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Medicinski Arhiv 2003Arcus corneae is the degeneration of the cornea, in which are depositing in its stroma, which is clinically manifested like cloudiness which is coincidental with edge of...
Arcus corneae is the degeneration of the cornea, in which are depositing in its stroma, which is clinically manifested like cloudiness which is coincidental with edge of cornea, by the corneoscleral limb, looking like white ring. During 2002 in ophthalmology cabinet in Dom zdravlja Fojnica, 32 patients, aged 54-56, with diagnosis arcus corneae were treated, which means that findings of lipoprotein fractions in serum has been made. Those findings showed us positive correlation between degeneration of cornea and raising of serums lipoproteins level, especially LDL, cholesterol, thriglicerids, and that there isn't reverse relation, negative correlation between serum's HDL and certain ophthalmology's manifestation.
Topics: Arcus Senilis; Cornea; Humans; Hyperlipoproteinemias; Middle Aged
PubMed: 12858656
DOI: No ID Found -
Indian Pediatrics Jun 2003
Topics: Arcus Senilis; Buttocks; Child; Elbow; Humans; Knee; Male; Xanthomatosis
PubMed: 12824670
DOI: No ID Found -
Dental Update Mar 2003
Topics: Arcus Senilis; Dental Care for Chronically Ill; Eyelid Diseases; Heart Diseases; Humans; Hyperlipidemias; Xanthomatosis
PubMed: 12705031
DOI: No ID Found -
Der Ophthalmologe : Zeitschrift Der... Feb 2003
Topics: Adult; Arcus Senilis; Corneal Dystrophies, Hereditary; Corneal Transplantation; Diagnosis, Differential; Humans; Keratoplasty, Penetrating; Male; Syndrome; Visual Acuity
PubMed: 12650173
DOI: 10.1007/s00347-002-0666-1 -
Journal of Cataract and Refractive... Oct 2002
Topics: Aged; Aged, 80 and over; Arcus Senilis; Cornea; Female; Humans; Male; Middle Aged
PubMed: 12388050
DOI: 10.1016/s0886-3350(02)01672-3 -
Journal of the Medical Association of... Jun 2002A cross sectional study based on 243 subjects with an age range of 20-63 years, was conducted to assess the prevalence of corneal arcus and the association between...
A cross sectional study based on 243 subjects with an age range of 20-63 years, was conducted to assess the prevalence of corneal arcus and the association between corneal arcus and dyslipidemia which is a coronary heart disease risk factor. The presence of corneal arcus was determined by hand-held slitlamp, serum lipids and serum plasma glucose collected on the same day as corneal arcus detection. Total cholesterol (CHOL), triglyceride (TG) and high density lipoprotein (HDL) were measured by enzymatic procedure, and low density lipoprotein (LDL) was estimated by the Friedewald formula. The prevalence of corneal arcus was divided into 3 age groups, 20-29 years (0%), 30-49 years (male 41.5%, female 26.13%) and 50-69 years (male 86.2%, female 59.1%) In the 30-49 year, female group, those with corneal arcus had higher serum LDL and total cholesterol concentration than those without corneal arcus. The mean difference of LDL was 22.21 mg/dl (p=0.001) and total cholesterol was 30.95 mg/dl (p=0.000). In the 30-49 year, male group people with corneal arcus had a lower serum HDL concentration than those without corneal arcus and the mean difference of the HDL was 8.6 mg/dl (p=0.014). There was no difference for corneal arcus and serum lipid in the 50-69 years group in both sexes. No association between corneal arcus and fasting plasma glucose was found in all ages and both sexes. It is concluded that while corneal arcus is primarily an aged-related change, if present in people under 50 years it should be considered for dyslipidemia which is one of the risk factors for coronary heart disease.
Topics: Adult; Age Distribution; Arcus Senilis; Cohort Studies; Comorbidity; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; Hyperlipidemias; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Prevalence; Risk Assessment; Risk Factors; Sex Distribution; Thailand
PubMed: 12188416
DOI: No ID Found -
American Journal of Human Genetics Jul 2002In the present study, we report a kindred with hearing loss, congenital heart defects, and posterior embryotoxon, segregating as autosomal dominant traits. Six of seven...
In the present study, we report a kindred with hearing loss, congenital heart defects, and posterior embryotoxon, segregating as autosomal dominant traits. Six of seven available affected patients manifested mild-to-severe combined hearing loss, predominantly affecting middle frequencies. Two patients were diagnosed with vestibular pathology. All patients had congenital heart defects, including tetralogy of Fallot, ventricular septal defect, or isolated peripheral pulmonic stenosis. No individual in this family met diagnostic criteria for any previously described clinical syndrome. A candidate-gene approach was undertaken and culminated in the identification of a novel Jagged 1 (JAG1) missense mutation (C234Y) in the first cysteine of the first epidermal-growth-factor-like repeat domain of the protein. JAG1 is a cell-surface ligand in the Notch signaling pathway. Mutations in JAG1 have been identified in patients with Alagille syndrome. Our findings revealed a unique phenotype with highly penetrant deafness, posterior embryotoxon, and congenital heart defects but with variable expressivity in a large kindred, which demonstrates that mutation in JAG1 can cause hearing loss.
Topics: Abnormalities, Multiple; Amino Acid Sequence; Amino Acid Substitution; Animals; Arcus Senilis; Base Sequence; Calcium-Binding Proteins; Cysteine; DNA; Deafness; Female; Genes, Dominant; Heart Defects, Congenital; Humans; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Male; Membrane Proteins; Molecular Sequence Data; Mutation; Pedigree; Protein Structure, Tertiary; Proteins; Sequence Homology, Amino Acid; Serrate-Jagged Proteins
PubMed: 12022040
DOI: 10.1086/341327 -
The Journal of Laboratory and Clinical... Dec 2001
Topics: Adult; Arcus Senilis; Arteriosclerosis; Cornea; Female; Humans; Hyperlipidemias; Male; Middle Aged
PubMed: 11774875
DOI: 10.1067/mlc.2001.120633 -
Canadian Family Physician Medecin de... Nov 2001
Topics: Adult; Arcus Senilis; Corneal Diseases; Corneal Transplantation; Diagnosis, Differential; Female; Humans; Keratoconus
PubMed: 11768918
DOI: No ID Found -
Postgraduate Medical Journal Sep 2001As a component of studies on biological age, the age of subjects from their appearance (perceived age) was estimated.
BACKGROUND
As a component of studies on biological age, the age of subjects from their appearance (perceived age) was estimated.
OBJECTIVE
To determine the factors associated with looking older.
METHODS
Cross sectional study of London civil servants (318 men, 129 women) in the Department of the Environment study. Perceived age was recorded by an observer and the difference between this age and chronological age was analysed according to 20 different variables.
RESULTS
Men had an average perceived age of 0.37 years older than their actual age and women a perceived age of 0.54 years younger. In men, looking older was related to greying of the hair, grade of arcus senilis, and grade of baldness. Less expected, looking older was positively related to total serum cholesterol (p=0.03) and blood haemoglobin (p<0.01). In women, looking older was related to greying of the hair, positively to blood erythrocyte sedimentation rate (ESR), and negatively to serum bilirubin (p=0.01). Looking older was not related to alcohol consumption, employment grade, serum high density lipoprotein cholesterol, glucose, albumin, and calcium in either sex.
CONCLUSION
The relationships between looking older and total cholesterol and haemoglobin in men and ESR and bilirubin in women, require further investigation.
Topics: Adult; Age Factors; Aging; Alopecia; Bilirubin; Blood Sedimentation; Cholesterol; Cross-Sectional Studies; Facies; Female; Hair Color; Hemoglobins; Humans; Male; Middle Aged
PubMed: 11524516
DOI: 10.1136/pmj.77.911.578