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JAAD Case Reports Mar 2022
PubMed: 35141383
DOI: 10.1016/j.jdcr.2021.12.018 -
Journal of the European Academy of... May 2022
Topics: COVID-19; Humans; Pityriasis Lichenoides; RNA, Messenger; Vaccination
PubMed: 35015904
DOI: 10.1111/jdv.17912 -
The American Journal of Dermatopathology Jun 2022Verruca plana in its regressing phase exhibits clinical and histological features distinct from classic verruca plana, but the ways in which these features should inform...
Verruca plana in its regressing phase exhibits clinical and histological features distinct from classic verruca plana, but the ways in which these features should inform treatment plans are still under investigation. We conducted a retrospective single-center analysis of 25 patients with features of classic verruca plana, or plane warts, who exhibited self-remission within 4 weeks of skin biopsy. Measures included lesion sites, clinical findings preceding regression, and histological analysis. Histological analysis involved review by 2 dermatologists followed by impressions given by 4 board-certified dermatologists who were blinded to the clinical characteristics of the patients. Histopathological findings of regressing plane warts showed superficial perivascular infiltration (96%), spongiosis and exocytosis (84%), basal vacuolization (64%), parakeratosis (64%), apoptotic keratinocytes (60%), and lichenoid infiltration (44%). These findings were more compatible with the histological patterns of pityriasis lichenoides, lichen planus, and spongiotic eczema, rather than classic verruca plana. This suggests that regressing verruca plana may be included in the differential diagnosis of lesions exhibiting a lichenoid or spongiotic reaction, and observation may be a favorable treatment plan in these patients.
Topics: Dermatologists; Humans; Lichen Planus; Retrospective Studies; Skin; Warts
PubMed: 34999600
DOI: 10.1097/DAD.0000000000002140 -
Pediatric Dermatology Nov 2021
Topics: Child; Exanthema; Humans; Necrosis; Pityriasis Lichenoides
PubMed: 34931361
DOI: 10.1111/pde.14713 -
JAAD Case Reports Feb 2022
PubMed: 34926748
DOI: 10.1016/j.jdcr.2021.11.021 -
Journal of the European Academy of... Mar 2022
Topics: BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Humans; Pharmaceutical Preparations; Pityriasis Lichenoides; SARS-CoV-2
PubMed: 34751995
DOI: 10.1111/jdv.17807 -
The Australasian Journal of Dermatology Feb 2022Pityriasis lichenoides chronica (PLC) lesions are reported to subside with post-inflammatory hypopigmentation (PIH); hence, the most widely perceived nature of... (Observational Study)
Observational Study
BACKGROUND/OBJECTIVES
Pityriasis lichenoides chronica (PLC) lesions are reported to subside with post-inflammatory hypopigmentation (PIH); hence, the most widely perceived nature of hypopigmented macules in PLC is PIH. However, to the best of our knowledge, no studies describing histopathological findings in these lesions are reported in literature. The aim of this study is to evaluate the hypopigmented lesions encountered in PLC patients and to shed light on their histopathological features.
METHODS
A cross-sectional observational study included twenty-one patients with PLC recruited in a period of twelve months. Clinical characteristics of each patient were collected. A skin biopsy from hypopigmented lesions whenever present was taken and assessed with routine haematoxylin and eosin stain.
RESULTS
Seventeen patients (81%) were less than 13 years old. Most patients (85.7%) demonstrated diffuse distribution of lesions. Hypopigmented lesions were present on the face in 12 (57.14%) patients. Histopathologically, hypopigmented lesions showed features of post-inflammatory hypopigmentation in 19% of patients, residual PLC in 52.4% and active PLC 28.6% of patients.
CONCLUSION
Hypopigmented lesions in PLC were noted mainly in younger ages, histopathologically they may show features of active or residual disease, beyond post-inflammatory hypopigmentation. Consequently active treatment for patients presenting predominantly with hypopigmented lesions could be required to control the disease.
Topics: Adolescent; Adult; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Hypopigmentation; Male; Pityriasis Lichenoides
PubMed: 34751445
DOI: 10.1111/ajd.13746 -
International Journal of Clinical and... 2021Pityriasis lichenoides-like drug reactions simulate pityriasis lichenoides clinically and histopathologically, though important differences exist. As a rule, pityriasis...
Pityriasis lichenoides-like drug reactions simulate pityriasis lichenoides clinically and histopathologically, though important differences exist. As a rule, pityriasis lichenoides has minimal to no eosinophils. However, this case illustrates that pityriasis lichenoides-like drug reaction can present with numerous eosinophils. This, in our experience is not rare, but contrasts with clinical reports in the literature that describe pityriasis lichenoides-like drug reactions with minimal to no eosinophils in the infiltrate. While similar, distinguishing these diseases is important given that pityriasis lichenoides is a lymphoproliferative disorder with a more protracted clinical course that is difficult to treat. We provide histopathological clues to aid in this important distinction.
PubMed: 34646420
DOI: No ID Found -
JAMA Dermatology Nov 2021
Topics: Antibodies, Monoclonal, Humanized; Cytokines; Herpes Simplex; Humans; Nitriles; Pityriasis Lichenoides; Pyrazoles; Pyrimidines
PubMed: 34643656
DOI: 10.1001/jamadermatol.2021.4047 -
Clinical and Experimental Dermatology Feb 2022
Abrupt onset of Sweet syndrome, pityriasis rubra pilaris, pityriasis lichenoides et varioliformis acuta and erythema multiforme: unravelling a possible common trigger, the COVID-19 vaccine.
Topics: 2019-nCoV Vaccine mRNA-1273; Aged; Aged, 80 and over; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Erythema Multiforme; Female; Humans; Male; Middle Aged; Pityriasis Lichenoides; Pityriasis Rubra Pilaris; SARS-CoV-2; Sweet Syndrome
PubMed: 34617317
DOI: 10.1111/ced.14970