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Lin Chuang Er Bi Yan Hou Tou Jing Wai... Jun 2021As one of the neurotrophic factors and insulin family, insulin like growth factor-1(IGF-1) can promote cell synthesis and metabolism in tissues and organs, activate... (Review)
Review
As one of the neurotrophic factors and insulin family, insulin like growth factor-1(IGF-1) can promote cell synthesis and metabolism in tissues and organs, activate cell growth, proliferation and differentiation, and inhibit cell apoptosis. Sensorineural hearing loss is the most common manifestation of the inner ear disease, which is mainly caused by the damage of cochlear hair cells. The lack of IGF-1 directly affects the growth, development and differentiation of cochlear hair cells, thus IGF-1 participates in the maintenance of cell survival and repair during inner ear cell injury. This article systematically reviews the recent research progress on the protective mechanism of IGF-1 on the inner ear.
Topics: Ear, Inner; Hair Cells, Auditory; Hearing Loss, Sensorineural; Humans; Insulin-Like Growth Factor I; Nerve Growth Factors; Spiral Ganglion
PubMed: 34304523
DOI: 10.13201/j.issn.2096-7993.2021.06.020 -
Growth Hormone & IGF Research :... 2021Insulin-like growth factor 1 (IGF-1) is an important factor related to cardiovascular disease. In recent years, studies have shown the involvement of IGF-1 and blood... (Meta-Analysis)
Meta-Analysis
OBJECTIVE
Insulin-like growth factor 1 (IGF-1) is an important factor related to cardiovascular disease. In recent years, studies have shown the involvement of IGF-1 and blood pressure (BP). Nevertheless, the results were inconsistent. Thus, the purpose of this study was to systematically evaluate the associations of circulating IGF-1 levels with BP in adults.
METHODS
Two reviewers independently searched and screened articles from the Pubmed, EMBASE, Cochrane Library, CNKI, and WANFANG databases up to May 2020. A total of 12 studies that reported the correlation coefficients between IGF-1, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were included.
RESULTS
IGF-1 was significantly correlated with SBP [r = -0.15; 95% CI = -0.21, -0.08; P < 0.0001] and DBP [r = -0.10; 95% CI = -0.16, -0.05; P = 0.0004]. Subgroup analysis further revealed that the relationship between IGF-1 and BP was influenced by race and age.
CONCLUSION
Circulating IGF-1 was negatively correlated with SBP and DBP. Further researches are necessary to explore the pathogenesis of this relationship and to evaluate the role of IGF-1 in the treatment of hypertension.
Topics: Blood Pressure; Humans; Hypertension; Insulin-Like Growth Factor I; Observational Studies as Topic
PubMed: 34273744
DOI: 10.1016/j.ghir.2021.101416 -
Journal of Alzheimer's Disease : JAD 2021Alterations in levels of peripheral insulin-like growth factor-1 (IGF-1) in Alzheimer's disease (AD) have been reported in several studies, and results are inconsistent. (Meta-Analysis)
Meta-Analysis
BACKGROUND
Alterations in levels of peripheral insulin-like growth factor-1 (IGF-1) in Alzheimer's disease (AD) have been reported in several studies, and results are inconsistent.
OBJECTIVE
We conducted a meta-analysis to investigate the relationship between peripheral and cerebrospinal fluid IGF-1 levels and AD or mild cognitive impairment (MCI).
METHODS
A systematic search in PubMed, Medline, Web of Science, Embase, and Cochrane Library was conducted and 18 studies were included.
RESULTS
Results of random-effects meta-analysis showed that there was no significant difference between AD patients and healthy control (17 studies; standard mean difference [SMD], -0.01; 95%CI, -0.35 to 0.32) and between MCI patients and healthy control (6 studies; SMD, -0.20; 95%CI, -0.52 to 0.13) in peripheral IGF-1 levels. Meta-regression analyses identified age difference might explain the heterogeneity (p = 0.017). However, peripheral IGF-1 levels were significantly decreased in AD subjects (9 studies; SMD, -0.44; 95%CI, -0.81 to -0.07) and MCI subjects exhibited a decreasing trend (4 studies; SMD, -0.31; 95%CI, -0.72 to 0.11) in studies with sample size≥80. Cerebrospinal fluid IGF-1 levels also significantly decreased in AD subjects (3 studies; SMD, -2.40; 95%CI, -4.36 to -0.43).
CONCLUSION
These findings suggest that decreased peripheral and cerebrospinal fluid IGF-1 levels might be a potential marker for the cognitive decline and progression of AD.
Topics: Alzheimer Disease; Biomarkers; Humans; Insulin-Like Growth Factor I
PubMed: 34151815
DOI: 10.3233/JAD-210516 -
Molecular Biology Reports Apr 2021Depressive disorders are common among the elderly. Major depressive disorder will be one of the highest healthcare costs in middle and higher income countries by 2030....
Depressive disorders are common among the elderly. Major depressive disorder will be one of the highest healthcare costs in middle and higher income countries by 2030. It is known that physical inactivity leads to negative effects on mental health in the elderly.The purpose of this review was to explore investigate the consequences of physical exercise (aerobic and resistance exercise) on major depressive disorder among elderly, and presenting its potential biological mechanisms. This study was designed according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Clinical trials or randomized clinical trials or cohort studies participated of the study design. Ten studies were evaluated and the main outcomes of each were reported. Aerobic and resistance training revealed to be effective in fighting the symptoms of depression. The most common physical exercise protocol adopted to reduce the consequences of major depressive disorder in humans was the prescription of aerobic exercise at moderate-intensity lasting 60 min per session, 3 times per week, for 24 weeks. Physical exercise enhances IGF-I and activates PGC-1α/FNDC5/Irisin pathway. Physical exercise also increases expression of BDNF and its receptor, TrkB, in the hippocampus and prefrontal cortex leading to upstream of ERK and inhibiting depressive-like behavior. Physical exercise brings mental health benefits and plays a crucial role in avoiding the development of major depressive disorder.
Topics: Aging; Brain-Derived Neurotrophic Factor; Depression; Exercise; Exercise Therapy; Humans; Insulin-Like Growth Factor I; Randomized Controlled Trials as Topic; Signal Transduction
PubMed: 33864590
DOI: 10.1007/s11033-021-06330-z -
Hormones (Athens, Greece) Jun 2021Findings regarding the effects of resistance training (RT) on muscle strength, serum level of IGF-1, and its binding proteins are contradictory. To resolve this... (Meta-Analysis)
Meta-Analysis
Effects of resistance training on muscle strength, insulin-like growth factor-1, and insulin-like growth factor-binding protein-3 in healthy elderly subjects: a systematic review and meta-analysis of randomized controlled trials.
BACKGROUND
Findings regarding the effects of resistance training (RT) on muscle strength, serum level of IGF-1, and its binding proteins are contradictory. To resolve this contradiction, we performed a systematic review and meta-analysis to investigate the effects of RT on muscle strength, the levels of serum IGF-1, and IGF-binding protein-3 in the elderly and aged.
MATERIALS AND METHODS
The PubMed, CINAHL, Medline, Google Scholar, and Scopus databases and reference lists of included studies were systematically searched to identify randomized controlled trials (RCTs) comparing subjects who underwent RT and control individuals up to May 15, 2020. This study was performed following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 11 eligible trials in this meta-analysis.
RESULTS
Pooled data displayed an overall significant elevation in IGF-1 (mean difference (MD): 17.34 ng/ml; 95% confidence interval (CI): 7.23, 27.46) and in muscle strength in leg press (SMD: 0.82; 95% CI: 0.30, 1.34) and bench press (SMD: 0.82; 95% CI: 0.42, 1.23) following RT. By contrast, the pooled estimate showed a non-significant elevation in IGFBP-3 (MD: 0.13 ng/ml; 95% CI: - 39.39, 39.65). Subgroup analysis revealed that the elevation in serum IGF-1 levels after RT was significant only in women (MD: 19.30 ng/ml); moreover, it increased after intervention durations of both > 12 weeks (MD: 21.98 ng/ml) and of ≤ 12 weeks (MD: 15.31 ng/ml).
CONCLUSION
RT was associated with elevated muscle strength. Moreover, RT was correlated with increased serum levels of IGF-1 among women and among those who received the training for ≤ 12 weeks or > 12 weeks. Further studies are required to elucidate the mechanisms underlying the impact of RT on IGF-1, IGFBP-3, and muscle strength.
Topics: Aged; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Muscle Strength; Randomized Controlled Trials as Topic; Resistance Training
PubMed: 33442864
DOI: 10.1007/s42000-020-00250-6 -
Mechanisms of Ageing and Development Mar 2021Physiological cascades of neurotrophic factors and inflammatory cytokines may mediate the exercise-induced amelioration of cognition in older adults. However, there is... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Physiological cascades of neurotrophic factors and inflammatory cytokines may mediate the exercise-induced amelioration of cognition in older adults. However, there is limited understanding on how different exercise modalities improving cognition alter biomarkers. Our aim was to evaluate the effects of different exercise modalities on blood biomarker concentrations in cognitive clinical trials of older adults.
METHODS
A systematic review (SR) and meta-analysis (MA) were performed using the databases PubMed, EMBASE, and SCOPUS. After exclusions, 17 trials with 18 distinct exercise interventions were included.
RESULTS
Aerobic training increased (n = 2) or did not significantly change BDNF (n = 5), and resistance training increased (n = 2) or did not significantly change (n = 2) IGF-1. Multimodal training significantly increased (n = 1) or did not change (n = 3) BDNF. Interventions that recruited sex-specific cohorts showed an advantage in males for blood marker concentrations and cognitive performance outcomes (n = 3) compared to females (n = 3). Only one of three interventions decreased concentrations of CRP. Eight studies examining BDNF changes were suited for MA and showed that higher BDNF concentrations were reached post intervention, although not reaching statistical significance (p = .26, I = 44 %).
DISCUSSION
Our results suggest that exercise has potential to ameliorate cognitive decline in older adults with divergent, modality-specific, neurotrophic mechanisms.
Topics: Age Factors; Aged; Aging; Biomarkers; Brain-Derived Neurotrophic Factor; Clinical Trials as Topic; Cognition; Exercise; Exercise Therapy; Female; Healthy Aging; Humans; Inflammation Mediators; Insulin-Like Growth Factor I; Male; Middle Aged; Neurons
PubMed: 33422561
DOI: 10.1016/j.mad.2021.111431 -
Annals of Palliative Medicine Nov 2020In recent years, a number of studies have shown abnormal levels of peripheral insulin growth factor-1 (IGF-1) in patients with mood disorder, but the results are not... (Meta-Analysis)
Meta-Analysis
BACKGROUND
In recent years, a number of studies have shown abnormal levels of peripheral insulin growth factor-1 (IGF-1) in patients with mood disorder, but the results are not uniform. Therefore, this paper focuses on such studies, conducts a systematic review and meta-analysis, and discusses the factors affecting peripheral IGF-1 in patients with mood disorder.
METHODS
Cochrane database, PubMed database, Embase database, CNKI database, Wanfang Database and Weipu database were searched by computer. The retrieval time was from June 2020 to search for a controlled study of the relationship between bipolar disorder (BD) or major depressive disorder and normal control peripheral IGF-1. Review Manager (version 5.3) software was used for meta-analysis.
RESULTS
A total of 14 articles in Chinese and English were included; 285 patients with BD and 503 patients with major depressive disorder. Meta-analysis showed that in comparison with the control group, IGF-1 levels in peripheral blood of patients with BD (MD =67.66, 95% CI: 7.01-128.31, P=0.03) and major depressive disorder (MD =8.01, 95% CI: 3.43-12.58, P=0.0006) were significantly increased. In the meta-analysis comparing the peripheral IGF-1 levels of patients before and after treatment, the results showed no significant change in the peripheral IGF-1 level before and after treatment (P=0.53).
CONCLUSIONS
High peripheral IGF-1 level is a related factor of BD and major depressive disorder, although this needs to be confirmed by further large sample studies.
Topics: Bipolar Disorder; Databases, Factual; Depressive Disorder, Major; Humans; Insulin; Insulin-Like Growth Factor I
PubMed: 33302664
DOI: 10.21037/apm-20-1967 -
Complementary Therapies in Medicine Jan 2021The results of human studies assessing the efficacy of lycopene on insulin-like growth factor 1 (IGF-1) levels are inconsistent. Thus, we performed a systematic review... (Meta-Analysis)
Meta-Analysis
BACKGROUND
The results of human studies assessing the efficacy of lycopene on insulin-like growth factor 1 (IGF-1) levels are inconsistent. Thus, we performed a systematic review and meta-analysis to examine the effects of lycopene supplementation on serum IGF-1 levels and cardiovascular disease.
METHODS
The literature published up to January 2020 was searched using the electronic databases Scopus, PubMed/Medline, Web of Science, Embase and Google Scholar.
RESULTS
Seven qualified trials were included in the current meta-analysis. IGF-1 levels were non-significantly decreased in lycopene group compared to the control (WMD: -6.74 ng/mL, 95 % CI: -23.01 to 9.52, p = 0.42; I = 94.3 %). Subgroup analysis revealed a significantly decrease in IGF-1 levels upon lycopene supplementation at doses ≥15 mg/d (WMD: -6.40 ng/mL), intervention period <12 weeks (WMD: -6.49 ng/mL), and subjects aged ≥60 years (WMD: -24.98 mg/dl). In addition, lycopene intake significantly reduced IGF-1 levels upon healthy conditions (WMD: -25.59 ng/mL) when compared with cancer patients (WMD: 0.35 ng/mL). In addition, the effect of lycopene supplementation was significant in patients diagnosed with cardiac disorders.
CONCLUSION
Overall, lycopene intake was not associated with reduced serum IGF-1 levels. However, association was significant when lycopene was administrated at doses >15 mg/d, for <12 weeks, as well as for healthy conditions and patients aged ≥60 years. In addition, lycopene supplementation exhibited potential health benefits in the management of patients with cardiac disorders.
Topics: Adult; Aged; Antioxidants; Cardiovascular Diseases; Female; Humans; Insulin-Like Growth Factor I; Lycopene; Male; Middle Aged; Randomized Controlled Trials as Topic
PubMed: 33259908
DOI: 10.1016/j.ctim.2020.102632 -
In Vivo (Athens, Greece) 2020The insulin-like growth factor bioregulation system is implicated in cancer biology. Herein, we aim to review the evidence on the expression of the insulin-like growth... (Review)
Review
BACKGROUND/AIM
The insulin-like growth factor bioregulation system is implicated in cancer biology. Herein, we aim to review the evidence on the expression of the insulin-like growth factor 1 and 2 (IGF1 and IGF2), their receptors (IGF-Rs) and IGF-binding proteins (IGFBPs) in thyroid tissue and their possible association with benign and malignant thyroid nodular diseases.
MATERIALS AND METHODS
We systematically reviewed Pubmed and Scopus databases up to May 2020. A total of 375 articles were retrieved and analyzed.
RESULTS
Among 375 articles, 45 were included in this systematic review study. IGF1 was investigated in 31 studies, IGF2 in 1, IGF1 receptor in 15 and IGF-binding proteins in 13 articles. IGF1 expression in humans was dependent on the number and compound of benign nodules as well as the method of measurement. In differentiated thyroid carcinoma, a positive correlation between IGF1 and immunohistological stage was documented in some studies while in others only a positive trend was observed. IGF-1R and IGFBPs expression was higher in malignant rather than benign lesions. There was only a positive trend for increased IGF2 expression in malignancy, while IGFBPs were in most studies statistically increased in various cancer types compared to benign nodular disease.
CONCLUSION
The present data demonstrate that in most studies there is statistically positive expression of IGF-1 and less of IGF-2 in thyroid cancer compared to normal thyroid tissue.
Topics: Humans; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Phosphorylation; Receptor, IGF Type 1; Signal Transduction; Thyroid Neoplasms
PubMed: 33144411
DOI: 10.21873/invivo.12141 -
Cells Sep 2020The number of diabetic patients grows constantly worldwide. Many patients suffer simultaneously from diabetes mellitus type 2 (T2DM) and intervertebral disc disease...
The number of diabetic patients grows constantly worldwide. Many patients suffer simultaneously from diabetes mellitus type 2 (T2DM) and intervertebral disc disease (IVDD), suggesting a strong link between T2DM and IVDD. T2DM rodent models provide versatile tools to study this interrelation. We hypothesized that the previously achieved studies in rodents approved it. Performing a search in the publicly available electronic databases according to our inclusion (e.g., experimental study with clearly outlined methods investigating IVDD in diabetic rodent models) and exclusion (e.g., non-experimental) criteria, we included 23 studies from 1992 to 2020 analyzing different aspects of IVDD in diabetic rodents, such as on pathogenesis (e.g., effects of hyperglycemia on IVD cells, sirtuin (SIRT)1/p53 axis in the interrelation between T2DM and IVDD), risk factors (e.g., high content of advanced glycation end-products (AGEs) in modern diets), therapeutical approaches (e.g., insulin-like growth factor (IGF-I)), and prophylaxis. Regarding their quality, 12 studies were classified as high, six as moderate, and five as low. One strong, 18 moderate, and three mild evidences of the link between DM and IVDD in rodents were found, while only one study has not approved this link. We concluded that T2DM has a devastating effect on IVD, particularly in advanced cases, which needs to be further evaluated.
Topics: Animals; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Insulin; Intervertebral Disc Degeneration; Male; Obesity; Rodentia; Somatomedins
PubMed: 33003542
DOI: 10.3390/cells9102208