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The American Journal of Dermatopathology Jun 2014
Topics: Eccrine Glands; Female; Humans; Lipoma; Male; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 23974223
DOI: 10.1097/DAD.0b013e31829871bd -
Korean Journal of Pathology Dec 2012We report here a case of adenolipoma of the skin, an unusual variant of lipoma, arising on the neck. A 56-year-old man visited our hospital due to an anterior neck mass....
We report here a case of adenolipoma of the skin, an unusual variant of lipoma, arising on the neck. A 56-year-old man visited our hospital due to an anterior neck mass. An excisional biopsy was performed. The mass revealed a tan-yellow soft cut surface. We could not find any difference from other lipoma on gross inspection. Microscopically, the mass showed proliferation of mature adipocytes admixed with several eccrine units. The eccrine units were demonstrated by periodic acid-Schiff-positive granules in the secretory portions and by positivity of smooth muscle actin in the myoepithelial cells surrounding the eccrine glands. The tumor was completely excised, and the patient has been followed up without any evidence of recurrence so far.
PubMed: 23323111
DOI: 10.4132/KoreanJPathol.2012.46.6.587 -
Endocrine Practice : Official Journal... 2012To outline the potential role for adrenal venous sampling in the diagnosis and management of adrenocorticotropic hormone (ACTH)-independent Cushing syndrome (CS).
OBJECTIVE
To outline the potential role for adrenal venous sampling in the diagnosis and management of adrenocorticotropic hormone (ACTH)-independent Cushing syndrome (CS).
METHODS
We present a case description and discuss the management of a 59-year-old woman with an 8-year history of weight gain, centripetal obesity, a round plethoric face, skin thinning, easy bruising, hirsutism, and progressive muscle weakness.
RESULTS
The patient reported a prior personal history of asthma, type 2 diabetes mellitus, hypertension, dyslipidemia, and bilateral leg ulcers, but she denied having any personal or family history of endocrinopathy and was not taking any corticosteroid medication. Elevated midnight serum cortisol, failure to suppress cortisol levels with a low-dose dexamethasone suppression test, and undetectable plasma ACTH all indicated ACTH-independent CS. Additional investigations including dynamic tests and adrenal imaging were supported by adrenal venous sampling in order to make a diagnosis and formulate a management plan. She was ultimately noted to have bilateral functioning adrenal nodules (adenoma and adenolipoma) and underwent successful bilateral laparoscopic adrenalectomy, with postoperative glucocorticoid and mineralocorticoid replacement.
CONCLUSION
Adrenal venous sampling may be an important step in the differential diagnosis of CS and localization of the source of cortisol excess. It may distinguish pheochromocytoma or benign nonfunctioning adrenal nodules from cortisol-secreting adenomas and may avoid unnecessary bilateral adrenalectomy. It can also ensure that the correct operation is completed, if required, and thus avoid the increased morbidity and mortality associated with repeated surgical interventions.
Topics: Adrenal Gland Neoplasms; Adrenocortical Adenoma; Adrenocorticotropic Hormone; Cushing Syndrome; Diagnosis, Differential; Female; Humans; Hydrocortisone; Middle Aged; Pheochromocytoma
PubMed: 22982799
DOI: 10.4158/EP12136.CR -
Pathologica Dec 2011Adenolipoma of the skin (ALS) is an uncommon histological variant of lipoma, characterized by the presence of normal eccrine sweat glands inside the fat proliferation. A...
Adenolipoma of the skin (ALS) is an uncommon histological variant of lipoma, characterized by the presence of normal eccrine sweat glands inside the fat proliferation. A 32-year-old woman presented to our department with a slow-growing, painless subcutaneous soft tumour located on the upper part of the right thigh. Microscopically, there was lobulated adipose tissue proliferation with well-differentiated eccrine glands and ducts in the periphery and centre of the nodule. These features were suggestive of ALS. ALS is a rare microscopic variant of cutaneous lipoma having similar clinical features to lipoma. The most frequent locations of this tumour are thighs (as in our patient), shoulders, chest and arms. Histologically, the tumour is composed of lobulated adipose tissue with larger and more prominent lobules than those in normal subcutaneous adipose tissue. A well-developed capsule may also be identified. Eccrine glands and ducts, without proliferative changes, are well-differentiated within the adipose tissue. Differential diagnosis of adenolipoma includes the common lipoma and its variants, skin tag and other hamartomatous lesions, such as nevus lipomatosus superficialis, and the lipomatous variant of eccrine angiomatous hamartoma.
Topics: Adult; Eccrine Glands; Female; Humans; Lipoma; Skin Neoplasms; Thigh
PubMed: 22558893
DOI: No ID Found -
The American Journal of Dermatopathology Feb 2013
Topics: Eccrine Glands; Female; Humans; Lipoma; Male; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 22534640
DOI: 10.1097/DAD.0b013e318252c7e9 -
The American Journal of Dermatopathology Feb 2011Adenolipoma refers to a variant of a lipoma with entrapped eccrine or, rarely, apocrine units. We present 5 cases of cutaneous adenolipoma to demonstrate the spectrum of...
Adenolipoma refers to a variant of a lipoma with entrapped eccrine or, rarely, apocrine units. We present 5 cases of cutaneous adenolipoma to demonstrate the spectrum of changes in the lipomatous and epithelial components. The cases include 3 lesions having a conventional lipomatous element and 1 with a spindle cell lipomatous component, each additionally featuring entrapped minimally altered eccrine units. In the remaining case, the epithelial component manifested a combination of hyperplastic and metaplastic changes (clear cell and squamous metaplasia) and unusually altered polarity of luminal cells with expression of myoepithelial cell markers on the luminal cells while focal absence of basal/myoepithelial cell in the corresponding area as evident microscopically and immunohistochemically.
Topics: Adult; Eccrine Glands; Female; Humans; Lipoma; Male; Middle Aged; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 21178580
DOI: 10.1097/DAD.0b013e3181ec8255 -
Kulak Burun Bogaz Ihtisas Dergisi : KBB... 2010Adenolipoma is a rare benign neoplasm composed of both mature adipose tissue and glandular elements. In this article we report a case of 19-year-old woman, who had nasal...
Adenolipoma is a rare benign neoplasm composed of both mature adipose tissue and glandular elements. In this article we report a case of 19-year-old woman, who had nasal blockage and deformity. On examination, a round, soft, nonpulsatile submucosal mass in the cartilagenous vault of the right nasal cavity was found. There was also alar rim notching, nostril asymmetry on the right side and septal deviation towards the opposite side. Computed tomography revealed a clearly demarcated dense mass located at the right submucopericondrial level obstructing the nasal passage. An open septorhinoplasty approach was preferred to remove the mass and also to correct the deformities caused by the mass. The histopathologic examination was reported as an adenolipoma. No recurrence was observed during postoperative two year follow-up. To our knowledge, this is the first case report of an adenolipoma of the nose in the English literature.
Topics: Adenoma; Female; Humans; Lipoma; Nose Neoplasms; Tomography, X-Ray Computed; Treatment Outcome; Young Adult
PubMed: 20815806
DOI: No ID Found -
Acta Medica Portuguesa 2010Thyroid adenolipomas or thyrolipomas are rare benign neoplasms composed of mature adipose tissue and glandular elements. The most common clinical manifestation is a...
Thyroid adenolipomas or thyrolipomas are rare benign neoplasms composed of mature adipose tissue and glandular elements. The most common clinical manifestation is a slowly enlarging neck mass. If thyroid fine-needle aspiration biopsy discloses a mixed population of adipocytes and follicular cells, the possibility of an adenolipoma should be considered in the differential diagnosis. Complete surgical excision is curative and the prognosis is favorable. We report a case of a 61 year-old female, with a recent diagnosis of multinodular goitre. The diagnosis of adenolipoma was only possible after surgery, performed because of a suspicious fine-needle aspiration biopsy. We also briefly discuss the pathogenesis, clinic and diagnosis of this entity.
Topics: Female; Humans; Lipoma; Middle Aged; Thyroid Neoplasms
PubMed: 20470478
DOI: No ID Found -
Annals of Diagnostic Pathology Dec 2009Because thyrolipoma (adenolipoma of thyroid) and thyrolipomatosis (diffuse lipomatosis of thyroid) are distinctively rare conditions with only few cases reported in the... (Review)
Review
Because thyrolipoma (adenolipoma of thyroid) and thyrolipomatosis (diffuse lipomatosis of thyroid) are distinctively rare conditions with only few cases reported in the literature, we are reporting 5 additional cases. All the 5 patients were adult females, with ages from 38 to 79 years, who presented with thyroid masses. Four of the patients had normal thyroid function tests and one had mild hypothyroidism. All patients received partial or total thyroidectomy. The thyroid specimens showed either circumscribed yellow-tan masses (cases 1, 2, and 3) or diffuse yellow-brown discoloration (cases 4 and 5). Histologic examination revealed abundant mature fat infiltrating the affected thyroid tissue in 3 distinct patterns: (1) fat infiltration limited to follicular adenomas (thyrolipoma); (2) fat diffusely infiltrating throughout the thyroid gland (thyrolipomatosis); or (3) fat infiltration involving both follicular adenoma and their surrounding thyroid tissue. Because of the rarity of thyroid fat-containing lesions, confusion in differential diagnosis may occasionally occur. It is important to be aware during frozen section that these lesions may present as extrathyroidal nodules, which can be radioactive on intraoperative scan for parathyroid glands. In addition, a papillary thyroid carcinoma was also identified in one case of thyrolipomatosis. All patients recovered well after surgery and there has been no recurrence of the lesions after 1 to 24 years of clinical follow-up. In summary, we are reporting 5 rare cases of thyrolipoma and thyrolipomatosis with distinct histologic patterns. Previously reported cases of thyrolipomatosis were reviewed and analyzed with the current cases.
Topics: Adult; Aged; Combined Modality Therapy; Female; Humans; Lipoma; Lipomatosis; Middle Aged; Thyroid Diseases; Thyroid Function Tests; Thyroidectomy; Thyroxine; Treatment Outcome
PubMed: 19917474
DOI: 10.1016/j.anndiagpath.2009.08.003 -
Indian Journal of Pathology &... 2009We report the case of a 45-year-old man who presented with a 4-year history of midline neck swelling associated with recent onset respiratory distress. Local examination...
We report the case of a 45-year-old man who presented with a 4-year history of midline neck swelling associated with recent onset respiratory distress. Local examination showed a lobulated diffuse thyroid enlargement. A subtotal thyroidectomy was performed. The right lobe weighed 225 g and the left lobe weighed 130 g. Multiple sections from both the lobes revealed diffuse infiltration of the stroma by mature adipose tissue. There was no evidence of amyloid deposits or papillary carcinoma. A final diagnosis of diffuse lipomatosis of the thyroid gland was rendered. Lipomatosis or adenolipomatosis of the thyroid gland is an extremely rare entity. The various differential diagnoses of fat in the thyroid include benign entities like amyloid goiter, adenolipoma, lymphocytic thyroiditis, intrathyroid thymic or parathyroid lipoma and malignant tumors like liposarcoma and encapsulated papillary carcinoma. Adequate clinical details and a thorough histopathological examination are mandatory for diagnosis.
Topics: Diagnosis, Differential; Humans; Lipomatosis; Male; Middle Aged; Thyroid Gland; Thyroidectomy
PubMed: 19332917
DOI: 10.4103/0377-4929.48922