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Oncology 1981The growth of a syngeneic Moloney lymphoma in CBA mice was inhibited by the injection of lymph node cells from normal CBA donors. This cytotherapeutic effect was also...
The growth of a syngeneic Moloney lymphoma in CBA mice was inhibited by the injection of lymph node cells from normal CBA donors. This cytotherapeutic effect was also seen after chemotherapy with cyclophosphamide (CY) or dimethylmyleran (DMM). Two other murine tumours, the Meth A sarcoma in Balb/c mice and the L1210 leukemia in BDF1 mice, did not respond to treatment with normal syngeneic cells. In the L1210 system, tumour-promoting effects of fetal liver cells were demonstrated. The tumour inhibitory effects of normal lymph node cells against the Moloney lymphoma may be a virus-dependent phenomenon mediated through interferon and natural killer' cells. The experiments also showed the sensitivity of the Moloney lymphoma and the Meth A sarcoma to CY and DMM and the responsiveness of the L1210 leukemia to AAFC.
Topics: Ancitabine; Animals; Antineoplastic Agents; Busulfan; Carcinogens; Cyclophosphamide; Female; Killer Cells, Natural; Leukemia, Experimental; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Moloney murine leukemia virus; Neoplasms, Experimental; Sarcoma, Experimental
PubMed: 6170919
DOI: 10.1159/000225581 -
Problemy Gematologii I Perelivaniia... Nov 1980
Clinical Trial
Topics: Adolescent; Adult; Aged; Ancitabine; Cancer Care Facilities; Child; Child, Preschool; Clinical Trials as Topic; Cytarabine; Follow-Up Studies; Humans; Infant; Interinstitutional Relations; Leukemia; Middle Aged; Remission, Spontaneous; USSR
PubMed: 6160576
DOI: No ID Found -
Cancer Clinical Trials 1980Results of a phase II study of AAFC in 32 patients with advanced measurable gastrointestinal cancer are presented. Fourteen patients were treated with a weekly schedule,...
Results of a phase II study of AAFC in 32 patients with advanced measurable gastrointestinal cancer are presented. Fourteen patients were treated with a weekly schedule, while 18 were treated with 5-day courses of the drug. There were 12 patients with pancreas cancer, eight with stomach cancer, seven with cancer of the esophagus, four with colorectal cancer, and one with cancer of the gallbladder. Response was observed in pancreas and stomach cancer. Two patients with pancreas cancer had partial remissions, three other patients (two pancreas and one stomach) had response of short duration, considered to be less than a partial remission. There appeared to be very little difference between the two different schedules of administration. AAFC shows limited activity in adenocarcinoma of pancreas and stomach; there does not appear to be a practical application for AAFC as a single agent.
Topics: Ancitabine; Antineoplastic Agents; Cytarabine; Drug Evaluation; Female; Gastrointestinal Neoplasms; Humans; Leukopenia; Male; Nausea; Vomiting
PubMed: 6159121
DOI: No ID Found -
Cancer Treatment Reports 1979Thirty-seven children and adolescents with acute leukemia in relapse were treated with cyclocytidine in a cooperative group setting. Only one of the 27 evaluable...
Thirty-seven children and adolescents with acute leukemia in relapse were treated with cyclocytidine in a cooperative group setting. Only one of the 27 evaluable patients achieved complete remission. A significant decrease (greater than or equal to 20%) in circulating and/or bone marrow leukemia cells occurred in an additional five patients. Drug toxicity was evaluated in 35 patients and included ten cases of jaw pain, two cases of hypotension, one case of fever, and one case of severe vomiting.
Topics: Adolescent; Ancitabine; Child; Cytarabine; Drug Evaluation; Drug Resistance; Humans; Hypotension; Jaw; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Remission, Spontaneous
PubMed: 93513
DOI: No ID Found -
Cancer Treatment Reports Aug 1979Cyclocytidine, a slow-release form of cytosine arabinoside, was evaluated in 69 children with advanced acute leukemia and solid tumors. One child with acute lymphocytic...
Cyclocytidine, a slow-release form of cytosine arabinoside, was evaluated in 69 children with advanced acute leukemia and solid tumors. One child with acute lymphocytic leukemia attained a complete remission. This child had received intrathecal cytosine arabinoside prior to the cyclocytidine. Eighteen of the 31 patients with acute lymphocytic leukemia/acute undifferentiated leukemia who did not respond received two or more courses of the drug. There were no responses in 15 children with acute myelogenous leukemia, in 11 children with neuroblastoma, or in 11 children with various solid tumors of childhood. A dose of 600 ng/m2/day for 10 consecutive days is tolerated in children.
Topics: Adolescent; Ancitabine; Child; Child, Preschool; Cytarabine; Drug Evaluation; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Neoplasms
PubMed: 89907
DOI: No ID Found -
Transplantation Proceedings Jun 1979
Topics: Ancitabine; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Hematopoiesis; Leukemia, Experimental; Liver; Liver Transplantation; Mice; Transplantation, Isogeneic
PubMed: 89744
DOI: No ID Found -
Biochimica Et Biophysica Acta Jan 1979We prepared the 5'- and 3'-O-phosphorothioate esters of the antitumor agent O2 : 2'-anhydro-1-beta-D-arabinosylcytosine. We also included in this study esters of...
We prepared the 5'- and 3'-O-phosphorothioate esters of the antitumor agent O2 : 2'-anhydro-1-beta-D-arabinosylcytosine. We also included in this study esters of 2'-thio-2'-deoxycytidine, namely, 2'-S-dCyd-2' : 3'-P, 2'-S-dCyd-2'-P, and 2'-S-dCyd-3'-P, along with natural nucleotides. These compounds were subjected to the action of Escherichia coli alkaline phosphatase, potato acid phosphatase, and bovine pancreatic ribonuclease A. The data were analyzed by Lineweaver-Burk plots to obtain Km and KI values. Only 2'-S-dCyd-2'-P was a substrate for alkaline phosphatase; the anhydro-araCyt phosphorothioates were good competitive inhibitors, while 2'-S-dCyd-3'-P did not associate with the enzyme. Acid phosphatase hydrolyzed all four monoesters investigated, including the S-phosphorothioate. The cyclic phosphorothioate, 2'-S-dCyd-2' : 3'-P was neither hydrolyzed by, nor associated with, ribonuclease A. ORD spectroscopy was also used in an attempt to relate the structural features of analogs to the peculiarity of their hydrolysis.
Topics: Acid Phosphatase; Alkaline Phosphatase; Ancitabine; Cytarabine; Deoxycytosine Nucleotides; Hydrolysis; Kinetics; Optical Rotatory Dispersion; Ribonucleases; Structure-Activity Relationship; Substrate Specificity; Thionucleotides
PubMed: 84687
DOI: 10.1016/0005-2787(79)90505-7 -
Cancer Chemotherapy and Pharmacology 1979The rationale and history of the development of physiologically based pharmacokinetic models are briefly reviewed in this paper. The methods of model construction and... (Review)
Review
The rationale and history of the development of physiologically based pharmacokinetic models are briefly reviewed in this paper. The methods of model construction and the previous application of this type of model to anticancer drugs are discussed. Future research should be focused on the following areas: (1) interspecies scaling, (2) the effects of disease states on the pharmacokinetics of anticancer drugs, and (3) the applications of pharmocokinetics to the studies of growth behavior of cancer cells. The ultimate goal will be to utilize this basic information to design an optimal dosage regimen and treatment schedule for the safe and effective cancer chemotherapy of each individual patient.
Topics: Ancitabine; Animals; Antineoplastic Agents; Blood Proteins; Cisplatin; Cytarabine; Dactinomycin; Doxorubicin; Humans; Kinetics; Methotrexate; Models, Biological; Protein Binding; Species Specificity
PubMed: 93986
DOI: 10.1007/BF00254079 -
Frontiers of Gastrointestinal Research 1979
Comparative Study
Topics: Abrin; Ancitabine; Animals; Colonic Neoplasms; Cytarabine; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Ricin
PubMed: 91567
DOI: 10.1159/000402313 -
Proceedings of the Society For... Dec 1978
Topics: Adrenergic Fibers; Ancitabine; Animals; Blood Pressure; Cats; Cytarabine; Dogs; Drug Tolerance; Hypotension, Orthostatic; Rats; Receptors, Adrenergic, alpha; Tyramine; Vasomotor System
PubMed: 83653
DOI: 10.3181/00379727-159-40351