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The Tohoku Journal of Experimental... Apr 1977Chronotropic effects of 6 coronary vasodilators, carbochromen, dilazep, diltiazem, dipyridamole, nifedipine and verapamil, were compared by close-arterial administration...
Chronotropic effects of 6 coronary vasodilators, carbochromen, dilazep, diltiazem, dipyridamole, nifedipine and verapamil, were compared by close-arterial administration to the isolated, blood-perfused sino-atrial node preparation of the dog. All drugs produced a dose-related decrease in sinus rate, and the order of negative chronotropic potency determined on a weight basis was as follows: (formula: see text). Higher doses of these drugs except dipyridamole caused atrial standstill. The order of potency causing atrial standstill determined on a weight basis was as follows: (formula: see text). Dipyridamole in lower doses produced a negative chronotropic effect alone, but with higher doses a positive chronotropic effect preceded a negative one. Carbochromen in a wide range of doses produced a triphasic response consisting of initial brief positive, succeeding main negative and final gradually-developing slight positive components.
Topics: Animals; Depression, Chemical; Dilazep; Dogs; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Nifedipine; Sinoatrial Node; Stimulation, Chemical; Vasodilator Agents; Verapamil
PubMed: 867424
DOI: 10.1620/tjem.121.383 -
British Heart Journal Jun 1976An asymptomatic patient with cardiomegaly caused by isolated right atrial standstill is reported. The right atrium showed no evidence of contraction on pressure records...
An asymptomatic patient with cardiomegaly caused by isolated right atrial standstill is reported. The right atrium showed no evidence of contraction on pressure records or angiographically, while the left atrium functioned normally.
Topics: Adult; Cardiomegaly; Electrocardiography; Female; Heart Atria; Heart Block; Humans; Myocardial Contraction
PubMed: 132178
DOI: 10.1136/hrt.38.6.646 -
British Heart Journal May 1962
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Cardiomyopathies; Genetic Diseases, Inborn; Heart Atria; Heart Block; Heart Conduction System; Humans; Hyperkalemia; Nephritis; Potassium
PubMed: 13923225
DOI: 10.1136/hrt.24.3.389