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JAAD Case Reports Sep 2020
PubMed: 32885010
DOI: 10.1016/j.jdcr.2020.07.008 -
Dermatopathology (Basel, Switzerland) Aug 2020Degos and Civatte first described clear cell acanthoma (CCA) in 1962 and later in a review article found that, in most instances, the lesion was a solitary red-brown... (Review)
Review
Degos and Civatte first described clear cell acanthoma (CCA) in 1962 and later in a review article found that, in most instances, the lesion was a solitary red-brown dome-shaped papule that involved the distal lower extremity. The first morphologic variant of CCA was reported as a "giant form of the acanthoma of Degos" which measured 45 × 40 mm, about twice the size of the largest CCA documented earlier. Since then, many variants of CCA have been described, including polypoid, pigmented and atypical. Herein, we describe a new variant of CCA and add another example of the polypoid variant to the literature. The new variant exhibits cellular features of trichilemmoma but architecturally differs from it. We also attempt to broaden the list of CCA variants summarized by Tempark and Shwayder by adding ours and a few more examples of CCA. The new variants of CCA include verrucous, linear, subungual and trichilemmal.
PubMed: 32854184
DOI: 10.3390/dermatopathology7020005 -
Postepy Dermatologii I Alergologii Jun 2020
PubMed: 32792892
DOI: 10.5114/ada.2020.96270 -
Clinical Case Reports Apr 2020Intralesional triamcinolone acetonide is an effective treatment for acanthoma fissuratum, and recognition of this condition can negate the need for unnecessary surgical...
Intralesional triamcinolone acetonide is an effective treatment for acanthoma fissuratum, and recognition of this condition can negate the need for unnecessary surgical intervention.
PubMed: 32274040
DOI: 10.1002/ccr3.2708 -
Anais Brasileiros de Dermatologia 2020
Topics: Acanthoma; Biopsy; Dermoscopy; Female; Humans; Middle Aged; Skin Neoplasms; Thorax
PubMed: 32265053
DOI: 10.1016/j.abd.2019.06.015 -
Journal of Cutaneous Pathology Jun 2020Epidermolytic acanthoma (EA) is a rare acquired lesion demonstrating a characteristic histopathological pattern of epidermal degeneration referred to as epidermolytic...
BACKGROUND
Epidermolytic acanthoma (EA) is a rare acquired lesion demonstrating a characteristic histopathological pattern of epidermal degeneration referred to as epidermolytic hyperkeratosis (EHK). On histopathological analysis, EA appears nearly identical to inherited EHK-associated dermatoses such as epidermolytic ichthyosis and ichthyosis bullosa of Siemens. While it has been speculated that EA is caused by mutations in KRT10, KRT1, or KRT2 found in these inherited dermatoses, none have yet been identified. Herein, we aim to identify the contributions of keratin mutations to EA.
METHODS
Using genomic DNA extracted from paraffin-embedded samples from departmental archives, we evaluated a discovery cohort using whole-exome sequencing (WES) and assessed remaining samples using Sanger sequencing screening and restriction fragment length polymorphism (RFLP) analysis.
RESULTS
DNA from 16/20 cases in our sample was of sufficient quality for polymerase chain reaction amplification. WES of genomic DNA from lesional tissue revealed KRT10 c.466C > T, p.Arg156Cys mutations in 2/3 samples submitted for examination. RFLP analysis of these samples as well as eight additional samples confirmed the mutations identified via WES and identified four additional cases with Arg156 mutations. In sum, 6/11 screened cases showed hotspot mutation in KRT10.
CONCLUSIONS
Hotspot mutations in the Arg156 position of KRT10, known to cause epidermolytic ichthyosis, also underlie EA.
Topics: Acanthoma; Adult; Aged; Aged, 80 and over; Female; Genomics; Humans; Hyperkeratosis, Epidermolytic; Ichthyosis Bullosa of Siemens; Keratin-10; Keratins; Male; Middle Aged; Mutation; Skin Neoplasms; Exome Sequencing
PubMed: 32045015
DOI: 10.1111/cup.13664 -
Anais Brasileiros de Dermatologia 2020The Borst-Jadassohn phenomenon is a morphological finding that consists of the presence of well-defined nests of cells located in the spiny stratum of an acanthotic...
The Borst-Jadassohn phenomenon is a morphological finding that consists of the presence of well-defined nests of cells located in the spiny stratum of an acanthotic epidermis. One of the neoplasms where this phenomenon is found is hidroacanthoma simplex. This neoplasm is considered the intraepidermal form of the eccrine poroma. Despite its benign nature, malignant transformations are reported. The present article reports a case of hidroacanthoma simplex and discusses the dermoscopy of this phenomenon.
Topics: Acanthoma; Aged, 80 and over; Biopsy; Dermoscopy; Epidermis; Female; Humans; Skin Neoplasms
PubMed: 31932162
DOI: 10.1016/j.abd.2019.03.004 -
JAAD Case Reports Jan 2020
PubMed: 31890829
DOI: 10.1016/j.jdcr.2019.10.028 -
Anais Brasileiros de Dermatologia 2019Melanoacanthoma is a rare variant of seborrheic keratosis, which is notable for dark pigmentation and fast radial growth, making it difficult to distinguish from...
Melanoacanthoma is a rare variant of seborrheic keratosis, which is notable for dark pigmentation and fast radial growth, making it difficult to distinguish from melanoma. Histologically, it is characterized by proliferation of keratinocytes and dendritic melanocytes. The authors report a scalp lesion, fast growing, suspected by dermoscopy and confocal microscopy examination, with dendritic cells distributed throughout the lesion. Based on these findings, it was not possible to classify this lesion as clearly benign, so it was excised. Histopathologic evaluation and immunostain were consistent with melanoacanthoma.
Topics: Acanthoma; Aged; Dendritic Cells; Dermoscopy; Humans; Keratosis, Seborrheic; Male; Melanocytes; Microscopy, Confocal; Scalp Dermatoses; Skin Neoplasms
PubMed: 31789261
DOI: 10.1016/j.abd.2019.01.002 -
Dermatopathology (Basel, Switzerland) 2019Epidermolytic acanthoma is a rare benign tumor that appears as a solitary papule or, rarely, multiple small papules on the trunk and extremities, or on genitalia. They...
Epidermolytic acanthoma is a rare benign tumor that appears as a solitary papule or, rarely, multiple small papules on the trunk and extremities, or on genitalia. They are generally asymptomatic, although they can be pruritic. The clinical presentation is often misleading, and the lesions are often misdiagnosed histologically and frequently confused with condyloma acuminatum. Here, we report a case of an epidermolytic acanthoma on the penis of a 57-year-old male, whose final diagnosis was made after several years.
PubMed: 31700841
DOI: 10.1159/000499366