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European Journal of Dermatology : EJD Dec 2023
Topics: Humans; Gastrointestinal Stromal Tumors; Pyrazoles; Pyrroles; Panniculitis; Mutation; Gastrointestinal Neoplasms; Protein Kinase Inhibitors; Antineoplastic Agents; Receptor, Platelet-Derived Growth Factor alpha; Triazines
PubMed: 38465561
DOI: 10.1684/ejd.2023.4632 -
Cureus Feb 2024Mesenteric panniculitis belongs to a spectrum of rare diseases affecting the fatty tissue of the mesentery. It is characterized by chronic inflammation and fibrosis of...
Mesenteric panniculitis belongs to a spectrum of rare diseases affecting the fatty tissue of the mesentery. It is characterized by chronic inflammation and fibrosis of the mesenteric adipose tissue of the bowel. Patients typically present with symptoms such as abdominal pain, nausea, vomiting, anorexia, bloating, and weight loss. Computed tomography (CT) is commonly used for diagnosis in most cases. We present a case of a 42-year-old male who experienced a significant escalation of abdominal pain over a 24-hour period. Despite seeking medical care at multiple hospitals and being prescribed analgesics, his pain remained unrelieved. Based on CT findings and the worsening pain, mesenteric panniculitis was suspected, leading to a diagnostic laparoscopy that confirmed the diagnosis. The patient was treated for idiopathic isolated mesenteric panniculitis during his hospital stay and was subsequently discharged. This article emphasizes the importance of considering mesenteric panniculitis as a possible differential diagnosis in patients with nonspecific abdominal pain, to avoid overlooking this condition.
PubMed: 38465096
DOI: 10.7759/cureus.53776 -
Revista Da Sociedade Brasileira de... 2024We report a case of eosinophilic meningitis associated with the ingestion of raw fish (Cichla sp.) from the Brazilian Amazon, likely caused by Gnathostoma. A 36-year-old...
We report a case of eosinophilic meningitis associated with the ingestion of raw fish (Cichla sp.) from the Brazilian Amazon, likely caused by Gnathostoma. A 36-year-old male visited Juruena river on a fishing trip. After 50 days, the patient presented with an intense frontal headache. A cerebrospinal fluid examination revealed 63% eosinophilia. Another individual who ingested raw fish developed linear dermatitis on the abdominal wall. Anti-Gnathostoma serum antibodies were detected, and the patient made a full recovery after treatment with corticosteroids and albendazole. To date, autochthonous Gnathostoma spp. infections in Latin American countries have only caused linear panniculitis. This report raises awareness of gnathostomiasis-causing meningitis.
Topics: Animals; Male; Humans; Adult; Gnathostomiasis; Brazil; Meningitis; Albendazole; Eating
PubMed: 38451691
DOI: 10.1590/0037-8682-0434-2023 -
Clinical Case Reports Mar 2024Subcutaneous panniculitis-like T-cell lymphoma, a primary cutaneous lymphoma, which is described as following a slow course, could claim life. The occurrence of facial...
KEY CLINICAL MESSAGE
Subcutaneous panniculitis-like T-cell lymphoma, a primary cutaneous lymphoma, which is described as following a slow course, could claim life. The occurrence of facial and breast nodules, the association with hemophagocytic lymphohistiocytosis, and the extent of necrosis and ulceration are signs of its aggressive nature needing early diagnosis and prompt treatment.
ABSTRACT
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare skin disease that accounts for <1% of all peripheral T-cell lymphomas. It is described as following a slow and gradual process. However, it can be associated with a variety of clinical symptoms ranging from mild to severe. Hemophagocytic lymphohistiocytosis (HLH), a rare and potentially fatal hematologic factor that complicates SPTCL in 20% of cases, is an important prognostic factor. We report here an aggressive case of disseminated SPTCL with HLH involving a young woman who presented with extensive necrosis and ulceration at diagnosis. The report highlights the aggressive course of the disease, the occurrence of facial and breast nodules, the association with HLH, and the extent of necrosis and ulceration. The report highlights the poor prognosis despite polychemotherapy regimen use.
PubMed: 38449891
DOI: 10.1002/ccr3.8342 -
Journal of Plastic, Reconstructive &... Apr 2024Subcutaneous fat necrosis of the newborn (SCFN) is a rare form of panniculitis manifesting as erythematous plaques or nodules at sites of brown fat in neonates. Surgical... (Review)
Review
BACKGROUND
Subcutaneous fat necrosis of the newborn (SCFN) is a rare form of panniculitis manifesting as erythematous plaques or nodules at sites of brown fat in neonates. Surgical management may be indicated in severe cases; however, there is a paucity of literature compiling presentations and outcomes of these surgical patients.
METHODS
The authors performed a systematic review, in consultation with a licensed librarian, on MEDLINE and Embase for studies including patients with SCFN who were surgically managed.
RESULTS
The search strategy generated 705 results, among which 213 (30.2%) were excluded for lack of discussion on surgical management. Twenty-two studies discussed surgical management of SCFN in 26 patients, but in 6 of these studies the patients were not surgically managed. Ultimately, 16 articles with 16 patients who were surgically managed were included in the study. Average age at diagnosis was 11.8 ± 9.8 days; average age at surgery was 39.5 ± 70.4 days. The most common etiologies were "unknown" (6, 37.5%), therapeutic hypothermia (4, 25.0%), and birth complications (4, 25.0%). Patients harbored nodules on the back (14, 87.5%), upper extremities (7, 43.8%), lower extremities (7, 43.8%), buttocks (5, 31.3%), and head or neck (3, 18.8%). Linear regression models revealed the presence of back lesions and predicted concomitant medical complications (β = 2.71, p = 0.021).
CONCLUSIONS
Patients undergoing surgical management for SCFN most commonly harbor lesions on the back and extremities that are secondary to therapeutic hypothermia or of unknown origin. Reporting of additional cases is needed to further elucidate surgical management and outcomes.
Topics: Infant, Newborn; Humans; Infant; Subcutaneous Fat; Fat Necrosis; Panniculitis; Hypothermia, Induced; Buttocks
PubMed: 38442509
DOI: 10.1016/j.bjps.2024.02.027 -
Sultan Qaboos University Medical Journal Feb 2024
Topics: Humans; Panniculitis, Lupus Erythematosus; Lymphoma, T-Cell
PubMed: 38434474
DOI: 10.18295/squmj.2.2024.012 -
Clinical and Experimental Dermatology Mar 2024
PubMed: 38430108
DOI: 10.1093/ced/llae071 -
Dermatologic Clinics Apr 2024Neutrophilic panniculitides are a heterogeneous group of inflammatory disorders encompassing many different entities. This review article focuses on the epidemiology,... (Review)
Review
Neutrophilic panniculitides are a heterogeneous group of inflammatory disorders encompassing many different entities. This review article focuses on the epidemiology, pathogenesis, clinicopathological features, diagnosis, and treatment of selected diseases. Patients often seek care due to systemic involvement, but the variable presentation of panniculitides can present a diagnostic challenge. Most therapeutic modalities for neutrophilic disorders are anecdotal at best with a notable lack of standardization of the responses to medications. There is an urgent need for a larger multi-institutional collaboration to address the unmet needs of these challenging, yet rare conditions.
Topics: Humans; Panniculitis
PubMed: 38423687
DOI: 10.1016/j.det.2023.08.005 -
The Australasian Journal of Dermatology May 2024
Topics: Humans; Dermatitis, Atopic; Antibodies, Monoclonal, Humanized; Erythema Induratum; Female; Male; Adult
PubMed: 38421820
DOI: 10.1111/ajd.14238 -
Journal of the European Academy of... Feb 2024
Therapeutic efficacy of allogenic haematopoietic stem cell transplantation from an appropriate sibling donor to a patient with subcutaneous panniculitis-like T-cell lymphoma with a germline homozygous HAVCR2 mutation.
PubMed: 38421052
DOI: 10.1111/jdv.19926