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Mediterranean Journal of Rheumatology Mar 2024Wilson disease is a rare genetic disorder, characterised by excessive deposition of copper in the liver, brain, and other tissues. Penicillamine, a copper-chelating...
INTRODUCTION
Wilson disease is a rare genetic disorder, characterised by excessive deposition of copper in the liver, brain, and other tissues. Penicillamine, a copper-chelating agent, is used in high doses in the treatment of Wilson disease leading to a variety of cutaneous reactions, including hyper-sensitivity reactions, pseudoxanthoma elasticum, elastosis perforans serpiginosa, anetoderma, and cutis laxa (CL). We present a rare case of localised CL induced by penicillamine for Wilson disease, in the absence of elastosis perforans serpiginosa.
CASE DESCRIPTION
A 41-year-old male with Wilson disease treated with long-term high-dose penicillamine was referred to us for a basal cell carcinoma on the scalp. On physical examination, diffusely flaccid and redundant skin on the right side of the neck were observed. Histopathology revealed findings consistent with CL.
CONCLUSION
Long-term treatment with penicillamine for Wilson disease may induce localized CL, possibly by direct inhibition of cross-linkage of collagen fibres.
PubMed: 38736957
DOI: 10.31138/mjr.280223.pil -
JAAD International Jun 2024
PubMed: 38545486
DOI: 10.1016/j.jdin.2024.02.002 -
Cureus Dec 2022Pilomatrixoma, or calcifying epithelioma of Malherbe, is a benign tumor with differentiation toward the hair matrix cells and is one of childhood's most common...
Pilomatrixoma, or calcifying epithelioma of Malherbe, is a benign tumor with differentiation toward the hair matrix cells and is one of childhood's most common epithelial tumors. Bullous pilomatrixoma has an extremely low incidence of occurrence, usually appears in the upper extremities, and is frequently associated with trauma. We report the case of a bullous pilomatrixoma in a patient with a rapid-growing neoformation one month after receiving a coronavirus disease 2019 (COVID-19) vaccine in his left upper arm, and we discuss whether the bullous appearance is part of the biology of the tumor or a secondary anetoderma.
PubMed: 36636528
DOI: 10.7759/cureus.32370 -
Dermatology Reports Jun 2022Syphilitic balanitis of Follmann (FB) is a rarely described manifestation of primary syphilis that was first reported in 1948. Its clinical appearance may be...
Syphilitic balanitis of Follmann (FB) is a rarely described manifestation of primary syphilis that was first reported in 1948. Its clinical appearance may be heterogeneous varying from painful edematous balanoposthitis to superficial erosive balanitis and asymptomatic glans induration. We described a patient presenting with FB, as manifestation of primary syphilis, and concurrent anetoderma, as manifestation of secondary syphilis. The association of these lesions was never described to date.
PubMed: 35795840
DOI: 10.4081/dr.2021.9271 -
Indian Pediatrics Jan 2022
Topics: Anetoderma; Humans; Skin
PubMed: 35060490
DOI: No ID Found -
Indian Journal of Sexually Transmitted... 2021Anetoderma also called macular atrophy is a rare, benign disorder characterized microscopically by the pan-dermal loss of elastic fibers in the dermis and presenting...
Anetoderma also called macular atrophy is a rare, benign disorder characterized microscopically by the pan-dermal loss of elastic fibers in the dermis and presenting clinically as circumscribed, skin-colored or gray-white atrophic macules and/or patches on the trunk and/or extremities. Lesions are described as having a "sac-like" appearance, since they bulge or herniate upon palpation. It is a rare benign condition of diverse etiology; whose characteristic is the diminution or absence of the dermal elastic fibers. Anetoderma is divided into primary (idiopathic) and secondary anetoderma, with the former occurring in areas of previously normal skin and the latter developing in areas of prior skin pathology. Both may occur in association with underlying systemic conditions and warrant evaluation for associated disorders. There are no effective treatment options for anetoderma at present. We report here an unusual case of generalized anetoderma occurring in association with secondary syphilis treated with injection benzathine penicillin.
PubMed: 34909625
DOI: 10.4103/ijstd.IJSTD_81_19 -
JAMA Dermatology Aug 2021This case series observes 5 patients treated with nivolumab and cabiralizumab with stereotactic radiotherapy who developed punctate, atrophic depressions with histologic...
Punctate Anetoderma After Colony-Stimulating Factor 1 Receptor and Programmed Cell Death 1 Blockade With Irradiation: Clinicopathologic Characterization of a Novel Eruption.
This case series observes 5 patients treated with nivolumab and cabiralizumab with stereotactic radiotherapy who developed punctate, atrophic depressions with histologic findings of elastolysis.
Topics: Anetoderma; Apoptosis; Exanthema; Humans; Neoplasm Proteins; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Transcription Factors
PubMed: 34190956
DOI: 10.1001/jamadermatol.2021.2049 -
Annals of Dermatology Apr 2020The treatment of choice for pilomatricomas is surgical excision; however, data for the optimal timing of treatment and cosmetic outcomes are limited.
BACKGROUND
The treatment of choice for pilomatricomas is surgical excision; however, data for the optimal timing of treatment and cosmetic outcomes are limited.
OBJECTIVE
This study aimed to investigate the optimal timing of treatment in pilomatricomas by considering clinicopathological findings and cosmetic outcomes.
METHODS
Seventy-three pilomatricomas patients aged ≤15 years were retrospectively reviewed. Patients were classified into early excision (disease duration ≤12 months, group A) and delayed excision groups (disease duration >12 months, group B). Tumor characteristics, and histopathological features with evolutionary stages were assessed. Cosmetic outcomes were evaluated by the Modified Vancouver Scar Scale (MVSS), 5-point patient satisfaction score, and complication rates.
RESULTS
Group A showed better cosmetic outcomes than group B in the MVSS (1.53±1.22 vs. 3.68±1.84), 5-point patient satisfaction score (4.08±0.89 vs. 3.18±1.01), and complication rates (11.8% vs. 36.4%), respectively (<0.05). Secondary anetoderma, tent sign, calcification, and late regressive stage (evolutionary stage IV) were more common in group B, (<0.05). Moreover, evolutionary stages showed a positive correlation with mean MVSS (r=0.670, <0.05).
CONCLUSION
Early excision (disease duration ≤12 months) provides superior cosmetic outcomes compared to delayed procedures. Early recognition, diagnosis, and management for pediatric pilomatricomas is important to improve overall cosmetic outcomes.
PubMed: 33911719
DOI: 10.5021/ad.2020.32.2.93 -
Clinical Case Reports Dec 2020Anetoderma is a rare cutaneous disorder presenting with atrophic skin lesions. It can be associated with several autoimmune and infectious diseases. With the current...
Anetoderma is a rare cutaneous disorder presenting with atrophic skin lesions. It can be associated with several autoimmune and infectious diseases. With the current resurgence of syphilis, clinicians must be aware of its association with anetoderma.
PubMed: 33363992
DOI: 10.1002/ccr3.3290