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Archives of Pathology & Laboratory... Mar 2003Two unusual examples of secondary tumors arising in adenolipomas were diagnosed in a 16-year-old girl and a 27-year-old woman, each of whom presented with asymmetric...
Two unusual examples of secondary tumors arising in adenolipomas were diagnosed in a 16-year-old girl and a 27-year-old woman, each of whom presented with asymmetric enlargement of the right breast. In both instances, a significant secondary lesion was associated with the adenolipoma. In the first case, a cyst appeared to have arisen in a fibroadenoma within the adenolipoma, which had apparently undergone infarction during a recent pregnancy and postpartum period. There was micropapillary duct epithelial hyperplasia of the cyst lining epithelium. In the second case, an adenofibroma with atypical lobular hyperplasia was present within the adenolipoma.
Topics: Adenoma; Adolescent; Adult; Breast Neoplasms; Female; Fibroadenoma; Humans; Lipoma; Neoplasms, Second Primary
PubMed: 12653605
DOI: 10.5858/2003-127-e151-STIMAA -
Radiology Dec 2002
Topics: Aged; Biopsy, Needle; Humans; Lipoma; Magnetic Resonance Imaging; Male; Thyroid Gland; Thyroid Neoplasms; Tomography, X-Ray Computed
PubMed: 12461256
DOI: 10.1148/radiol.2253010663 -
American Family Physician Mar 2002Lipomas are adipose tumors that are often located in the subcutaneous tissues of the head, neck, shoulders, and back. Lipomas have been identified in all age groups but... (Review)
Review
Lipomas are adipose tumors that are often located in the subcutaneous tissues of the head, neck, shoulders, and back. Lipomas have been identified in all age groups but usually first appear between 40 and 60 years of age. These slow-growing, nearly always benign, tumors usually present as nonpainful, round, mobile masses with a characteristic soft, doughy feel. Rarely, lipomas can be associated with syndromes such as hereditary multiple lipomatosis, adiposis dolorosa, Gardner's syndrome, and Madelung's disease. There are also variants such as angiolipomas, neomorphic lipomas, spindle cell lipomas, and adenolipomas. Most lipomas are best left alone, but rapidly growing or painful lipomas can be treated with a variety of procedures ranging from steroid injections to excision of the tumor. Lipomas must be distinguished from liposarcoma, which can have a similar appearance.
Topics: Adult; Diagnosis, Differential; Female; Humans; Lipoma; Male; Middle Aged; Neoplasms, Adipose Tissue; Postoperative Complications
PubMed: 11898962
DOI: No ID Found -
Seminars in Diagnostic Pathology Nov 2001Benign and malignant lipomatous tumors are the most common neoplasms of subcutaneous and deep soft tissues in adults. In contrast, purely cutaneous lipogenic neoplasms... (Review)
Review
Benign and malignant lipomatous tumors are the most common neoplasms of subcutaneous and deep soft tissues in adults. In contrast, purely cutaneous lipogenic neoplasms are exceptionally rare, and some entities and variants of adipocytic neoplasms have not yet been described in the skin. In addition, some dermal lipogenic neoplasms are characterized by different specific clinicopathologic features in comparison with more deeply located tumors. Cutaneous angiolipoleiomyoma ("angiomyolipoma") is seen most often in male patients and in an acral location. It is characterized histologically by mature adipocytes, thick-walled blood vessels, and smooth muscle cells arranged in well-defined fascicles and around blood vessels. Smooth muscle cells in cutaneous angiolipoleiomyoma stain negatively for HMB-45, in contrast to renal and extrarenal angiomyolipoma. Adenolipoma of the skin is a superficially located form of lipoma composed of large lobules of mature adipocytic tissue admixed with eccrine ducts and glands. Cutaneous spindle cell/pleomorphic lipomas, in contrast to subcutaneous forms, are more common in female patients and have a wide anatomic distribution. Histologically, cutaneous spindle cell/pleomorphic lipomas are characterized by an infiltrative growth pattern mimicking more aggressive lesions. Rarely, liposarcoma may occur as a purely cutaneous lesion with a favorable clinical prognosis despite high-grade morphologic features in many cases.
Topics: Adipocytes; Humans; Lipoma; Liposarcoma; Male; Skin Neoplasms
PubMed: 11757864
DOI: No ID Found -
The American Journal of Gastroenterology Feb 2001
Topics: Adipose Tissue; Colon; Colonic Neoplasms; Humans; Lipoma; Male; Middle Aged
PubMed: 11232729
DOI: 10.1111/j.1572-0241.2001.03578.x -
Annals of Diagnostic Pathology Dec 1999We describe the histologic findings in thyroid glands from six female and five male patients with Cowden disease. The patients were aged 9 to 43 years (mean age, 26...
We describe the histologic findings in thyroid glands from six female and five male patients with Cowden disease. The patients were aged 9 to 43 years (mean age, 26 years). The salient thyroid lesions in this syndrome were multicentric follicular adenomas and adenomatous (parenchymatous, hyperplastic) nodules showing a wide range of nonspecific cytoarchitectural patterns. Multiple tiny cellular foci, so-called microadenomas, were also a feature. Specific lesions composed of oxyphil or clear cells, a tumor with features of hyalinizing trabecular adenoma, and an adenolipoma also occurred. Two cases showed a follicular carcinoma in addition to multiple benign follicular cell proliferations. The follicular carcinomas occurred at an older age and were larger in size than the clinically significant benign nodular lesions, suggesting tumor progression. All tumors showed thyroglobulin immunoreactivity and were negative for calcitonin. The histologic findings of a multiple adenomatous goiter or multiple follicular adenomas, particularly in children and young adults, should alert the pathologist and physician to the possibility of an inherited trait, such as Cowden disease, with its implications for family screening. The tumors are usually benign and well demarcated, but, because of multicentricity and increased risk of recurrence or progression to carcinoma, total thyroidectomy should be advocated.
Topics: Adenocarcinoma, Follicular; Adenoma; Adolescent; Adult; Calcitonin; Child; Female; Hamartoma Syndrome, Multiple; Humans; Immunohistochemistry; Male; Thyroglobulin; Thyroid Gland; Thyroid Neoplasms; Thyroid Nodule
PubMed: 10594284
DOI: 10.1016/s1092-9134(99)80011-2 -
Auris, Nasus, Larynx Apr 1999A case of diffuse lipomatosis of the thyroid gland is presented. Previously documented cases of this rare disorder are reviewed. Diffuse lipomatosis of the thyroid,... (Review)
Review
A case of diffuse lipomatosis of the thyroid gland is presented. Previously documented cases of this rare disorder are reviewed. Diffuse lipomatosis of the thyroid, amyloid goiter with adipose tissue, and the relationship between lipomatosis and adenolipoma are discussed.
Topics: Adult; Diagnosis, Differential; Humans; Lipomatosis; Male; Thyroid Diseases; Thyroid Gland; Thyroidectomy
PubMed: 10214903
DOI: 10.1016/s0385-8146(98)00049-2 -
Annales de Dermatologie Et de... 1997Adenolipoma of the skin is an unusual microscopic variant of the solitary lipoma, superposable to the adenolipoma of the breast, characterized by the presence of normal...
INTRODUCTION
Adenolipoma of the skin is an unusual microscopic variant of the solitary lipoma, superposable to the adenolipoma of the breast, characterized by the presence of normal eccrine sweat glands inside the fat proliferation.
OBSERVATIONS
Two new cases are reported.
DISCUSSION
Adenolipoma of the skin is a benign lesion whose clinical features are similar to those of solitary lipoma. Probably, it is only a histological curiosity in which the eccrine glands are entrapped and carried by the adipose proliferation.
Topics: Adult; Diagnosis, Differential; Eccrine Glands; Female; Hamartoma; Humans; Lipoma; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 9732760
DOI: No ID Found -
Annales de Dermatologie Et de... 1997We identified in our files 11 cases of a new variant of the superficial lipoma recently described by Hitchcock, Hurt and Santa Cruz, characterized by the presence of... (Review)
Review
INTRODUCTION
We identified in our files 11 cases of a new variant of the superficial lipoma recently described by Hitchcock, Hurt and Santa Cruz, characterized by the presence of eccrine sweat glands and denominated "adenolipoma of the skin".
PATIENTS AND METHOD
We examined 1,742 skin lesions registered in the Laboratory for Skin Histopathology from January 1989 to August 1996. These lesions were 397 lipomas, 1,325 skin tags (acrochordons) of which 120 with a fatty stroma and 20 connective tissue hamartomas of which 7 superficial lipomatous hamartomas. Among these lesions we looked for those corresponding to the prime description of the cutaneous adenolipoma.
RESULTS
We identified 11 cases of adenolipoma, i.e. a frequency of 0.65 p. 100 for the whole examined lesions and 2 p.100 among the 524 lesions with a fatty component (lipomas, lipomatous hamartomas and fibrolipomas). The mean age of the patients was 50 years and the sex-ratio F/M 1.75. The lesions were localized on the lower limbs (7 cases), especially on the thighs (4 cases), on the trunk (3 cases) and on the shoulder (1 case).
DISCUSSION
The adenolipoma is quite different from the common cutaneous lipomas. It develops within the dermis or the fatty layer. It is a solitary lipoma most often localized on the proximal parts of the limbs, especially on the thighs. Histologically it presents as a lobulated and capsulated tumor where eccrine sweat glands and ducts are present inside the fatty lobules. Apparently the adenolipoma originates from the fat pad around the sweat coils without proliferation of the sweat glands or ducts; this entity should therefore be denominated "perisudoral lipoma" rather than adenolipoma. It has to be differentiated from the skin tags with a fatty stroma (fibrolipomas) and from the superficial lipomatous hamartomas.
Topics: Adult; Aged; Diagnosis, Differential; Eccrine Glands; Female; Hamartoma; Humans; Lipoma; Male; Middle Aged; Sweat Gland Neoplasms
PubMed: 9732757
DOI: No ID Found -
The Journal of Laryngology and Otology Nov 1996Thyroid adenomas containing adipose tissue are rare. Only scattered case reports have been recorded. We describe an additional case of an adenolipoma of the thyroid...
Thyroid adenomas containing adipose tissue are rare. Only scattered case reports have been recorded. We describe an additional case of an adenolipoma of the thyroid gland, incidentally found in residual gland subsequent to excision of a papillary carcinoma.
Topics: Adenoma; Female; Humans; Lipoma; Middle Aged; Thyroid Neoplasms
PubMed: 8944891
DOI: 10.1017/s0022215100135832