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ACS Central Science Dec 2021Extreme fast charging (XFC), with a recharging time of 15 min, is the key to the mainstream adoption of battery electric vehicles. Lithium metal, in the meantime, has...
Extreme fast charging (XFC), with a recharging time of 15 min, is the key to the mainstream adoption of battery electric vehicles. Lithium metal, in the meantime, has re-emerged as the ultimate anode because of its ultrahigh specific capacity and low electrochemical potential. However, the low lithium-ion concentration near the lithium electrode surface can result in uncontrolled dendrite growth aggravated by high plating current densities. Here, we reveal the beneficial effects of an adaptively enhanced internal electric field in a constant voltage charging mode in XFC via a molecular understanding of the electrolyte-electrode interfaces. With the same charging time and capacity, the increased electric field stress in dozens of millivolts, compared with that in a constant current mode, can facilitate Li migrating toward the negatively charged lithium electrode, mitigating Li depletion at the interface and thereby suppressing dendrites. In addition, more NO ions are involved in the solvation sheath that is constructed on the lithium electrode surface, leading to the nitride-enriched solid electrolyte interphase and thus favoring lower barriers for Li transport. On the basis of these merits, the Li||LiTiO battery runs steadily for 550 cycles with charging current peaks up to 27 mA cm, and the Li||S full cells exhibit extended life-spans charged within 12 min.
PubMed: 34963895
DOI: 10.1021/acscentsci.1c01014 -
Nuclear Medicine decision makers in need of help: The remote places' cyclotron installation example.Hellenic Journal of Nuclear Medicine 2021
Topics: Cyclotrons; Decision Making; Humans; Nuclear Medicine; Radionuclide Imaging
PubMed: 34901971
DOI: 10.1967/s002449912414 -
Giant negative thermopower of ionic hydrogel by synergistic coordination and hydration interactions.Science Advances Nov 2021The design of ultrasensitive ionic thermopiles is important for low-grade heat collection and temperature sensing. However, high-quality ionic thermoelectric materials...
The design of ultrasensitive ionic thermopiles is important for low-grade heat collection and temperature sensing. However, high-quality ionic thermoelectric materials with negative thermopower have been rarely reported to date. Effective adjustment of the interaction between the polymer network and the electrolyte anion/cation is an important method to achieve notable thermopower. Here, we demonstrate an ionic hydrogel thermoelectric material with giant negative thermopower obtained by synergistic coordination and hydration interactions. The ionic hydrogel, made of polyvinyl alcohol and sodium hydroxide, is prepared by simple dry-annealed process and exhibits a thermopower of up to −37.61 millivolts per kelvin, an extremely high absolute thermopower for electronic and ionic conductors. This ionic hydrogel is promising for the design of high-thermopower ionic thermoelectric materials and the low-grade heat energy harvesting.
PubMed: 34818039
DOI: 10.1126/sciadv.abi7233 -
Pharmaceutical Development and... Feb 2022Contact lens have been proposed as a mean of ocular drug delivery, but the conventional soaking method to load hydrophobic drugs, such as latanoprost shows low drug...
Contact lens have been proposed as a mean of ocular drug delivery, but the conventional soaking method to load hydrophobic drugs, such as latanoprost shows low drug loading and high burst release with alteration in the critical lens properties. In this paper, a novel latanoprost-loaded PEGylated solid lipid nanoparticles (LP-pSLNs) were developed to increase the latanoprost loading capacity of contact lenses (LP-pSLN-L), while also sustaining ocular drug delivery. The pSLNs were spherical in shape with an average size of 105‒132 nm (nanometer) and a zeta potential ranging from ‒29.1 to ‒26.7 mV (millivolt). The LP-pSLNs led to improved swelling, transmittance, and protein adherence of the lens compared to the non-pegylated SLNs congeners (LP-SLN-L) and conventional soaked lens (LP-SM-L). The LP-SM-L lens showed low drug loading, high burst release, and a short release duration of 24 h. The LP-SLN-L and LP-pSLN-L lenses showed high drug uptake and sustained drug release up to 120 h and 96 h, respectively. The pegylation reduced the size of nanoparticles and improved the drug loading capacity, while the release rate was high in the initial hours. The LP-pSLN-L lens was found to be safe based in histopathological studies. In animal studies, the LP-pSLN-10-L batch showed high drug concentration at all-time points up to 96 h compared to the LP-SM-L and eye drop solution. In conclusion, pSLNs improved the latanoprost loading in the contact lens and showed sustained drug release, and thus can be used as a substitute to eye drop therapy.
Topics: Animals; Contact Lenses, Hydrophilic; Drug Delivery Systems; Glaucoma; Latanoprost; Liposomes; Nanoparticles; Ophthalmic Solutions; Polyethylene Glycols
PubMed: 34704874
DOI: 10.1080/10837450.2021.1999471 -
Nature Communications Oct 2021Exploring new materials is essential in the field of material science. Especially, searching for optimal materials with utmost atomic utilization, ideal activities and...
Exploring new materials is essential in the field of material science. Especially, searching for optimal materials with utmost atomic utilization, ideal activities and desirable stability for catalytic applications requires smart design of materials' structures. Herein, we report iridium metallene oxide: 1 T phase-iridium dioxide (IrO) by a synthetic strategy combining mechanochemistry and thermal treatment in a strong alkaline medium. This material demonstrates high activity for oxygen evolution reaction with a low overpotential of 197 millivolt in acidic electrolyte at 10 milliamperes per geometric square centimeter (mA cm). Together, it achieves high turnover frequencies of 4.2 s (3.0 s) at 1.50 V vs. reversible hydrogen electrode. Furthermore, 1T-IrO also shows little degradation after 126 hours chronopotentiometry measurement under the high current density of 250 mA cm in proton exchange membrane device. Theoretical calculations reveal that the active site of Ir in 1T-IrO provides an optimal free energy uphill in *OH formation, leading to the enhanced performance. The discovery of this 1T-metallene oxide material will provide new opportunities for catalysis and other applications.
PubMed: 34650084
DOI: 10.1038/s41467-021-26336-2 -
Journal of Ocular Pharmacology and... 2022To evaluate the reliability of intensity of light scatter (ILS) for diagnosing mild-to-moderate uveitis, which is difficult to score by the subjective standardized...
To evaluate the reliability of intensity of light scatter (ILS) for diagnosing mild-to-moderate uveitis, which is difficult to score by the subjective standardized uveitis nomenclature (SUN) grading. ILS (in millivolts) was measured in healthy subjects and uveitis patients by a custom-made Spot fluorometer. The reliability was assessed by noise analysis of the instrument using turbid samples and intra- and interobserver variabilities. ILS increased with the severity of inflammation: healthy (0.1498 ± 0.0564) and SUN0 (0.1590 ± 0.0564) < SUN1+ (0.2050 ± 0.0887) < SUN2+ (0.4283 ± 0.1895). The increase in ILS was more significant between healthy and SUN1+ ( < 0.0001) compared to the difference between SUN0 and SUN1+ ( = 0.0006). The instrument noise was small (σ = 0.002). Intraobserver measurements revealed no variability ( > 0.98) between measurements and predicted repeatability coefficients of 0.0754, 0.0522, and 0.0532 in healthy, SUN0, and SUN1+, respectively. Interobserver measurements also showed no variability ( > 0.88) and predicted intraclass correlation coefficient > 0.63 in healthy and uveitis subjects. The fluorometer enables precise measurement of ILS with negligible instrument noise, and the measurements are unaffected by intra- and interobserver variabilities. However, the difference in mean ILS between SUN0 and SUN1+ is greater than the instrument noise and comparable to intra- and interobserver variabilities. Thus, ILS measurements are likely impacted by blinking, eye movements, and focusing jitter. The impact of these factors must be reduced before using the fluorometer to distinguish mild-to-moderate uveitis.
Topics: Adult; Aqueous Humor; Dynamic Light Scattering; Eye Movements; Female; Fluorometry; Humans; Male; Middle Aged; Observer Variation; Patient Acuity; Reproducibility of Results; Uveitis
PubMed: 34648719
DOI: 10.1089/jop.2021.0053 -
Science Advances Sep 2021The biophysical characteristics of the extracellular matrix (ECM), such as a three-dimensional (3D) network and bioelectricity, have a profound influence on cell...
The biophysical characteristics of the extracellular matrix (ECM), such as a three-dimensional (3D) network and bioelectricity, have a profound influence on cell development, migration, function expression, etc. Here, inspired by these biophysical cues of ECM, we develop an electromechanical coupling bio-nanogenerator (bio-NG) composed of highly discrete piezoelectric fibers. It can generate surface piezopotential up to millivolts by cell inherent force and thus provide in situ electrical stimulation for the living cells. Besides, the unique 3D space in the bio-NGs provides an ECM-like growth microenvironment for cells. As a result, our bio-NGs effectively promote cell viability and development and, more importantly, maintain its specific functional expression. These advanced in vitro bio-NGs are expected to fill the gap between the inaccurate 2D systems and the expensive and time-consuming animal models, mimicking the complexity of the ECM and the physiological relevance of an in vivo biological system.
PubMed: 34559554
DOI: 10.1126/sciadv.abh2350 -
Journal of Medical Internet Research Sep 2021Measuring weight bearing is an essential aspect of clinical care for lower limb injuries such as sprains or meniscopathy surgeries. This care often involves the use of... (Observational Study)
Observational Study
Versatile GCH Control Software for Correction of Loads Applied to Forearm Crutches During Gait Recovery Through Technological Feedback: Development and Implementation Study.
BACKGROUND
Measuring weight bearing is an essential aspect of clinical care for lower limb injuries such as sprains or meniscopathy surgeries. This care often involves the use of forearm crutches for partial loads progressing to full loads. Therefore, feasible methods of load monitoring for daily clinical use are needed.
OBJECTIVE
The main objective of this study was to design an innovative multifunctional desktop load-measuring software that complements GCH System 2.0-instrumented forearm crutches and monitors the applied loads, displaying real-time graphical and numerical information, and enabling the correction of inaccuracies through feedback technology during assisted gait. The secondary objective was to perform a preliminary implementation trial.
METHODS
The software was designed for indoor use (clinics/laboratories). This software translates the crutch sensor signal in millivolts into force units, records and analyzes data (10-80 Hz), and provides real-time effective curves of the loads exerted on crutches. It covers numerous types of extrinsic feedback, including visual, acoustic (verbal/beeps), concurrent, terminal, and descriptive feedback, and includes a clinical and research use database. An observational descriptive pilot study was performed with 10 healthy subjects experienced in bilateral assisted gait. The Wilcoxon matched-pairs signed-rank test was used to evaluate the load accuracy evolution of each subject (ie, changes in the loads exerted on crutches for each support) among various walks, which was interpreted at the 95% confidence level.
RESULTS
GCH Control Software was developed as a multifunctional desktop tool complementing GCH System 2.0-instrumented forearm crutches. The pilot implementation of the feedback mechanism observed 96/100 load errors at baseline (walk 0, no feedback) with 7/10 subjects exhibiting crutch overloading. Errors ranged from 61.09% to 203.98%, demonstrating heterogeneity. The double-bar feedback found 54/100 errors in walk 1, 28/100 in walk 2, and 14/100 in walk 3. The first walk with double-bar feedback (walk 1) began with errors similar to the baseline walk, generally followed by attempts at correction. The Wilcoxon matched-pairs signed-rank test used to evaluate each subject's progress showed that all participants steadily improved the accuracy of the loads applied to the crutches. In particular, Subject 9 required extra feedback with two single-bar walks to focus on the total load. The participants also corrected the load balance between crutches and fluency errors. Three subjects made one error of load balance and one subject made six fluctuation errors during the three double-bar walks. The latter subject performed additional feedback with two balance-bar walks to focus on the load balance.
CONCLUSIONS
GCH Control Software proved to be useful for monitoring the loads exerted on forearm crutches, providing a variety of feedback for correcting load accuracy, load balance between crutches, and fluency. The findings of the complementary implementation were satisfactory, although clinical trials with larger samples are needed to assess the efficacy of the different feedback mechanisms and to select the best alternatives in each case.
Topics: Crutches; Feedback; Forearm; Gait; Humans; Pilot Projects; Software; Technology
PubMed: 34550073
DOI: 10.2196/27602 -
Nanoscale Aug 2021Lead-based halide perovskites have been proposed as potential candidates for resistive switching memristors due to the high ON/OFF ratio along with millivolt-level low...
Lead-based halide perovskites have been proposed as potential candidates for resistive switching memristors due to the high ON/OFF ratio along with millivolt-level low operational voltage. However, lead-free perovskites with 3-dimensional structures, such as CsAgBiBr, were reported to suffer from low ON/OFF ratios. We report here that reduction of dimensionality is an effective method to improve remarkably the ON/OFF ratio in lead-free perovskites. Introduction of butylammonium (BA) into the double perovskite CsAgBiBr forms 2-dimensional BACsAgBiBr, which is confirmed by the well-developed (00l) peaks from powder X-ray diffraction. A 230 nm thick BACsAgBiBr film is sandwiched in between Ag and Pt electrodes, which demonstrates bipolar resistive switching behavior with a potential ON/OFF ratio up to 10. Reliable and reproducible SET and RESET processes occur at +0.13 V and -0.20 V, respectively. Endurance of 1000 cycles and a retention time of 2 × 10 s are measured. Multi-level storage capability is confirmed by controlling the compliance current. Schottky conduction at the high resistance state (HRS) and ohmic conduction at the low resistance state (LRS) are found to be responsible for resistive switching. The stability test at 85 °C or for 22 days under ambient conditions indicates that BACsAgBiBr is durably operable.
PubMed: 34477612
DOI: 10.1039/d1nr03245c -
Saudi Journal of Biological Sciences Aug 2021Asthma as chronic airway disease has high prevalence in children and imbalance of Th1/Th2 is a critical mechanism in pathogenesis of the asthma. Baicalein as a cell...
Asthma as chronic airway disease has high prevalence in children and imbalance of Th1/Th2 is a critical mechanism in pathogenesis of the asthma. Baicalein as a cell protective and anti-inflammatory flavonoid may have anti-asthma effect. Therefore, for better using lung, baicalein was used in chitosan-nanoparticle as anti-asthma treatment. Baicalein was loaded and encapsulated in chitosan nanoparticle. The morphology, physical characters (particle size, zeta potential and FT-IR) were analyzed. Drug encapsulation and loading capacity, accumulative release-time were studied. After asthma model producing, the mice were treated with L-B-NP and E-B-NP. At least, MCh challenge test, Cytokines measurement and Lung Histopathology were done. Nanoparticles had average size 285 ± 25 nm with negative charge -2.5 mV. The L-B-NP decreased penh value and E-B-NP decreased inflammation. Both nanoparticles increased IL-12 and decreased IL-5. Also, L-B-NP decreased mucus secretion in bronchi. L-B-NP and E-B-NP control immune-allergo-inflammatory response of asthma. L-B-NP controlled AHR and E-B-NP controlled inflammation that can be used as controlling anti-asthma drug.
PubMed: 34354413
DOI: 10.1016/j.sjbs.2021.04.009