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Orphanet Journal of Rare Diseases Sep 2006Plummer-Vinson or Paterson-Kelly syndrome presents as a classical triad of dysphagia, iron-deficiency anemia and esophageal webs. Exact data about epidemiology of the... (Review)
Review
Plummer-Vinson or Paterson-Kelly syndrome presents as a classical triad of dysphagia, iron-deficiency anemia and esophageal webs. Exact data about epidemiology of the syndrome are not available; the syndrome is extremely rare. Most of the patients are white middle-aged women, in the fourth to seventh decade of life but the syndrome has also been described in children and adolescents. The dysphagia is usually painless and intermittent or progressive over years, limited to solids and sometimes associated with weight loss. Symptoms resulting from anemia (weakness, pallor, fatigue, tachycardia) may dominate the clinical picture. Additional features are glossitis, angular cheilitis and koilonychia. Enlargement of the spleen and thyroid may also be observed. One of the most important clinical aspects of Plummer-Vinson syndrome is the association with upper alimentary tract cancers. Etiopathogenesis of Plummer-Vinson syndrome is unknown. The most important possible etiological factor is iron deficiency. Other possible factors include malnutrition, genetic predisposition or autoimmune processes. Plummer-Vinson syndrome can be treated effectively with iron supplementation and mechanical dilation. In case of significant obstruction of the esophageal lumen by esophageal web and persistent dysphagia despite iron supplementation, rupture and dilation of the web are necessary. Since Plummer-Vinson syndrome is associated with an increased risk of squamous cell carcinoma of the pharynx and the esophagus, the patients should be followed closely.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Deglutition Disorders; Diagnosis, Differential; Female; Global Health; Humans; Iron; Male; Middle Aged; Plummer-Vinson Syndrome; Prevalence; Prognosis; Rare Diseases; Sex Distribution; Young Adult
PubMed: 16978405
DOI: 10.1186/1750-1172-1-36 -
The Turkish Journal of Gastroenterology... Dec 2005Plummer-Vinson syndrome is known as the association of postcricoid dysphagia, upper esophageal web, and iron deficiency anemia. Although correction of iron deficiency...
Plummer-Vinson syndrome is known as the association of postcricoid dysphagia, upper esophageal web, and iron deficiency anemia. Although correction of iron deficiency may result in resolution of dysphagia and sometimes disappearance of the webs, dilation therapy is usually necessary to remove webs and relieve dysphagia. We report two cases of Plummer-Vinson syndrome. Both patients presented with significant and longstanding dysphagia, sideropenia, glossitis and koilonychia. Our two patients had occasional choking and aspiration episodes at eating and endoscope did not pass through at the level of the upper esophagus. Patients' esophagograms revealed the presence of webs in part of the post-cricoid region. Both patients were treated with esophageal bougienage or balloon dilation, and iron supplementation. The patients were examined periodically for two years after the initial treatment and found to be in good general condition.
Topics: Catheterization; Diagnosis, Differential; Endoscopy, Gastrointestinal; Female; Follow-Up Studies; Humans; Middle Aged; Plummer-Vinson Syndrome; Severity of Illness Index
PubMed: 16547853
DOI: No ID Found -
World Journal of Gastroenterology Nov 2005Plummer-Vinson syndrome (sideropenic dysphagia) is characterized by dysphagia due to an upper esophageal or hypopharyngeal web in patients with chronic iron deficiency...
Plummer-Vinson syndrome (sideropenic dysphagia) is characterized by dysphagia due to an upper esophageal or hypopharyngeal web in patients with chronic iron deficiency anemia. The main cause of dysphagia is the presence of the web in the cervical esophagus, and abnormal motility of the pharynx or esophagus is also found to play a significant role in this condition. This syndrome is thought to be precancerous because squamous cell carcinoma of hypopharynx, oral cavity or esophagus takes place in 10% of those patients suffering from this malady, but it is even more unusual that Plummer-Vinson syndrome should be accompanied by gastric cancer. We have reported here a case of a 43-year-old woman with Plummer-Vinson syndrome who developed stomach cancer and recovered after a radical total gastrectomy with D2 nodal dissection.
Topics: Adult; Female; Humans; Plummer-Vinson Syndrome; Radiography; Stomach Neoplasms
PubMed: 16437616
DOI: 10.3748/wjg.v11.i44.7048 -
Indian Journal of Otolaryngology and... Mar 2003A prospective clinico pathological study of Head and Neck Cancer cases presenting in E.N.T. OPD was done and its observations were compared with retrospective studies...
A prospective clinico pathological study of Head and Neck Cancer cases presenting in E.N.T. OPD was done and its observations were compared with retrospective studies done earlier by Gupta et al (1986), It was seen that carcinoma laryngopharynx was the commonest (38.18%) malignancy seen in the present study followed by carcinoma of Larynx (16.36%) and Oesophagus (14.54%). Carcinoma of the nasopharynx was seen in 12.72% cases followed by carcinoma oropharynx (10.91%), Histopathologically; 98.18% cases were of squamous cell carcinomas and out of these only 31.48% were well differentiated carcinoma. There was only 1 case (1.81%) of occult primary. In the retrospective study, the incidence of cancer of Laryngopharynx was 33.33% followed by oropharynx 16.66% and Larynx and Lymphoma (11.11%) each. Occult primary was observed in 3 cases (5.33%) and carcinoma naspoharynx in 4 cases (4.44%). Poor socioeconomic status, bad orodental hygiene, Plummer-vinson syndrome in females were the commonest predisposing factors in addition to smoking, Pan Masala, Zarda and Gutka chewing in the causation of Head and Neck cancer both in prospective and retrospective studies.
PubMed: 23119927
DOI: 10.1007/BF02968745 -
MedGenMed : Medscape General Medicine Aug 2002
Topics: Anemia, Iron-Deficiency; Arthritis, Rheumatoid; Deglutition Disorders; Diagnosis, Differential; Endoscopy, Digestive System; Endoscopy, Gastrointestinal; Esophageal Diseases; Female; Humans; Middle Aged; Plummer-Vinson Syndrome
PubMed: 12466753
DOI: No ID Found -
Journal of the Royal College of... Oct 1992
Topics: Anemia; Deglutition Disorders; Eponyms; Esophagus; Glossitis; Humans; Syndrome
PubMed: 1432899
DOI: No ID Found -
Journal of the Royal College of... Apr 1992
Topics: Anemia, Hypochromic; Deglutition Disorders; Esophageal Stenosis; Female; Humans; Plummer-Vinson Syndrome
PubMed: 1588541
DOI: No ID Found -
Journal of the Royal College of... Oct 1991
Topics: Deglutition Disorders; Eponyms; Humans; Pharynx; Plummer-Vinson Syndrome; Syndrome
PubMed: 1960702
DOI: No ID Found -
Journal of the Royal College of... Jul 1991
Topics: Eponyms; History, 20th Century; Humans; Plummer-Vinson Syndrome; United Kingdom
PubMed: 1801780
DOI: No ID Found -
The Keio Journal of Medicine Jun 1990Plummer-Vinson syndrome has been brought to attention as a precancerous lesion of hypopharyngeal and cervical lesions of the esophagus, but that involving the stomach is... (Review)
Review
Plummer-Vinson syndrome has been brought to attention as a precancerous lesion of hypopharyngeal and cervical lesions of the esophagus, but that involving the stomach is uncommon. We report a case of Plummer-Vinson syndrome with gastric cancer. A brief literature review of this disorder is presented, and possible causes in this unusual case are discussed.
Topics: Aged; Aged, 80 and over; Female; Humans; Iron; Plummer-Vinson Syndrome; Stomach Neoplasms
PubMed: 2214499
DOI: 10.2302/kjm.39.106