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Revista Alergia Mexico (Tecamachalco,... 2012Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Most HPV infections are cleared within two years by the immune system....
BACKGROUND
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Most HPV infections are cleared within two years by the immune system. Only in 5% to 10% of infected women the infection persists determining a high risk of developing cervical intraepithelial neoplasia. The transfer factor (TF) or dialyzable leukocyte extract is an immunomodulator that has been successfully used as an adjuvant in the treatment of intracelular infections such as recurrent herpes virus diseases.
METHODS
One daily dose of transfer factor was given for five days and subsequently each week for five weeks to a group of women with persistent genital papillomavirus infection.
RESULTS
We included 13 patients, aged 19 to 45 years, with first intercourse between the ages of 14 to 23, and a mean of three sexual partners in their lifetime. All of them had persistent HPV that had been treated before with local and ablative therapeutic options, including cervical freezing, cervical conization, cauterizing loop, imiquimod and podophyllin. Transfer factor was administered daily for 5 days, and subsequently at 7-day intervals for 5 weeks. We found a clinical significant improvement in the gynaecological evaluation of cervical, vaginal, vulvar and perineal lesions. No recurrences have developed for at least 1 year of follow-up.
CONCLUSIONS
The use of transfer factor in women with HPV showed resolution of genital lesions, without recurrences for at least one year after the treatment was ended.
Topics: Humans; Neoplasm Recurrence, Local; Papillomavirus Infections; Risk Factors; Transfer Factor; Uterine Cervical Neoplasms; Uterine Cervical Dysplasia
PubMed: 24007985
DOI: No ID Found -
American Family Physician Mar 2012The prevalence of benign anorectal conditions in the primary care setting is high, although evidence of effective therapy is often lacking. In addition to recognizing...
The prevalence of benign anorectal conditions in the primary care setting is high, although evidence of effective therapy is often lacking. In addition to recognizing common benign anorectal disorders, physicians must maintain a high index of suspicion for inflammatory and malignant disorders. Patients with red flags such as increased age, family history, persistent anorectal bleeding despite treatment, weight loss, or iron deficiency anemia should undergo colonoscopy. Pruritus ani, or perianal itching, is managed by treating the underlying cause, ensuring proper hygiene, and providing symptomatic relief with oral antihistamines, topical steroids, or topical capsaicin. Effective treatments for anal fissures include onabotulinumtoxinA, topical nitroglycerin, and topical calcium channel blockers. Symptomatic external hemorrhoids are managed with dietary modifications, topical steroids, and analgesics. Thrombosed hemorrhoids are best treated with hemorrhoidectomy if symptoms are present for less than 72 hours. Grades I through III internal hemorrhoids can be managed with rubber band ligation. For the treatment of grade III internal hemorrhoids, surgical hemorrhoidectomy has higher remission rates but increased pain and complication rates compared with rubber band ligation. Anorectal condylomas, or anogenital warts, are treated based on size and location, with office treatment consisting of topical trichloroacetic acid or podophyllin, cryotherapy, or laser treatment. Simple anorectal fistulas can be treated conservatively with sitz baths and analgesics, whereas complex or nonhealing fistulas may require surgery. Fecal impaction may be treated with polyethylene glycol, enemas, or manual disimpaction. Fecal incontinence is generally treated with loperamide and biofeedback. Surgical intervention is reserved for anal sphincter injury.
Topics: Anus Diseases; Condylomata Acuminata; Fissure in Ano; Hemorrhoids; Humans; Pruritus Ani; Rectal Diseases
PubMed: 22534276
DOI: No ID Found -
Journal of Lower Genital Tract Disease Jan 2012Verruciform xanthoma is a benign mucocutaneous, verrucous, papillary lesion characterized by large foam cells in the parakeratotic layer, lipid-laden macrophages...
BACKGROUND
Verruciform xanthoma is a benign mucocutaneous, verrucous, papillary lesion characterized by large foam cells in the parakeratotic layer, lipid-laden macrophages (xanthoma cells), epidermal hyperplasia, and hyperkeratosis. Verruciform xanthoma is thought to be a reactive rather than a neoplastic process secondary to epithelial damage and the presence of foamy histiocytes. The human papillomavirus has not been proven to be a causative factor. Differential diagnoses include verrucous carcinoma, condyloma acuminatum, seborrheic keratosis, verruca simplex, and vulvar intraepithelial neoplasia.
CASE
We describe the clinical and pathologic findings of a 16-year-old girl with verruciform xanthoma of the vulva, the third such reported case in an adolescent girl.
COMMENT
It is important to recognize this rare entity because it can mimic many other conditions, and the usual treatment modalities for wartlike growths on the vulva (i.e., imiquimod, podophyllin, and trichloroacetic acid) are not effective. Wide local excision seems to be the only effective and curative treatment modality for verruciform xanthoma, as has been reported in the literature and is such with our case.
Topics: Adolescent; Carcinoma, Verrucous; Female; Humans; Vulvar Neoplasms; Xanthomatosis
PubMed: 22126832
DOI: 10.1097/LGT.0b013e31822fcadd -
Lupus Mar 2012Females with systemic lupus erythematosus (SLE) have higher prevalence of human papillomavirus (HPV) infection, which can lead to the development of warts. Herein we...
INTRODUCTION
Females with systemic lupus erythematosus (SLE) have higher prevalence of human papillomavirus (HPV) infection, which can lead to the development of warts. Herein we report the first case of giant disseminated condylomatosis (GDC) in a SLE female on mycophenolate mofetil (MMF).
CASE REPORT
The patient, a 33-year-old, Black female, was diagnosed with SLE during her first pregnancy in 2003 based on the features of arthritis, skin rash, seizures, nephritis and presence of antinuclear antibodies. Her pregnancy resulted in preterm delivery of a stillborn fetus at 28 weeks. Since that time she has been treated with steroids and different regimens of immunosuppressive drugs such as cyclophosphamide, azathioprine and lately MMF. In the last few years she presented GDC involving the genital area in addition to skin on the lower abdomen. Topical therapy with trichloroacetic acid, imiquimod and podophyllin was only partially effective. Different types of HPV were identified in the lesions, being HPV-11 in abdomen, HPV 6, 11, 42 in vulva, HPV-6, 11 in vagina and HPV-6, 11 in endocervix.
CONCLUSIONS
GDC may be a complication of SLE, secondary to the disease itself, its treatment or other factors not yet identified.
Topics: Adult; Aminoquinolines; Condylomata Acuminata; Drug Therapy, Combination; Female; Humans; Imiquimod; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mycophenolic Acid; Papillomaviridae; Podophyllin; Treatment Outcome; Trichloroacetic Acid
PubMed: 21965277
DOI: 10.1177/0961203311421207 -
Journal of Child Neurology Feb 2012Accidental podophyllin poisoning is rare, but it can be associated with high morbidity and mortality. The authors describe severe encephalopathy and cerebral atrophy...
Accidental podophyllin poisoning is rare, but it can be associated with high morbidity and mortality. The authors describe severe encephalopathy and cerebral atrophy caused by accidental podophyllin ingestion in a 3-year-old boy. This case illustrates the permanent neurological damage in a developmentally normal child from a preventable cause.
Topics: Child, Preschool; Humans; Male; Muscle Spasticity; Peripheral Nervous System Diseases; Podophyllin
PubMed: 21911415
DOI: 10.1177/0883073811415682 -
Revista de Gastroenterologia de Mexico 2011Buschke-Löwenstein tumor is a slowly growing neoplasm with high potential of local invasion. We described a 29 year-old female with acquired immunodeficiency syndrome...
Buschke-Löwenstein tumor is a slowly growing neoplasm with high potential of local invasion. We described a 29 year-old female with acquired immunodeficiency syndrome who was surgically treated for a Buschke- Löwenstein tumor with a wide local excision, bilateral gluteal flaps and loop ileostomy. At 12 months follow-up, there was no evidence of recurrence. Despite it does not metastasize, Buschke-Löwenstein tumor has a high recurrence rate and a 50% risk of malignant transformation into squamous cell carcinoma. Surgery is considered the treatment of choice for this disease. Podophyllin, immunotherapy, interferon and radiotherapy are other treatments with a limited therapeutic response.
Topics: Adult; Anus Neoplasms; Buschke-Lowenstein Tumor; Condylomata Acuminata; Digestive System Surgical Procedures; Female; HIV Infections; Humans; Ileostomy
PubMed: 21724495
DOI: No ID Found -
Akusherstvo I Ginekologiia 2011The treatment of Condylomata acuminata often causes disappointment to both the physician and the patient since most of the current medical approaches require multiple... (Comparative Study)
Comparative Study Review
The treatment of Condylomata acuminata often causes disappointment to both the physician and the patient since most of the current medical approaches require multiple examines while on the other hand success rates are low and recurrence rates remain high. The treatment approaches include surgical as well as non-surgical methods. The non-surgical treatment includes the application of local agents such as imiquimod, podophyllotoxin, and 5-fluorouracil. Other local agents, used in outpatient treatment settings, include trichloroacetic acid (TCA), podophyllin, or the intralesional application of agents such as interferon and bleomycin. The surgical methods include cryotherapy, electrosurgery, excision and laser therapy. Their major goal is the removal of the visible lesions. The development of the laser systems and the new HPV vaccines are a significant progress in the treatment and prevention of the HPV infections.
Topics: Alphapapillomavirus; Aminoquinolines; Antimetabolites; Caustics; Condylomata Acuminata; Cryotherapy; Electrosurgery; Female; Fluorouracil; Genital Diseases, Female; Humans; Imiquimod; Interferon Inducers; Podophyllin; Trichloroacetic Acid
PubMed: 22479897
DOI: No ID Found -
The Journal of Dermatology Feb 2011The pathological transformation of the skin into a thick and hard callus due to repetitive trauma or friction is commonly known as corn. Although a variety of medical... (Clinical Trial)
Clinical Trial
The pathological transformation of the skin into a thick and hard callus due to repetitive trauma or friction is commonly known as corn. Although a variety of medical and operative treatment choices have been proposed, an ideal treatment method is yet to be defined. Effectiveness of tangential excision together with topical cantharidin has been evaluated. We used Canthacur-PS as an adjunct to excision in an outpatient setting. Canthacur-PS is a commercially available topical solution that includes 1% cantharidin, 30% salicylic acid and 5% podophyllin. The treatment has been applied to 72 patients. We found that 65 patients (90.3%) had corn on their feet and seven patients (9.7%) on their hands. Thick, hard and hyperkeratotic skin area was scraped with the help of a no. 15 blade. The solution was applied on and around the periphery (up to 1–2 mm) of the lesion with a cotton swab, and kept closed for 5 days with an antibiotic dressing. All the patients had been followed up for at least 1 year and evaluated by clinical examination and patient satisfaction query. One session of treatment succeeded in 57 (79.2%) corn patients. Two sessions in nine corn patients (12.5%), three sessions in five corn patients (6.9%) and four sessions in one patient (1.4%) were needed. Only one recurrence (1.4%) was seen. No scar formation or other side-effects were seen. Our findings show that this treatment method is a simple, minimally invasive and reliable treatment for calluses.
Topics: Administration, Topical; Adult; Callosities; Cantharidin; Chemotherapy, Adjuvant; Combined Modality Therapy; Dermatologic Agents; Female; Follow-Up Studies; Foot Dermatoses; Hand Dermatoses; Humans; Male; Middle Aged; Patient Satisfaction; Podophyllin; Recurrence; Salicylic Acid; Treatment Outcome; Young Adult
PubMed: 21182541
DOI: 10.1111/j.1346-8138.2010.00978.x -
Oral Surgery, Oral Medicine, Oral... Nov 2010The aim of this study was to present a new topical treatment protocol for oral hairy leukoplakia (OHL), consisting of a 25% podophyllin resin with a 1% penciclovir cream... (Comparative Study)
Comparative Study Randomized Controlled Trial
OBJECTIVE
The aim of this study was to present a new topical treatment protocol for oral hairy leukoplakia (OHL), consisting of a 25% podophyllin resin with a 1% penciclovir cream (PP), and to compare this topical treatment protocol's efficacy with that of 2 other topical treatment protocols: a 25% podophyllin resin (P) and a 25% podophyllin resin with a 5% acyclovir cream (PA).
STUDY DESIGN
Forty-two human immunodeficiency virus-positive patients with 69 OHL lesions were randomly treated using P, PA, or PP (14 patients in each topical treatment protocol). Clinical healing was determined when the white plaque could no longer be seen in the primary location of the lesion. Topical treatment performance was evaluated by clinical healing within each week of topical treatment protocol as well as by the recurrence of the lesion. Statistical survival analysis was performed using a Cox proportional hazards model.
RESULTS
Approximately 55% of the patients presented with clinical healing of OHL within 7-8 weeks of each topical treatment protocol. After the sixth week, the PA treatment protocol presented a faster clinical healing rate of OHL. Recurrence was observed in 3 and 7 OHL lesions treated with P and PP treatment protocols, respectively.
CONCLUSIONS
The PP treatment protocol proved to be effective; however, the PA treatment protocol was more effective in the clinical healing rate for OHL than P and PP after the sixth week of treatment, and no recurrent OHL was observed in the PA treatment group.
Topics: Acyclovir; Administration, Topical; Adult; Antifungal Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Candidiasis, Oral; Double-Blind Method; Female; Follow-Up Studies; Guanine; HIV Infections; HIV Seropositivity; Heterosexuality; Humans; Leukoplakia, Hairy; Male; Middle Aged; Neoplasm Recurrence, Local; Podophyllin; Proportional Hazards Models; Remission Induction; Time Factors; Tongue Neoplasms; Treatment Outcome; Young Adult
PubMed: 20813564
DOI: 10.1016/j.tripleo.2010.05.015 -
Journal Der Deutschen Dermatologischen... Oct 2010Plant extracts and isolated compounds are increasingly used in cosmetics and food supplements to improve skin conditions. We first introduce the positive plant...
Plant extracts and isolated compounds are increasingly used in cosmetics and food supplements to improve skin conditions. We first introduce the positive plant monographs with dermatological relevance of the former German Commission E. Subsequently clinical studies with botanicals for atopic dermatitis, psoriasis, acne, condylomata acuminata and herpes simplex are discussed. The best studies have been conducted with atopic dermatitis and psoriasis patients. Mahonia aquifolium, Hypericum perforatum, Glycyrrhiza glabra and certain traditional Chinese therapies have been shown to be effective in the treatment of atopic dermatitis. Mahonia aquifolium, Indigo naturalis and Capsicum frutescens are effective treatments for psoriasis. Green tea extract and tea tree oil have been investigated in the treatment of acne. Podophyllin and green tea extract are effective treatments for condylomata acuminata. Balm mint and a combination of sage and rhubarb have been shown to be effective in the treatment of herpes simplex in proof of concept studies.
Topics: Acne Vulgaris; Condylomata Acuminata; Dermatitis, Atopic; Herpes Simplex; Humans; Plant Extracts; Psoriasis; Treatment Outcome
PubMed: 20707875
DOI: 10.1111/j.1610-0387.2010.07496.x