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Current therapy for condyloma acuminata of the patients attending female STD Unit, Siriraj Hospital.Journal of the Medical Association of... Jun 2010To describe the treatment pattern of condyloma acuminata in female.
OBJECTIVE
To describe the treatment pattern of condyloma acuminata in female.
MATERIAL AND METHOD
The 5-year medical records of 449 women treated for genital condyloma acuminata at the Gynecologic Infectious Diseases and Female Sexually Transmitted Disease (GID-FSTD) unit were reviewed. Data included the distribution of age, client by category, anatomical site and size, serologically coexisting sexually transmitted infection (STI), and treatment modalities.
RESULTS
About half, 50.1%, of treatment was the application of topical trichloroacetic acid; followed by podophylline in the proportion of 35.5%. While the electric cauterization and imiquimod applications were uncommon therapy. Two-fifth ofthe subjects, 40.7%, was completely cured, and the remaining cases required additional management.
CONCLUSION
The present setting, the wide range of treatment available is reflection of the fact that there is no ideal management.
Topics: Adjuvants, Immunologic; Administration, Topical; Adult; Aminoquinolines; Caustics; Cautery; Condylomata Acuminata; Female; Genital Diseases, Female; Humans; Imiquimod; Ointments; Podophyllin; Retrospective Studies; Treatment Outcome; Trichloroacetic Acid; Young Adult
PubMed: 20572367
DOI: No ID Found -
European Journal of Obstetrics,... Jul 2010
Topics: Aged; Anus Diseases; Condylomata Acuminata; Female; Humans; Papillomaviridae; Papillomavirus Infections; Podophyllin; Postmenopause
PubMed: 20427114
DOI: 10.1016/j.ejogrb.2010.03.019 -
BMJ Clinical Evidence Aug 2010External genital warts (EGWs) are sexually transmitted benign epidermal growths caused by the human papillomavirus (HPV), on the anogenital areas of both females and... (Review)
Review
INTRODUCTION
External genital warts (EGWs) are sexually transmitted benign epidermal growths caused by the human papillomavirus (HPV), on the anogenital areas of both females and males. About 50% to 60% of sexually active women aged 18 to 49 years have been exposed to HPV infection, but only 10% to 15% will have genital warts.
METHODS AND OUTCOMES
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for external genital warts? What are the effects of interventions to prevent transmission of external genital warts? We searched: Medline, Embase, The Cochrane Library, and other important databases up to December 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
RESULTS
We found 55 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
CONCLUSIONS
In this systematic review we present information relating to the effectiveness and safety of the following interventions: bi- and trichloroacetic acid; condoms; cryotherapy; electrosurgery; imiquimod; intralesional, topical, or systemic interferons; laser surgery; podophyllin; podophyllotoxin; surgical excision; and vaccines.
Topics: Condylomata Acuminata; Double-Blind Method; Humans; Papillomaviridae; Papillomavirus Infections; Papillomavirus Vaccines; Podophyllin
PubMed: 21418685
DOI: No ID Found -
Journal of Pediatric and Adolescent... Oct 2009It is rare for a benign or malignant neoplasm to develop in a neovagina. (Review)
Review
BACKGROUND
It is rare for a benign or malignant neoplasm to develop in a neovagina.
CASE
This is the first report of a squamous papilloma with hyperpigmentation which developed in the neovagina 12 years after a McIndoe procedure was done with a split-thickness skin graft from the patient's buttock. The patient had congenital absence of the vagina and uterus (Rokitansky syndrome, Mayer-Rokitansky-Küster-Hauser syndrome, MRKH syndrome). It presented as post-coital blood spotting for 3 months.
CONCLUSION
As a routine, all cases of vaginal construction regardless of the reason for the surgery or the lining of the neovagina should have a continuous annual examination and careful inspection of the entire vagina. Biopsy of any unusual finding should be done. Despite the dark color of the vaginal lesion, bleeding and rapid appearance our patient had a benign tumor. Radiation therapy to the neovagina and prolonged treatment with podophyllin and cauterization should be avoided.
Topics: Adult; Female; Humans; Hyperpigmentation; Papilloma; Plastic Surgery Procedures; Skin Transplantation; Surgically-Created Structures; Syndrome; Uterine Hemorrhage; Uterus; Vagina
PubMed: 19616457
DOI: 10.1016/j.jpag.2008.12.009 -
Journal of Pediatric Urology Aug 2009Human papilloma virus (HPV) is the most common sexually transmitted disease among adults in the USA; however, the presence of HPV in infants is rare. Condyloma...
Human papilloma virus (HPV) is the most common sexually transmitted disease among adults in the USA; however, the presence of HPV in infants is rare. Condyloma acuminata, a cutaneous, fungating lesion caused by HPV, has a generally mild course that often resolves spontaneously or can be managed both medically and surgically. Typical treatments for condyloma include imiquimoid cream, podofilox gel, podophyllin resin, cryotherapy, laser surgery, tangential shave excision, and electrocautery. Rapidly progressing condyloma acuminata followed by a fatal course of Neisseria meningitis in an infant is an extremely rare presentation that merits further investigation into possible immunologic etiology. A 7-month-old circumcised Caucasian boy presented with a rapidly progressing giant penile condyloma acuminatum. This is the youngest documented case of this type. Refractory to medical and surgical treatments, this otherwise apparently healthy child was referred to pediatric immunology. Normal complete blood count led to deferment, suggesting further medical and surgical treatment. Five days after such treatment, the baby presented with progressive systemic rash, fever and tachycardia. The patient died from meningococcemia. This case serves as a warning concerning the course of condyloma in infants. Immunologic investigation may be critically important in young patients refractory to designated treatments for condyloma.
Topics: Condylomata Acuminata; Diaper Rash; Fatal Outcome; Humans; Infant; Male; Meningitis, Meningococcal; Neisseria meningitidis; Penile Diseases
PubMed: 19596116
DOI: 10.1016/j.jpurol.2009.02.201 -
Drug and Chemical Toxicology 2009The genotoxic potential of podophyllin (PD) was investigated in this study. PD increased bacterial revertants and abnormal chromosomal structures in a...
The genotoxic potential of podophyllin (PD) was investigated in this study. PD increased bacterial revertants and abnormal chromosomal structures in a concentration-dependent manner, both with and without metabolic activating enzymes, and increased the incidence of micronuclei in imprinted control region mouse reticulocytes. Results from three studied constituents of PD, such as podophyllotoxin, kampferol, and quercetin, suggested that the mutagenic effect of PD was not due to the presence of podophyllotoxin, kampferol, and quercetin and might be related to other components and the formation of reactive oxygen species. The detailed mutagenic mechanisms need further investigation, and the medicinal use of PD needs to be cautioned against.
Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Kaempferols; Male; Mice; Mice, Inbred ICR; Micronuclei, Chromosome-Defective; Mutagenicity Tests; Mutagens; Podophyllin; Podophyllotoxin; Quercetin; Rats; Rats, Wistar; Reactive Oxygen Species; Reticulocytes
PubMed: 19514941
DOI: 10.1080/01480540802433757 -
Journal of the European Academy of... Jun 2009
Topics: Adult; Angiofibroma; Face; Female; Humans; Podophyllin; Tuberous Sclerosis
PubMed: 18785889
DOI: 10.1111/j.1468-3083.2008.03004.x -
Pediatric Emergency Care Apr 2008Although cutaneous warts are one of the most common skin conditions affecting children, their management can be challenging, especially in complex cases and even more so... (Review)
Review
Although cutaneous warts are one of the most common skin conditions affecting children, their management can be challenging, especially in complex cases and even more so during a single emergency department encounter. Anogenital warts require particular attention because of their possible but nonspecific association with sexual abuse. This review will focus on cutaneous warts and anogenital warts, with a discussion of their recognition and treatment, especially in the emergency department. The medicolegal implications of anogenital warts in children are also reviewed.
Topics: Adolescent; Child; Child Abuse, Sexual; Condylomata Acuminata; Cryotherapy; Diagnosis, Differential; Emergency Service, Hospital; Female; Humans; Keratolytic Agents; Medicine, Traditional; Papillomavirus Infections; Papillomavirus Vaccines; Pediatrics; Podophyllin; Salicylic Acid; Skin Diseases; Uterine Cervical Neoplasms; Warts
PubMed: 18418266
DOI: 10.1097/PEC.0b013e31816bc7a2 -
Clinical and Experimental Dermatology Jul 2008A 40-year-old woman presented with a delusion of warts on the forehead, for which she was applying podophyllin toxin. A skin biopsy was taken, which showed prominent...
A 40-year-old woman presented with a delusion of warts on the forehead, for which she was applying podophyllin toxin. A skin biopsy was taken, which showed prominent mitotic figures in the basal and suprabasal layers of the epidermis and apoptotic keratinocytes. Histopathologically Bowen's disease was suspected, but was discounted after clinicopathological correlation was obtained and showed absence of epidermal atypia or disorganization. This case demonstrates the histological resemblance of podophyllin reaction to Bowen's disease. Differentiation of self-inflicted from organic skin disease may be difficult, especially where histopathological findings are confounded by cutaneous application of toxins.
Topics: Adult; Bowen's Disease; Caustics; Delusions; Diagnosis, Differential; Female; Humans; Parakeratosis; Podophyllin; Scalp Dermatoses; Self Medication; Skin Neoplasms; Warts
PubMed: 18261136
DOI: 10.1111/j.1365-2230.2007.02668.x -
The West Indian Medical Journal Jan 2008Longitudinal data from a case series indicated that clearance rates (95% CIs) of anogenital warts (AGW) by silver nitrate (n = 14) and podophyllin (n = 34) were 93%...
Longitudinal data from a case series indicated that clearance rates (95% CIs) of anogenital warts (AGW) by silver nitrate (n = 14) and podophyllin (n = 34) were 93% (79.35, 100) and 14.7% (3, 27) respectively; and RR, 6.31 (95% CI 2.77, 14.37, p = 0.052), relative benefit increase, 532% (410, 654), and NNT, 1 (1, 2). The total effort needed US$28(BB$56) vs US$598 in 1-3 vs 1-37 visits to achieve one successfully treated patient respectively. While subject to the errors of an open, non-randomized case series, silver nitrate was highly efficacious and cost-effective and should replace podophyllin at the Winston Scot Polyclinic.
Topics: Adolescent; Adult; Antiviral Agents; Condylomata Acuminata; Cost-Benefit Analysis; Female; Humans; Male; Middle Aged; Podophyllin; Retrospective Studies; Silver Nitrate; Treatment Outcome; Young Adult
PubMed: 19565941
DOI: No ID Found