our findings indicate that RMET performance was better in controls compared with those diagnosed with ASD. We found that RMET performance is dependent on full and verbal IQ and age in controls. However, RMET performance is negatively correlated with performance IQ in individuals diagnosed with ASD. These results suggest that the methodology applied by ASD when taking the RMET is different from control individuals and might depend less on verbal abilities.
Topics: Autism Spectrum Disorder; Female; Fixation, Ocular; Humans; Intelligence Tests; Male; Photic Stimulation; Reading; Thinking
PubMed: 30406435
DOI: 10.1007/s10803-018-3814-4 -
Psychological Medicine Apr 2019Cognitive models of posttraumatic stress disorder (PTSD) implicate threat-related attentional biases in the etiology and phenomenology of the disorder. However, extant...
BACKGROUND
Cognitive models of posttraumatic stress disorder (PTSD) implicate threat-related attentional biases in the etiology and phenomenology of the disorder. However, extant attentional research using reaction time (RT)-based paradigms and measures has yielded mixed results. Eye-tracking methodology has emerged in recent years to overcome several inherent drawbacks of RT-based tasks, striving to better delineate attentional processes.
METHODS
A systematic review of experimental studies examining threat-related attention biases in PTSD, using eye-tracking methodology and group-comparison designs, was conducted conforming to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Studies were selected following a systematic search for publications between 1980 and December 2017 in PsycINFO, MEDLINE and the National Center for PTSD Research's Published International Literature on Traumatic Stress (PILOTS) database. Additional records were identified by employing the Similar Articles feature in PubMed, and the Cited Reference Search in ISI Web of Science. Reference sections of review articles, book chapters and studies selected for inclusion were searched for further studies. Ongoing studies were also sought through Clinicaltrials.gov.
RESULTS
A total of 11 studies (n = 456 participants in total) were included in the final review. Results indicated little support for enhanced threat detection, hypervigilance and attentional avoidance. However, consistent evidence emerged for sustained attention on threat (i.e. attention maintenance) in PTSD.
CONCLUSIONS
This review is the first to systematically evaluate extant findings in PTSD emanating from eye-tracking studies employing group-comparison designs. Results suggest that sustained attention on threat might serve as a potential target for therapeutic intervention.
Topics: Attention; Fixation, Ocular; Humans; Reaction Time; Stress Disorders, Post-Traumatic; Visual Perception
PubMed: 30178728
DOI: 10.1017/S0033291718002313 -
Survey of Ophthalmology 2018Microperimetry is a novel technique for assessing visual function that appears particularly suitable for age-related macular degeneration (AMD). Compared with standard... (Review)
Review
Microperimetry is a novel technique for assessing visual function that appears particularly suitable for age-related macular degeneration (AMD). Compared with standard automated perimetry, microperimetry offers several unique features. It simultaneously images the fundus, incorporates an eye-tracking system to correct the stimulus location for fixation loss, and identifies any preferred retinal loci. We identified 52 articles that met the inclusion criteria for a systematic review of microperimetry in the assessment of visual function in AMD. We discuss microperimetry and AMD in relation to disease severity, structural imaging outcomes, other measures of visual function, and evaluation of the efficacy of surgical and/or medical therapies in clinical trials. The evidence for the use of microperimetry in the functional assessment of AMD is encouraging. Disruptions of the ellipsoid zone band and retinal pigment epithelium are clearly associated with reduced differential light sensitivity despite the maintenance of good visual acuity. Reduced differential light sensitivity is also associated with outer segment thinning and retinal pigment epithelium thickening in early AMD and with both a thickening and a thinning of the whole retina in choroidal neovascularization. Microperimetry, however, lacks the robust diffuse and focal loss age-corrected probability analyses associated with standard automated perimetry, and the technique is currently limited by this omission.
Topics: Choroidal Neovascularization; Fixation, Ocular; Geographic Atrophy; Humans; Macula Lutea; Macular Degeneration; Vision Disorders; Visual Field Tests; Visual Fields
PubMed: 28579549
DOI: 10.1016/j.survophthal.2017.05.007 -
Asia-Pacific Journal of Ophthalmology... 2017We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test... (Review)
Review
We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test was retinal sensitivity measurement assessed by microperimetry and comparators were other functional measures (best-corrected and low-luminance visual acuities, and fixation stability) and structural parameters [retinal thickness, choroidal thickness, and area of geographic atrophy (GA) determined by color fundus photographs, short-wave or near-infrared fundus autofluorescence]. The reference standard was area of GA. The literature search was conducted in January 2016 and included MEDLINE, EMBASE, the Cochrane Library, Biosis, Science Citation Index, ProQuest Health and Medicine, CINAHL, and Highwire Press. We included 6 studies that enrolled 41 eyes with intermediate AMD (from a single study) and 80 eyes with GA secondary to AMD. Retinal sensitivity measured by microperimetry was the only functional measure that consistently detected progression in each cohort. Insufficient reported data precluded meta-analysis. Various microperimetry parameters were used to assess cohort-level change in retinal sensitivity, but the methods of analysis have yet to mature in complexity in comparison with established glaucoma field progression analysis. Microperimetry-assessed retinal sensitivity measurement may be more sensitive in detecting progression than other functional measures in non-neovascular AMD. However, the lack of standardized testing protocol and methods of progression analysis hindered comparison. Harmonization of testing protocol and development of more robust methods of analyzing raw microperimetric data will facilitate clinical implementation of this valuable retinal assessment tool.
Topics: Disease Progression; Fixation, Ocular; Geographic Atrophy; Humans; Macular Degeneration; Tomography, Optical Coherence; Visual Acuity; Visual Field Tests; Visual Fields
PubMed: 28161925
DOI: 10.22608/APO.201643