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Pediatric Blood & Cancer Mar 2022
Topics: Adolescent; Head and Neck Neoplasms; Hemangiopericytoma; Humans; Immunohistochemistry; Male; Myopericytoma
PubMed: 34665513
DOI: 10.1002/pbc.29406 -
Annales de Pathologie Nov 2021Glomus tumor are rare mesenchymal neoplasm, belonging to the pericytic (perivascular) tumor family, witch recent molecular characterization has allowed highlight...
Glomus tumor are rare mesenchymal neoplasm, belonging to the pericytic (perivascular) tumor family, witch recent molecular characterization has allowed highlight recurrent molecular abnormalities. In fact, glomus tumor involves frequent MIR143-NOTCH gene fusion whereas others pericytic tumor (myopericytoma and myofibroma) involve mutations of PDGFRB gene. Glomus tumor are usually developed in superficial localization. However visceral locations have been described. Cardiac location is exceptional with only one case reported in literature. Here, we report the case of cardiac glomus tumor (glomangiomyoma) developed in the left ventricle in a 34 year-old patient, diagnosed after chest pain. The length of tumor was 4cm in greatest dimension. Histologically, the tumor concerned both round glomus cells and smooth muscle cells with prominent branching thin-walled vessels. By immunohistochemistry, these two contingents exhibited diffuse expression of smooth muscle actin and heterogeneous expression of H-caldesmone whereas cytokeratins, melanocytic markers and chomogranine were negative. Next Generation molecular analysis using RNA sequencing highlighted the characteristic MIR143-NOTCH gene fusion witch supports the diagnosis of glomus tumor. In this observation, we recall histological and immunohistochemistry features of glomus tumor and we make a synthesis concerning the molecular data recently described in sporadic glomus tumor.
Topics: Adult; Biomarkers, Tumor; Glomus Tumor; Humans; Immunohistochemistry; MicroRNAs; Myofibroma; Pericytes
PubMed: 34629216
DOI: 10.1016/j.annpat.2021.06.007 -
Chinese Medical Journal Sep 2021
Topics: Castleman Disease; Fluorodeoxyglucose F18; Humans; Myopericytoma; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 34561326
DOI: 10.1097/CM9.0000000000001626 -
Journal of Orthopaedic Case Reports May 2021Myopericytoma (MPC) is an uncommon benign smooth muscle cell neoplasm which frequently arises in lower extremities, sparsely they can be found in upper extremities and...
INTRODUCTION
Myopericytoma (MPC) is an uncommon benign smooth muscle cell neoplasm which frequently arises in lower extremities, sparsely they can be found in upper extremities and head and neck region. Very few case reports are available in the literature documenting hand localization of this tumor.
CASE PRESENTATION
In this report, we present a case of 83-year-old male individual with a mass lesion on the proximal phalanx of index finger of the right hand. Recent trivial trauma led the patient to medical assistance. Imaging mimicked Giant cell tumor of tendon sheath due to site of the lesion. The lesion was excised surgically. The final diagnosis of the specimen confirmed by histopathology was MPC, a benign smooth-muscle cell neoplasm.
CONCLUSION
MPC is a rare entity; however, definitive diagnosis is often challenging because it mimics some malignant soft-tissue neoplasms. A multidisciplinary approach is required to identify this lesion as being benign and thus define the correct modality of treatment.
PubMed: 34557448
DOI: 10.13107/jocr.2021.v11.i05.2220 -
International Journal of Surgery Case... Sep 2021Angioleiomyoma is a rare benign soft tissue tumor of smooth muscle getting its origin from the muscular layer of vessel walls. The localized type of leiomyoma occurs on...
INTRODUCTION AND IMPORTANCE
Angioleiomyoma is a rare benign soft tissue tumor of smooth muscle getting its origin from the muscular layer of vessel walls. The localized type of leiomyoma occurs on the skin, deep soft tissues, in the genitourinary, gastrointestinal, and respiratory tracts.
CASE PRESENTATION
We report a case of a 16-year-old patient who presented with an intra-articular leiomyoma developed in the anterior cruciate ligament and treated with arthroscopy.
CLINICAL DISCUSSION
Angioleiomyoma can occur anywhere in the body and is most often seen in the extremities, particularly the lower limbs, but is very rare in the knee joint. Angioleiomyoma should be included in the differential diagnosis of nodular lesions mimicking loose body, such as lipomas, inclusion cysts, ganglion, pigmented villonodular synovitis (PVNS), fibroma, nodular synovitis, hemangioma, synovial sarcoma, myopericytoma, leiomyosarcomas, glomus tumor.
CONCLUSION
Angioleiomyoma related to the cruciate ligaments of the knee should be considered in the differential diagnosis of a painful knee especially when associated with a decreased of range of motion of knee. The arthroscopic debridement should be considered the treatment of choice in order to reliably restore active ROM.
PubMed: 34419722
DOI: 10.1016/j.ijscr.2021.106320 -
International Journal of Molecular... Jul 2021We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other... (Review)
Review
We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis-e.g., interface (erythema multiforme), acantholytic (pemphigus, Hailey-Hailey disease), lichenoid (lichen planus), subepidermal vesicular (bullous pemphigoid), psoriasiform (psoriasis), granulomatous (granuloma annulare)-vasculitis (leukocytoclastic and lymphocytic vasculitis), folliculitis, perifolliculitis and inflammation of the sweat and sebaceous glands (perifolliculitis and rosacea) and infectious dermatitis (verruca vulgaris). In skin tumor and tumor-like conditions, we studied examples of those in which CD34+ stromal cells are (1) the neoplastic component (dermatofibrosarcoma protuberans, sclerotic fibroma and solitary fibrous tumor), (2) a neoplastic component with varying presentation (fibroepithelial polyp and superficial myxofibrosarcoma) and (3) a reactive component in other tumor/tumor-like cell lines, such as those deriving from vessel periendothelial cells (myopericytoma), epithelial cells (trichoepithelioma, nevus sebaceous of Jadassohn and seborrheic keratosis), Merkel cells (Merkel cell carcinoma), melanocytes (dermal melanocytic nevi) and Schwann cells (neurofibroma and granular cell tumor).
Topics: Animals; Antigens, CD34; Dermatitis; Dermis; Humans; Neoplasm Proteins; Skin Neoplasms; Telocytes
PubMed: 34298962
DOI: 10.3390/ijms22147342 -
International Journal of Surgery Case... Aug 2021Myopericytoma (MPC) is a rare benign soft tissue neoplasm that arises from perivascular smooth muscle-like myoid cells that share features of both glomus and smooth...
INTRODUCTION AND IMPORTANCE
Myopericytoma (MPC) is a rare benign soft tissue neoplasm that arises from perivascular smooth muscle-like myoid cells that share features of both glomus and smooth muscle cells. It usually slow growing solitary tumor that might mimic aggressive sarcoma.
CASE PRESENTATION
45 years old male, with unremarkable medical history, presented with fast growing mass on the left 1st webspace that was noticed 6 months prior to presentation. Investigations with US and MRI showed highly vascular solid mass that was worrisome for malignant lesion. Surgical excision was done and histopathology confirmed the diagnosis of myopericytoma.
CLINICAL DISCUSSION
MPC is a rare perivascular neoplasm that's reported mainly in the extremities with lower limbs are most affected sites. Usually it presents as solid painless slowly growing mass. However, Multiple papers reported different rare presentations like multiple, painful and some with malignant transformation.
CONCLUSION
MPC is a benign tumor that might mimic aggressive sarcoma. Such cases should be approached with high suspicion and proper investigation and management should be followed promptly.
PubMed: 34298419
DOI: 10.1016/j.ijscr.2021.106220 -
British Journal of Neurosurgery Jun 2024Malignant myopericytoma is an exceedingly rare soft tissue tumour with only 14 documented cases in the scientific literature. Myopericytomas can occur in association... (Review)
Review
Malignant myopericytoma is an exceedingly rare soft tissue tumour with only 14 documented cases in the scientific literature. Myopericytomas can occur in association with HIV-AIDS and have a predilection for internal organs such as the bronchus, larynx, liver and brain. Ebstein-Barr virus encoded small RNA(EBER) was positive in three out of 14 cases. In this case report we present the second documented case of a malignant myopericytoma, with a positive EBER found intracranially - specifically in the supratentorial compartment - invading the superior sagittal sinus. Gross total excision of the tumour was achieved, and the patient responded well with no recurrence with only highly active antiretroviral therapy (HAART). No chemotherapy or radiotherapy has been necessary.
Topics: Humans; Myopericytoma; Male; Brain Neoplasms; Middle Aged; Antiretroviral Therapy, Highly Active; Magnetic Resonance Imaging; HIV Infections; Female; Adult
PubMed: 34259108
DOI: 10.1080/02688697.2021.1950630 -
Child's Nervous System : ChNS :... Mar 2022Myopericytomas are benign soft tissue tumors which are rarely found as intracranial masses. (Review)
Review
BACKGROUND
Myopericytomas are benign soft tissue tumors which are rarely found as intracranial masses.
METHODS
A review of SCOPUS and PubMed databases for case reports and case series was done for patients with intracranial myopericytomas. Data on demographics, clinical features, imaging, surgical management employed, and outcomes were collected.
RESULTS
We found a total of 9 cases in the literature and we describe an additional case from our own experience. The mean age at presentation was 50.1 years (32-64 years), with a female predominance. Most tumors were in the posterior fossa and were multifocal in AIDS patients. The most common clinical manifestations were visual disturbances, headaches, and vomiting. An association with EBV was reported in two cases and was also found in our own case. Gross total excision and even subtotal excision were definitive therapies with no recurrences reported with a mean follow-up of 22.7 months. Our case is the first EBV-associated intracranial myopericytoma in a child.
CONCLUSION
Intracranial myopericytomas are rare; some have an association with EBV and immunodeficient states. Surgery is the only necessary treatment and outcomes are generally favorable for these benign neoplasms.
Topics: Brain Neoplasms; Child; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Male; Myopericytoma; Soft Tissue Neoplasms
PubMed: 34104988
DOI: 10.1007/s00381-021-05220-w -
Otology & Neurotology : Official... Oct 2021
Topics: Humans; Mastoid; Myopericytoma
PubMed: 33993144
DOI: 10.1097/MAO.0000000000003173