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American Journal of Ophthalmology Aug 2018
Topics: Arcus Senilis; Asian People; Cardiovascular Diseases; Humans; Risk Factors
PubMed: 29884543
DOI: 10.1016/j.ajo.2018.03.046 -
American Journal of Ophthalmology Aug 2018
Topics: Arcus Senilis; Asian People; Cardiovascular Diseases; Humans
PubMed: 29853153
DOI: 10.1016/j.ajo.2018.05.016 -
Indian Journal of Ophthalmology Apr 2018
Topics: Adult; Arcus Senilis; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia
PubMed: 29582807
DOI: 10.4103/ijo.IJO_296_18 -
American Journal of Ophthalmology Apr 2018
Topics: Arcus Senilis; Asian People; Cardiovascular Diseases; Humans
PubMed: 29433742
DOI: 10.1016/j.ajo.2017.12.027 -
American Journal of Ophthalmology Apr 2018
Topics: Arcus Senilis; Asian People; Cardiovascular Diseases; Humans
PubMed: 29422407
DOI: 10.1016/j.ajo.2018.01.024 -
BMJ (Clinical Research Ed.) Feb 2018
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anticholesteremic Agents; Arcus Senilis; Cholesterol; Corneal Diseases; Coronary Artery Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Injections, Subcutaneous; Middle Aged; Mutation; PCSK9 Inhibitors; Receptors, LDL; Xanthomatosis
PubMed: 29419393
DOI: 10.1136/bmj.j5884 -
Japanese Journal of Ophthalmology Mar 2018To assess the safety and efficacy of femtosecond laser-assisted cataract surgery (FLACS) in Japanese eyes.
PURPOSE
To assess the safety and efficacy of femtosecond laser-assisted cataract surgery (FLACS) in Japanese eyes.
STUDY DESIGN
Retrospective case series.
METHODS
The clinical records of 529 consecutive eyes of 312 Japanese patients who underwent FLACS from 2013 to 2016 were reviewed. The completion rates of anterior capsulotomy and corneal incisions using the femtosecond laser (LenSx, Alcon) and the number of attempts to achieve secure docking between the cornea and laser system were recorded. The uncorrected and corrected distance visual acuities (VAs) and uncorrected and distance-corrected near VAs 1 week postoperatively were evaluated.
RESULTS
Anterior capsulotomies were completed in 98.7% of eyes. The corneal incisions were incomplete in 8.3%, which included eyes with arcus senilis and neovascularization. The mean corneal endothelial cell reduction rate was 5.5%. Multiple docking attempts were required in 22.9% of eyes, while canthotomy was performed in two eyes. The postoperative VAs were favorable.
CONCLUSION
FLACS was safe and reliable in Japanese eyes. Further improvements in docking are required to accommodate small corneas and narrow palpebral spaces.
Topics: Adult; Aged; Aged, 80 and over; Cataract Extraction; Female; Humans; Intraoperative Complications; Laser Therapy; Male; Middle Aged; Pseudophakia; Reproducibility of Results; Retrospective Studies; Treatment Outcome; Visual Acuity
PubMed: 29264862
DOI: 10.1007/s10384-017-0553-6 -
Journal of Epidemiology and Community... Dec 2017Visible age-related signs indicate biological age, as individuals that appear old for their age are more likely to be at poor health, compared with people that appear...
BACKGROUND
Visible age-related signs indicate biological age, as individuals that appear old for their age are more likely to be at poor health, compared with people that appear their actual age. The aim of this study was to investigate whether alcohol and smoking are associated with four visible age-related signs (arcus corneae, xanthelasmata, earlobe crease and male pattern baldness).
METHODS
We used information from 11 613 individuals in the Copenhagen City Heart Study (1976-2003). Alcohol intake, smoking habits and other lifestyle factors were assessed prospectively and visible age-related signs were inspected during subsequent examinations.
RESULTS
The risk of developing arcus corneae, earlobe crease and xanthelasmata increased stepwise with increased smoking as measured by pack-years. For alcohol consumption, a high intake was associated with the risk of developing arcus corneae and earlobe crease, but not xanthelasmata.
CONCLUSIONS
High alcohol consumption and smoking predict development of visible age-related signs. This is the first prospective study to show that heavy alcohol use and smoking are associated with generally looking older than one's actual age.
Topics: Adult; Alcohol Drinking; Alopecia; Arcus Senilis; Denmark; Ear Auricle; Exercise; Female; Humans; Life Style; Male; Prevalence; Prospective Studies; Smoking; Xanthomatosis
PubMed: 29114032
DOI: 10.1136/jech-2016-208568 -
BMC Ophthalmology Sep 2017Femtosecond laser-assisted cataract surgery (FLACS) has grown in popularity among ophthalmologists as a novel technique. However, descemet membrane detachment (DMD)...
BACKGROUND
Femtosecond laser-assisted cataract surgery (FLACS) has grown in popularity among ophthalmologists as a novel technique. However, descemet membrane detachment (DMD) began to be found as the complication after FLACS. We report a case of serious DMD following FLACS due to the inappropriate incision design.
CASE PRESENTATION
An 85-year-old man with apparent cornea arcus senilis underwent femtosecond laser-assisted cataract surgery in his right eye. A biplanar model was chosen for the main incision. A serious descemet membrane detachment (DMD) occurred at the end of phacoemulsification, which was connected with the main incision. However, the surgeon confused it with the transient swelling of corneal endothelium, and did not treated DMD timely. DMD was confirmed by anterior segment optical coherence tomography (AS-OCT) at the postoperative 1-month follow-up. Eventually DMD was resolved by intracameral perfluropropane (C3F8) gas injection.
CONCLUSIONS
This case suggests that a careful incision separation and a triplanar incision design in FLACS may reduce the incidence of DMD in cataract surgery.
Topics: Aged, 80 and over; Corneal Diseases; Descemet Membrane; Humans; Laser Therapy; Male; Phacoemulsification; Postoperative Complications
PubMed: 28915807
DOI: 10.1186/s12886-017-0566-4 -
American Journal of Ophthalmology Nov 2017To examine the longitudinal relationship between baseline corneal arcus (CA) and incident cardiovascular disease (CVD) in ethnic Indian and Malay adults in Singapore.
PURPOSE
To examine the longitudinal relationship between baseline corneal arcus (CA) and incident cardiovascular disease (CVD) in ethnic Indian and Malay adults in Singapore.
DESIGN
Population-based cohort study.
METHODS
Indian and Malay adults aged 40-80 years were recruited for baseline and 6-year follow-up visits between 2004-2009 and 2010-2015, respectively (follow-up response rate 73.9%). CA was assessed by ophthalmologists using slit-lamp biomicroscopy. The main outcome was self-reported incident CVD, defined as new myocardial infarction, angina pectoris, or stroke, which developed between baseline and follow-up. Multivariable logistic regression models assessed independent associations between baseline CA and incident CVD, adjusting for traditional CVD risk factors including age, sex, serum cholesterol, hypertension, diabetes, and smoking. We further conducted sex-stratified analyses to identify possible effect modifications.
RESULTS
Of the total 3637 participants (overall mean [SD] age: 56 [9] years, 46% male) with available follow-up data, without history of CVD at baseline, 208 (5.7%) incident CVD cases were reported. Participants with CA were more likely to have incident CVD (7.5%) than those without (4.9%). After controlling for traditional CVD risk factors, CA was independently associated with incident CVD (odds ratio [95% confidence interval]: 1.52 [1.07-2.16]) in adjusted models. In sex-stratified models, associations between CA and incident CVD were seen in men (1.73 [1.12-2.67]) and not in women (1.05 [0.56-1.97]).
CONCLUSIONS
CA is associated with incident CVD, independent of serum lipids and traditional CVD risk factors, in ethnic Malay and Indian men. Our finding suggests that CA is an additional observable indicator of CVD in men.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Arcus Senilis; Cardiovascular Diseases; Cornea; Ethnicity; Female; Follow-Up Studies; Humans; Incidence; Male; Microscopy, Acoustic; Middle Aged; Population Surveillance; Prospective Studies; Risk Assessment; Risk Factors; Sex Distribution; Singapore; Time Factors
PubMed: 28911992
DOI: 10.1016/j.ajo.2017.09.002