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JAAD Case Reports Aug 2018
PubMed: 30128341
DOI: 10.1016/j.jdcr.2018.04.009 -
Dermatology Practical & Conceptual Jul 2018
PubMed: 30116672
DOI: 10.5826/dpc.0803a18 -
Anais Brasileiros de Dermatologia Jun 2018Clear cell acanthoma is an uncommon type of benign epithelial tumor. Typically, it is a solitary lesion found on the lower limbs. It presents as a nodule or small plaque...
Clear cell acanthoma is an uncommon type of benign epithelial tumor. Typically, it is a solitary lesion found on the lower limbs. It presents as a nodule or small plaque with slow and well-defined growth. Diagnosis used to be clinical and histopathological, but the advent of dermoscopy has led to an increase in diagnostic accuracy. We describe a case in which dermoscopy proved highly useful for diagnosis of the lesion.
Topics: Acanthoma; Dermoscopy; Diagnosis, Differential; Humans; Leg; Male; Middle Aged; Skin Neoplasms
PubMed: 29924237
DOI: 10.1590/abd1806-4841.20186977 -
Indian Journal of Dermatology 2018
PubMed: 29692468
DOI: 10.4103/ijd.IJD_524_17 -
Head and Neck Pathology Jun 2019Laugier-Hunziker syndrome (LHS, also termed idiopathic lenticular mucocutaneous hyperpigmentation) is an unusual condition characterized by progressive pigmentation of...
Laugier-Hunziker syndrome (LHS, also termed idiopathic lenticular mucocutaneous hyperpigmentation) is an unusual condition characterized by progressive pigmentation of the mucous membranes. LHS displays a benign course and is not associated with malignancy. Here we present a case of LHS with a 7-year follow-up. We document metachronous oral melanoacanthomas in this individual. In addition, we found that the oral melanotic macules in this patient waxed and waned in a cyclical manner. To our knowledge, this is the first report of these findings in the context of LHS. Finally, we provide an overview of other conditions that can present with mucosal hyperpigmentation. It is critical to distinguish LHS from other conditions characterized by mucosal pigmentation in order to facilitate optimal patient care.
Topics: Acanthoma; Female; Humans; Hyperpigmentation; Middle Aged; Mouth Neoplasms; Skin Neoplasms
PubMed: 29450847
DOI: 10.1007/s12105-018-0897-3 -
Anais Brasileiros de Dermatologia 2017The coiled and dotted vessels in a serpiginous arrangement or "string of pearls" is considered a classical vascular pattern associated with clear cell acanthoma. We...
The coiled and dotted vessels in a serpiginous arrangement or "string of pearls" is considered a classical vascular pattern associated with clear cell acanthoma. We present three cases of epidermal tumors different from clear cell acanthoma that have the same "string of pearls" vascular pattern. Even though most authors keep considering the "string of pearls" vascular pattern an almost pathognomonic sign of clear-cell acanthoma, the cases presented here suggest that some other epidermal tumors can also show this pattern.
Topics: Acanthoma; Aged; Dermoscopy; Diagnosis, Differential; Epidermis; Female; Humans; Keratosis; Keratosis, Seborrheic; Lichen Planus; Male; Middle Aged; Skin Neoplasms
PubMed: 29267474
DOI: 10.1590/abd1806-4841.20176255 -
Anais Brasileiros de Dermatologia 2017Clear cell acanthoma is a rare, epidermal tumor not common in the area of the nipples; indeed, the literature describes only 8 cases, all showing unilateral...
UNLABELLED
Clear cell acanthoma is a rare, epidermal tumor not common in the area of the nipples; indeed, the literature describes only 8 cases, all showing unilateral presentation. We here report the first case of bilateral clear cell acanthoma with good response to topical corticosteroids.
CASE REPORT
A sixteen-year old girl presented with 2 excrescent, fleshy, and exudative tumor masses in both nipples and areola mammae. A biopsy was conducted and confirmed clear cell acanthoma histopathologically. Treatment with strong corticosteroids resulted in rapid improvement and resolution. After one year of follow-up, the patient developed atopic dermatitis.
DISCUSSION
We describe the first case of bilateral clear cell acanthoma localized in the nipple/areola that resolved with powerful corticosteroids, suggesting a reactive etiology of the lesion.
Topics: Acanthoma; Administration, Topical; Adolescent; Biopsy; Clobetasol; Female; Glucocorticoids; Humans; Neoplasms, Multiple Primary; Nipples; Skin Neoplasms; Treatment Outcome
PubMed: 29267438
DOI: 10.1590/abd1806-4841.20175683 -
Dermatology Practical & Conceptual Jul 2017Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described...
Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. We report the first case of RASD mimicking both clinically and dermoscopically a melanoma.
PubMed: 29085717
DOI: 10.5826/dpc.0703a07 -
Case Reports in Dermatology 2017Epidermolytic acanthoma (EA) is a benign cutaneous condition. It is characterized by warty or flat-topped, keratotic papules that show epidermolytic hyperkeratosis in...
Epidermolytic acanthoma (EA) is a benign cutaneous condition. It is characterized by warty or flat-topped, keratotic papules that show epidermolytic hyperkeratosis in histology. EA has been described to occur in various locations, namely the trunk, face, and genitoscrotal area. However, it has not been previously reported to involve the palmar area. To the best of our knowledge, we present the first reported case of EA involving the palms and fingers.
PubMed: 28868008
DOI: 10.1159/000478890 -
Archives of Endocrinology and Metabolism 2017Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of...
Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of multifocal oral melanoacanthoma in a patient diagnosed with Addison's disease and concomitant Graves' disease with hyperthyroidism. The patient presented with oral pigmented lesions, which were hypothesized to be mucosal pigmentation associated with Addison's disease. Due to their unusual clinical pattern, these oral lesions were biopsied and diagnosed as oral melanoacanthoma on histopathology and immunohistochemistry for HMB-45. At the moment of this report, the patient was being treated for her systemic conditions, but the lesions had not regressed. Reactive hyperpigmentation of the skin and mucous membranes may be found in Addison's disease and hyperthyroidism. This case reinforces the hypothesis of a reactive nature for oral melanoacanthoma and highlights the need for investigation of endocrine disorders in patients with multifocal oral melanoacanthoma.
Topics: Acanthoma; Addison Disease; Biopsy; Female; Graves Disease; Humans; Hyperpigmentation; Middle Aged; Mouth Neoplasms; Skin Neoplasms
PubMed: 28658350
DOI: 10.1590/2359-3997000000273