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Journal of the European Academy of... Feb 2016
Review
Topics: Administration, Topical; Aminoquinolines; Antineoplastic Agents; Biopsy; Female; Follow-Up Studies; Humans; Imiquimod; Middle Aged; Pagetoid Reticulosis; Skin; Skin Neoplasms
PubMed: 25258027
DOI: 10.1111/jdv.12718 -
Histopathology May 2015CD30-positive primary cutaneous lymphoproliferative disorders include several entities with differing clinical presentation but overlapping histological features,...
AIMS
CD30-positive primary cutaneous lymphoproliferative disorders include several entities with differing clinical presentation but overlapping histological features, including lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma (C-ALCL). DUSP22-IRF4 locus translocation is present in 20-57% of C-ALCLs, and has also been described in a series of 11 lymphomatoid papulosis patients, where it was associated with a particular biphasic histological pattern, including pagetoid reticulosis-type epidermal infiltration. We aimed to study whether the presence of this translocation may define distinctive histological features in C-ALCL.
METHODS AND RESULTS
We collected three cases of C-ALCL with histological features similar to those described in the new variant of lymphomatoid papulosis with 6p25.3 rearrangement. We studied their histological features and immunophenotype, using a panel of antibodies against CD30, TCR-βF1, TCR-γ, CD4, CD8, CD20, Ki-67 and ALK. FISH analyses were performed using an IRF4-DUSP22 break-apart probe for the study of the 6p25.3 rearrangement. FISH results were positive in the three cases, which all showed distinctive histological and immunohistochemical features: a diffuse dermal infiltrate of atypical medium-to-large cells, and marked epidermotrophism with small, atypical intra-epidermal lymphocytes.
CONCLUSIONS
Our findings suggest that the presence of 6p25.3 rearrangement might be related to this particular biphasic pattern.
Topics: Aged; Chromosomes, Human, Pair 6; Female; Gene Rearrangement; Humans; Immunophenotyping; In Situ Hybridization, Fluorescence; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Male; Middle Aged; Skin Neoplasms
PubMed: 25131361
DOI: 10.1111/his.12529 -
Surgical Pathology Clinics Jun 2014Mycosis fungoides (MF) is a cutaneous T-cell lymphoma that usually manifests as patches and plaques with a propensity for nonphotoexposed areas. MF is a common mimicker... (Review)
Review
Mycosis fungoides (MF) is a cutaneous T-cell lymphoma that usually manifests as patches and plaques with a propensity for nonphotoexposed areas. MF is a common mimicker of inflammatory and infectious skin diseases, because it can be manifested with a wide variety of clinical and pathologic presentations. These atypical presentations of MF may be difficult to diagnose, requiring a high level of suspicion and careful clinicopathologic correlation. Within this array of clinical presentations, the World Health Organization classification recognizes 3 MF variants: folliculotropic MF, pagetoid reticulosis, and granulomatous slack skin. These 3 variants, as well as hypopigmented MF, are addressed in this article.
PubMed: 26837197
DOI: 10.1016/j.path.2014.02.003 -
Dermatologic Therapy 2014A cutaneous lymphoproliferative disorder, localized pagetoid reticulosis (LPR), is rare but distinctive in its clinical and histopathological manifestations. Without an...
A cutaneous lymphoproliferative disorder, localized pagetoid reticulosis (LPR), is rare but distinctive in its clinical and histopathological manifestations. Without an evidence-based medicine treatment guideline because of extremely low incidence, LPR poses a therapeutic challenge. We describe a 67-year-old Chinese woman with LRP who showed complete response to narrow-band ultraviolet B combined with intramuscular interferon alpha-2b.
Topics: Aged; Combined Modality Therapy; Female; Humans; Interferon alpha-2; Interferon-alpha; Pagetoid Reticulosis; Recombinant Proteins; Skin Neoplasms; Treatment Outcome; Ultraviolet Therapy
PubMed: 24673843
DOI: 10.1111/dth.12123 -
Journal of Cutaneous Pathology Sep 2014Cutaneous T-cell lymphomas (CTCL) account for almost 65-92% of all cutaneous lymphomas, many of which usually present with multiple lesions. However, a number of... (Review)
Review
Cutaneous T-cell lymphomas (CTCL) account for almost 65-92% of all cutaneous lymphomas, many of which usually present with multiple lesions. However, a number of well-recognized and rare types of CTCL, including mycosis fungoides, can present in isolated fashion. These solitary lesions often run a relatively indolent clinical course but often pose diagnostic difficulties. We review histopathologically challenging solitary cutaneous T-cell lymphomas, including criteria for diagnosis, clinical course and prognosis, particularly for primary cutaneous CD4+ small/medium pleomorphic lymphoma and indolent CD8+ lymphoid proliferation of acral sites. In addition, we suggest an algorithm and nomenclature to aid in the diagnosis of such problematic lesions.
Topics: Diagnosis, Differential; Disease Progression; Humans; Lymphoma, T-Cell, Cutaneous; Prognosis; Skin Neoplasms
PubMed: 24666254
DOI: 10.1111/cup.12353 -
Anais Brasileiros de Dermatologia 2013Ketron-Goodman disease was formerly considered a disseminated type of pagetoid reticulosis. However, according to the new classification consensus, it should be regarded...
Ketron-Goodman disease was formerly considered a disseminated type of pagetoid reticulosis. However, according to the new classification consensus, it should be regarded as aggressive epidermotropic CD8 T-cutaneous lymphoma, cutaneous gamma/delta T-lymphoma, or tumor-stage mycosis fungoides, depending on the clinical-histological picture. This case highlights a rare and challenging presentation of Ketron-Goodman disease with an indolent presentation and evolution and good response to a low-grade treatment regimen, not fitting well into the new classification criteria.
Topics: Biopsy; Humans; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Pagetoid Reticulosis; Skin Neoplasms; Time Factors; Treatment Outcome
PubMed: 24173195
DOI: 10.1590/abd1806-4841.20132258 -
Journal Der Deutschen Dermatologischen... Dec 2013
Topics: Aged; Alitretinoin; Antineoplastic Agents; Hand; Humans; Male; Pagetoid Reticulosis; Skin Neoplasms; Treatment Outcome; Tretinoin
PubMed: 23879462
DOI: 10.1111/ddg.12166 -
Skinmed 2013
Topics: Diagnosis, Differential; Humans; Pagetoid Reticulosis; Skin Neoplasms
PubMed: 23540072
DOI: No ID Found -
Cutis Dec 2012Woringer-Kolopp disease, also known as localized pagetoid reticulosis, is a rare cutaneous lymphoproliferative disorder classified as a solitary variant of mycosis...
Woringer-Kolopp disease, also known as localized pagetoid reticulosis, is a rare cutaneous lymphoproliferative disorder classified as a solitary variant of mycosis fungoides (MF). Despite the indolent and benign nature of the disease, misdiagnosis and inappropriate treatment may result in years of debilitating symptoms and even loss of function. We present the case of a patient with long-standing Woringer-Kolopp disease that mimicked foot dermatitis. Histopathologic examination demonstrated epidermotropic infiltration of atypical lymphocytes that were CD3+ CD4- CD8-. The patient was successfully treated with topical keratolytics and bexarotene gel 1% with minimal residual lesions after 8 years of follow-up. We discuss the characteristics of this rare disease in contrast with localized MF as well as more aggressive forms of epidermotropic T-cell lymphoma.
Topics: Aged; Anticarcinogenic Agents; Bexarotene; CD3 Complex; Dermatologic Agents; Diagnosis, Differential; Foot Dermatoses; Humans; Male; Pagetoid Reticulosis; Skin Neoplasms; T-Lymphocytes; Tetrahydronaphthalenes; Urea
PubMed: 23409481
DOI: No ID Found -
The American Journal of Surgical... Mar 2013Primary cutaneous γδ T-cell lymphomas (PCGD-TCLs) are considered a subgroup of aggressive cytotoxic T-cell lymphomas (CTCLs). We have taken advantage of a new,...
Primary cutaneous γδ T-cell lymphomas (PCGD-TCLs) are considered a subgroup of aggressive cytotoxic T-cell lymphomas (CTCLs). We have taken advantage of a new, commercially available antibody that recognizes the T-cell receptor-γ (TCR-γ) subunit of the TCR in paraffin-embedded tissue. We have analyzed a series of 146 primary cutaneous T-cell lymphomas received for consultation or a second opinion in the CNIO Pathology Department. Cases were classified according to the World Health Organization 2008 classification as mycosis fungoides (MF; n=96), PCGD-TCLs (n=5), pagetoid reticulosis (n=6), CD30(+) primary cutaneous anaplastic large cell lymphomas (n=5), primary cutaneous CD8 aggressive epidermotropic CTCLs (n=3), primary cutaneous CTCL, not otherwise specified (n=4), and extranodal nasal-type NK/T-cell lymphomas primarily affecting the skin or subcutaneous tissue (n=11). Sixteen cases of the newly named lymphomatoid papulosis type D (LyP-D; n=16) were also included. In those cases positive for TCR-γ, a further panel of 13 antibodies was used for analysis, including TIA-1, granzyme B, and perforin. Clinical and follow-up data were recorded in all cases. Twelve cases (8.2%) were positive for TCR-γ, including 5 PCGD-TCLs, 2 MFs, and 5 LyP-Ds. All 5 PCGD-TCL patients and 1 MF patient died of the disease, whereas the other MF patient and all those with LyP-D were alive. All cases expressed cytotoxic markers, were frequently CD3(+)/CD8(+), and tended to lose CD5 and CD7 expressions. Eight of 12 and 5 of 11 cases were CD30(+) and CD56(+), respectively. Interestingly, 5/12 TCR-γ-positive cases also expressed TCR-BF1. All cases analyzed were negative for Epstein-Barr virus-encoded RNA. In conclusion, TCR-γ expression seems to be rare and is confined to cytotoxic primary cutaneous TCLs. Nevertheless, its expression is not exclusive to PCGD-TCLs, as TCR-γ protein can be found in other CTCLs. Moreover, its expression does not seem to be associated with bad prognosis by itself, as it can be found in cases with good and bad outcomes.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Immunohistochemistry; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Polymerase Chain Reaction; Receptors, Antigen, T-Cell, gamma-delta; Skin Neoplasms; Tissue Array Analysis
PubMed: 23348211
DOI: 10.1097/PAS.0b013e318275d1a2