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Journal of Cosmetic Dermatology Jan 2022Although many laser systems have been used in the treatment for Poikiloderma of Civatte (POC), there is no standard treatment guideline.
BACKGROUND
Although many laser systems have been used in the treatment for Poikiloderma of Civatte (POC), there is no standard treatment guideline.
OBJECTIVES
We aimed to present our data on the efficacy and safety of single-session pro-yellow laser treatment for POC.
METHODS
The study included 14 patients treated with pro-yellow laser (QuadroStarPRO YELLOW Asclepion Laser Technologies, Germany) between 2017 and 2019. Treatment had been applied in two passes during the same session; a general pass with 22 j/cm over the whole lesion, then, one more pass only on the telangiectatic lesions with 18 j/cm fluence. They were evaluated based on their pictures taken before and 4 weeks after the treatment and scored by a 4-item scoring in terms of the improvement (0:no change, 1:1%-25% mild, 2:26%-50% moderate, 3:51%-75% well, and 4:76%-100% excellent improvement).
RESULTS
The mean age of the patients (1 female, 13 males) was 59.64 ± 8.16 years. Five patients had Fitzpatrick-2 and 9 patients had Fitzpatrick-3 skin types. Six patients had mild, 8 patients had moderate improvement, one of them has been illustrated in Figure 1. Sixty-minute mild erythema was the only adverse effect observed.
CONCLUSIONS
We think that pro-yellow laser is a good treatment option for POC treatment. Repeated sessions are required for the complete healing of the lesions, while one single session has proved to be deficient. We observed that it was a quite safe treatment option, especially for the neck region, which was inclined to scarring and atrophy development.
Topics: Aged; Atrophy; Cicatrix; Female; Humans; Lasers; Lasers, Solid-State; Male; Middle Aged; Pigmentation Disorders; Treatment Outcome
PubMed: 34889036
DOI: 10.1111/jocd.14609 -
The Journal of Dermatology Feb 2022
Topics: Blister; Epidermolysis Bullosa; Female; Humans; Middle Aged; Periodontal Diseases; Photosensitivity Disorders; Syndactyly
PubMed: 34791714
DOI: 10.1111/1346-8138.16236 -
Journal of Drugs in Dermatology : JDD Nov 2021Fractional laser treatment was introduced in 2004 as a non-invasive technique to treat sun-damaged and aging skin. Since then, numerous ablative and non-ablative...
BACKGROUND
Fractional laser treatment was introduced in 2004 as a non-invasive technique to treat sun-damaged and aging skin. Since then, numerous ablative and non-ablative photothermolysis technologies and devices have been introduced, increasing the options for clinicians and patients but also increasing the complexity regarding which system to use and the techniques to optimize outcomes. No two devices are the same and the user-manuals preset dosimetry does not address many clinical situations, which can create confusion for new and inexperienced users.
METHODS
An online survey addressing use of a 1550 nm /1927 nm dual wavelength, non-ablative, fractional laser was sent to eight (8) US board certified dermatologists with extensive experience in the use of the device. The survey included 39 questions, addressing experience, best practices and recommendations for use.
RESULTS
The survey data suggests that the device can be used to treat patients of all ages and skin types for indications including photoaging and photodamage, periorbital wrinkles, freckles, (ephelides), solar lentigines, poikiloderma, scarring due to acne or surgery. It can be used on both facial and non-facial areas, including neck, chest, hands, arms, abdomen, legs, and buttocks. Unexpected and adverse effects were rarely reported and those that did were mild and transient.
CONCLUSIONS
This position paper provides practical real-world guidelines resulting from a small survey of experienced users, for new and early uses of the novel 1550 nm /1927 nm dual wavelength, non-ablative, fractional laser. J Drugs Dermatol. 2021;20(11):1150-1157. doi:10.36849/JDD.6181.
Topics: Acne Vulgaris; Cicatrix; Hand; Humans; Laser Therapy; Lasers, Gas; Lasers, Solid-State; Skin Aging
PubMed: 34784135
DOI: 10.36849/jdd.6181 -
Indian Journal of Dermatology 2021
PubMed: 34759414
DOI: 10.4103/ijd.IJD_764_19 -
Clinical Case Reports Oct 2021There are various causes of childhood poikiloderma. A proper history and clinical examination may help to get conclusion and narrow down the differentials for the causes...
There are various causes of childhood poikiloderma. A proper history and clinical examination may help to get conclusion and narrow down the differentials for the causes of poikiloderma.
PubMed: 34703608
DOI: 10.1002/ccr3.4977 -
JAAD Case Reports Oct 2021
PubMed: 34541270
DOI: 10.1016/j.jdcr.2021.07.032 -
Genetics and Molecular Biology 2021Two Italian patients with the initial clinical diagnosis of Rothmund-Thomson syndrome were negative for RECQL4 mutations but showed in peripheral blood cells a...
Spontaneous chromosomal instability in peripheral blood lymphocytes from two molecularly confirmed Italian patients with Hereditary Fibrosis Poikiloderma: insights into cancer predisposition.
Two Italian patients with the initial clinical diagnosis of Rothmund-Thomson syndrome were negative for RECQL4 mutations but showed in peripheral blood cells a spontaneous chromosomal instability significantly higher than controls. Revisiting after time their clinical phenotype, the suggestive matching with the autosomal dominant syndrome Poikiloderma, Hereditary Fibrosing with Tendon Contracture, Myopathy and Pulmonary fibrosis (POIKTMP) was confirmed by identification of the c.1879A>G (p.Arg627Gly) alteration in FAM111B. We compare the overall clinical signs of our patients with those of reported carriers of the same mutation and present the up-to-date mutational repertoire of FAM111B and the related phenotypic spectrum. Our snapshot highlights the age-dependent clinical expressivity of POIKTMP and the need to follow-up patients to monitor the multi-tissue impairment caused by FAM111B alterations. We link our chromosomal instability data to the role of FAM111B in cancer predisposition, pointed out by its implication in DNA-repair pathways and the outcome of pancreatic cancer in 2 out of 17 adult POIKTMP patients. The chromosomal instability herein highlighted well connects POIKTMP to cancer-predisposing syndromes, such as Rothmund-Thomson which represents the first hereditary poikiloderma entering in differential diagnosis with POIKTMP.
PubMed: 34358284
DOI: 10.1590/1678-4685-GMB-2020-0332 -
The American Journal of Dermatopathology Dec 2021
Topics: Dermatitis, Exfoliative; Female; Fever; Humans; Mycosis Fungoides; Skin Abnormalities; Young Adult
PubMed: 34291747
DOI: 10.1097/DAD.0000000000002031 -
International Journal of Dermatology Jan 2022Dermoscopy has traditionally been used for the diagnosis of neoplasms and more recently in the evaluation of inflammatory conditions. Recent observational studies have... (Review)
Review
Dermoscopy has traditionally been used for the diagnosis of neoplasms and more recently in the evaluation of inflammatory conditions. Recent observational studies have suggested a role for dermoscopy in identifying and differentiating acquired pigmentary disorders. This comprehensive review will summarize the growing literature on the use of dermoscopy for pigmentary disorders. A literature review was performed on PubMed dating from inception to October 2020. The following pigmentary disorders were included in this study: melasma, solar lentigines, poikiloderma of Civatte, exogenous ochronosis, lichen planus pigmentosus, erythromelanosis follicularis faciei et colli, pigmented contact dermatitis, Riehl's melanosis, postinflammatory hyperpigmentation, erythema dyschromicum perstans, ashy dermatosis, confluent and reticulated papillomatosis, acanthosis nigricans, pityriasis versicolor, tinea versicolor, idiopathic guttate hypomelanosis, and vitiligo. Search terms used included each pigmentary disorder along with the terms "dermoscopy" or "dermatoscopy." Relevant case reports and case series were included. Many pigmentary disorders have unique and distinguishable features on dermoscopy. Given that these disorders can be clinically challenging for clinicians and emotionally distressing for patients, dermoscopy provides an additional, useful tool in the evaluation and assessment process.
Topics: Dermoscopy; Erythema; Humans; Hyperpigmentation; Lichen Planus; Melanosis
PubMed: 34235719
DOI: 10.1111/ijd.15741