-
Journal of the Royal College of... Oct 1972
Topics: Acetohexamide; Administration, Oral; Animals; Chlorpropamide; Diabetes Mellitus; Diet Therapy; Evaluation Studies as Topic; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Obesity; Phenformin; Pyrimidines; Sulfonamides; Time Factors; Tolbutamide
PubMed: 4627653
DOI: No ID Found -
British Medical Journal Sep 1972
Topics: Acetohexamide; Body Weight; Chlorpropamide; Diabetes Mellitus; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Middle Aged; Tolazamide; Tolbutamide
PubMed: 4631184
DOI: 10.1136/bmj.3.5828.692 -
The Journal of Clinical Investigation Sep 1972Long-term clinical studies have associated tolbutamide therapy with an increased incidence of cardiovascular deaths. The effects of this and other sulfonylurea drugs on...
Long-term clinical studies have associated tolbutamide therapy with an increased incidence of cardiovascular deaths. The effects of this and other sulfonylurea drugs on contractility and rate of isolated rabbit atria, automaticity of isolated dog Purkinje fibers, and adenyl cyclase activity in particulate preparations of rabbit and human hearts were studied. At concentrations that are attained clinically, tolbutamide (10 mg/100 ml) increased contractility of driven rabbit atria to 124+/-5% of control, acetohexamide (3.9 mg/100 ml) to 140+/-5%, chlorpropamide (8.3 mg/100 ml) to 139+/-6%, and tolazamide (3.1 mg/100 ml) to 119+/-6%. These effects were accentuated in the presence of 2.5 x 10(-4) M theophylline and were not blocked by 1 x 10(-5) M propranolol. Adenyl cyclase was activated by each of these drugs at concentrations below those which increase contractility. The drugs also increased the rate and slope of phase 4 depolarization in spontaneously beating Purkinje fibers, but did not alter the spontaneous rate of isolated rabbit atria. Since inotropic and chronotropic stimulation can be deleterious in some clinical settings, these findings may be of significance in interpretation of cardiovascular mortality data.
Topics: Acetohexamide; Adenylyl Cyclases; Animals; Chlorpropamide; Culture Techniques; Cyclic AMP; Dogs; Heart; Heart Atria; Heart Conduction System; Humans; Membrane Potentials; Microelectrodes; Myocardium; Phenformin; Propranolol; Rabbits; Stimulation, Chemical; Sulfonylurea Compounds; Theophylline; Tolazamide; Tolbutamide
PubMed: 4344732
DOI: 10.1172/JCI107056 -
Canadian Medical Association Journal Nov 1971
Topics: Acetohexamide; Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Female; Health Education; Humans; Insulin; Male; Patient Care Team; Personality; Phenformin; Pregnancy; Pregnancy in Diabetics; Tolbutamide
PubMed: 5150198
DOI: No ID Found -
British Medical Journal Jul 1971
Topics: Acetohexamide; Acidosis; Administration, Oral; Anemia; Chlorpropamide; Drug Antagonism; Drug Synergism; England; Ethanol; Female; Fetus; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Metformin; Phenformin; Pregnancy; Scotland; Skin Diseases; Skin Manifestations; Tolazamide; Tolbutamide; Wales
PubMed: 5091891
DOI: 10.1136/bmj.3.5765.29 -
Archives of Disease in Childhood Oct 1970Three infants whose diabetic mothers were given chlorpropamide and one infant whose diabetic mother was given acetohexamide up to the time of delivery were studied in...
Three infants whose diabetic mothers were given chlorpropamide and one infant whose diabetic mother was given acetohexamide up to the time of delivery were studied in the neonatal period because each became severely hypoglycaemic. The sulphonylurea drugs given to the mother crossed the placenta, and fetal plasma concentrations were in the therapeutic range for adults with diabetes mellitus. Each baby had severe hyperinsulinaemia resulting in profound hypoglycaemia. These acutely ill infants needed vigorous and prolonged treatment to correct the hypoglycaemia. In two infants exchange transfusion was performed to remove the drug. These sulphonylurea drugs should not be used to control diabetes mellitus in pregnancy.
Topics: Acetohexamide; Chlorpropamide; Exchange Transfusion, Whole Blood; Female; Fetus; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Insulin; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy in Diabetics
PubMed: 5477685
DOI: 10.1136/adc.45.243.696 -
British Medical Journal Mar 1969
Topics: Acetohexamide; Animals; Chlorpropamide; Guinea Pigs; Humans; Hypoglycemic Agents; Metformin; Phenformin; Tolbutamide
PubMed: 5774083
DOI: No ID Found -
Effects of puromycin, acetoxycycloheximide and actinomycin D on protein synthesis in goldfish brain.Journal of Neurochemistry Oct 1966
Topics: Acetohexamide; Animals; Brain; Dactinomycin; Fishes; In Vitro Techniques; Injections, Intraperitoneal; Leucine; Nerve Tissue Proteins; Puromycin; Tritium
PubMed: 5927758
DOI: 10.1111/j.1471-4159.1966.tb10284.x -
British Medical Journal Apr 1964
Topics: Acetohexamide; Blood Chemical Analysis; Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Gastroenterology; Geriatrics; Glucose Tolerance Test; Hypoglycemic Agents; Leukopenia; Middle Aged; Tolbutamide; Toxicology
PubMed: 14104973
DOI: 10.1136/bmj.1.5387.868