-
Pathology International Jan 1996Three cases of mammary hamartoma were investigated immunohistochemically and are described. Case 1 was a 42 year old woman with an elastic hard tumor, 1.5 cm in...
Three cases of mammary hamartoma were investigated immunohistochemically and are described. Case 1 was a 42 year old woman with an elastic hard tumor, 1.5 cm in diameter, in her left breast. Case 2 was a 49 year old woman with a semisoft tumor, 5 x 2 cm, in her right breast. Case 3 was a 47 year old woman with a hard tumor, 5 cm in diameter, in her left breast. In each case, mammography and ultrasonography revealed a benign-looking, well-circumscribed mass without calcification. Histologically, the tumors were composed of adipose tissue, mammary glands, and fibrous and/or fibromuscular tissue. The tumor in case 3 also contained small islands of hyaline cartilage. Immunohistochemical analysis was performed, and epithelial and mesenchymal components were discretely and differentially immunostained except that the smooth muscle component seemed to be derived from myoepithelial cells. Cartilage formation might be the result of metaplasia, and 'metaplastic variant of the mammary hamartoma' or 'choristoma' may be an appropriate term for cartilage-containing mammary hamartoma. Using proliferating cell nuclear antigen (PCNA)-immunostaining, we observed that each component of the tumors had an individual growth rate. This finding may reflect one aspect of the biological characteristics of hamartoma.
Topics: Adenoma; Adult; Biomarkers; Breast Neoplasms; Female; Hamartoma; Humans; Immunoenzyme Techniques; Middle Aged; Muscle, Smooth; Proliferating Cell Nuclear Antigen; Treatment Outcome
PubMed: 10846551
DOI: 10.1111/j.1440-1827.1996.tb03534.x -
Cancer Genetics and Cytogenetics Oct 1995Cytogenetic studies of a breast adenolipoma (hamartoma) of a 58-year-old patient revealed a karyotype 46,XX,add(4)(?),add(6)(q?),der(7)t(7;12)(q11.1 or q11.2;q11 or...
Cytogenetic studies of a breast adenolipoma (hamartoma) of a 58-year-old patient revealed a karyotype 46,XX,add(4)(?),add(6)(q?),der(7)t(7;12)(q11.1 or q11.2;q11 or q12),der(12). To our knowledge, this is the second report of an aberration involving 12q12-15 in a hamartoma of the breast. By FISH studies, we found this chromosome 12 translocation breakpoint to be mapping within the MAR (Multiple Aberration Region). MAR is known to be a major cluster region of chromosome 12 breakpoints of benign solid tumors such as uterine leiomyoma, lipoma, and pleomorphic salivary gland adenomas, therefore raising the possibility that the same gene is involved in hamartoma of the breast as in these three benign solid tumors.
Topics: Breast Neoplasms; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 12; Female; Hamartoma; Humans; In Situ Hybridization, Fluorescence; Middle Aged
PubMed: 7497449
DOI: 10.1016/0165-4608(95)00060-7 -
Pathology International Mar 1995A rare case of adenolipoma (thyrolipoma) of the thyroid gland is reported. Previously reported cases are reviewed and the pathogenesis of this unusual thyroid lesion is... (Review)
Review
A rare case of adenolipoma (thyrolipoma) of the thyroid gland is reported. Previously reported cases are reviewed and the pathogenesis of this unusual thyroid lesion is discussed.
Topics: Adenoma; Aged; Female; Humans; Thyroid Neoplasms
PubMed: 7787996
DOI: 10.1111/j.1440-1827.1995.tb03449.x -
Cancer Genetics and Cytogenetics Feb 1994Cytogenetic analysis of adenolipomas of the breast, a tumor type that has not been chromosomally characterized before, revealed the karyotypes 47,XX, +del(1)(p22) in one...
Cytogenetic analysis of adenolipomas of the breast, a tumor type that has not been chromosomally characterized before, revealed the karyotypes 47,XX, +del(1)(p22) in one tumor and 46,XX, t(12;16)(q15;q24) in the other. Breast adenolipomas thus seem to be karyotypically identical to sporadic lipomas in other locations: rearrangements of 12q13-15 are the most common cytogenetic aberrations in lipomas, and also breaks in and around 1p22 have been reported in such tumors. The similarity with lipoma could be documented further in case 2, in which epithelial and mesenchymal cells were cultured separately; the t(12;16) was present in the latter but not in the former. This is evidence that the connective tissue is the neoplastic parenchyma in adenolipomas of the breast, whereas the glandular elements show concomitant but nonneoplastic proliferation.
Topics: Adenoma; Breast Neoplasms; Chromosome Aberrations; Female; Humans; Karyotyping
PubMed: 8143274
DOI: 10.1016/0165-4608(94)90131-7 -
Journal of the American Academy of... Jul 1993We have identified nine cases of a variant of superficial lipoma that are characterized by the presence of eccrine sweat glands.
BACKGROUND
We have identified nine cases of a variant of superficial lipoma that are characterized by the presence of eccrine sweat glands.
OBJECTIVE
The purpose of this study was to elucidate the clinical and histopathologic features of this distinctive lesion.
METHODS
Nine cases of lipoma that contain eccrine glands were retrieved from our pathology files from 1989 through 1992. Their clinical and histopathologic features were studied and compared with those of conventional lipoma.
RESULTS
The clinical features of these lesions did not deviate appreciably from those of the usual lipomas. However, their microscopic appearances differed by the presence of displaced and distorted eccrine glands. One lesion had the added features of a myxolipoma.
CONCLUSION
Adenolipoma of the skin is a distinct lesion that can occur in the dermis or subcutaneous tissue.
Topics: Adipose Tissue; Adult; Aged; Eccrine Glands; Female; Humans; Lipoma; Male; Middle Aged; Skin Neoplasms
PubMed: 8315082
DOI: 10.1016/0190-9622(93)70157-o -
Annali Italiani Di Chirurgia 1993
Review
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Thyroid Neoplasms
PubMed: 8154663
DOI: No ID Found -
Experimental and Toxicologic Pathology... May 1993
Topics: Adenoma; Animals; Female; Mammary Neoplasms, Animal; Microscopy, Electron; Rats; Rats, Sprague-Dawley
PubMed: 8329870
DOI: 10.1016/S0940-2993(11)80462-8 -
Annali Italiani Di Chirurgia 1992In order to highlight the occult pathology of the thyroid in the aged, the authors examined all the glands withdrawn from 507 consecutive autopsies on subjects of 67.10...
In order to highlight the occult pathology of the thyroid in the aged, the authors examined all the glands withdrawn from 507 consecutive autopsies on subjects of 67.10 years of median age. In 10 tables there are weight and measurements of the thyroids, macro and microscopic details and pathologic appearances. Adenomas were found in 17.1% of cases and histologically besides the known cases referred also to the Hürtle cells type, 4 clear cells adenomas and 5 adenolipomas were found. In 27.42% the subjects were affected or were dead for a malignant extrathyroidal neoplasm, and in 26% of these there was a metastasis in the thyroid. Never a primitive thyroid carcinoma, macroscopically and clinically evident, but in 53 thyroid glands, 54 occult carcinomas (OC) were found, particularly 37 papillary and 17 medullary. IN 57% of 165 histologically treated thyroids, to evidence C-cells, hyperplasia of these cells was found associated with various pathologic conditions, more in aged subjects. In 147 glands were found 170 nodules of various number of cells, at times positive for calcitonin. These solid cellular nodes (SCN) were evaluated as nodular C-cells hyperplasia. Besides isolated cases of acute thyroiditis (also the mycotic type), of tubercular thyroiditis and Hashimoto's, in 12% of the glands a lymphocytic chronic thyroiditis was found, frequently with Hürtle cells. Others observations were: basophilic thickening of colloid also with calcium oxalate crystals, lipoid degeneration of follicular cells and fat interfollicular and interlobular infiltration, thyroid amyloidosis, inner and media elastic calcification of thyroid arteries, presence of cysts with squamous cells coating, parathyroid glands and cartilage intrathyroidal plaques.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Autopsy; Cause of Death; Child; Female; Humans; Incidence; Italy; Male; Middle Aged; Sex Factors; Thyroid Diseases; Thyroid Gland
PubMed: 1305380
DOI: No ID Found -
The Tokai Journal of Experimental and... Oct 1992Adenolipoma of the breast is a rare tumor. Two cases are described here and the literature is reviewed. Case 1 was a 52-year-old woman who had a 3-cm-long elastic hard... (Review)
Review
Adenolipoma of the breast is a rare tumor. Two cases are described here and the literature is reviewed. Case 1 was a 52-year-old woman who had a 3-cm-long elastic hard tumor in the left breast. Case 2 was a 40-year-old woman who had a 3-cm-long elastic soft tumor in the left breast. In each case, mammography revealed well demarcated soft tissue density. Ultrasonography demonstrated well defined tumors composed of echogenic and sonolucent areas. These tumors were easily enucleated at surgery. Histologically, the tumors consisted of mammary ducts, fibrous stroma and adipose tissue, findings which are characteristic of mammary adenolipoma. An adenolipoma may still be misdiagnosed as a fibroadenoma or a fibrocystic disease. Characteristic findings of mammography and ultrasonography are emphasized.
Topics: Adenofibroma; Adenoma; Adult; Breast Neoplasms; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Hamartoma; Humans; Middle Aged
PubMed: 1300672
DOI: No ID Found -
Ceskoslovenska Patologie Aug 1992Adipose tissue in the thyroid gland was observed in 7 biopsies and 2 autopsies: in 3 cases of solitary adenolipoma, 3 cases of multiple adenolipoma, 1 case of pure...
Adipose tissue in the thyroid gland was observed in 7 biopsies and 2 autopsies: in 3 cases of solitary adenolipoma, 3 cases of multiple adenolipoma, 1 case of pure lipomatosis and 2 cases of lipomatosis with multiple adenolipomas combined with amyloidosis of lobules as well of adenomas in one bioptic case. Pathogenesis of this unusual phenomenon was discussed.
Topics: Adenoma; Adult; Aged; Amyloidosis; Female; Humans; Lipomatosis; Male; Middle Aged; Thyroid Diseases; Thyroid Neoplasms
PubMed: 1340401
DOI: No ID Found