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The Journal of International Medical... 1981The safety and effectiveness of prazosin hydrochloride combined with polythiazide for the treatment of hypertension was studied in four European countries by ten...
The safety and effectiveness of prazosin hydrochloride combined with polythiazide for the treatment of hypertension was studied in four European countries by ten investigators. One-hundred and seventy-seven adult male and female patients, 91% with essential hypertension were treated for an average of 7 months. Reductions from placebo-controlled baseline blood pressure exceeded 15% over the 8-week short-term phase of the study with further reductions of up to 22% observed at the end of the study. Ninety-six per cent of all patients completed therapy with a diastolic blood pressure of 90 mm Hg or less. Most patients were adequately controlled on 2 tablets or less once daily. Each tablet contained 0.5 mg prazosin hydrochloride and 0.25 mg polythiazide. Long-term toleration was excellent. Side-effects were typical of those expected with antihypertensive medication and nearly all were reported during the first 8 weeks of treatment with no interruption or discontinuation of drug. Nearly all patients were followed throughout for laboratory changes. There were minimal changes consistent with the therapy and there was no pattern indicative of toxic potential. It is concluded that the drug combination, Minizide, is effective and well tolerated as initial and long-term therapy in hypertension and that the convenient dosage regimen will lead to enhanced treatment compliance for this chronic condition.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Drug Combinations; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Polythiazide; Prazosin; Quinazolines; Time Factors
PubMed: 7297755
DOI: 10.1177/030006058100900502 -
The Journal of International Medical... 1981In a multicentre study conducted by thirty-two investigators in ten European, Asian, and Latin-American countries the combination of prazosin 0.5 mg and polythiazide...
In a multicentre study conducted by thirty-two investigators in ten European, Asian, and Latin-American countries the combination of prazosin 0.5 mg and polythiazide 0.25 mg per tablet was used as the only drug treatment for all grades of hypertension in 551 adult male and female out-patients. After a 2-week placebo period, patients received 1 tablet daily. The dosage was increased, as necessary, by 1 tablet every 2 weeks to a maximum of 4 tablets daily to provide an adequate blood pressure response. Duration of therapy averaged 7.8 weeks. Blood pressure was reduced by an average of 15% systolic and 17% diastolic and the degree of severity of blood pressure improved in 93% of patients. Two-thirds of the patients ended the study with a diastolic blood pressure equal to or less than 90 mm Hg. The dosage at the end of the therapy period averaged 2 tablets of Minizide as a single daily dose. Side-effects were mostly mild or moderate and were typical of those expected for antihypertensive medication. It is concluded that this combination drug is efficacious in the treatment of hypertension and, together with its good toleration profile and ease of administration, will enhance compliance with therapy.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Drug Combinations; Female; Humans; Hypertension; Male; Middle Aged; Polythiazide; Prazosin; Quinazolines
PubMed: 7297754
DOI: 10.1177/030006058100900501 -
Pharmacology 1981The interaction between thiazide diuretics and contractile responses produced by 5-hydroxytryptamine, acetylcholine, noradrenaline and angiotensin II, has been examined...
The interaction between thiazide diuretics and contractile responses produced by 5-hydroxytryptamine, acetylcholine, noradrenaline and angiotensin II, has been examined on isolated rat uterus and guinea pig aorta. Hydrochlorothiazide, polythiazide and cyclopenthiazide inhibited the contraction of isolated tissue induced by the spasmogens. These data demonstrated that the tested diuretics possess antagonistic activity on contractions induced by various spasmogens.
Topics: Animals; Benzothiadiazines; Diuretics; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rats; Sodium Chloride Symporter Inhibitors; Uterine Contraction
PubMed: 7208592
DOI: 10.1159/000137478 -
Acta Medica Scandinavica 1980A case of symptomatic diabetes mellitus in a 65-year-old woman with 14 years of polythiazide treatment and hypokalemia is described. The condition was cured by potassium...
A case of symptomatic diabetes mellitus in a 65-year-old woman with 14 years of polythiazide treatment and hypokalemia is described. The condition was cured by potassium administration and withdrawal of the thiazide diuretic.
Topics: Aged; Blood Glucose; Diabetes Mellitus; Female; Humans; Hypertension; Polythiazide; Potassium
PubMed: 7435241
DOI: 10.1111/j.0954-6820.1980.tb01165.x -
Cardiology 1980
Clinical Trial Randomized Controlled Trial
Topics: Diuretics; Drug Evaluation; Drug Therapy, Combination; Humans; Hypertension; Polythiazide; Prazosin; Quinazolines
PubMed: 7285033
DOI: 10.1159/000172993 -
Cardiology 1980
Topics: Adult; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Hypotension, Orthostatic; Male; Middle Aged; Polythiazide; Prazosin; Quinazolines; Time Factors; Triamterene
PubMed: 7285022
DOI: 10.1159/000173016 -
Cardiology 1980
Clinical Trial
Topics: Adult; Aged; Cardiomegaly; Clinical Trials as Topic; Drug Therapy, Combination; Electrocardiography; Heart Failure; Heart Rate; Humans; Hypertension; Male; Middle Aged; Polythiazide; Prazosin; Quinazolines
PubMed: 6456812
DOI: 10.1159/000173019 -
Journal of Cardiovascular Pharmacology 1979Prazosin, in daily doses of 6--16 mg, was used along with furosemide and polythiazide in 11 hypertensive heart failure patients. Average supine and standing blood...
Prazosin, in daily doses of 6--16 mg, was used along with furosemide and polythiazide in 11 hypertensive heart failure patients. Average supine and standing blood pressures were reduced from 180/108 and 171/106 to 130/84 and 135/86, respectively. Average heart rate decreased from 83 to 73 supine and from 84 to 75 standing. Changes in the indices of cardiac function--indlucing the ejection fraction, ejection time, and apical indices--each indicated improvement of left ventricular function. Thus prazosin along with diuretic agents may be particularly useful in the treatment simultaneously of heart failure and of elevated blood pressure with few side effects.
Topics: Adult; Aged; Blood Pressure; Electrocardiography; Heart Failure; Heart Rate; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines
PubMed: 94640
DOI: No ID Found -
JAMA Oct 1979
Topics: Chlorthalidone; Diuretics; Humans; Hydrochlorothiazide; Hypercholesterolemia; Hypertension; Polythiazide; Sodium Chloride Symporter Inhibitors
PubMed: 480576
DOI: No ID Found -
Indian Heart Journal 1979
Topics: Adolescent; Adult; Child; Female; Humans; Hypertension; Male; Middle Aged; Polythiazide; Prazosin; Propranolol; Quinazolines
PubMed: 437820
DOI: No ID Found