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Revista Paulista de Pediatria : Orgao... 2022The aim of this study was to evaluate the influence of early exposure to agricultural pesticides and their relationship with autism spectrum disorder.
OBJECTIVE
The aim of this study was to evaluate the influence of early exposure to agricultural pesticides and their relationship with autism spectrum disorder.
DATA SOURCE
This systematic review was registered at PROSPERO as CRD42020204842. The subject was systematically analyzed on PubMed, Scopus, and Web of Science databases until April 2021. Only studies with humans with early exposure to agricultural pesticides and diagnosis of autism were included. Exclusion criteria were studies on pesticides for domestic or veterinary use and late exposure. There were no language and time restriction. The quality analysis of the studies used the Newcastle-Ottawa Scale.
DATA SYNTHESIS
Six case-control studies were included; three of them measured the route of exposure by maternal biomarkers and the others by the residence address. The studies had scores between moderate and high in the quality assessment tool. It was found high rates of association between early exposure to agricultural pesticides and autism and detection limit above the quantification for a sample of polychlorinated biphenyls, hexachlorobenzene, and dichlorodiphenyldichloroethylene.
CONCLUSIONS
There is evidence concerning the exposure to agricultural pesticides in early life and the development of the autism spectrum disorder; however, more studies are required to better understand their possible association.
Topics: Autism Spectrum Disorder; Autistic Disorder; Case-Control Studies; Humans; Pesticides; Polychlorinated Biphenyls
PubMed: 36102405
DOI: 10.1590/1984-0462/2023/41/2021360 -
RMD Open Jun 2022Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review (SLR) was performed to summarise existing knowledge on... (Review)
Review
BACKGROUND
Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review (SLR) was performed to summarise existing knowledge on associations between OA and pollutants.
METHODS
PubMed was used to identify studies reporting data on OA and pollutants in humans (examples of MeSH terms: "Pesticides" or "Polychlorinated Biphenyls" or 'Lead'). Reports included epidemiological clinical studies, pollutant assessments in ex vivo OA joint, and in vitro effects of pollutants on chondrocytes.
RESULTS
Among the 193 potentially relevant articles, 14 were selected and combined with 9 articles obtained by manual search. Among these 23 articles there were: (1) 11 epidemiological studies on the relationship between OA and pollutants exposure, (2) 8 on pollutant concentrations in ex vivo OA joint, (3) 4 on the in vitro effects of pollutants on human chondrocytes. Epidemiological studies investigating mainly chlorinated and fluorinated pollutants suggested a possible link with OA. In cross-sectional studies, radiographic knee OA prevalence increased with higher serum lead levels. There was also a relationship between serum lead levels and serum/urine joint biomarkers. A high concentration of heavy metals in the cartilage tidemark was found in ex vivo joints. In vitro, the viability of chondrocytes was reduced in presence of some pollutants. However, the level of knowledge currently remains low, justifying the need for new methodologically sound studies.
CONCLUSIONS
This SLR supports the hypothesis of a possible involvement of pollutants in OA disease risk. Large-scale epidemiological and biological studies and ideally big-data analysis are needed to confirm that pollutants could be risk factors for OA.
Topics: Biomarkers; Cross-Sectional Studies; Environmental Pollutants; Humans; Lead; Osteoarthritis, Knee; Risk Factors
PubMed: 35701010
DOI: 10.1136/rmdopen-2021-001983 -
Environmental Science and Pollution... Aug 2022This systematic review aims to identify the sources of exposure to polychlorinated biphenyls (PCBs), portioning, and human health risk assessment in Iran. The literature... (Review)
Review
This systematic review aims to identify the sources of exposure to polychlorinated biphenyls (PCBs), portioning, and human health risk assessment in Iran. The literature was searched in the international databases of Web of Science, PubMed, Scopus, Google Scholar, and the national databases of SID and MagIran up to November 14, 2020. Among all 153 articles, 21 eligible papers were identified. Among them, only one article was related to drinking water, the rest was related to food and soil, and no article was found on ambient air. The corrected portion of each exposure source was determined to be 90% for food, 9% for water, and 1% for air. The total hazard quotient (HQ) was determined to be within an unsafe range, and the total excess lifetime cancer risk (ELCR) was determined to be at a high risk of oral carcinogenesis. It is suggested that a comprehensive study be conducted in a specific period for all sources of exposure in all counties of Iran. Moreover, it is recommended that the policymakers set national standards for this pollutant in near future in some sources of exposure (e.g., drinking water) which have no standards in Iran.
Topics: Drinking Water; Environmental Monitoring; Humans; Iran; Polychlorinated Biphenyls; Risk Assessment; Soil
PubMed: 35676570
DOI: 10.1007/s11356-022-21274-y -
Environmental Pollution (Barking, Essex... Aug 2022Micropollutants (MPs) include a wide range of biological disruptors that can be toxic to wildlife and humans at very low concentrations (<1 μg/L). These mainly...
Micropollutants (MPs) include a wide range of biological disruptors that can be toxic to wildlife and humans at very low concentrations (<1 μg/L). These mainly anthropogenic pollutants have been widely detected in different areas of the planet, including the deep sea, and have impacts on marine life. Because of this potential toxicity, the global distribution, quantity, incidence, and potential impacts of deep-sea MPs were investigated in a systematic review of the literature. The results showed that MPs have reached different zones of the ocean and are more frequently reported in the Northern Hemisphere, where higher concentrations are found. MPs are also concentrated in depths up to 3000 m, where they are also more frequently studied, but also extend deeper than 10,000 m. Potentially toxic metals (PTMs), polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDTs), organotins, and polycyclic aromatic hydrocarbons (PAHs) were identified as the most prevalent and widely distributed MPs at ≥200 m depth. PTMs are widely distributed in the deep sea in high concentrations; aluminum is the most prevalent up to 3000 m depth, followed by zinc and copper. PCBs, organotins, hexachlorocyclohexanes (HCHs), PAHs, and phenols were detected accumulated in both organisms and environmental samples above legislated thresholds or known toxicity levels. Our assessment indicated that the deep sea can be considered a sink for MPs.
Topics: Copper; DDT; Environmental Monitoring; Hexachlorocyclohexane; Organotin Compounds; Phenols; Polychlorinated Biphenyls; Polycyclic Aromatic Hydrocarbons; Water Pollutants, Chemical; Zinc
PubMed: 35598814
DOI: 10.1016/j.envpol.2022.119414 -
Environmental Health : a Global Access... May 2022To conduct a comprehensive systematic review and meta-analysis to estimate the relationship between endocrine-disrupting chemicals (EDCs), including polychlorinated... (Meta-Analysis)
Meta-Analysis
OBJECTIVE
To conduct a comprehensive systematic review and meta-analysis to estimate the relationship between endocrine-disrupting chemicals (EDCs), including polychlorinated biphenyls (PCBs), poly-brominated diphenyl ethers (PBDEs), phthalates (PAEs), and per- and polyfluoroalkyl substances (PFAS) exposure and risk of gestational diabetes mellitus (GDM).
METHODS
Relevant studies from their inception to November 2021 were identified by searching EMBASE, PubMed, and Web of Science. The cohort and case-control studies that reported effect size with 95% confidence intervals (CIs) of EDC exposure and GDM were selected. The heterogeneity among the included studies was quantified by I statistic. Publication bias was evaluated through the Begg and Egger tests.
RESULTS
Twenty-five articles with a total of 23,796 participants were found. Results indicated that exposure to PCBs has a significant influence on the incidence of GDM (OR = 1.14; 95% CI = 1.00--1.31; n = 8). The risk of GDM was found to be associated with PBDE exposure (OR = 1.32; 95% CI = 1.15-1.53; n = 4). PAEs and PFASs exposure were also positively associated with the risk of GDM, with summary ORs of 1.10 (95% CI = 1.03-1.16; n = 7 for PAEs) and 1.09 (95% CI = 1.02-1.16; n = 11 for PFASs), respectively. When only cohort studies were considered, the summary OR between PCBs exposure and the risk of GDM was 0.99 (95% CI = 0.91-1.09; n = 5). Meanwhile, the summary ORs from cohort studies for PBDEs, PAEs, and PFASs exposure were 1.12 (95% CI = 1.00-1.26; n = 2), 1.08 (95% CI = 1.02-1.15; n = 5), and 1.06 (95% CI = 1.00-1.12; n = 8), respectively. The Beggs and Egger tests did not show publication bias, and the sensitivity analyses did not change the results in this meta-analysis.
CONCLUSION
These results support that exposure to certain EDCs, including PCBs, PBDEs, PAEs, and PFAS, increase the risk of GDM. Further large-sample epidemiologic researches and mechanistic studies are needed to verify the potential relationship and biological mechanisms. These results are of public health significance because the daily EDC exposure is expected to increase the risk of GDM development.
Topics: Diabetes, Gestational; Endocrine Disruptors; Environmental Pollutants; Female; Fluorocarbons; Halogenated Diphenyl Ethers; Humans; Polychlorinated Biphenyls; Pregnancy
PubMed: 35578291
DOI: 10.1186/s12940-022-00858-8 -
International Journal of Environmental... Apr 2022(1) Background: Globally there is a vast legacy of contaminated sites from past industrial, commercial and military activity, waste disposal, and mineral extraction.... (Review)
Review
(1) Background: Globally there is a vast legacy of contaminated sites from past industrial, commercial and military activity, waste disposal, and mineral extraction. This review examined the extent to which the remediation of contaminated sites reduces health risks to new and existing populations. (2) Methods: Standard academic databases were searched for papers that reported on health-related outcomes in humans following remediation and redevelopment of contaminated sites. Title/abstract screening, followed by full-text screening identified sixteen papers that met the eligibility criteria. (3) Results: Most studies were set in the United States of America and reported changes in blood lead concentrations in children, following soil remediation and, in some cases, public health campaigns to reduce exposure. Two further studies examined the impacts of remediation on soil contaminated with chromium and sediments contaminated with polychlorinated biphenyls (PCBs). (4) Conclusions: Overall, the evidence suggests that remediation via removal, capping, and replacing soil, and planting vegetation is effective at reducing concentrations of lead and chromium in blood and urine in children. There is also evidence that sediment dredging can reduce PCB concentrations in umbilical cords in infants. Study designs are relatively weak and some recommendations are provided for those wishing to examine the health impacts of remediation.
Topics: Child; Chromium; Environmental Restoration and Remediation; Humans; Lead; Polychlorinated Biphenyls; Soil; Soil Pollutants
PubMed: 35564674
DOI: 10.3390/ijerph19095278 -
Ecotoxicology and Environmental Safety Apr 2022Exposure to endocrine disrupting chemicals (EDCs) may lead to dysregulated inflammatory responses, however, the detailed relationship between different EDCs and... (Review)
Review
Exposure to endocrine disrupting chemicals (EDCs) may lead to dysregulated inflammatory responses, however, the detailed relationship between different EDCs and inflammation remains unclear. A systematic review and meta-analysis was conducted to evaluate the associations between four types of EDCs (bisphenol A (BPA), phthalates (PAEs), organochlorine pesticides (OCPs), and polychlorinated biphenyls (PCBs)) and markers of inflammation and immune responses in humans. Three databases were searched, and 36 studies with a total of 22055 participants were included. The associations between EDCs and 26 inflammation-related acute phase proteins and cytokines were analyzed. The results demonstrated that exposure to BPA was positively associated with circulating levels of C-reactive protein (CRP) and interleukin (IL)-6. Exposure to PAEs was associated with elevated levels of CRP, IL-6 and IL-10. Subgroup analysis found that three PAE metabolites mono-benzyl phthalate (MBzP), mono-isobutyl phthalate (MiBP), and mono-n-butyl phthalate (MnBP) were directly associated with a higher level of CRP, and two other PAE metabolites mono-carboxyisononyl phthalate (MCNP) and mono-3-carboxypropyl phthalate (MCPP) were positively associated with IL-6. The positive associations between PAEs and CRP, IL-6 and IL-10 were significant in the high-molecular-weight phthalate (HMWP) exposure group, not the low-molecular-weight phthalate (LMWP) exposure group. Exposure to OCPs was positively associated with CRP, IL-1β, IL-2, and IL-10. No significant association was found between PCBs and inflammatory markers. These findings demonstrate that exposure to EDCs is closely linked to dysregulated inflammatory responses. More studies should be conducted in the future to get a comprehensive view of the associations between different EDCs and inflammation, and investigations on the underlying mechanisms are needed.
PubMed: 35276610
DOI: 10.1016/j.ecoenv.2022.113382 -
Obesity Reviews : An Official Journal... Jan 2022We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) and childhood obesity. We... (Meta-Analysis)
Meta-Analysis
We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) and childhood obesity. We focused on organochlorines (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], and polychlorinated biphenyls [PCBs]), perfluoroalkyl and polyfluoroalkyl substances (PFAS), and polybrominated diphenyl ethers (PBDEs) that are the POPs more widely studied in environmental birth cohorts so far. We search two databases (PubMed and Embase) through July/09/2021 and identified 33 studies reporting associations with prenatal organochlorine exposure, 21 studies reporting associations with prenatal PFAS, and five studies reporting associations with prenatal PBDEs. We conducted a qualitative review. Additionally, we performed random-effects meta-analyses of POP exposures, with data estimates from at least three prospective studies, and BMI-z. Prenatal DDE and HCB levels were associated with higher BMI z-score in childhood (beta: 0.12, 95% CI: 0.03, 0.21; I : 28.1% per study-specific log increase of DDE and beta: 0.31, 95% CI: 0.09, 0.53; I : 31.9% per study-specific log increase of HCB). No significant associations between PCB-153, PFOA, PFOS, or pentaPBDEs with childhood BMI were found in meta-analyses. In individual studies, there was inconclusive evidence that POP levels were positively associated with other obesity indicators (e.g., waist circumference).
Topics: Child; Environmental Pollutants; Female; Humans; Pediatric Obesity; Persistent Organic Pollutants; Polychlorinated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies
PubMed: 34766696
DOI: 10.1111/obr.13383 -
Reproductive Toxicology (Elmsford, N.Y.) Oct 2021The impact of environmental chemicals like persistent organic pollutants (POPs) on reproductive health is still poorly understood, despite the high societal and...
Associations between human internal chemical exposure to Persistent Organic Pollutants (POPs) and In Vitro Fertilization (IVF) outcomes: Systematic review and evidence map of human epidemiological evidence.
The impact of environmental chemicals like persistent organic pollutants (POPs) on reproductive health is still poorly understood, despite the high societal and economical costs. The aim of the present study was to systematically review and evaluate the human evidence on the associations between internal levels of POPs and in vitro Fertilization (IVF) outcomes among women. We applied a protocol based on the National Toxicology Program Office of Health Assessment and Translation's guidelines for the study search, selection and quality assessment. Fifteen studies were finally retained in the present work. The results showed that main families of POPs are still pervasive in follicular fluid and serum of women undergoing IVF treatments. Globally, we found inconsistent findings across studies for specific exposure-outcome dyads, suggesting that adverse effects of POPs on IVF outcomes cannot be ruled out. Specifically, there is evidence that POPs, notably some polychlorinated biphenyls and organochlorine pesticides, may impair embryo quality and pregnancy rates. Most studies have been performed in small cohorts (n<50) and focused on PCBs and OCPs, whereas major research gaps remain for emerging compounds (e.g. perfluoroalkylated substances) and the most clinically relevant outcome, live birth rate. The overall evidence presented 'serious' or 'very serious' risk of bias, mainly due to the lack of consideration of relevant confounding variables, low sample size or underreporting of methods. Globally, we judged the level of evidence being "low". Given the high economical and societal costs associated to infertility and IVF, further well-designed research is urged to fill the highlighted gaps.
Topics: Environmental Exposure; Female; Fertilization in Vitro; Humans; Persistent Organic Pollutants; Pregnancy; Treatment Outcome
PubMed: 34517099
DOI: 10.1016/j.reprotox.2021.09.005 -
Journal of Environmental Management Dec 2021Despite the increasing use of chemical additives in construction and their potential threat to the environment and human health, many C&DW studies lack a comprehensive... (Review)
Review
Despite the increasing use of chemical additives in construction and their potential threat to the environment and human health, many C&DW studies lack a comprehensive view of chemicals of concern (COC) in C&DW. This study systematically reviewed published studies from 2010 to August 2021 using a keyword search methodology to explore COC in C&DW fine residues based on 73 articles identified from 5 prominent databases. Results show that trace/heavy metals (As, Cr, Cu, Cd, and Pb) as well as high concentrations of toxic gasses (methane, hydrogen sulphide and mercury vapour) have been reported in landfills. Besides, organic chemicals such as polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and brominated flame retardants have been found in landfill leachates in the Netherlands and widely detected in landfill leachates in Sweden, Japan, and Canada. The potential of these contaminants to cause health complications has also been reported. Carcinogenicity, liver and kidney damage, cumulative damage, neurological disorders and foetal damage were reported as associated health implications of exposure to COC from C&DW. A waste disposal lens was used to explore the factors that influence the environment and human health impacts (pH, gypsum and organic content, size fraction, atmospheric exposure and liquid infiltration rate). Despite environmental and health issues relating to C&DW fine residues, the ultimate destination for C&DW fine residues remains in general landfills. Although significant efforts in managing C&DW have been implemented at various levels, those specifically targeting C&DW fine residues remain sparse.
Topics: Environmental Monitoring; Flame Retardants; Humans; Refuse Disposal; Waste Disposal Facilities; Water Pollutants, Chemical
PubMed: 34482107
DOI: 10.1016/j.jenvman.2021.113654