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Frontiers in Human Neuroscience 2022Parkinson's disease (PD) patients have a significantly higher risk of developing dementia in later disease stages, leading to severe impairments in quality of life and...
INTRODUCTION
Parkinson's disease (PD) patients have a significantly higher risk of developing dementia in later disease stages, leading to severe impairments in quality of life and self-functioning. Questions remain on how deep brain stimulation (DBS) affects cognition, and whether we can individualize therapy and reduce the risk for adverse cognitive effects. Our aim in this systematic review is to assess the current knowledge in the field and determine if the findings could influence clinical practice.
METHODS
We have conducted a systematic review according to PRISMA guidelines through MEDLINE and Embase databases, with studies being selected for inclusion a set inclusion and exclusion criteria.
RESULTS
Sixty-seven studies were included in this systematic review according to the selected criteria. This includes 6 meta-analyses, 18 randomized controlled trials, 17 controlled clinical trials, and 26 observational studies with no control arms. The total number of PD patients encompassed in the studies cited in this review is 3677, not including the meta-analyses.
CONCLUSION
Cognitive function in PD patients can deteriorate, in most cases mildly, but still impactful to the quality of life. The strongest evidence is present for deterioration in verbal fluency, while inconclusive evidence is still present for executive function, memory, attention and processing speed. Global cognition does not appear to be significantly impacted by DBS, especially if cognitive screening is performed prior to the procedure, as lower baseline cognitive function is connected to poor outcomes. Further randomized controlled studies are required to increase the level of evidence, especially in the case of globus pallidus internus DBS, pedunculopontine nucleus DBS, and the ventral intermediate nucleus of thalamus DBS, and more long-term studies are required for all respective targets.
PubMed: 35634211
DOI: 10.3389/fnhum.2022.867055 -
JCPP Advances Jun 2022Peer adversity and aggression are common experiences in childhood and adolescence which lead to poor mental health outcomes. To date, there has been no review conducted...
BACKGROUND
Peer adversity and aggression are common experiences in childhood and adolescence which lead to poor mental health outcomes. To date, there has been no review conducted on the neurobiological changes associated with relational peer-victimisation, bullying and cyberbullying.
METHODS
This systematic review assessed structural and functional brain changes associated with peer-victimisation, bullying, and cyberbullying from 1 January 2000 to April 2021. A systematic search of Psychoinfo, Pubmed, and Scopus was performed independently by two reviewers using predefined criteria. Twenty-six studies met the selection criteria and were considered for review.
RESULTS
The data collected shows altered brain activation of regions implicated in processing reward, social pain, and affect; and heightened sensitivity and more widespread activation of brain regions during acute social exclusion, most notably in the amygdala, left parahippocampal gyrus, and fusiform gyrus, associated with victimisation exposure. In addition, victimised youths also demonstrated greater risk-taking behaviours following acute social exclusion showing greater ventral striatum-inferior frontal gyrus coupling, activation in the bilateral amygdala, orbital frontal cortex (OFC), medial prefrontal cortex (MPFC), temporoparietal junction (TPJ), medial posterior parietal cortex (MPPC) and dorsomedial prefrontal cortex (dmPFC), suggesting greater social monitoring, seeking of inclusion, and more effortful cognitive control. The studies included participants from a very broad developmental age range, mostly using cross-sectional measure of peer-victimisation exposure, at varying developmental stages.
CONCLUSIONS
This review highlights the need for more neuroimaging studies in cyberbullying, as well as longitudinal studies across more diverse samples for investigating gender, age, and developmental interactions with peer-victimising. This also brings to attention the importance of addressing bullying victimisation particularly in adolescence, given the evidence for social stress in heightening developmentally sensitive processes which are associated with depression, anxiety, and externalising symptoms.
PubMed: 37431463
DOI: 10.1002/jcv2.12081 -
Journal of Personalized Medicine Apr 2022The importance of large-scale brain networks in higher-order human functioning is well established in neuroscience, but has yet to deeply penetrate neurosurgical... (Review)
Review
The importance of large-scale brain networks in higher-order human functioning is well established in neuroscience, but has yet to deeply penetrate neurosurgical thinking due to concerns of clinical relevance. Here, we conducted the first systematic review examining the clinical importance of non-traditional, large-scale brain networks, including the default mode (DMN), central executive (CEN), salience (SN), dorsal attention (DAN), and ventral attention (VAN) networks. Studies which reported evidence of neurologic, cognitive, or emotional deficits in relation to damage or dysfunction in these networks were included. We screened 22,697 articles on PubMed, and 551 full-text articles were included and examined. Cognitive deficits were the most common symptom of network disturbances in varying amounts (36-56%), most frequently related to disruption of the DMN (n = 213) or some combination of DMN, CEN, and SN networks (n = 182). An increased proportion of motor symptoms was seen with CEN disruption (12%), and emotional (35%) or language/speech deficits (24%) with SN disruption. Disruption of the attention networks (VAN/DAN) with each other or the other networks mostly led to cognitive deficits (56%). A large body of evidence is available demonstrating the clinical importance of non-traditional, large-scale brain networks and suggests the need to preserve these networks is relevant for neurosurgical patients.
PubMed: 35455703
DOI: 10.3390/jpm12040587 -
BMC Surgery Mar 2022Parastomal hernia after ileal conduit urinary diversion is an underestimated and undertreated clinical entity, which heavily impairs patients' quality of life due to...
BACKGROUND
Parastomal hernia after ileal conduit urinary diversion is an underestimated and undertreated clinical entity, which heavily impairs patients' quality of life due to symptoms of pain, leakage, application or skin problems. As for all gastrointestinal stomata the best surgical repair technique has yet to be determined. Thereby, surgery for ileal conduit parastomal hernias poses some specific perioperative challenges. This review aims to give an overview of current evidence on the surgical treatment of parastomal hernia after cystectomy and ileal conduit urinary diversion, and on the use of prophylactic mesh at index surgery in its prevention.
METHODS
A systematic review was performed according to PRISMA-guidelines. The electronic databases Embase, PubMed, Cochrane Library, and Web of Science were searched. Studies were included if they presented postoperative outcomes of patients undergoing surgical treatment of parastomal hernia at the ileal conduit site, irrespective of the technique used. A search was performed to identify additional studies on prophylactic mesh in the prevention of ileal conduit parastomal hernia, that were not identified by the initial search.
RESULTS
Eight retrospective case-series were included for analysis, reporting different surgical techniques. If reported, highest complication rate was 45%. Recurrence rates varied highly, ranging from 0 to 80%. Notably, lower recurrence rates were reported in studies with shorter follow-up. Overall, available data suggest significant morbidity after the surgical treatment of ileal conduit parastomal hernias. Data from five conference abstracts on the matter were retrieved, and systematically reported. Regarding prophylactic mesh in the prevention of ileal conduit parastomal hernia, 5 communications were identified. All of them used keyhole mesh in a retromuscular position, and reported on favorable results in the mesh group without an increase in mesh-related complications.
CONCLUSION
Data on the surgical treatment of ileal conduit parastomal hernias and the use of prophylactic mesh in its prevention is scarce. Given the specific perioperative challenges and the paucity of reported results, more high-quality evidence is needed to determine the optimal treatment of this specific surgical problem. Initial results on the use of prophylactic mesh in the prevention of ileal conduit parastomal hernias seem promising.
Topics: Cystectomy; Hernia, Ventral; Humans; Quality of Life; Retrospective Studies; Surgical Mesh; Urinary Diversion
PubMed: 35351086
DOI: 10.1186/s12893-022-01509-y -
European Radiology Sep 2022Systematic review of CT measurements to predict the success or failure of subsequent ventral hernia repair has found limited data available in the indexed literature. To...
OBJECTIVES
Systematic review of CT measurements to predict the success or failure of subsequent ventral hernia repair has found limited data available in the indexed literature. To rectify this, we investigated multiple preoperative CT metrics to identify if any were associated with postoperative reherniation.
METHODS
Following ethical permission, we identified patients who had undergone ventral hernia repair and had preoperative CT scanning available. Two radiologists made multiple measurements of the hernia and abdominal musculature from these scans, including loss of domain. Patients were divided subsequently into two groups, defined by hernia recurrence at 1-year subsequent to surgery. Hypothesis testing investigated any differences between CT measurements from each group.
RESULTS
One hundred eighty-eight patients (95 male) were identified, 34 (18%) whose hernia had recurred by 1-year. Only three of 34 CT measurements were significantly different when patients whose hernia had recurred were compared to those who had not; these significant findings were assumed contingent on multiple testing. In particular, preoperative hernia volume (recurrence 155.3 cc [IQR 355.65] vs. no recurrence 78.2 [IQR 303.52], p = 0.26) nor loss of domain, whether calculated using the Tanaka (recurrence 0.02 [0.04] vs. no recurrence 0.009 [0.04], p = 0.33) or Sabbagh (recurrence 0.019 [0.05] vs. no recurrence 0.009 [0.04], p = 0.25) methods, differed between significantly between groups.
CONCLUSIONS
Preoperative CT measurements of ventral hernia morphology, including loss of domain, appear unrelated to postoperative recurrence. It is likely that the importance of such measurements to predict recurrence is outweighed by other patient factors and surgical reconstruction technique.
KEY POINTS
• Preoperative CT scanning is often performed for ventral hernia but systematic review revealed little data regarding whether CT variables predict postoperative reherniation. • We found that the large majority of CT measurements, including loss of domain, did not differ significantly between patients whose hernia did and did not recur. • It is likely that the importance of CT measurements to predict recurrence is outweighed by other patient factors and surgical reconstruction technique.
Topics: Abdominal Wall; Case-Control Studies; Female; Hernia, Ventral; Herniorrhaphy; Humans; Male; Retrospective Studies; Surgical Mesh; Tomography, X-Ray Computed
PubMed: 35348860
DOI: 10.1007/s00330-022-08701-x -
Chirurgia (Bucharest, Romania : 1990) Dec 2021Incisional hernia is considered to be one of the most frequent complication of abdominal surgery, with an incidence up to 20% or 35-50%. Given the latest focus on...
Incisional hernia is considered to be one of the most frequent complication of abdominal surgery, with an incidence up to 20% or 35-50%. Given the latest focus on laparoscopic approach of any surgical pathology, there is a tendency in managing the incisional hernias in this particular manner, which impose intraperitoneal onlay mesh placement (IPOM). The aim of this review is to gather more information regarding the possible complications that can be associated with this technique. The study was conducted based on a bibliographic research using the databases: PubMed, Scopus and Web of Science. The work was reported in line with PRISMA guidelines. The study conducted shows that the short-term risks of intraperitoneal mesh placement for incisional hernia repair are not life-threatening and are comparable to other prosthetic surgical techniques. The most frequent complications can be devided in minor: seroma, hematoma and recurrent pain, and major: enterocutaneous fistula, mesh infection and Adhesions-Bowel obstruction. The high rate of unavailability for follow-up, especially regarding major complications that usually occur after a significant period of time, limits the results of the studies documented and they lack the quality-of-life assessment.
Topics: Hernia, Ventral; Herniorrhaphy; Humans; Incisional Hernia; Surgical Mesh; Treatment Outcome
PubMed: 35274610
DOI: No ID Found -
Neuropsychology Review Mar 2023The current systematic review examines the behavioral effects of TMS on reading. Transcranial magnetic stimulation (TMS) to targeted nodes of the brain's reading network... (Review)
Review
The current systematic review examines the behavioral effects of TMS on reading. Transcranial magnetic stimulation (TMS) to targeted nodes of the brain's reading network has been shown to impact reading. Extracted data included (a) study characteristics, (b) methodology, (c) targeted nodes, (d) control paradigm, (e) type of reading task, (f) adverse effects, and (g) main findings. Data was classified by type of reading task: 1) phonological processing, 2) semantic judgment, 3) lexical decision, 4) whole word reading, and 5) visual or text characteristics. Seventy records from 46 studies (n = 844) were identified. Results indicate that TMS modulates semantic judgments when focused in the anterior aspects of the reading circuit, phonological processes after stimulation within the dorsal circuit, and impacts single word recognition and contextual reading when administered to the ventral circuit. Findings suggest that changes in specific behavioral aspects of reading following TMS may contribute to identification of foci for use as part of reading interventions.
Topics: Humans; Transcranial Magnetic Stimulation; Brain Mapping; Magnetic Resonance Imaging; Semantics
PubMed: 35119625
DOI: 10.1007/s11065-022-09534-7 -
The International Journal of... Jun 2022The mechanisms underlying placebo effects of psychotropic drugs remain poorly understood. We carried out the first, to our knowledge, systematic review of functional...
BACKGROUND
The mechanisms underlying placebo effects of psychotropic drugs remain poorly understood. We carried out the first, to our knowledge, systematic review of functional neuroimaging correlates of placebo response in adults with anxiety/depressive disorders.
METHODS
We systematically searched a large set of databases up to February 2021 based on a pre-registered protocol (PROSPERO CRD42019156911). We extracted neuroimaging data related to clinical improvement following placebo or related to placebo mechanisms. We did not perform a meta-analysis due to the small number of included studies and significant heterogeneity in study design and outcome measures.
RESULTS
We found 12 relevant studies for depressive disorders and 4 for anxiety disorders. Activity in the ventral striatum, rostral anterior cingulate cortex and other default mode network regions, orbitofrontal cortex, and dorsolateral prefrontal cortex correlated with placebo antidepressant responses. Activity in regions of the default mode network, including posterior cingulate cortex, was associated with placebo anxiolysis. There was also evidence for possible involvement of the endogenous opioid, dopamine, and serotonin systems in placebo antidepressant and anxiolytic effects.
CONCLUSIONS
Several brain regions and molecular systems may be involved in these placebo effects. Further adequately powered studies exploring causality and controlling for confounders are required.
Topics: Adult; Antidepressive Agents; Anxiety Disorders; Functional Neuroimaging; Humans; Neuroimaging; Placebo Effect
PubMed: 35078210
DOI: 10.1093/ijnp/pyac009 -
Hernia : the Journal of Hernias and... Dec 2022The enhanced view totally extraperitoneal (eTEP) approach is becoming increasingly more widely accepted as a promising technique in the treatment of ventral hernia.... (Meta-Analysis)
Meta-Analysis
Short-term outcomes of minimally invasive retromuscular ventral hernia repair using an enhanced view totally extraperitoneal (eTEP) approach: systematic review and meta-analysis.
BACKGROUND
The enhanced view totally extraperitoneal (eTEP) approach is becoming increasingly more widely accepted as a promising technique in the treatment of ventral hernia. However, evidence is still lacking regarding the perioperative, postoperative and long-term outcomes of this technique. The aim of this meta-analysis is to summarize the current available evidence regarding the perioperative and short-term outcomes of ventral hernia repair using eTEP.
STUDY DESIGN
A systematic search was performed of PubMed, EMBASE, Cochrane Library and Web of Science electronic databases to identify studies on the laparoscopic or robotic-enhanced view totally extraperitoneal (eTEP) approach for the treatment of ventral hernia. A pooled meta-analysis was performed. The primary end point was focused on short-term outcomes regarding perioperative characteristics and postoperative parameters.
RESULTS
A total of 13 studies were identified involving 918 patients. Minimally invasive eTEP resulted in a rate of surgical site infection of 0% [95% CI 0.0-1.0%], a rate of seroma of 5% [95% CI 2.0-8.0%] and a rate of major complications (Clavien-Dindo III-IV) of 1% [95% CI 0.0-3.0%]. The rate of intraoperative complications was 2% [95% CI 0.0-4.0%] with a conversion rate of 1.0% [95% CI 0.0-3.0%]. Mean hospital length of stay was 1.77 days [95% CI 1.21-2.24]. After a median follow-up of 6.6 months (1-24), the rate of recurrence was 1% [95% CI 0.0-1.0%].
CONCLUSION
Minimally invasive eTEP is a safe and effective approach for ventral hernia repair, with low reported intraoperative complications and good outcomes.
Topics: Humans; Herniorrhaphy; Surgical Mesh; Hernia, Ventral; Laparoscopy; Intraoperative Complications; Incisional Hernia
PubMed: 35044545
DOI: 10.1007/s10029-021-02557-8 -
European Journal of Paediatric Dentistry Dec 2021The term Riga-Fede disease has been used historically to describe traumatic ulceration that occurs on the ventral surface of tongue, buccal mucosa, gum or floor of the...
AIM
The term Riga-Fede disease has been used historically to describe traumatic ulceration that occurs on the ventral surface of tongue, buccal mucosa, gum or floor of the tongue in newborns and infants. It is most often associated with natal and neonatal teeth in newborns. The painful symptoms may be absent or acute, up to the point of preventing the baby from feeding. The aim of this work is to offer a description of the therapeutic solutions for the treatment of this pathological condition, with a review of the literature and the report of two cases.
MATERIALS
A systematic review of the literature of articles presenting Riga-Fede Disease associated with natal and neonatal teeth was performed following the PRISMA protocol (Prefered Reporting Items for Systematic Reviews and Meta-Analyses). This bibliographic search was performed through two databases, PubMed and Google Scholar.
CONCLUSION
Extraction and ameloplasty are the most effective treatments in the resolution of the Riga-Fede disease associated with natal/neonatal teeth. In the case of high dental mobility, resulting in an increased risk of exfoliation and possible tooth ingestion/inhalation, extraction is the therapeutic treatment of choice. When nutrition is not compromised, ameloplasty is the treatment of choice, as it is less invasive and more conservative.
Topics: Humans; Infant; Infant, Newborn; Mouth Mucosa; Natal Teeth; Oral Ulcer; Tongue; Tongue Diseases
PubMed: 35034468
DOI: 10.23804/ejpd.2021.22.04.11