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Cancer Letters Jan 1982The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by...
The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by drug/nitrite interaction was examined. On the reaction of 50 micrometers drug and 500 micrometers nitrite at pH 3.0--3.4 and 37 degrees C for 4 h, the considerable formation of nitroso compounds was observed for ethambutol, cinnarizine and pyridinol carbamate. The reaction product of pyridinol carbamate and nitrite was remarkably mutagenic to Salmonella typhimurium TA100 in the absence of S-9 mix. Under conditions presumed to resemble those in the stomach after ingestion of a therapeutic dose of the drug, the formation of nitroso compounds was observed for ethambutol and significant mutagenicity was detected in the reaction product of pyridinol carbamate.
Topics: Benzothiazoles; Cinnarizine; Ethambutol; Mutagens; Nitrites; Nitroso Compounds; Piperazines; Piromidic Acid; Pyridinolcarbamate; Salmonella typhimurium; Thiazoles
PubMed: 7037170
DOI: 10.1016/0304-3835(82)90075-1 -
Journal of Bacteriology Nov 1981In Escherichia coli K-12 mutants which had a new nalidixic acid resistance mutation at about 82 min on the chromosome map, cell growth was resistant to or...
In Escherichia coli K-12 mutants which had a new nalidixic acid resistance mutation at about 82 min on the chromosome map, cell growth was resistant to or hypersusceptible to nalidixic acid, oxolinic acid, piromidic acid, pipemidic acid, and novobiocin. Deoxyribonucleic acid gyrase activity as tested by supercoiling of lambda phage deoxyribonucleic acid inside the mutants was similarly resistant or hypersusceptible to the compounds. The drug concentrations required for gyrase inhibition were much higher than those for cell growth inhibition but similar to those for inhibition of lambda phage multiplication. Transduction analysis with lambda phages carrying the chromosomal fragment of the tnaA-gyrB region suggested that one of the mutations, nal-31, was located on the gyrB gene.
Topics: Bacteriophage lambda; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Mutation; Nalidixic Acid; Transduction, Genetic
PubMed: 6271730
DOI: 10.1128/jb.148.2.450-458.1981 -
Ugeskrift For Laeger Sep 1981
Clinical Trial Randomized Controlled Trial
[Patients with symptoms of acute urinary infections treated with piromidic acid or sulfamethizole in general practice. A double-blind clinical controlled multicentre study].
Topics: Acute Disease; Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotinic Acids; Piromidic Acid; Sulfamethizole; Sulfathiazoles; Urinary Tract Infections
PubMed: 7029845
DOI: No ID Found -
Deutsche Medizinische Wochenschrift... Apr 1981
Topics: Acute Kidney Injury; Aged; Female; Humans; Nicotinic Acids; Piromidic Acid
PubMed: 7215176
DOI: No ID Found -
Chemical & Pharmaceutical Bulletin Aug 1980
Topics: Bacteria; Nicotinic Acids; Piromidic Acid
PubMed: 7428132
DOI: 10.1248/cpb.28.2531 -
La Clinica Terapeutica Sep 1979
Topics: Adolescent; Adult; Bacterial Infections; Female; Humans; Nicotinic Acids; Piromidic Acid; Pregnancy; Pregnancy Complications, Infectious; Puerperal Disorders; Urinary Tract Infections
PubMed: 535334
DOI: No ID Found -
Bollettino Chimico Farmaceutico Jul 1979
Topics: Bacteria; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Nicotinic Acids; Oxolinic Acid; Piromidic Acid; Urinary Tract Infections
PubMed: 526354
DOI: No ID Found -
Zentralblatt Fur Bakteriologie,... 1979Hexacyanoferrate-compounds are suitable to indicate the efficacy of antimicrobial substances to sulfate-reducing bacteria. They act as a cytochemical indicator system....
Hexacyanoferrate-compounds are suitable to indicate the efficacy of antimicrobial substances to sulfate-reducing bacteria. They act as a cytochemical indicator system. (Stübner, 9), e. g. K3FeIII(CN)6 showes FeS formation before any visible blackening of the medium. By using hexacyanoferrate compounds it is easier to determine the efficacy of antimicrobial agents. In addition a microscopical control is recommended to detect damaged or avital bacteria in the limiting concentrations of the agents.
Topics: Acridines; Anti-Bacterial Agents; Cephalothin; Chloramines; Desulfovibrio; Ferrocyanides; Formaldehyde; Indicators and Reagents; Piromidic Acid
PubMed: 44792
DOI: No ID Found -
The Journal of Toxicological Sciences Nov 1978Pipemidic acid (PPA) orally given in a dose of 100 mg/kg/day or more was found to cause lame gait in immature beagle dogs of about 3 months old. Their diarthrodial...
Pipemidic acid (PPA) orally given in a dose of 100 mg/kg/day or more was found to cause lame gait in immature beagle dogs of about 3 months old. Their diarthrodial joints were abnormal with increased synovial fluid and blister formation under the outer layer of the articular cartilage. However, such an abnormality was not found in dogs younger than 2 weeks or older than 12 months. The blisters were formed at the joint areas bearing the body weight at a time when PPA was considered to be present there. Nalidixic and piromidic acids, structural analogues of PPA, also caused abnormality similar to PPA. The severity of the arthropathy was slight with piromidic acid as compared with PPA and nalidixic acid. The gait abnormality was almost disappeared spontaneously even if medication was continued. The incidence of the arthropathy was not or rarely observed in any young rats, rabbits and monkeys.
Topics: Aging; Animals; Dogs; Female; Gait; Haplorhini; Joint Diseases; Macaca; Macaca mulatta; Male; Nalidixic Acid; Nicotinic Acids; Physical Exertion; Pipemidic Acid; Piromidic Acid; Rabbits; Rats; Species Specificity
PubMed: 105148
DOI: 10.2131/jts.3.357 -
Antimicrobial Agents and Chemotherapy Aug 1978Spontaneous mutants with various patterns of resistance to pipemidic acid (PPA), piromidic acid (PA), and nalidixic acid (NAL) were isolated from Escherichia coli K-12....
Spontaneous mutants with various patterns of resistance to pipemidic acid (PPA), piromidic acid (PA), and nalidixic acid (NAL) were isolated from Escherichia coli K-12. Most mutants were less resistant to PPA than to PA and NAL, and some mutants resistant to PA and NAL were hypersusceptible to PPA. As for the mutants tested, resistance to the drugs was conferred by mutations at nalA and new nal genes designated as nalC and nalD, both of which were located at about 82 min on the recalibrated map. Resistance to PA and NAL was due to decreased sensitivity of the bacterial DNA synthesizing system to them and insufficient drug transport, whereas resistance to PPA was only due to the former.
Topics: Chromosome Mapping; Conjugation, Genetic; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Mutation; Nalidixic Acid; Nicotinic Acids; Pipemidic Acid; Piromidic Acid; Transduction, Genetic
PubMed: 358918
DOI: 10.1128/AAC.14.2.240