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Frontiers in Immunology 2021Current vaccination strategies against pertussis are sub-optimal. Optimal protection against , the causative agent of pertussis, likely requires mucosal immunity....
BACKGROUND
Current vaccination strategies against pertussis are sub-optimal. Optimal protection against , the causative agent of pertussis, likely requires mucosal immunity. Current pertussis vaccines consist of inactivated whole cells or purified antigens thereof, combined with diphtheria and tetanus toxoids. Although they are highly protective against severe pertussis disease, they fail to elicit mucosal immunity. Compared to natural infection, immune responses following immunization are short-lived and fail to prevent bacterial colonization of the upper respiratory tract. To overcome these shortcomings, efforts have been made for decades, and continue to be made, toward the development of mucosal vaccines against pertussis.
OBJECTIVES
In this review we systematically analyzed published literature on protection conferred by mucosal immunization against pertussis. Immune responses mounted by these vaccines are summarized.
METHOD
The PubMed Library database was searched for published studies on mucosal pertussis vaccines. Eligibility criteria included mucosal administration and the evaluation of at least one outcome related to efficacy, immunogenicity and safety.
RESULTS
While over 349 publications were identified by the search, only 63 studies met the eligibility criteria. All eligible studies are included here. Initial attempts of mucosal whole-cell vaccine administration in humans provided promising results, but were not followed up. More recently, diverse vaccination strategies have been tested, including non-replicating and replicating vaccine candidates given by three different mucosal routes: orally, nasally or rectally. Several adjuvants and particulate formulations were tested to enhance the efficacy of non-replicating vaccines administered mucosally. Most novel vaccine candidates were only tested in animal models, mainly mice. Only one novel mucosal vaccine candidate was tested in baboons and in human trials.
CONCLUSION
Three vaccination strategies drew our attention, as they provided protective and durable immunity in the respiratory tract, including the upper respiratory tract: acellular vaccines adjuvanted with lipopeptide LP1569 and c-di-GMP, outer membrane vesicles and the live attenuated BPZE1 vaccine. Among all experimental vaccines, BPZE1 is the only one that has advanced into clinical development.
Topics: Humans; Immunity, Mucosal; Pertussis Vaccine; Whooping Cough
PubMed: 34211481
DOI: 10.3389/fimmu.2021.701285 -
Frontiers in Pediatrics 2021Due to its numerous health benefits, breast milk (BM) is recommended for preterm infants. Despite such recommendations, the rates of breastfeeding in preterm infants...
Due to its numerous health benefits, breast milk (BM) is recommended for preterm infants. Despite such recommendations, the rates of breastfeeding in preterm infants are lower than that in term infants. Quality improvement (QI) bundles increase breastfeeding in preterm infants, but their replication in neonatal intensive care units has had inconsistent outcomes. We used the Population or Problem, Intervention, Comparison, and Outcomes (PICO) framework to develop our search strategy, and searched MEDLINE, Embase, and the Cochrane Library from inception through January 15, 2021. Studies describing any active QI intervention to increase BM use in preterm infants were included. The primary outcome measure was the rate of any breastfeeding or exclusive mother's own milk (MOM) at discharge or during hospitalization. Sixteen studies were eligible for inclusion and showed an acceptable risk of bias, and included 1 interrupted time series, study 3 controlled before-and-after studies, and 12 uncontrolled before-and-after studies; of these, 3 studies were excluded due to insufficient dichotomous data, 13 were included in the meta-analysis. In the meta-analysis, the rate of any breastfeeding was significantly improved at discharge and during hospitalization after QI [risk ratio () = 1.23, 95% confidence interval (CI): 1.14-1.32, < 0.00001 and = 1.89, 95% CI: 1.09-3.29, = 0.02, respectively]. The rate of exclusive MOM after QI was also significantly increased at discharge ( = 1.51, 95% CI: 1.04-2.18, = 0.03), but not during hospitalization ( = 1.53, 95% CI: 0.78-2.98, = 0.22). However, after sensitivity analysis, the comprehensive results still suggested that QI could significantly improve the rate of exclusive MOM during hospitalization ( = 1.21, 95% CI: 1.08-1.35, = 0.001). Funnel plots and Egger's test indicated publication bias in the rate of any BF at discharge. We corrected publication bias by trim and fill analysis, and corrected to 1.272, 95% CI: (1.175, 1.369), which was consistent with the results of the initial model. A QI bundle appears to be effective for promoting BM use in preterm infants at discharge or during hospitalization.
PubMed: 34178897
DOI: 10.3389/fped.2021.681341 -
Schizophrenia Bulletin Oct 2021The nature of the relationship between cognition and brain morphology in schizophrenia-spectrum disorders (SSD) and bipolar disorder (BD) is uncertain. This review aimed...
The nature of the relationship between cognition and brain morphology in schizophrenia-spectrum disorders (SSD) and bipolar disorder (BD) is uncertain. This review aimed to address this, by providing a comprehensive systematic investigation of links between several cognitive domains and brain volume, cortical thickness, and cortical surface area in SSD and BD patients across early and established illness stages. An initial search of PubMed and Scopus databases resulted in 1486 articles, of which 124 met inclusion criteria and were reviewed in detail. The majority of studies focused on SSD, while those of BD were scarce. Replicated evidence for specific regions associated with indices of cognition was minimal, however for several cognitive domains, the frontal and temporal regions were broadly implicated across both recent-onset and established SSD, and to a lesser extent BD. Collectively, the findings of this review emphasize the significance of both frontal and temporal regions for some domains of cognition in SSD, while highlighting the need for future BD-related studies on this topic.
Topics: Bipolar Disorder; Cerebral Cortex; Cognitive Dysfunction; Humans; Neuroimaging; Schizophrenia
PubMed: 34097043
DOI: 10.1093/schbul/sbab054 -
Journal of Dental Research Dec 2021Dentistry increasingly integrates artificial intelligence (AI) to help improve the current state of clinical dental practice. However, this revolutionary technological... (Review)
Review
Dentistry increasingly integrates artificial intelligence (AI) to help improve the current state of clinical dental practice. However, this revolutionary technological field raises various complex ethical challenges. The objective of this systematic scoping review is to document the current uses of AI in dentistry and the ethical concerns or challenges they imply. Three health care databases (MEDLINE [PubMed], SciVerse Scopus, and Cochrane Library) and 2 computer science databases (ArXiv, IEEE Xplore) were searched. After identifying 1,553 records, the documents were filtered, and a full-text screening was performed. In total, 178 studies were retained and analyzed by 8 researchers specialized in dentistry, AI, and ethics. The team used Covidence for data extraction and Dedoose for the identification of ethics-related information. PRISMA guidelines were followed. Among the included studies, 130 (73.0%) studies were published after 2016, and 93 (52.2%) were published in journals specialized in computer sciences. The technologies used were neural learning techniques for 75 (42.1%), traditional learning techniques for 76 (42.7%), or a combination of several technologies for 20 (11.2%). Overall, 7 countries contributed to 109 (61.2%) studies. A total of 53 different applications of AI in dentistry were identified, involving most dental specialties. The use of initial data sets for internal validation was reported in 152 (85.4%) studies. Forty-five ethical issues (related to the use AI in dentistry) were reported in 22 (12.4%) studies around 6 principles: prudence (10 times), equity (8), privacy (8), responsibility (6), democratic participation (4), and solidarity (4). The ratio of studies mentioning AI-related ethical issues has remained similar in the past years, showing that there is no increasing interest in the field of dentistry on this topic. This study confirms the growing presence of AI in dentistry and highlights a current lack of information on the ethical challenges surrounding its use. In addition, the scarcity of studies sharing their code could prevent future replications. The authors formulate recommendations to contribute to a more responsible use of AI technologies in dentistry.
Topics: Artificial Intelligence; Delivery of Health Care; Dentistry; Forecasting
PubMed: 34060359
DOI: 10.1177/00220345211013808 -
Campbell Systematic Reviews Jun 2021In spite of the large number of anti-corruption reforms implemented in different countries, there has been little research that empirically and systematically assesses... (Review)
Review
BACKGROUND
In spite of the large number of anti-corruption reforms implemented in different countries, there has been little research that empirically and systematically assesses the impact of these efforts.
OBJECTIVES
The main objective of this review is to identify what works in curbing corruption in the public sector, by meta-analyzing the findings of published and unpublished evaluations of different types of anti-corruption interventions in different countries. The focus of this review is administrative corruption, namely corrupt acts involving civil servants in their dealings with their superiors, during the implementation of public policies, or while interacting with the public for service delivery. Political corruption (in the adoption of laws, regulations, and policies), and private-to-private corruption (involving only private actors) are excluded from this review.
SEARCH METHODS
The literature search was conducted by querying three widely recognized electronic databases: RePEc, SSRN, and Web of Science. These databases are considered the most comprehensive in the socio-economic field of research. The main grey literature repositories were also queried. Both published and unpublished studies were searched on the basis of specific combinations of keywords. The terms used to define queries were based on the "types of corruption", "types of interventions/policies/reforms" and "study design" search strings. Specific conventions were used to "explode" or "truncate" keywords as appropriate. Screening of the references (i.e., snowballing) of the identified studies was also performed, and a reverse snowballing approach on Google Scholar was used. In order to ensure replicability, all searches were stored into Covidence, an online software developed by the Cochrane community for screening studies and extracting data for systematic reviews.
SELECTION CRITERIA
Any study that included experimental evaluations (randomized controlled trials) of interventions developed for use in the public sector (e.g., public administration, education, health, etc.) to curb administrative corruption has been included in this review without any geographical or temporal limitations. Only studies written in or translated into English have been considered.
DATA COLLECTION AND ANALYSIS
Two review authors read the titles and abstracts of identified studies in order to determine their eligibility against the inclusion/exclusion criteria. When a title or abstract could not be included or rejected with certainty, the full text of the article was reviewed. In case of disagreement about whether or not a study should be included, the lead author (Giulia Mugellini), together with Martin Killias acted as arbitrator. The relevant information from identified studies was extracted independently by two review authors, following the guidelines of the Campbell Collaboration. The studies were assessed using the Cochrane Risk of Bias checklist as a basis.The effect size selected for the analysis was the Fisher's z-score transformation of the partial correlation coefficient. For the meta-analysis, random effect(s) models were estimated. Meta-regression analysis models were then used to investigate the determinants behind the observed between- and within-study heterogeneity. Ten different covariates were included in the meta-regression models in order to control for the type of intervention, the type of corruption, the level of national income, the quality of the study and the type of participants involved in laboratory experiments.
RESULTS
The initial literature search led to the identification of 70 studies. Approximately one-third of the studies were excluded at the title/abstract stage because they either did not evaluate any anti-corruption intervention but simply assessed the relationship between corruption and other phenomena, or because the study design was not based on randomized controlled trials. Another 14 studies were excluded only after a full-text assessment. At this stage, the main reasons for exclusion were related to an unsuitable type of corruption (e.g., when the focus of the paper was political corruption, or private-to-private corruption instead of administrative corruption), the lack of regression output, or an unsuitable study design. At the end of the selection process, 29 studies resulted as eligible for inclusion.All the selected studies were written in English. The publication years ranged from 2007 to 2018. The majority of the selected studies (20) investigates the effect of anti-corruption interventions in high- and upper-middle income countries (Austria, Brazil, Canada, China, Germany, Italy, Mexico, the Netherlands, Thailand, the United Kingdom, and the United States). Nine studies focused on low- and low-middle income countries (Burkina Faso, Burundi, Ethiopia, India, Indonesia, Pakistan, Tanzania, and Uganda). All of them were randomized experiments. Twenty-five of these experiments were conducted in a laboratory, while four of them were field experiments.As to the type of outcome, the majority (18) of the selected studies addressed bribery (either active or passive), while 11 studies considered misappropriation of public resources (embezzlement). In terms of anti-corruption interventions, 19 studies tested the effect of deterrence interventions, while 10 studies focused on policies based on organizational and cultural change.Overall, the meta-analysis' findings indicate that the identified interventions decrease the level of corruption. Results are statistically significant (p < 0.01) and robust to different heterogeneity estimators-that is, (restricted) maximum likelihood and method of moment estimators. The observed high level of heterogeneity- is equal to 92.36%, of which 43.78% is due to between-study heterogeneity and 48.57% to within-study heterogeneity-albeit in line with other meta-analyses in economics, suggests the need for meta-regression analyses.To investigate the determinants behind the between- and within-study heterogeneity of the observed effect, both a random effect model and a multilevel model were adopted.The results of the multilevel model show that: 1)Control and deterrence interventions are more effective than organizational and cultural reforms in reducing corruption in the public sector.2)Combining different interventions reduces corruption more than single interventions.3)Interventions are more effective in preventing misappropriation of public resources (embezzlement) than passive or active bribery. Finally, the Funnel Asymmetry Test (FAT), conducted with both additive and multiplicative dispersion terms, shows no evidence of a strong publication bias in the literature.
AUTHORS’ CONCLUSIONS
The results of this systematic review, based on a combination of laboratory and field experiments, demonstrate that increasing the expected monetary costs (e.g., sanctions) of corruption or the probability of detection (e.g., audit risk) is more effective than organizational, cultural and educational interventions in curbing administrative corruption, at least in the short term. However, this result might be due to the fact that the majority of selected studies are based on lab-experiments, where the assessment of the intervention is almost concurrent to its development. Short-term evaluations might fail to identify the effect of organizational and cultural interventions. Indeed, these interventions are based on structural changes in the organization of the system and the ethical and cultural education of public officials and might, thus, entail long periods to display their results on the level of corruption. Nevertheless, a combination of different interventions proves to be more effective than single interventions. For example, policies guaranteeing impunity to officials or citizens who report corrupt practices (principal witness/leniency treatment) are more effective if associated with a high probability of audit than leniency alone. A low probability of detection can be compensated by the threat of high fines in reducing both the amount and the likelihood of bribe demands. To the contrary, a high probability of detection had no effect in the absence of severe sanction threats.The importance of the organizational and cultural environment in which the intervention is implemented clearly emerged in the literature. When possible, the characteristics of the settings where the interventions were developed were included in the meta-regression analysis (such as the level of income of the countries). When it was not possible to measure contextual factors and their interaction with the main intervention, a qualitative analysis was performed to reveal the complexities of these interactions.This additional analysis shows that the impact of the interventions was found to be affected by the likelihood of the continued interactions between bribe takers and givers, the amount and probability of fines, and the size of the bribe, among others. For example, reporting mechanisms and leniency policies increase their potential in combination with interventions that limit agent's exposure to one another - such as staff rotation. The success of audit risk on corruption is strongly dependent on the seriousness of the potential sanction and the probability that a sanction is applied. Some differences also emerge between high- and low-corruption countries regarding the effectiveness of anti-corruption interventions. For example, measures tending to increase social blame of corrupt practices work in low-corruption countries. Adding punishments in environments where actors' behavior is tightly monitored increases compliance, but more so in environments where corruption is the exception rather than the rule.In terms of implications for research, the fact that control and deterrence turns out to be more effective than organizational and cultural interventions in curbing administrative corruption confirms the importance of economic theories (and cost-benefit analysis). However, the meta-analysis also demonstrates the effectiveness of combining different types of interventions.This is true not only when combining policies reinforcing control and deterrence (monitoring frequency, detection probability and amount of fines), but also when policies based on organizational and cultural change are added (e.g., staff rotation and leniency). In particular, the role of moral levers in preventing corruption emerges, and especially the importance of strengthening professional identity and values in order to avoid conflicts between an individual's private interests and his/her public role. These results highlight the importance of going beyond economic models for explaining corruption, and considering the moral and cultural mechanisms underlying this phenomenon.It also emerges the need to understand how different forms of corruption operate in practice at macro- (cross-country), meso- (country/nation-state) and micro- (individual) level. In particular, individual-level factors, such as the strive for power, low self-control, loss aversion and risk acceptance would need to be addressed.It would be interesting to distinguish, when more experimental studies will be available, between top-down (from supervisors to officials) and bottom-up (from citizens to officials) interventions.From a methodological point of view, it could be tested whether the results change according to the types of games used as a basis for the corruption experiments (e.g., behavioral game theory, trust game, etc.) and according to the setting in which the experiment was conducted (e.g., context-free versus in-context presentation of experimental tasks).Considering the effect of sensitization messages in reducing bribery demand, we would encourage researchers to develop other corruption experiments that explore the impact of interventions in fostering professional self-identity, as well as the impact of organizational family culture on corruption. Furthermore, this review highlights the need for a comprehensive classification of anti-corruption policies that distinguishes interventions by type of corruption, risk factors, type of policy tool and administrative sector.
PubMed: 37131927
DOI: 10.1002/cl2.1173 -
JBI Evidence Synthesis Sep 2021The aim of this review was to evaluate the association between anti-thyroid antibodies and quality of life in people with euthyroid Hashimoto thyroiditis. (Meta-Analysis)
Meta-Analysis
OBJECTIVE
The aim of this review was to evaluate the association between anti-thyroid antibodies and quality of life in people with euthyroid Hashimoto thyroiditis.
INTRODUCTION
Patients with Hashimoto thyroiditis report symptom distress more often than those with non-autoimmune thyroid disorders. Therefore, anti-thyroid antibodies may be related to decreased quality of life in persons with Hashimoto thyroiditis. The etiology of lingering symptoms, even in euthyroidism, remains unknown. The relationship between anti-thyroid antibodies and quality of life for people with Hashimoto thyroiditis has not been evaluated in a systematic review.
INCLUSION CRITERIA
The participants were males and females at least 12 years of age, in any country, with Hashimoto thyroiditis. Participants not in a euthyroid state were excluded from this review. In this review, the exposure was the presence of anti-thyroid antibodies and the primary outcome was quality of life as measured by a validated scale.
METHODS
A three-step search strategy was implemented with an initial search of PubMed and CINAHL. A comprehensive database search using all identified keywords and index terms was undertaken in March 2019 for relevant published literature, gray literature, and clinical trial registries. The final updates to the search strategies were conducted in December 2019. The search was limited to studies published in English after 1956. Two independent reviewers completed screening for inclusion and utilized the recommended JBI approach to critical appraisal, study selection, data extraction, and data synthesis. The findings are presented in a meta-analysis and in a narrative synthesis, which includes tables and figures.
RESULTS
All 13 studies had high methodological quality. Four studies found a significant correlation (P < 0.05) between the presence of anti-thyroid antibodies and quality of life. A fifth study found a significant correlation (P < 0.001) between higher antibody levels and quality of life. A meta-analysis was conducted using two cross-sectional studies, which revealed that the summative small effect size was statistically significant and suggested a lower quality of life in antibody-positive patients. Due to the heterogeneity of the studies, a narrative synthesis was conducted for the three secondary outcomes: symptom distress, executive function, and mental health. Three studies found a statistically significant (P < 0.05) correlation between symptom distress and antibodies, two studies found a statistically significant (P < 0.05) association between executive function and antibodies, and all but one study found a statistically significant (P < 0.05) relationship between mental health and antibodies.
CONCLUSIONS
The findings in this review did not reveal a definitive relationship between antibodies and quality of life. However, our meta-analysis suggested a link between anti-thyroid antibodies and decreased quality of life in euthyroid children and adults. Though not conclusive, poor mental health and symptom distress may be associated with anti-thyroid antibodies. Therefore, it may be beneficial to periodically evaluate the quality of life and mental health in euthyroid patients with positive antibodies. It is unlikely that antibodies and executive functions are related. The studies and our review's limitations require replication of findings to confirm a connection between antibodies, quality of life, and the secondary outcomes. Future research should continue to evaluate the relationship between anti-thyroid antibodies and the quality of life in individuals with euthyroid Hashimoto thyroiditis.
SYSTEMATIC REVIEW REGISTRATION NUMBER
PROSPERO CRD42018084663.
Topics: Adult; Child; Cross-Sectional Studies; Female; Hashimoto Disease; Humans; Male; Quality of Life
PubMed: 33741837
DOI: 10.11124/JBIES-20-00043 -
Frontiers in Nutrition 2021Human diet comprises several classes of phytochemicals some of which are potentially active against human pathogenic viruses. This study examined available evidence that...
Human diet comprises several classes of phytochemicals some of which are potentially active against human pathogenic viruses. This study examined available evidence that identifies existing food plants or constituents of edible foods that have been reported to inhibit viral pathogenesis of the human respiratory tract. SCOPUS and PUBMED databases were searched with keywords designed to retrieve articles that investigated the effect of plant-derived food grade substances (PDFGS) on the activities of human pathogenic viruses. Eligible studies for this review were those done on viruses that infect the human respiratory tract. Forty six (46) studies met the specified inclusion criteria from the initial 5,734 hits. The selected studies investigated the effects of different PDFGS on the infectivity, proliferation and cytotoxicity of different respiratory viruses including influenza A virus (IAV), influenza B virus (IBV), Respiratory syncytial virus (RSV), human parainfluenza virus (hPIV), Human coronavirus NL63 (HCoV-NL63), and rhinovirus (RV) in cell lines and mouse models. This review reveals that PDFGS inhibits different stages of the pathological pathways of respiratory viruses including cell entry, replication, viral release and viral-induced dysregulation of cellular homeostasis and functions. These alterations eventually lead to the reduction of virus titer, viral-induced cellular damages and improved survival of host cells. Major food constituents active against respiratory viruses include flavonoids, phenolic acids, tannins, lectins, vitamin D, curcumin, and plant glycosides such as glycyrrhizin, acteoside, geniposide, and iridoid glycosides. Herbal teas such as guava tea, green and black tea, adlay tea, cistanche tea, kuding tea, licorice extracts, and edible bird nest extracts were also effective against respiratory viruses . The authors of this review recommend an increased consumption of foods rich in these PDFGS including legumes, fruits (e.g berries, citrus), tea, fatty fish and curcumin amongst human populations with high prevalence of respiratory viral infections in order to prevent, manage and/or reduce the severity of respiratory virus infections.
PubMed: 33634160
DOI: 10.3389/fnut.2021.606782 -
Techniques in Coloproctology Apr 2021Crohn's anal fistula is a challenging condition, and may require multiple surgical procedures. To replicate successful procedures, these must be adequately reported in... (Review)
Review
A systematic review of the quality of reporting of interventions in the surgical treatment of Crohn's anal fistula: an assessment using the TIDiER and Blencowe frameworks.
BACKGROUND
Crohn's anal fistula is a challenging condition, and may require multiple surgical procedures. To replicate successful procedures, these must be adequately reported in the literature. The aim of this study was to review the quality of reporting of components of surgical interventions for Crohn's anal fistula.
METHODS
A systematic review was conducted. It was registered with PROSPERO (CRD:42019135157). The Medline and EMBASE databases were searched for studies reporting interventions intended to close fistula in patients with Crohn's disease, published between 1999 and August 2019. Abstracts and full texts were screened for inclusion by two reviewers. Dual extraction of data was performed to compare reporting to the TIDiER and Blencowe frameworks for reporting of interventions.
RESULTS
Initial searches identified 207 unique studies; 38 full texts were screened for inclusion and 33 were included. The most common study design was retrospective cohort (17/33), and the most frequently reported interventions were anal fistula plug (n = 8) and fibrin glue (n = 6). No studies showed coverage of all domains of TIDieR. Reporting was poor among domains related to who provided an intervention, where it was provided, and how it was tailored. Reporting of domains in the Blencowe framework was poor; the majority of studies did not report the component steps of procedures or efforts to standardise them.
CONCLUSIONS
This study demonstrates that reporting on technical aspects of interventions for Crohn's anal fistula is poor. Surgeons should aim to improve reporting to allow accurate reproduction of techniques both in clinical practice and in clinical trials.
Topics: Crohn Disease; Digestive System Surgical Procedures; Humans; Rectal Fistula; Retrospective Studies; Treatment Outcome
PubMed: 33599902
DOI: 10.1007/s10151-020-02359-7 -
Clinical Neurophysiology : Official... Feb 2021Repetitive transcranial magnetic stimulation (rTMS) is an evidenced based treatment for depression and an emerging treatment for several other neuropsychiatric...
OBJECTIVE
Repetitive transcranial magnetic stimulation (rTMS) is an evidenced based treatment for depression and an emerging treatment for several other neuropsychiatric disorders. The objective of this systematic review was to assess molecular changes produced by rTMS or molecular markers that predict treatment response in neuropsychiatric disorders.
METHODS
PubMed, PsycINFO, and Embase were searched through July 2019 for studies published in peer-reviewed journals. Eighty-nine studies were identified examining healthy adults and patients with neuropsychiatric disorders including depression, chronic pain, post-stroke deficits, and movement disorders.
RESULTS
Our ability to synthesize the information was limited by the large variability in treatment parameters and a limited number of placebo-controlled studies. While few findings were replicated by multiple strong studies, brain derived neurotrophic factor (BDNF) and gamma aminobutyric acid (GABA) in depression, BDNF in post-stroke deficits, and β-endorphin in chronic pain may be altered by rTMS.
CONCLUSION
BDNF, GABA and β-endorphin were identified as potential molecular markers of rTMS and warrant further exploration.
SIGNIFICANCE
This study, which is the first systematic review to examine molecular markers of rTMS in both neurological and psychiatric disorders, provides an updated review of this subject and highlight the need for more placebo-controlled and adequately powered studies to identify biomarkers of rTMS.
Topics: Biomarkers; Brain-Derived Neurotrophic Factor; Humans; Mental Disorders; Nervous System Diseases; Transcranial Magnetic Stimulation; beta-Endorphin; gamma-Aminobutyric Acid
PubMed: 33465534
DOI: 10.1016/j.clinph.2020.11.025 -
Neurobiology of Stress Nov 2020Since its development in 1993, the Trier Social Stress Test (TSST) has been used widely as a psychosocial stress paradigm to activate the sympathetic nervous system and... (Review)
Review
Since its development in 1993, the Trier Social Stress Test (TSST) has been used widely as a psychosocial stress paradigm to activate the sympathetic nervous system and hypothalamic-pituitary-adrenal axis (HPAA) stress systems, stimulating physiological functions (e.g. heart rate) and cortisol secretion. Several methodological variations introduced over the years have led the scientific community to question replication between studies. In this systematic review, we used the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) to synthesize procedure-related data available about the TSST protocol to highlight commonalities and differences across studies. We noted significant discrepancies across studies in how researchers applied the TSST protocol. In particular, we highlight variations in testing procedures (e.g., number of judges, initial number in the arithmetic task, time of the collected saliva samples for cortisol) and discuss possible misinterpretation in comparing findings from studies failing to control for variables or using a modified version from the original protocol. Further, we recommend that researchers use a standardized background questionnaire when using the TSST to identify factors that may influence physiological measurements in tandem with a summary of this review as a protocol guide. More systematic implementation and detailed reporting of TSST methodology will promote study replication, optimize comparison of findings, and foster an informed understanding of factors affecting responses to social stressors in healthy people and those with pathological conditions.
PubMed: 33344691
DOI: 10.1016/j.ynstr.2020.100235